Parkinson-dementia complex and development of a new stable isotope dilution assay for BMAA detection in tissue

Toxicology and Applied Pharmacology

Volumn 240, Issue 2, 2009, Pages 180-188

  Snyder, Laura R ^a   Cruz Aguado, Reyniel ^c   Sadilek, Martin ^a   Galasko, Douglas ^b   Shaw, Christopher A ^c   Montine, Thomas J ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Methylamino l alanine; Alzheimer's disease; BMAA; Mass spectrometry; Parkinson dementia complex

Indexed keywords

2 AMINO 3 METHYLAMINOPROPIONIC ACID;

ADULT; AGED; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; DIETARY INTAKE; FRONTAL CORTEX; HUMAN; HUMAN TISSUE; ISOTOPE DILUTION ASSAY; LIVER; MASS FRAGMENTOGRAPHY; MOUSE; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; PARKINSON DISEASE; SENSITIVITY AND SPECIFICITY; TEMPORAL CORTEX; TISSUE DISTRIBUTION;

ADMINISTRATION, ORAL; AGED; AGED, 80 AND OVER; AMINO ACIDS, DIAMINO; ANIMALS; BIOLOGICAL MARKERS; CALIBRATION; CASE-CONTROL STUDIES; CEREBRUM; DEMENTIA; DEUTERIUM; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GUAM; HUMANS; INDICATOR DILUTION TECHNIQUES; LIVER; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; MIDDLE AGED; PARKINSON DISEASE; SENSITIVITY AND SPECIFICITY; WASHINGTON;

ANIMALIA; MUS;

EID: 70349240200     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.06.025     Document Type: Article

References (50)

1. Allen C.N., Omelchenko I., Ross S.M., and Spencer P. The neurotoxin, beta-N-methylamino-l-alanine (BMAA) interacts with the strychnine-insensitive glycine modulatory site of the N-methyl-d-aspartate receptor. Neuropharmacology 34 (1995) 651-658
2. Banack S.A., Murch S.J., and Cox P.A. Neurotoxic flying foxes as dietary items for the Chamorro people, Marianas Islands. J. Ethnopharmacol. 106 (2006) 97-104
3. Cox P.A., and Banack S.A. A nonprotein amino acid and neurodegeneration. Science 314 (2006) 1242
4. Cox P.A., Banack S.A., and Murch S.J. Biomagnification of cyanobacterial neurotoxins and neurodegenerative disease among the Chamorro people of Guam. Proc. Natl. Acad. Sci. U.S.A. 100 (2003) 13380-13383
5. Cruz-Aguado R., Winkler D., and Shaw C.A. Lack of behavioral and neuropathological effects of dietary beta-methylamino-l-alanine (BMAA) in mice. Pharmacol. Biochem. Behav. 84 (2006) 294-299
6. Duncan M.W. beta-Methylamino-l-alanine (BMAA) and amyotrophic lateral sclerosis-parkinsonism dementia of the western Pacific. Ann. N. Y. Acad. Sci. 648 (1992) 161-168
7. Duncan M.W., and Marini A.M. Debating the cause of a neurological disorder. Science 313 (2006) 1737
8. Duncan M.W., Kopin I.J., Crowley J.S., Jones S.M., and Markey S.P. Quantification of the putative neurotoxin 2-amino-3-(methylamino)propanoic acid (BMAA) in cycadales: analysis of the seeds of some members of the family Cycadaceae. J. Anal. Toxicol. 13 Suppl. A-G (1989)
9. Duncan M.W., Steele J.C., Kopin I.J., and Markey S.P. 2-Amino-3-(methylamino)-propanoic acid (BMAA) in cycad flour: an unlikely cause of amyotrophic lateral sclerosis and parkinsonism-dementia of Guam. Neurology 40 (1990) 767-772
10. Duncan M.W., Villacreses N.E., Pearson P.G., Wyatt L., Rapoport S.I., Kopin I.J., Markey S.P., and Smith Q.R. 2-Amino-3-(methylamino)-propanoic acid (BMAA) pharmacokinetics and blood-brain-parrier permeability in the rat. J. Pharmacol. Exp. Ther. 258 (1991) 27-35
11. Duncan M.W., Markey S.P., Weick B.G., Pearson P.G., Ziffer H., Hu Y., and Kopin I.J. 2-Amino-3-(methylamino)propanoic acid (BMAA) bioavailability in the primate. Neurobiol. Aging 13 (1992) 333-337
12. Esclaire F., Kisby G., Spencer P., Milne J., Lesort M., and Hugon J. The Guam cycad toxin methylazoxymethanol damages neuronal DNA and modulates tau mRNA expression and excitotoxicity. Exp. Neurol. 155 (1999) 11-21
13. Fountoulakis M., and Lahm H.W. Hydrolysis and amino acid composition analysis of proteins. J. Chromatogr. A 826 (1998) 109-134
14. Galasko D., Salmon D.P., Craig U.K., Thal L.J., Schellenberg G., and Wiederholt W. Clinical features and changing patterns of neurodegenerative disorders on Guam, 1997-2000. Neurology 58 (2002) 90-97
15. Garruto R.M., Fukatsu R., Yanagihara R., Gajdusek D.C., Hook G., and Fiori C.E. Imaging of calcium and aluminum in neurofibrillary tangle-bearing neurons in parkinsonism-dementia of Guam. Proc. Natl. Acad. Sci. U.S.A. 81 (1984) 1875-1879
16. Garruto R.M., Yanagihara R., and Gajdusek D.C. Disappearance of high-incidence amyotrophic lateral sclerosis and parkinsonism-dementia on Guam. Neurology 35 (1985) 193-198
17. Guo T., Geis S., Hedman C., Arndt M., Krick W., and Sonzogni W. Characterization of ethyl chloroformate derivative of beta-methylamino-l-alanine. J. Am. Soc. Mass. Spectrom. 18 (2007) 817-825
18. Hampton T. Food chain of evidence points to brain toxin. JAMA 290 (2003) 2788-2789
19. Hirano A., Kurland L.T., Krooth R.S., and Lessell S. Parkinsonism-dementia complex, an endemic disease on the island of Guam. I. Clinical features. Brain 84 (1961) 642-661
20. Hudson A.J., and Rice G.P. Similarities of Guamanian ALS/PD to post-encephalitic parkinsonism/ALS: possible viral cause. Can. J. Neurol. Sci. 17 (1990) 427-433
21. Kisby G.E., Ellison M., and Spencer P.S. Content of the neurotoxins cycasin (methylazoxymethanol beta-d-glucoside) and BMAA (beta-N-methylamino-l-alanine) in cycad flour prepared by Guam Chamorros. Neurology 42 (1992) 1336-1340
22. Kuehn B.M. Environmental neurotoxin may pose health threat. JAMA 293 (2005) 2460-2462
23. Lobner D., Piana P.M., Salous A.K., and Peoples R.W. beta-N-Methylamino-l-alanine enhances neurotoxicity through multiple mechanisms. Neurobiol. Dis. 25 (2007) 360-366
24. Miller G. Neurodegenerative disease. Guam's deadly stalker: on the loose worldwide?. Science 313 (2006) 428-431
25. Montine T.J., Li K., Perl D.P., and Galasko D. Lack of beta-methylamino-l-alanine in brain from controls, AD, or Chamorros with PDC. Neurology 65 (2005) 768-769
26. Morris H.R., Steele J.C., Crook R., Wavrant-De Vrieze F., Onstead-Cardinale L., Gwinn-Hardy K., Wood N.W., Farrer M., Lees A.J., McGeer P.L., Siddique T., Hardy J., and Perez-Tur J. Genome-wide analysis of the parkinsonism-dementia complex of Guam. Arch. Neurol. 61 (2004) 1889-1897
27. Munro M. Algae toxin linked to Alzheimer's (2005), Victoria Times Colonist
28. Murakami N. Parkinsonism-dementia complex on Guam - overview of clinical aspects. J. Neurol. 246 Suppl. 2 (1999) II16-II18
29. Murch S.J., Cox P.A., and Banack S.A. A mechanism for slow release of biomagnified cyanobacterial neurotoxins and neurodegenerative disease in Guam. Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 12228-12231
30. Murch S.J., Cox P.A., Banack S.A., Steele J.C., and Sacks O.W. Occurrence of beta-methylamino-l-alanine (BMAA) in ALS/PDC patients from Guam. Acta Neurol. Scand. 110 (2004) 267-269
31. Oyanagi K., and Wada M. Neuropathology of parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam: an update. J. Neurol. 246 Suppl. 2 (1999) II19-II27
32. Pablo J., Banack S.A., Cox P.A., Johnson T.E., Papapetropoulos S., Bradley W.G., Buck A., and Mash D.C. Cyanobacterial neurotoxin BMAA in ALS and Alzheimer's disease. Acta Neurol. Scand. (2009). http://doi:10.1111/j.1600-0404.2008.01150.x (Electronic publication ahead of print). doi:10.1111/j.1600-0404.2008.01150.x
33. Plato C.C., Galasko D., Garruto R.M., Plato M., Gamst A., Craig U.K., Torres J.M., and Wiederholt W. ALS and PDC of Guam: forty-year follow-up. Neurology 58 (2002) 765-773
34. Plato C.C., Garruto R.M., Galasko D., Craig U.K., Plato M., Gamst A., Torres J.M., and Wiederholt W. Amyotrophic lateral sclerosis and parkinsonism-dementia complex of Guam: changing incidence rates during the past 60 years. Am. J. Epidemiol. 157 (2003) 149-157
35. Rao S.D., Banack S.A., Cox P.A., and Weiss J.H. BMAA selectively injures motor neurons via AMPA/kainate receptor activation. Exp. Neurol. 201 (2006) 244-252
36. Santiago M., Matarredona E.R., Machado A., and Cano J. Acute perfusion of BMAA in the rat's striatum by in vivo microdialysis. Toxicol. Lett. 167 (2006) 34-39
37. Smith Q.R., Nagura H., Takada Y., and Duncan M.W. Facilitated transport of the neurotoxin, beta-N-methylamino-l-alanine, across the blood-brain barrier. J. Neurochem. 58 (1992) 1330-1337
38. Snyder L.R., Cruz-Aguado R., Sadilek M., Galasko D., Shaw C.A., and Montine T.J. Lack of cerebral BMAA in human cerebral cortex. Neurology 72 (2009) 1360-1361
39. Spencer P.S., Nunn P.B., Hugon J., Ludolph A.C., Ross S.M., Roy D.N., and Robertson R.C. Guam amyotrophic lateral sclerosis-parkinsonism-dementia linked to a plant excitant neurotoxin. Science 237 (1987) 517-522
40. Steele J.C., and McGeer P.L. The ALS/PDC syndrome of Guam and the cycad hypothesis. Neurology 70 (2008) 1984-1990
41. Stein R. Algae Toxin Is Widespread (2005), Washington Post
42. The Boston Globe, 2005. Algae that produces threat to humans is more common than thought.
43. Waring S.C. Amyotrophic lateral sclerosis and parkinsonism-dementia complex of Guam: descriptive epidemiology, secular trends, and birth cohort effects on incidence, 1950-1989. School of Public Health (1994), University of Texas Health Science Center, Houston
44. Waring S.C., Esteban-Santillan C., Reed D.M., Craig U.K., Labarthe D.R., Petersen R.C., and Kurland L.T. Incidence of amyotrophic lateral sclerosis and of the parkinsonism-dementia complex of Guam, 1950-1989. Neuroepidemiology 23 (2004) 192-200
45. Weiner J. The tangle. The New Yorker (2005) 42
46. Whitfield J. Bug makes bats bad for brains. Nature.com (2003)
47. Wiederholt W.C. Neuroepidemiologic research initiatives on Guam: past and present. Neuroepidemiology 18 (1999) 279-291
48. Wilson J.M., Khabazian I., Wong M.C., Seyedalikhani A., Bains J.S., Pasqualotto B.A., Williams D.E., Andersen R.J., Simpson R.J., Smith R., Craig U.K., Kurland L.T., and Shaw C.A. Behavioral and neurological correlates of ALS-parkinsonism dementia complex in adult mice fed washed cycad flour. Neuromol. Med. 1 (2002) 207-221
49. Yanagihara R., Garruto R.M., Gajdusek D.C., Tomita A., Uchikawa T., Konagaya Y., Chen K.M., Sobue I., Plato C.C., and Gibbs Jr. C.J. Calcium and vitamin D metabolism in Guamanian Chamorros with amyotrophic lateral sclerosis and parkinsonism-dementia. Ann. Neurol. 15 (1984) 42-48
50. 15N]-methylamino)propanoic (BMAA). J. Labelled Compd Radiopharm. 28 (1990) 581-586