Acute myocarditis in children: Current concepts and management

Current Treatment Options in Cardiovascular Medicine

Volumn 11, Issue 5, 2009, Pages 383-391

  Vashist, Sudhir ^a   Singh, Gautam K ^b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMIODARONE; AZATHIOPRINE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CARVEDILOL; CATECHOLAMINE; CYCLOSPORIN; DIGITALIS; DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; IMMUNOGLOBULIN; IMMUNOMODULATING AGENT; IMMUNOSUPPRESSIVE AGENT; INTERFERON; INTERFERON BETA SERINE; LIDOCAINE; MILRINONE; NESIRITIDE; PLACEBO; PREDNISONE; STEROID; VASOPRESSIN;

ACUTE DISEASE; ACUTE HEART FAILURE; ANTIVIRAL ACTIVITY; ARTIFICIAL HEART PACEMAKER; ARTIFICIAL VENTILATION; ASSISTED CIRCULATION; ATRIOVENTRICULAR BLOCK; CARDIOGENIC SHOCK; CARDIOMYOPATHY; CARDIOVERSION; CHILD; CHILDHOOD DISEASE; CLINICAL TRIAL; CONGESTIVE CARDIOMYOPATHY; CONGESTIVE HEART FAILURE; DEVICE INFECTION; DEVICE THERAPY; DIAGNOSTIC TEST; DIAGNOSTIC VALUE; DOSE RESPONSE; DRUG DOSE TITRATION; EXTRACORPOREAL CIRCULATION; HEART ASSIST DEVICE; HEART DISEASE; HEART FAILURE; HEART LEFT VENTRICLE FAILURE; HEART MUSCLE BIOPSY; HEART TRANSPLANTATION; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE FIBRILLATION; HUMAN; IMMUNOADSORPTION; IMMUNOSUPPRESSIVE TREATMENT; LOW DRUG DOSE; LUNG INSUFFICIENCY; MYOCARDITIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; REVIEW; SUPRAVENTRICULAR TACHYCARDIA; THROMBOEMBOLISM; UNSPECIFIED SIDE EFFECT; VIRUS MYOCARDITIS;

EID: 70349251390     PISSN: 10928464     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11936-009-0039-z     Document Type: Review

References (58)

1. Aretz HA, Billingham ME, Edwards WD, et al.: Myocarditis: a histopathologic definition and classification. Am J Cardiovasc Pathol 1987, 1:3-14.
2. Bowles NE, Bowles KR, Towbin JA: Viral genome detection and outcome in myocarditis. Heart Failure Clin 2005, 1:407-417.
3. Köhl U, Pauschinger M, Noutsias M, et al.: High prevalence of viral genomes and multiple viral infections in the myocardium of adults with "idiopathic" left ventricular dysfunction. Circulation 2005, 111:887-893.
4. Cooper LT: Myocarditis. N Engl J Med 2009, 360:1526-1538.
5. Bowles NE, Ni J, Kearney DL, et al.: Detection of viruses in myocardial tissues by polymerase chain reaction. Evidence of adenovirus as a common cause of myocarditis in children and adults. J Am Coll Cardiol 2003, 42:466-472.
6. Maron BJ, Doerer JJ, Haas TS, et al.: Sudden deaths in young competitive athletes: Analysis of 1866 deaths in the United States, 1980-2006. Circulation 2009, 119:1085-1092.
7. Nugent AW, Daubeney PEF, Chondros P, et al.: The epidemiology of childhood cardiomyopathy in Australia. N Engl J Med 2003, 348:1639-1646.
8. Towbin JA, Lowe AM, Colan SD, et al.: Incidence, causes, and outcomes of dilated cardiomyopathy in children. JAMA 2006, 296:1867-1876.
9. Friedrich MG, Sechtem U, Schulz-Menger J, et al.: Cardiovascular magnetic resonance in myocarditis: A JACC white paper. J Am Coll Card 2009, 53:1475-1487.
10. Liu PP, Yan AT: Cardiovascular magnetic resonance for the diagnosis of acute myocarditis. Prospects for detecting myocardial inflammation. J Am Coll Cardiol 2005, 45:1823-1825.
11. Grogan M, Redfield MM, Bailey KR, et al.: Long-term outcome of patients with biopsy-proven myocarditis: Comparison with idiopathic dilated cardiomyopathy. J Am Coll Cardiol 1995, 26:80-84.
12. Cooper LT, Baughman KL, Feldman AM, et al.: The role of endomyocardial biopsy in the management of cardiovascular disease: A scientific statement from the American Heart Association, The American College of Cardiology, and the European Society of Cardiology. Circulation 2007, 116:2216-2233.
13. Foerester S, Canter C, Carey A, et al.: A comparative analysis of outcomes for pediatric patients with biopsy-proven myocarditis, clinically-diagnosed myocarditis and idiopathic dilated cardiomyopathy. Circulation 2007, 116:II-565.
14. Laissy JP, Hyafil F, Feldman LJ, et al.: Differentiating acute myocardial infarction from myocarditis: Diagnostic value of early- and delayed-perfusion cardiac MR imaging. Radiology 2005, 237:75-82.
15. Vashist S, Woodard PK, Singh G, et al.: MRI characteristics of acute myocarditis in pediatric patients: Patterns and predictors of outcomes. J Am Coll Cardiol 2009, 53:A144-A197.
16. Rosenthal D, Chrisant MR, Edens E, et al.: International Society for Heart and Lung Transplantation: Practice guidelines for management of heart failure in children. J Heart Lung Transplant 2004, 23:1313-1333.
17. Rosenzweig EB, Starc TJ, Chen JM, et al.: Intravenous arginine-vasopressin in children with vasodilatory shock after cardiac surgery. Circulation 1999, 100:II182-II186.
18. Feingold B, Law YM: Nesiritide use in pediatric patients with congestive heart failure. J Heart Lung Transplant 2004, 23:1455-1459.
19. Emanuele C, Roberto P, Filippo M, et al.: Mechanical circulatory support for patients with fulminant myocarditis: The role of echocardiography to address diagnosis, choice of device, management, and recovery. J Cardiothorac Vasc Anesth 2009, 23:87-94.
20. Duncan BW: Mechanical circulatory support for infants and children with cardiac disease. Ann Thorac Surg 2002, 73:1670-1677.
21. Fiser WP, Yetman AT, Gunselman RJ, et al.: Pediatric arteriovenous extracorporeal membrane oxygenation (ECMO) as a bridge to cardiac transplantation. J Heart Lung Transplant 2003, 22:770-777.
22. Chen YS, Yu HS, Huang SC, et al.: Experience and results of extracorporeal membrane oxygenation in treating fulminant myocarditis with shock: What mechanical support should be considered first? J Heart Lung Transplant 2005, 24:81-87.
23. Reinhartz O, Copeland JG, Farrar DJ: Thoratec ventricular assist devices in children with less than 1.3 m2 body surface area. ASAIO J 2003, 49:727-730.
24. Cooper DS, Jacobs JP, Moore L, et al.: Cardiac extracorporeal life support: State of the art in 2007. Cardiol Young 2007, 17:104-115.
25. Davies RR, Russo MJ, Hong KN, et al.: The use of mechanical circulatory support as a bridge to transplantation in pediatric patients: An analysis of the United Network for Organ Sharing database. J Thorac Cardiovasc Surg 2008, 135:421-427.
26. Gandhi SK, Huddleston CB, Balzer DT, et al.: Biventricular assist devices as a bridge to heart transplantation in small children. Circulation 2008, 118:S89-S93.
27. Matsurnori A, Igata H, Ono K, et al.: High doses of digitalis increase the myocardial production of proinflammatory cytokines and worsen myocardial injury in viral myocarditis: A possible mechanism of digitalis toxicity. Jpn Circ J 1999, 63:2476-2478.
28. Adams KF Jr, Gheorghiade M, Uretsky BE, et al.: Clinical benefits of low serum digoxin on the treatment of heart failure. J Am Coll Cardiol 2002, 39:946-953.
29. Feldman AM, McNamara D: Myocarditis. N Engl J Med 2000, 343:1388-1398.
30. Bruns LA, Chrisant MK, Lamour JM, et al.: Carvedilol as therapy in pediatric heart failure: An initial multicenter experience. J Pediatr 2001, 138:505-511.
31. Rusconi P, Gomez-Marin O, Rossique-Gonzalez M, et al.: Carvedilol in children with cardiomyopathy: 3 years experience in a single institution. J Heart Lung Transplant 2004, 23:832-838.
32. Frobel AK, Hulpke-Wette M, Schmidt KG, et al.: Betablockers for congestive heart failure in children. Cochrane Database Syst Rev 2009, CD007037.
33. Shaddy RE, Boucek MM, Canter CE, et al.: Carvedilol for children and adolescents with heart failure: A randomized controlled trial. JAMA 2007, 298:1171-1179.
34. Maisch B, Herzum M, Hufnagel G, et al.: Immunosuppressive treatment for myocarditis and dilated cardiomyopathy. Eur Heart J 1995, 16(Suppl O):153-161.
35. Gouton M, Difilippo S, Sassolas F, et al.: Acute infectious myocarditis in childhood: Results from 2 series from Lyon. Arch Mal Coeur Vaiss 1995, 88:753-759.
36. Kawai C: From myocarditis to cMrdiomyopathy: mechanisms of inflammation and cell death. Circulation 1999, 99:1091-1100.
37. Liu PP, Mason JW: Advances in the understanding of myocarditis. Circulation 2001, 104:1076-1082.
38. Cooper JT Jr: GianD cell myocarditis: diagnosis and treatment. Herz 2000, 25:291-298.
39. Galiuto L, Enriquez-Sarano M, Reeder GS, et al.: Eosinophilic myocarditis manifesting as myocardial infarction: Early diagnosis and successful treatment. Mayo Clin Proc 1997, 72:603-610.
40. Mason JW, O'Connell JB, Herskowitz A, et al.: A clinical trial of immunosuppressive therapy for myocarditis. N Engl J Med 1995, 333:269-275.
41. Parillo JE: Inflammatory cardiomyopathy (myocarditis). Which patients should be treated with anti-inflammatory therapy? Circulation 2001, 104:4-6.
42. Heart Failure Society of America (HFSA) practice guidelines. HFSA guidelines for management of patients with heart failure caused by left ventricular systolic dysfunction-pharmacologic approaches. J Card Fail 1999, 5:357-382.
43. Wojnicz R, Nowalany-Kozielska E, Wojciechowaska C, et al.: Randomized, placebo-controlled study for immunosuppressive treatment of inflammatory dilated cardiomyopathy. Circulation 2001, 104:39-45.
44. Frustaci A, Chimenti C, Calabrese F, et al.: Immunosuppressive therapy for active lymphocytic myocarditis. Virological and immunological profile of responders versus nonresponders. Circulation 2003, 107:857-863.
45. Hia CP, Yip WC, Tai BC, Quek SC: Immunosuppressive therapy in acute myocarditis: An 18-year systematic review. Arch Dis Child 2004, 89:580-584.
46. Gagliardi MG, Bevilacqua M, Bassano C, et al.: Long-term follow up of children with myocarditis treated by immunosuppression and of children with dilated cardiomyopathy. Heart 2004, 90:1167-1171.
47. Burch M: Immune suppressive treatment in paediatriS myocarditis: still awaiting the evidence. Heart 2004, 90:1103-1104.
48. Liu C, Chen J, Liu K: Immunosuppressive treatment for inflammatory cardiomyopathy: Meta-analysis of randomized controlled trials. Int Heart J 2005, 46:113-122.
49. Drucker A, Colan SD, Lewis AB, et al.: Gamma-globulin treatment of acute myocarditis in the pediatric population. Circulation 1994, 89:252-257.
50. McNamara DM, Rosenblum WD, Janosko KM, et al.: Intravenous immune globulin in the therapy of myocarditis and acute cardiomyopathy. Circulation 1997, 95:2476-2478.
51. McNamara DM, Holubkov R, Starling RC, et al.: Controlled trial of intravenous immune globulin in recent-onset dilated cardiomyopathy. Circulation 2001, 103:2254-2259.
52. Robinson J, Hartling L, Vandermeer B, et al.: Intravenous immunoglobulin for presumed viral myocarditis in children and adults. Cochrane Database Syst Rev 2005, CD004370.
53. Kuhl U, Pauschinger M, Schwimmbeck PL, et al.: Interferon-beta treatment eliminates cardiotropic viruses and improves left ventricular function in patients with myocardial persistence of viral genomes and left ventricular dysfunction. Circulation 2003, 107:2793-2798.
54. Keren A: InvitId for debate: is virus persistence a determinant for disease progression? Ernst Schering Res Found Workshop 2006, 55-61.
55. Heymans S, Hirsch E, Anker SD, et al.: Inflammation as a therapeutic target in heart failure? A scientific statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail 2009, 11:119-129.
56. Nugent AW, Davis AM, Kleinert S, et al.: Clinical, electrocardiographic, and histologic correlations in children with dilated cardiomyopathy. J Heart Lung Transplant 2001, 20:1152-1157.
57. Duncan BW, Bohn EJ, Atz AM, et al.: Mechanical circulatory support for the treatment of children with acute fulminant myocarditis. J Thorac Cardiovasc Surg 2001, 122:440-448.
58. Lee KJ, McCrindle BW, Bohn DJ, et al.: Clinical outcomes of acute myocarditis in childhood. Heart 1999, 82:226-233.