A B-cell lymphoma diagnosed in "floater" tissue: Implications of the diagnosis and resolution of a laboratory error

American Journal of the Medical Sciences

Volumn 338, Issue 3, 2009, Pages 248-251

  Mosse, Claudio A ^a,b   Stumph, Jennifer R ^a,c   Best, D Hunter ^a   Vnencak Jones, Cindy L ^a,d  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c SPECTRUM HEALTH   (United States)

^d VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Analytical errors; Floater tissue; Microdissection; Quality assurance; Short tandem repeats

Indexed keywords

ADULT; ARTICLE; B CELL LYMPHOMA; CASE REPORT; DNA DETERMINATION; DNA EXTRACTION; FEMALE; HISTOPATHOLOGY; HUMAN; INVERSE POLYMERASE CHAIN REACTION; MEDICAL ERROR; NONHODGKIN LYMPHOMA; SHORT TANDEM REPEAT; DIAGNOSTIC ERROR; GENETICS; MICRODISSECTION; PATHOLOGY; POLYMERASE CHAIN REACTION; QUALITY CONTROL;

DNA; MICROSATELLITE DNA; PARAFFIN;

ADULT; DIAGNOSTIC ERRORS; DNA, NEOPLASM; FEMALE; HUMANS; LYMPHOMA, B-CELL; MICRODISSECTION; MICROSATELLITE REPEATS; PARAFFIN EMBEDDING; POLYMERASE CHAIN REACTION; QUALITY CONTROL;

EID: 70349245592     PISSN: 00029629     EISSN: None     Source Type: Journal    
DOI: 10.1097/MAJ.0b013e3181a88dc0     Document Type: Article

References (12)

1. Gephardt GN, Zarbo RJ. Extraneous tissue in surgical pathology: a College of American Pathologists Q-probes study of 275 laboratories. Arch Pathol Lab Med 1996;120:1009-1014 (Pubitemid 26382874)
2. Troxel DB. Medicolegal aspects of error in pathology. Arch Pathol Lab Med 2006;130:617-619
3. Ota M, Fukushima H, Akamatsu T, et al. Availability of immunostaining methods for identification of mixed-up tissue specimens. Am J Clin Pathol 1989;92:665-669 (Pubitemid 19272883)
4. Worsham MJ, Wolman SR, Zarbo RJ. Molecular approaches to identification of tissue contamination in surgical pathology sections. J Mol Diagn 2001;3:11-15
5. Vnencak-Jones CL. Bone marrow engraftment studies. Curr Protoc Hum Genet 2009; Chapter 9; Unit 9.17.
6. Tsongalis GJ, Berman MM. Application of forensic identity testing in a clinical setting. Specimen identification. Diagn Mol Pathol 1997;6:111-114
7. Mariappan MR, Zehnder J, Arber DA, et al. Identification of mislabeled specimen by molecular methods: case report and review. Int J Surg Pathol 2005;13:253-258 (Pubitemid 41117499)
8. Tsongalis GJ, Wu AH, Silver H, et al. Applications of forensic identity testing in the clinical laboratory. Am J Clin Pathol 1999; 112(suppl 1):S93-103. (Pubitemid 30219467)
9. Hunt JL, Swalsky P, Sasatom E, et al. A microdissection and molecular genotyping assay to confirm the identity of tissue floaters in paraffin-embedded tissue blocks. Arch Pathol Lab Med 2003;127:213-217 (Pubitemid 36231770)
10. Venditti M, Hay RW, Kulaga A, et al. Diagnosis of ectopic tissue versus contamination by genetic fingerprinting in a routine surgical pathology specimen. Hum Pathol 2007;38:378-382 (Pubitemid 46096560)
11. Ren ZP, Sallstrom J, Sundstrom C, et al. Recovering DNA and optimizing PCR conditions from microdissected formalin-fixed and paraffin-embedded materials. Pathobiology 2000;68:215-217 (Pubitemid 32247258)
12. Nakhleh RE. Patient safety and error reduction in surgical pathology. Arch Pathol Lab Med 2008;132:181-185