Focal Liver Lesions Hyperintense on T1-Weighted Magnetic Resonance Images

Seminars in Ultrasound, CT and MRI

Volumn 30, Issue 5, 2009, Pages 436-449

  Furlan, Alessandro ^a,b   Marin, Daniele ^c,d   Bae, Kyongtae T ^a   Lagalla, Roberto ^e   Agnello, Francesco ^e   Bazzocchi, Massimo ^b   Brancatelli, Giuseppe ^a,e,f  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b UNIVERSITY OF UDINE   (Italy)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

^d SAPIENZA UNIVERSITY OF ROME   (Italy)

^e UNIVERSITY OF PALERMO   (Italy)

^f LA MADDALENA CANCER CENTER   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

COPPER; FAT; MELANIN; PROTEIN;

ANGIOMYOLIPOMA; ARTICLE; FATTY LIVER; HUMAN; IMAGE ANALYSIS; IMAGE DISPLAY; IMAGE PROCESSING; LIPOMA; LIVER ADENOMA; LIVER CELL CARCINOMA; LIVER CYST; LIVER DISEASE; LIVER FOCAL NODULAR HYPERPLASIA; LIVER HEMORRHAGE; LIVER METASTASIS; LIVER NODULE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RISK FACTOR; VASODILATATION;

CONTRAST MEDIA; DIAGNOSIS, DIFFERENTIAL; HUMANS; IMAGING, THREE-DIMENSIONAL; LIVER DISEASES; MAGNETIC RESONANCE IMAGING;

EID: 70349242009     PISSN: 08872171     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.sult.2009.07.002     Document Type: Article

References (64)

1. Farraher S.W., Jara H., Chang K.J., et al. Differentiation of hepatocellular carcinoma and hepatic metastasis from cysts and hemangiomas with calculated T2 relaxation times and the T1/T2 relaxation times ratio. J Magn Reson Imaging 24 (2006) 1333-1341
2. de Bazelaire C.M., Duhamel G.D., Rofsky N.M., et al. MR imaging relaxation times of abdominal and pelvic tissues measured in vivo at 3.0 T: Preliminary results. Radiology 230 (2004) 652-659
3. Hamm B., Thoeni R.F., Gould R.G., et al. Focal liver lesions: Characterization with nonenhanced and dynamic contrast material-enhanced MR imaging. Radiology 190 (1994) 417-423
4. Kelekis N.L., Semelka R.C., and Woosley J.T. Malignant lesions of the liver with high signal intensity on T1-weighted MR images. J Magn Reson Imaging 6 (1996) 291-294
5. Mathieu D., Paret M., Mahfouz A.E., et al. Hyperintense benign liver lesions on spin-echo T1-weighted MR images: Pathologic correlations. Abdom Imaging 22 (1997) 410-417
6. Lee M.J., Hahn P.F., Saini S., et al. Differential diagnosis of hyperintense liver lesions on T1-weighted MR images. AJR Am J Roentgenol 159 (1992) 1017-1020
7. Martin D.R., Danrad R., and Hussain S.M. MR imaging of the liver. Radiol Clin North Am 43 (2005) 861-886
8. Mitchell D.G., and Fast M.R. Imaging techniques: Impact in the abdomen. J Magn Reson Imaging 6 (1996) 812-821
9. Hussain H.K., Chenevert T.L., Londy F.J., et al. Hepatic fat fraction: MR imaging for quantitative measurement and display-Early experience. Radiology 237 (2005) 1048-1055
10. Cassidy F.H., Yokoo T., Aganovic L., et al. Fatty liver disease: MR imaging techniques for the detection and quantification of liver steatosis. Radiographics 29 (2009) 231-260
11. Rofsky N.M., Lee V.S., Laub G., et al. Abdominal MR imaging with a volumetric interpolated breath-hold examination. Radiology 212 (1999) 876-884
12. Cameron I.L., Ord V.A., and Fullerton G.D. Characterization of proton NMR relaxation times in normal and pathological tissues by correlation with other tissue parameters. Magn Reson Imaging 2 (1984) 97-106
13. Mitchell D.G., Palazzo J., Hann H.W., et al. Hepatocellular tumors with high signal on T1-weighted MR images: Chemical shift MR imaging and histologic correlation. J Comput Assist Tomogr 15 (1991) 762-769
14. Premkumar A., Sanders L., Marincola F., et al. Visceral metastases from melanoma: Findings on MR imaging. AJR Am J Roentgenol 158 (1992) 293-298
15. Bottomley P.A., Foster T.H., Argersinger R.E., et al. A review of normal tissue hydrogen NMR relaxation times and relaxation mechanisms from 1-100 MHz: Dependence on tissue type, NMR frequency, temperature, species, excision, and age. Med Phys 11 (1984) 425-448
16. Basaran C., Karcaaltincaba M., Akata D., et al. Fat-containing lesions of the liver: Cross-sectional imaging findings with emphasis on MRI. AJR Am J Roentgenol 184 (2005) 1103-1110
17. Prasad S.R., Wang H., Rosas H., et al. Fat-containing lesions of the liver: Radiologic-pathologic correlation. Radiographics 25 (2005) 321-331
18. Merkle E.M., and Nelson R.C. Dual gradient-echo in-phase and opposed-phase hepatic MR imaging: A useful tool for evaluating more than fatty infiltration or fatty sparing. Radiographics 26 (2006) 1409-1418
19. Outwater E.K., Blasbalg R., Siegelman E.S., et al. Detection of lipid in abdominal tissues with opposed-phase gradient-echo images at 1.5 T: Techniques and diagnostic importance. Radiographics 18 (1998) 1465-1480
20. Honda H., Kaneko K., Kanazawa Y., et al. MR imaging of hepatocellular carcinomas: Effect of Cu and Fe contents on signal intensity. Abdom Imaging 22 (1997) 60-66
21. Ebara M., Fukuda H., Kojima Y., et al. Small hepatocellular carcinoma: Relationship of signal intensity to histopathologic findings and metal content of the tumor and surrounding hepatic parenchyma. Radiology 210 (1999) 81-88
22. Soyer P., Bluemke D.A., Fishman E.K., et al. Fluid-fluid levels within focal hepatic lesions: Imaging appearance and etiology. Abdom Imaging 23 (1998) 161-165
23. Arrive L., Flejou J.F., Vilgrain V., et al. Hepatic adenoma: MR findings in 51 pathologically proved lesions. Radiology 193 (1994) 507-512
24. Vilgrain V., Flejou J.F., Arrive L., et al. Focal nodular hyperplasia of the liver: MR imaging and pathologic correlation in 37 patients. Radiology 184 (1992) 699-703
25. Hamer O.W., Aguirre D.A., Casola G., et al. Imaging patterns and pitfalls. Radiographics 26 (2006) 1637-1653
26. Kawamori Y., Matsui O., Takahashi S., et al. Focal hepatic fatty infiltration in the posterior edge of the medial segment associated with aberrant gastric venous drainage: CT, US, and MR findings. J Comput Assist Tomogr 20 (1996) 356-359
27. Kroncke T.J., Taupitz M., Kivelitz D., et al. Multifocal nodular fatty infiltration of the liver mimicking metastatic disease on CT: Imaging findings and diagnosis using MR imaging. Eur Radiol 10 (2000) 1095-1100
28. Grazioli L., Federle M.P., Brancatelli G., et al. Hepatic adenomas: Imaging and pathologic findings. Radiographics 21 (2001) 877-892 discussion, 892-874
29. Paulson E.K., Mcclellan J.S., Washington K., et al. Hepatic adenoma: MR characteristics and correlation with pathologic findings. AJR Am J Roentgenol 163 (1994) 113-116
30. Lewin M., Handra-Luca A., Arrive L., et al. Liver adenomatosis: Classification of MR imaging features and comparison with pathologic findings. Radiology 241 (2006) 433-440
31. Bartolozzi C., Cioni D., Donati F., et al. Focal liver lesions: MR imaging-pathologic correlation. Eur Radiol 11 (2001) 1374-1388
32. Lee M.J., Saini S., Hamm B., et al. Focal nodular hyperplasia of the liver: MR findings in 35 proved cases. AJR Am J Roentgenol 156 (1991) 317-320
33. Mortele K.J., Praet M., Van Vlierberghe H., et al. Ros PR. CT and MR imaging findings in focal nodular hyperplasia of the liver: Radiologic-pathologic correlation. AJR Am J Roentgenol 175 (2000) 687-692
34. Stanley G., Jeffrey Jr. R.B., and Feliz B. Findings and histopathology of intratumoral steatosis in focal nodular hyperplasia: Case report and review of the literature. J Comput Assist Tomogr 26 (2002) 815-817
35. Attal P., Vilgrain V., Brancatelli G., et al. Telangiectatic focal nodular hyperplasia: US, CT, and MR imaging findings with histopathologic correlation in 13 cases. Radiology 228 (2003) 465-472
36. Paradis V., Benzekri A., Dargere D., et al. Telangiectatic focal nodular hyperplasia: A variant of hepatocellular adenoma. Gastroenterology 126 (2004) 1323-1329
37. Vilgrain V., Lewin M., Vons C., et al. Hepatic nodules in Budd-Chiari syndrome: Imaging features. Radiology 210 (1999) 443-450
38. Brancatelli G., Federle M.P., Grazioli L., et al. Large regenerative nodules in Budd-Chiari syndrome and other vascular disorders of the liver: CT and MR imaging findings with clinicopathologic correlation. AJR Am J Roentgenol 178 (2002) 877-883
39. Cha I., Cartwright D., Guis M., et al. Angiomyolipoma of the liver in fine-needle aspiration biopsies: Its distinction from hepatocellular carcinoma. Cancer 87 (1999) 25-30
40. Hooper L.D., Mergo P.J., and Ros P.R. Multiple hepatorenal angiomyolipomas: Diagnosis with fat suppression, gadolinium-enhanced MRI. Abdom Imaging 19 (1994) 549-551
41. Ahmadi T., Itai Y., Takahashi M., et al. Angiomyolipoma of the liver: Significance of CT and MR dynamic study. Abdom Imaging 23 (1998) 520-526
42. Vilgrain V., Silbermann O., Benhamou J.P., et al. MR imaging in intracystic hemorrhage of simple hepatic cysts. Abdom Imaging 18 (1993) 164-167
43. Mendez Montero J.V., Arrazola Garcia J., Lopez Lafuente J., et al. Fat-fluid level in hepatic hydatid cyst: A new sign of rupture into the biliary tree?. AJR Am J Roentgenol 167 (1996) 91-94
44. Balci N.C., Semelka R.C., Noone T.C., et al. Pyogenic hepatic abscesses: MRI findings on T1- and T2-weighted and serial gadolinium-enhanced gradient-echo images. J Magn Reson Imaging 9 (1999) 285-290
45. Shimizu A., Ito K., Sasaki K., et al. Small hyperintense hepatic lesions on T1-weighted images in patients with cirrhosis: Evaluation with serial MRI and imaging features for clinical benignity. Magn Reson Imaging 25 (2007) 1430-1436
46. Bruix J., and Sherman M. Management of hepatocellular carcinoma. J Hepatol 42 (2005) 1208-1236
47. Ohtomo K., Itai Y., Ohtomo Y., et al. Regenerating nodules of liver cirrhosis: MR imaging with pathologic correlation. AJR Am J Roentgenol 154 (1990) 505-507
48. Krinsky G.A., and Israel G. Nondysplastic nodules that are hyperintense on T1-weighted gradient-echo MR imaging: Frequency in cirrhotic patients undergoing transplantation. AJR Am J Roentgenol 180 (2003) 1023-1027
49. Roncalli M., Roz E., Coggi G., et al. The vascular profile of regenerative and dysplastic nodules of the cirrhotic liver: Implications for diagnosis and classification. J Hepatol 30 (1999) 1174-1178
50. Earls J.P., Theise N.D., Weinreb J.C., et al. Dysplastic nodules and hepatocellular carcinoma: Thin-section MR imaging of explanted cirrhotic livers with pathologic correlation. Radiology 201 (1996) 207-214
51. Eguchi A., Nakashima O., Okudaira S., et al. Adenomatous hyperplasia in the vicinity of small hepatocellular carcinoma. J Hepatol 15 (1992) 843-848
52. Krinsky G.A., Theise N.D., Rofsky N.M., et al. Dysplastic nodules in cirrhotic liver: arterial phase enhancement at CT and MR imaging-A case report. Radiology 209 (1998) 461-464
53. Kelekis N.L., Semelka R.C., Worawattanakul S., et al. Hepatocellular carcinoma in North America: A multiinstitutional study of appearance on T1-weighted, T2-weighted, and serial gadolinium-enhanced gradient-echo images. AJR Am J Roentgenol 170 (1998) 1005-1013
54. Kadoya M., Matsui O., Takashima T., et al. Hepatocellular carcinoma: Correlation of MR imaging and histopathologic findings. Radiology 183 (1992) 819-825
55. Kutami R., Nakashima Y., Nakashima O., et al. Pathomorphologic study on the mechanism of fatty change in small hepatocellular carcinoma of humans. J Hepatol 33 (2000) 282-289
56. Yu J.S., Kim Y.H., and Rofsky N.M. Dynamic subtraction magnetic resonance imaging of cirrhotic liver: Assessment of high signal intensity lesions on nonenhanced T1-weighted images. J Comput Assist Tomogr 29 (2005) 51-58
57. De Santis M., Alborino S., Tartoni P.L., et al. Effects of lipiodol retention on MRI signal intensity from hepatocellular carcinoma and surrounding liver treated by chemoembolization. Eur Radiol 7 (1997) 10-16
58. Dromain C., de Baere T., Elias D., et al. Hepatic tumors treated with percutaneous radio-frequency ablation: CT and MR imaging follow-up. Radiology 223 (2002) 255-262
59. Leyendecker J.R., Gorengaut V., and Brown J.J. MR imaging of maternal diseases of the abdomen and pelvis during pregnancy and the immediate postpartum period. Radiographics 24 (2004) 1301-1316
60. Tajima T., Funakoshi A., Ikeda Y., et al. Nonfunctioning adrenal rest tumor of the liver: Radiologic appearance. J Comput Assist Tomogr 25 (2001) 98-101
61. Gupta P., Naran A., Auh Y.H., et al. Focal intrahepatic extramedullary hematopoiesis presenting as fatty lesions. AJR Am J Roentgenol 182 (2004) 1031-1032
62. Quinn A.M., and Guzman-Hartman G. Pseudolipoma of Glisson's capsule. Arch Pathol Lab Med 127 (2003) 503-504
63. Radin D.R. Langerhans' cell histiocytosis of the liver: Imaging findings. AJR Am J Roentgenol 159 (1992) 63-64
64. Winter III T.C., and Freeny P. Hepatic teratoma in an adult. Case report with a review of the literature. J Clin Gastroenterol 17 (1993) 308-310