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1
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0028833485
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Physician office visits for low back pain: Frequency, clinical evaluation, and treatment patterns from a US National Survey
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Hart LG, Deyo RA, Cherkin DC. Physician office visits for low back pain: frequency, clinical evaluation, and treatment patterns from a US National Survey. Spine.. 1995; 20: 11-19.
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(1995)
Spine.
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Hart, L.G.1
Deyo, R.A.2
Cherkin, D.C.3
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2
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0025308318
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Abnormal magnetic resonance scans of the lumbar spine in asymptomatic subjects
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Boden SC, Davis DO, Dina TS, et al. Abnormal magnetic resonance scans of the lumbar spine in asymptomatic subjects. J Bone Joint Surg. 1990; 72 (A): 403-408.
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J Bone Joint Surg.
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Boden, S.C.1
Davis, D.O.2
Dina, T.S.3
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6
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38049087670
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Amidic alginate hydrogel for nucleus pulposus replacement
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This study evaluated the viscoelastic properties of an amidic alginate hydrogel in vitro and found it comparable to non-degenerated human lumbar nucleus pulposus. They also found that their hydrogel scaffold could stimulate extracellular matrix components such as cathepsin B, aggrecan and type II collagen.
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Leone G, Torricelli P, Chiumiento A, et al. Amidic alginate hydrogel for nucleus pulposus replacement. J Biomed Mat Res Part A. 2007; 84A-2: 391-401. This study evaluated the viscoelastic properties of an amidic alginate hydrogel in vitro and found it comparable to non-degenerated human lumbar nucleus pulposus. They also found that their hydrogel scaffold could stimulate extracellular matrix components such as cathepsin B, aggrecan and type II collagen.
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(2007)
J Biomed Mat Res Part A.
, vol.84 A
, Issue.2
, pp. 391-401
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Leone, G.1
Torricelli, P.2
Chiumiento, A.3
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7
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70349246286
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Tissue-engineered composite of three dimensional PLGA scaffold seeded with nucleus pulposus cells for intervertebral disc regeneration
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Zhang C, Dike R, Zhang R, et al. Tissue-engineered composite of three dimensional PLGA scaffold seeded with nucleus pulposus cells for intervertebral disc regeneration. Proceedings of the NASS 23rd Annual Meeting. The Spine. Journal. 2008; 8: 117S-119S.
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(2008)
Proceedings of the NASS 23rd Annual Meeting. The Spine. Journal.
, vol.8
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Zhang, C.1
Dike, R.2
Zhang, R.3
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8
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36249008658
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An injectable cross-linked scaffold for nucleus pulposus regeneration
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These investigators seeded bovine calf tail NP cells in an atecollagen type II scaffold with and without mTGase cross-linking and with varying concentrations of aggrecan and hyaluronan. Seeded scaffolds were analyzed for DNA content, cell viability, glycosaminoglycan uptake, and sulfate incorporation. They found that the scaffolds were able to support NP viability and normal phenotypic expression, and that mTGase cross-linking provided a more stable cellular scaffold than non-enzymatically linked scaffolds
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Halloran D, Grad S, Stoddart M, et al. An injectable cross-linked scaffold for nucleus pulposus regeneration. Biomaterials. 2008; 29: 438-447. These investigators seeded bovine calf tail NP cells in an atecollagen type II scaffold with and without mTGase cross-linking and with varying concentrations of aggrecan and hyaluronan. Seeded scaffolds were analyzed for DNA content, cell viability, glycosaminoglycan uptake, and sulfate incorporation. They found that the scaffolds were able to support NP viability and normal phenotypic expression, and that mTGase cross-linking provided a more stable cellular scaffold than non-enzymatically linked scaffolds.
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(2008)
Biomaterials
, vol.29
, pp. 438-447
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Halloran, D.1
Grad, S.2
Stoddart, M.3
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9
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50649096453
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Regeneration of intervertebral disc tissue by resorbable cell-free polyglycolic acid-based implants in a rabbit model of disc degeneration
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In this in vivo study, a PGA felt and hyaluronic acid scaffold was immersed in serum and implanted into nucleotomized rabbits. The rabbits were evaluated by T2 weighted MRI and by histology. The investigators found that after 1 week postoperatively both the implanted group and the controls demonstrated MRI evidence of degeneration, but at 6 months the implanted discs showed MRI evidence of regeneration while the degenerating controls continued to degenerate. Histological examination demonstrated cell migration into the nucleotomy defect and tissue regeneration.
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Abushi A, Endres M, Cabraja M, et al. Regeneration of intervertebral disc tissue by resorbable cell-free polyglycolic acid-based implants in a rabbit model of disc degeneration. Spine.. 2008; 33: 1527-1532. In this in vivo study, a PGA felt and hyaluronic acid scaffold was immersed in serum and implanted into nucleotomized rabbits. The rabbits were evaluated by T2 weighted MRI and by histology. The investigators found that after 1 week postoperatively both the implanted group and the controls demonstrated MRI evidence of degeneration, but at 6 months the implanted discs showed MRI evidence of regeneration while the degenerating controls continued to degenerate. Histological examination demonstrated cell migration into the nucleotomy defect and tissue regeneration.
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(2008)
Spine.
, vol.33
, pp. 1527-1532
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Abushi, A.1
Endres, M.2
Cabraja, M.3
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10
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23244447213
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Evaluation of polymer scaffolds to be used in a composite injectable system for intervertebral disc tissue engineering
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Brown RQ, Mount A, Burg KJL. Evaluation of polymer scaffolds to be used in a composite injectable system for intervertebral disc tissue engineering. J Biomed Mat Res A. 2005; 74A: 32-39.
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(2005)
J Biomed Mat Res A.
, vol.74 A
, pp. 32-39
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Brown, R.Q.1
Mount, A.2
Burg, K.J.L.3
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11
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17144411117
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Biological evaluation of chitosan salts cross-linked to genipin as a cell scaffold for disk tissue engineering
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Mwale F, Iordanova M, Demers CN, et al. Biological evaluation of chitosan salts cross-linked to genipin as a cell scaffold for disk tissue engineering. Tissue Eng. 2005; 11: 130-141.
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(2005)
Tissue Eng.
, vol.11
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Mwale, F.1
Iordanova, M.2
Demers, C.N.3
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12
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47049099935
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Rheological characterization of photopolymerized poly(vinyl alcohol) hydrogels for potential use in nucleus pulposus replacement
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This biomechanical study compared PVA with normal nucleus pulposus in vitro using sheep lumbar spines under conditions of dynamic torsional shear at physiologic frequencies. They also subjected the hydrogel discs to degradation conditions by submerging them in Hank's solution and then evaluating rheological behavior at various time intervals. The investigators found the PVA to be comparable to natural tissue when conditions of photopolymerization were properly modulated, and that the PVA did not degrade after submersion in Hank's media
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Bader RA, Rochefort WE. Rheological characterization of photopolymerized poly(vinyl alcohol) hydrogels for potential use in nucleus pulposus replacement. J Biomed Mat Res A. 2008; 86A: 494-501. This biomechanical study compared PVA with normal nucleus pulposus in vitro using sheep lumbar spines under conditions of dynamic torsional shear at physiologic frequencies. They also subjected the hydrogel discs to degradation conditions by submerging them in Hank's solution and then evaluating rheological behavior at various time intervals. The investigators found the PVA to be comparable to natural tissue when conditions of photopolymerization were properly modulated, and that the PVA did not degrade after submersion in Hank's media.
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(2008)
J Biomed Mat Res A.
, vol.86 A
, pp. 494-501
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Bader, R.A.1
Rochefort, W.E.2
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13
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34447326168
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Antidegenerative effects of partial disc replacement in an animal surgery model
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In this in vivo study investigators pierced L2-3 and L3-4 of Japanese White Rabbits with a Kirshner wire and implanted a poly(vinyl alcohol) rod into the hole. They evaluated the discs radiologically and histologically at 1, 3 and 6 months and found that the PVA rods prevented disc height collapse and delayed degeneration of the annulus fibrosus
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So K, Takemoto M, Fujibayashi S, et al. Antidegenerative effects of partial disc replacement in an animal surgery model. Spine.. 2007; 32: 1586-1591. In this in vivo study investigators pierced L2-3 and L3-4 of Japanese White Rabbits with a Kirshner wire and implanted a poly(vinyl alcohol) rod into the hole. They evaluated the discs radiologically and histologically at 1, 3 and 6 months and found that the PVA rods prevented disc height collapse and delayed degeneration of the annulus fibrosus.
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(2007)
Spine.
, vol.32
, pp. 1586-1591
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So, K.1
Takemoto, M.2
Fujibayashi, S.3
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14
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36148989224
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Material properties in unconfined compression of human nucleus pulposus, injectable hyaluronic acid-based hydrogels and tissue engineering scaffolds
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Five non-degenerate human lumbar discs were removed and implanted with an experimental synthetic hyaluronic acid-based hydrogel and then subjected to incremental stress-relaxation in a compression chamber. The investigators described the importance of Poisson's ratio (constrained lateral expansion under axial compression) as it applies to the load transfer between the NP and the annulus fibrosus
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Cloyd JM, Malhotra NR, Weng L, et al. Material properties in unconfined compression of human nucleus pulposus, injectable hyaluronic acid-based hydrogels and tissue engineering scaffolds. Euro Spine.. 2007; 16: 1892-1898. Five non-degenerate human lumbar discs were removed and implanted with an experimental synthetic hyaluronic acid-based hydrogel and then subjected to incremental stress-relaxation in a compression chamber. The investigators described the importance of Poisson's ratio (constrained lateral expansion under axial compression) as it applies to the load transfer between the NP and the annulus fibrosus.
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(2007)
Euro Spine.
, vol.16
, pp. 1892-1898
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Cloyd, J.M.1
Malhotra, N.R.2
Weng, L.3
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15
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37549042456
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Evaluation of novel injectable hydrogels for nucleus pulposus replacement
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This in vitro biomechanical study investigated compression and stress-relaxation on a group of temperature sensitive injectable hydrogels composed of poly-N-isopropylacrylamide with variable concentrations of polyethylene glycol. The authors identified a polyethylene glycol concentration that optimizes elasticity, stiffness, and water content, and proposed this construct as a candidate for future study
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Vernego J, Fussell GW, Smith NG, et al. Evaluation of novel injectable hydrogels for nucleus pulposus replacement. J Biomed Mat Res B. 2008; 84B: 64-69. This in vitro biomechanical study investigated compression and stress-relaxation on a group of temperature sensitive injectable hydrogels composed of poly-N-isopropylacrylamide with variable concentrations of polyethylene glycol. The authors identified a polyethylene glycol concentration that optimizes elasticity, stiffness, and water content, and proposed this construct as a candidate for future study.
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(2008)
J Biomed Mat Res B.
, vol.84 B
, pp. 64-69
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Vernego, J.1
Fussell, G.W.2
Smith, N.G.3
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16
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42149185511
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PH-Responsive microgel dispersions for repairing damaged load-bearing soft tissue
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These investigators induced controlled localized degeneration of bovine intervertebral discs using collagenase (which lyses type II collagen). Then a pH-sensitive microgel was implanted, followed immediately by an alkaline solution to induce gelling. The implanted discs exhibited hysteresis and creep under loading conditions. The microgel demonstrated good biocompatibility, but was found to re-disperse after 5 days. Future work with this pH-responsive microgel will seek to control the rate of biodegradation
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Freemont TJ. Saunders BR. pH-Responsive microgel dispersions for repairing damaged load-bearing soft tissue. Soft Matter. 2008; 4: 919-924. These investigators induced controlled localized degeneration of bovine intervertebral discs using collagenase (which lyses type II collagen). Then a pH-sensitive microgel was implanted, followed immediately by an alkaline solution to induce gelling. The implanted discs exhibited hysteresis and creep under loading conditions. The microgel demonstrated good biocompatibility, but was found to re-disperse after 5 days. Future work with this pH-responsive microgel will seek to control the rate of biodegradation.
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(2008)
Soft Matter.
, vol.4
, pp. 919-924
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Freemont, T.J.1
Saunders, B.R.2
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17
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70349257126
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Two-Year interim European clinical results of nucleus replacement using an in situ cured balloon contained injectable polyurethane device. Proceedings of the NASS 23rd Annual Meeting
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Sherman J, Ahrens M, Yuan H, et al. Two-Year interim European clinical results of nucleus replacement using an in situ cured balloon contained injectable polyurethane device. Proceedings of the NASS 23rd Annual Meeting. Spine. J. 2008; 8: 7S.
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Spine. J.
, vol.8
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Sherman, J.1
Ahrens, M.2
Yuan, H.3
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18
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28044471355
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Mechanical testing of a novel hydrogel nucleus replacement implant
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Bertagnoli R, Sabatino CT, Edwards JT, et al. Mechanical testing of a novel hydrogel nucleus replacement implant. Spine. J. 2005; 5: 672-681.
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Bertagnoli, R.1
Sabatino, C.T.2
Edwards, J.T.3
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19
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0036033927
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The PDN Prosthetic disc-nucleus device
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Ray CD. The PDN Prosthetic disc-nucleus device. Euro Spine.. 2002; 11 (supplement 2): S137-S142.
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(2002)
Euro Spine.
, vol.11
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Ray, C.D.1
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20
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0036032344
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Surgical and clinical results with the PDN Prosthetic Disc-Nucleus Device
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Bertagnoli R, Schonmayr R. Surgical and clinical results with the PDN Prosthetic Disc-Nucleus Device. Euro Spine.. 2002; 11 (supplement 2): S143-S148.
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Euro Spine.
, vol.11
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Bertagnoli, R.1
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Artificial nucleus replacement
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Klara PM, Ray CD. Artificial nucleus replacement. Spine.. 2002; 27: 1374-1377.
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Klara, P.M.1
Ray, C.D.2
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22
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0036034166
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A spiral implant as nucleus prosthesis in the lumbar spine
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Korge A, Nydegger T, Polard JL, et al. A spiral implant as nucleus prosthesis in the lumbar spine. Euro Spine.. 2002; 11 (supplement 2): S149-S153.
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Euro Spine.
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Korge, A.1
Nydegger, T.2
Polard, J.L.3
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23
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0043071120
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A memory coiling spiral as nucleus pulposus prosthesis: concept, specifications, bench testing, and first clinical results
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Husson JL, Korge A, Polard JL, et al. A memory coiling spiral as nucleus pulposus prosthesis: concept, specifications, bench testing, and first clinical results. J Spinal Disord Tech. 2003; 16: 405-411.
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, vol.16
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Husson, J.L.1
Korge, A.2
Polard, J.L.3
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24
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Is a collagen scaffold for a tissue engineered nucleus replacement capable of restoring disc height and stability in an animal model?
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Wilke HJ, Heuer F, Neidlinger-Wilke C, et al. Is a collagen scaffold for a tissue engineered nucleus replacement capable of restoring disc height and stability in an animal model? Euro Spine.. 2006; 15 (3 Supplement): 433-438.
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, vol.15
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Wilke, H.J.1
Heuer, F.2
Neidlinger-Wilke, C.3
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25
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55249106898
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Biomechanical evaluation of conventional annulus fibrosus closure methods required for nucleus replacement
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Investigators performed a nucleotomy on 30 calf lumbar functional spinal units and implanted a collagen matrix through a custom-built application tube. They compared the strength of annular defect closure using sutures, fibrin-thrombin glue, cryanoacrylate glue, and combinations thereof, using a cyclical loading robot. They found that sutures and cryanoacrylate glue resisted the greatest number of fatigue cycles, but all methods eventually failed
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Heuer F, Ulrich S, Claes L, et al. Biomechanical evaluation of conventional annulus fibrosus closure methods required for nucleus replacement. J Neurosurg: Spine.. 2008; 9: 307-313. Investigators performed a nucleotomy on 30 calf lumbar functional spinal units and implanted a collagen matrix through a custom-built application tube. They compared the strength of annular defect closure using sutures, fibrin-thrombin glue, cryanoacrylate glue, and combinations thereof, using a cyclical loading robot. They found that sutures and cryanoacrylate glue resisted the greatest number of fatigue cycles, but all methods eventually failed.
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(2008)
J Neurosurg: Spine..
, vol.9
, pp. 307-313
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Heuer, F.1
Ulrich, S.2
Claes, L.3
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26
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Preclinical evaluation of a poly(vinyl alcohol) hydrogel implant as a replacement for the nucleus pulposus
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Allen MJ, Schoonmaker JE, Bauer TW, et al. Preclinical evaluation of a poly(vinyl alcohol) hydrogel implant as a replacement for the nucleus pulposus. Spine.. 2004; 29: 515-523.
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(2004)
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, vol.29
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Allen, M.J.1
Schoonmaker, J.E.2
Bauer, T.W.3
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27
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70349244608
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Prosthetic disc nucleus (PDN) replacement for lumbar disc herniation report with four year follow-up. Proceedings of the NASS 23rd Annual Meeting
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Zhao L, Qu D, Jin D, et al. Prosthetic disc nucleus (PDN) replacement for lumbar disc herniation report with four year follow-up. Proceedings of the NASS 23rd Annual Meeting. Spine.. 2008; 8: 60S.
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, vol.8
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Zhao, L.1
Qu, D.2
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33748577711
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Injectable biomaterials and vertebral endplate treatment for repair and regeneration of the intervertebral disc
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Boyd LM, Carter AJ. Injectable biomaterials and vertebral endplate treatment for repair and regeneration of the intervertebral disc. Euro Spine.. 2006; 15 (supplement 3): S414-S421.
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Euro Spine.
, vol.15
, Issue.SUPPL. 3
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Boyd, L.M.1
Carter, A.J.2
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23944489338
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Nucleus pulposus replacement: basic science and indications for clinical use
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Di Martino A, Vaccaro AR, Lee JY, et al. Nucleus pulposus replacement: basic science and indications for clinical use. Spine.. 2005; 30 (16S): S16-S22.
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Spine.
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Di Martino, A.1
Vaccaro, A.R.2
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Biphasic scaffold for annulus fibrosus tissue regeneration
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Wan Y, Feng G, Shen FH, et al. Biphasic scaffold for annulus fibrosus tissue regeneration. J Biomat. 2008; 29: 643-652.
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Wan, Y.1
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