EANM guidelines for ventilation/perfusion scintigraphy : PPPPart 1. Pulmonary imaging with ventilation/perfusion single photon emission tomography

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 36, Issue 8, 2009, Pages 1356-1370

  Bajc, M ^a   Neilly, J B ^b   Miniati, M ^c   Schuemichen, C ^d   Meignan, M ^e   Jonson, B ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b GLASGOW ROYAL INFIRMARY   (United Kingdom)

^c UNIVERSITY OF FLORENCE   (Italy)

^d UNIVERSITY OF ROSTOCK   (Germany)

^e HENRI MONDOR HOSPITAL   (France)

Author keywords

Multidetector CT scan'; Pulmonary embolism; Radioncuclide imaging; Single photon emission tomography; Ventilation perfusion scintigraphy

Indexed keywords

KRYPTON; KRYPTON 81M; LOW MOLECULAR WEIGHT HEPARIN; MACROSALB TC 99M; PENTETATE TECHNETIUM TC 99M; PENTETIC ACID; RADIOISOTOPE; RUBIDIUM 81; TECHNEGAS; TECHNETIUM; UNCLASSIFIED DRUG; XENON 131; XENON 133; DIAGNOSTIC AGENT; RADIOPHARMACEUTICAL AGENT;

AEROSOL; CHRONIC OBSTRUCTIVE LUNG DISEASE; COMORBIDITY; DEEP VEIN THROMBOSIS; DIAGNOSTIC ACCURACY; DRUG CLEARANCE; DRUG EXCRETION; DRUG HALF LIFE; HEART FAILURE; HUMAN; INCIDENCE; INHALATION; INJECTION; LUNG EMBOLISM; LUNG PERFUSION; LUNG VENTILATION; PATHOPHYSIOLOGY; PNEUMONIA; PREGNANCY; QUALITY CONTROL; RADIATION EXPOSURE; REVIEW; SCINTIGRAPHY; SENSITIVITY AND SPECIFICITY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; VENTILATION/PERFUSION SCINTIGRAPHY; ARTICLE; CHRONIC DISEASE; COMPUTER ASSISTED DIAGNOSIS; EUROPE; FEMALE; HEALTH CARE ORGANIZATION; IMAGE PROCESSING; LUNG; MALE; METHODOLOGY; NUCLEAR MEDICINE; PRACTICE GUIDELINE; RADIATION DOSE; SCINTISCANNING;

CHRONIC DISEASE; EUROPE; FEMALE; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; IMAGE PROCESSING, COMPUTER-ASSISTED; INJECTIONS; LUNG; MALE; NUCLEAR MEDICINE; PERFUSION IMAGING; PREGNANCY; PULMONARY EMBOLISM; PULMONARY VENTILATION; QUALITY CONTROL; RADIATION DOSAGE; RADIOPHARMACEUTICALS; SOCIETIES; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 70349238965     PISSN: 16197070     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00259-009-1170-5     Document Type: Review

References (119)

1. DW Barritt SC Jordan 1960 Anticoagulant drugs in the treatment of pulmonary embolism. A controlled trial Lancet 1 1309 1312 10.1016/S0140-6736(60) 92299-6 13797091 1:STN:280:DyaF3c7hslCmuw%3D%3D
2. R Coulden 2006 State-of-the-art imaging techniques in chronic thromboembolic pulmonary hypertension Proc Am Thorac Soc 3 577 583 10.1513/pats.200605-119LR 16963537 (Pubitemid 44411623)
3. RH White 2003 The epidemiology of venous thromboembolism Circulation 107 I4 I8 10.1161/01.CIR.0000078468.11849.66 12814979 (Pubitemid 41289265)
4. JA Heit 2006 The epidemiology of venous thromboembolism in the community: implications for prevention and management J Thromb Thrombolysis 21 23 29 10.1007/s11239-006-5572-y 16475038 (Pubitemid 43231124)
5. M Nordstrom B Lindblad 1998 Autopsy-verified venous thromboembolism within a defined urban population - the city of Malmo, Sweden APMIS 106 378 384 9548426 1:STN:280:DyaK1c3gvVajtw%3D%3D
6. VF Tapson 2008 Acute pulmonary embolism N Engl J Med 358 1037 1052 10.1056/NEJMra072753 18322285 1:CAS:528:DC%2BD1cXjtVahtbY%3D (Pubitemid 351347103)
7. R Lehmann C Suess M Leus B Luxembourg W Miesbach E Lindhoff-Last, et al. 2009 Incidence, clinical characteristics, and long-term prognosis of travel-associated pulmonary embolism Eur Heart J 30 233 241 19028781
8. VV Kakkar CT Howe C Flanc MB Clarke 1969 Natural history of postoperative deep-vein thrombosis Lancet 2 230 232 10.1016/S0140-6736(69)90002-6 4184105 1:STN:280:DyaF1M3lsVCktQ%3D%3D
9. KM Moser PF Fedullo JK LitteJohn R Crawford 1994 Frequent asymptomatic pulmonary embolism in patients with deep venous thrombosis JAMA 271 223 225 10.1001/jama.271.3.223 8277550 1:STN:280:DyaK2c7gsVSktw%3D%3D (Pubitemid 24041261)
10. SZ Goldhaber L Visani M De Rosa 1999 Acute pulmonary embolism: clinical outcomes in the International Cooperative Pulmonary Embolism Registry (ICOPER) Lancet 353 1386 1389 10.1016/S0140-6736(98)07534-5 10227218 1:STN:280: DyaK1M3ktFOmtQ%3D%3D (Pubitemid 29192409)
11. M Nijkeuter MM Hovens BL Davidson MV Huisman 2006 Resolution of thromboemboli in patients with acute pulmonary embolism: a systematic review Chest 129 192 197 10.1378/chest.129.1.192 16424432 (Pubitemid 43265262)
12. W James S Menn 1978 Rapid resolution of pulmonary embolism in man Wis Med J 128 60 64
13. H Fredin M Arborelius Jr 1982 Scintigraphic evaluation of pulmonary embolism after total hip replacement, using a dry 99mTc-microaerosol for regional ventilation Eur J Nucl Med 7 494 499 10.1007/BF00257214 6217071 1:STN:280:DyaL3s%2FnvFektA%3D%3D
14. AJ Coakley 1995 Timing of VQ ventilation perfusion scanning Eur J Nucl Med 22 1099 1100 8542890 1:STN:280:DyaK287hvF2mtA%3D%3D
15. SZ Goldhaber CG Elliott 2003 Acute pulmonary embolism: part I: epidemiology, pathophysiology, and diagnosis Circulation 108 2726 2729 10.1161/01.CIR.0000097829.89204.0C 14656907 (Pubitemid 37498971)
16. CH Lee GJ Hankey WK Ho JW Eikelboom 2005 Venous thromboembolism: diagnosis and management of pulmonary embolism Med J Aust 182 569 574 15938684
17. L Eriksson P Wollmer CG Olsson U Albrechtsson H Larusdottir R Nilsson, et al. 1989 Diagnosis of pulmonary embolism based upon alveolar dead space analysis Chest 96 357 362 10.1378/chest.96.2.357 2752819 1:STN:280: DyaL1MzisVyjtg%3D%3D
18. A Torbicki A Perrier S Konstantinides G Agnelli N Galie P Pruszczyk, et al. 2008 Guidelines on the diagnosis and management of acute pulmonary embolism: the Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC) Eur Heart J 29 2276 2315 18757870 1:CAS:528:DC%2BD1cXht1enu7zE
19. RR Meacham 3rd AS Headley MS Bronze JB Lewis MM Rester 1998 Impending paradoxical embolism Arch Intern Med 158 438 448 10.1001/archinte.158.5.438 9508221
20. M Miniati R Prediletto B Formichi C Marini G Di Ricco L Tonelli, et al. 1999 Accuracy of clinical assessment in the diagnosis of pulmonary embolism Am J Respir Crit Care Med 159 864 871 10051264 1:STN:280:DyaK1M7mtVOqtQ%3D%3D
21. EM Baile GG King NL Muller Y D'Yachkova EE Coche PD Pare, et al. 2000 Spiral computed tomography is comparable to angiography for the diagnosis of pulmonary embolism Am J Respir Crit Care Med 161 1010 1015 10712356 1:STN:280:DC%2BD3c7nsl2gtg%3D%3D
22. UJ Schoepf P Costello 2004 CT angiography for diagnosis of pulmonary embolism: state of the art Radiology 230 329 337 10.1148/radiol.2302021489 14752178 (Pubitemid 38133787)
23. PD Stein JW Henry A Gottschalk 1999 Reassessment of pulmonary angiography for the diagnosis of pulmonary embolism: relation of interpreter agreement to the order of the involved pulmonary arterial branch Radiology 210 689 691 10207468 1:STN:280:DyaK1M3itlyktw%3D%3D
24. RD Hull GE Raskob G Coates AA Panju 1990 Clinical validity of a normal perfusion lung scan in patients with suspected pulmonary embolism Chest 97 23 26 10.1378/chest.97.1.23 2295242 1:STN:280:DyaK3c7gslGmsQ%3D%3D
25. KM Moser M Guisan A Cuomo WL Ashburn 1971 Differentiation of pulmonary vascular from parenchymal diseases by ventilation-perfusion scintiphotography Ann Intern Med 75 597 605 5094074 1:STN:280:DyaE38%2FgtlSlsg%3D%3D
26. EJ van Beek PM Kuyer BE Schenk DP Brandjes JW ten Cate HR Buller 1995 A normal perfusion lung scan in patients with clinically suspected pulmonary embolism. Frequency and clinical validity Chest 108 170 173 10.1378/chest.108.1. 170 7606954
27. DK Li SE Seltzer BJ McNeil 1978 V/Q mismatches unassociated with pulmonary embolism: case report and review of the literature J Nucl Med 19 1331 1333 731320 1:STN:280:DyaE1M%2FptVentA%3D%3D
28. HI Palevsky A Alavi 1991 A noninvasive strategy for the management of patients suspected of pulmonary embolism Semin Nucl Med 21 325 331 10.1016/S0001-2998(05)80135-7 1754894 1:STN:280:DyaK38%2FpsVCjuw%3D%3D
29. HD Sostman A Gottschalk 1992 Prospective validation of the stripe sign in ventilation-perfusion scintigraphy Radiology 184 455 459 1620847 1:STN:280:DyaK38zhvF2msQ%3D%3D
30. HD Sostman CE Ravin DC Sullivan SR Mills MG Glickman GS Dorfman 1982 Use of pulmonary angiography for suspected pulmonary embolism: influence of scintigraphic diagnosis AJR Am J Roentgenol 139 673 677 6981926 1:STN:280:DyaL3s%2FhvFertA%3D%3D
31. H Creutzig S Gonda A Creutzig H Reilmann H Hundeshagen 1983 Frequencies of segmental perfusion and ventilation abnormalities in lung scintigraphy Eur J Nucl Med 8 401 403 6628441 1:STN:280:DyaL2c%2FivVOgsQ%3D%3D
32. CT Dollery PM Gillam 1963 The distribution of blood and gas within the lungs measured by scanning after administration of 133Xe Thorax 18 316 325 10.1136/thx.18.4.316 14085650 1:STN:280:DyaF2c%2Fktleisg%3D%3D
33. HW Knipping W Bolt H Venrath H Valentin H Ludes P Endler 1955 A new method of heart and lung function testing, the regional functional analysis in the lung and heart clinic by the radioactive noble gas xenon 133 (isotope thoracography) Dtsch Med Wochenschr 80 1146 1147 13250979 1:STN:280: DyaG28%2Fgt1OrsA%3D%3D
34. The PIOPED Investigators 1990 Value of the ventilation/perfusion scan in acute pulmonary embolism. Results of the prospective investigation of pulmonary embolism diagnosis (PIOPED) JAMA 263 2753 2759 10.1001/jama.263
35. Schümichen C, Krause T, Reinartz P. Leitlinie für die Lungenszintigraphie (Version 2). In: Eckardt J, Geworski L, Lerch H, Reiners C, Schober O: Empfehlungen zur Qualitätskontrolle in der Nuklearmedizin. Schattauer Stuttgart, 2009, 71-82.
36. F Fazio T Jones 1975 Assessment of regional ventilation by continuous inhalation of radioactive krypton-81m BMJ 3 673 676 10.1136/bmj.3.5985.673 1182453 1:STN:280:DyaE28%2FktV2gtQ%3D%3D
37. SO Valind CG Rhodes B Jonson 1987 Quantification of regional ventilation in humans using a short-lived radiotracer - theoretical evaluation of the steady-state model J Nucl Med 28 1144 1154 3598703 1:STN:280: DyaL2s3ltlCjtw%3D%3D
38. G Ciofetta A Piepsz I Roca S Fisher K Hahn R Sixt, et al. 2007 Guidelines for lung scintigraphy in children Eur J Nucl Med Mol Imaging 34 1518 1526 10.1007/s00259-007-0485-3 17602223 (Pubitemid 47312599)
39. Gutte H, Mortensen J, Jensen C, Johnbeck C, von der Recke P, Petersen C, et al. Detection of pulmonary embolism with combined ventilation/perfusion SPECT and low dose CT: head-to-head comparison with CT-angiography. J Nucl Med 2009; in press
40. E Itti S Nguyen F Robin S Desarnaud J Rosso A Harf, et al. 2002 Distribution of ventilation/perfusion ratios in pulmonary embolism: an adjunct to the interpretation of ventilation/perfusion lung scans J Nucl Med 43 1596 1602 12468507
41. Y Ohno H Koyama D Takenaka M Nogami Y Kotani Y Nishimura, et al. 2007 Coregistered ventilation and perfusion SPECT using krypton-81m and Tc-99m-labeled macroaggregated albumin with multislice CT utility for prediction of postoperative lung function in non-small cell lung cancer patients Acad Radiol 14 830 838 10.1016/j.acra.2007.03.013 17574133 (Pubitemid 46898851)
42. Y Sando T Inoue R Nagai K Endo 1997 Ventilation/perfusion ratios and simultaneous dual-radionuclide single-photon emission tomography with krypton-81m and technetium-99m macroaggregated albumin Eur J Nucl Med 24 1237 1244 10.1007/s002590050147 9323264 1:STN:280:DyaK2svmslWkug%3D%3D (Pubitemid 27477616)
43. G Oberdorster 2001 Pulmonary effects of inhaled ultrafine particles Int Arch Occup Environ Health 74 1 8 10.1007/s004200000185 11196075 1:CAS:528:DC%2BD3cXotVSktro%3D (Pubitemid 32123735)
44. PA Jaques CS Kim 2000 Measurement of total lung deposition of inhaled ultrafine particles in healthy men and women Inhal Toxicol 12 715 731 10.1080/08958370050085156 10880153 1:CAS:528:DC%2BD3cXmsFKjs7c%3D
45. C O'Callaghan PW Barry 1997 The science of nebulised drug delivery Thorax 52 Suppl 2 S31 S44 9155849
46. MA Dolovich 2000 Influence of inspiratory flow rate, particle size, and airway caliber on aerosolized drug delivery to the lung Respir Care 45 597 608 10894453 1:STN:280:DC%2BD3M%2FivVSisA%3D%3D
47. WD Bennett W Mitzner 1985 Use of aerosols to measure in vivo volume-dependent changes in lung air space dimensions J Appl Physiol 59 875 883 4055576 1:STN:280:DyaL28%2FjtlChsg%3D%3D
48. JE Agnew RA Francis D Pavia SW Clarke 1982 Quantitative comparison of 99Tcm-aerosol and 81Krm ventilation images Clin Phys Physiol Meas 3 21 30 10.1088/0143-0815/3/1/002 7049510 1:STN:280:DyaL383mtVegtw%3D%3D (Pubitemid 12050799)
49. T Isawa BT Lee K Hiraga 1996 High-resolution electron microscopy of technegas and pertechnegas Nucl Med Commun 17 147 152 8778639 1:CAS:528:DyaK28Xit1Ght7o%3D (Pubitemid 26081929)
50. TJ Senden KH Moock JF Gerald WM Burch RJ Browitt CD Ling, et al. 1997 The physical and chemical nature of technegas J Nucl Med 38 1327 1333 9255177 1:STN:280:DyaK2szpvFSnug%3D%3D
51. JC Strong JE Agnew 1989 The particle size distribution of technegas and its influence on regional lung deposition Nucl Med Commun 10 425 430 10.1097/00006231-198906000-00008 2788848 1:STN:280:DyaL1Mzms1SitA%3D%3D
52. E Bondesson T Bengtsson LE Nilsson P Wollmer 2007 Site of deposition and absorption of an inhaled hydrophilic solute Br J Clin Pharmacol 63 722 731 10.1111/j.1365-2125.2006.02835.x 17244190 1:CAS:528:DC%2BD2sXntl2rs78%3D (Pubitemid 46753572)
53. C Beadsmoore HK Cheow K Szczepura P Ruparelia AM Peters 2007 Healthy passive cigarette smokers have increased pulmonary alveolar permeability Nucl Med Commun 28 75 77 10.1097/MNM.0b013e328013eb1e 17198345 (Pubitemid 46041489)
54. J Rinderknecht L Shapiro M Krauthammer G Taplin K Wasserman JM Uszler, et al. 1980 Accelerated clearance of small solutes from the lungs in interstitial lung disease Am Rev Respir Dis 121 105 117 7352693 1:STN:280: DyaL3c7gslKmtA%3D%3D
55. J Palmer U Bitzen B Jonson M Bajc 2001 Comprehensive ventilation/ perfusion SPECT J Nucl Med 42 1288 1294 11483693 1:STN:280: DC%2BD3MvjslyisA%3D%3D
56. K Tagil E Evander P Wollmer J Palmer B Jonson 2000 Efficient lung scintigraphy Clin Physiol 20 95 100 10.1046/j.1365-2281.2000.00232.x 10735975 1:STN:280:DC%2BD3c3gtVOktw%3D%3D (Pubitemid 30135957)
57. E Evander P Wollmer S Valind L Sornmo J John B Jonson 1994 Biexponential pulmonary clearance of 99mTc-DTPA induced by detergent aerosol J Appl Physiol 77 190 196 7525528 1:CAS:528:DyaK2cXmt1GitL4%3D
58. J Kotzerke J van den Hoff W Burchert TF Wagner M Emter H Hundeshagen 1996 A compartmental model for alveolar clearance of pertechnegas J Nucl Med 37 2066 2071 8970536 1:STN:280:DyaK2s7isFCmuw%3D%3D
59. H Van der Wall IP Murray PD Jones DW Mackey BM Walker P Monaghan 1991 Optimising technetium 99m diethylene triamine penta-acetate lung clearance in patients with the acquired immunodeficiency syndrome Eur J Nucl Med 18 235 240 2070802
60. WM Burch PJ Sullivan FE Lomas VA Evans CJ McLaren RN Arnot 1986 Lung ventilation studies with technetium-99m Pseudogas J Nucl Med 27 842 846 3712096 1:STN:280:DyaL283is1KktA%3D%3D
61. WM Burch IJ Tetley JL Gras 1984 Technetium-99m 'pseudogas' for diagnostic studies in the lung Clin Phys Physiol Meas 5 79 85 10.1088/0143-0815/5/2/003 6467872 1:STN:280:DyaL2c3otl2qsQ%3D%3D (Pubitemid 14071296)
62. M Lemb TH Oei H Eifert B Gunther 1993 Technegas: a study of particle structure, size and distribution Eur J Nucl Med 20 576 579 10.1007/BF00176550 8053994 1:STN:280:DyaK3szotVCmtA%3D%3D
63. K Kawakami A Iwamura E Goto Y Mori T Abe Y Hirasawa, et al. 1990 Kinetics and clinical application of 99mTc-technegas Kaku Igaku 27 725 733 2172605 1:STN:280:DyaK3M%2FktVWmsg%3D%3D
64. G Cook SE Clarke 1992 An evaluation of Technegas as a ventilation agent compared with krypton-81m in the scintigraphic diagnosis of pulmonary embolism Eur J Nucl Med 19 770 774 10.1007/BF00182818 1327796 1:STN:280: DyaK3s%2FhtFentw%3D%3D
65. IJ Hartmann PJ Hagen MP Stokkel OS Hoekstra MH Prins 2001 Technegas versus (81m) Kr ventilation-perfusion scintigraphy: a comparative study in patients with suspected acute pulmonary embolism J Nucl Med 42 393 400 11337513 1:STN:280:DC%2BD3MvjsFKguw%3D%3D
66. JM James JJ Lloyd BC Leahy S Church CC Hardy RA Shields, et al. 1992 99Tcm-Technegas and krypton-81m ventilation scintigraphy: a comparison in known respiratory disease Br J Radiol 65 1075 1082 1337496 1:STN:280: DyaK3s7mtFSlsg%3D%3D
67. J Magnant L Vecellio M de Monte D Grimbert C Valat E Boissinot, et al. 2006 Comparative analysis of different scintigraphic approaches to assess pulmonary ventilation J Aerosol Med 19 148 159 10.1089/jam.2006.19.148 16796539 1:STN:280:DC%2BD28zotFKksA%3D%3D (Pubitemid 43993381)
68. P Peltier P De Faucal A Chetanneau JF Chatal 1990 Comparison of technetium-99m aerosol and krypton-81m in ventilation studies for the diagnosis of pulmonary embolism Nucl Med Commun 11 631 638 10.1097/00006231-199009000- 00006 2172881 1:STN:280:DyaK3M%2Fktl2rtw%3D%3D
69. T Inoue N Watanabe N Oriuchi M Tateno K Tomiyoshi O Mitomo, et al. 1990 Clinical evaluation of lung scintigraphy with 99mTc-technegas Nippon Igaku Hoshasen Gakkai Zasshi 50 1590 1600 1965228 1:STN:280:DyaK3M3ht1Wksg%3D%3D
70. LL Heck JW Duley Jr 1974 Statistical considerations in lung imaging with 99mTc albumin particles Radiology 113 675 679 4428055 1:CAS:528: DyaE2MXht1Wjs7o%3D
71. ICRP 1998 Radiation dose to patients from radiopharmaceuticals (addendum 2 to ICRP 53) Ann ICRP 28 1 126
72. ICRP. Radiation dose to patients from radiopharmaceuticals, publication 53. Oxford, New York: ICRP; 1988. p. 121.
73. MG Stabin MJ Gelfand 1998 Dosimetry of pediatric nuclear medicine procedures Q J Nucl Med 42 93 112 9695662 1:STN:280:DyaK1czmtVOktw%3D%3D
74. JA Camps C Zuur JA Blokland JJ Broerse EK Pauwels 1988 A breathing lung phantom for 81mKr lung ventilation studies its use in dosimetry and quality control Eur J Nucl Med 14 529 532 10.1007/BF00286770 3208782 1:STN:280:DyaL1M%2FptFaisA%3D%3D
75. LM Hurwitz T Yoshizumi RE Reiman PC Goodman EK Paulson DP Frush, et al. 2006 Radiation dose to the fetus from body MDCT during early gestation AJR Am J Roentgenol 186 871 876 10.2214/AJR.04.1915 16498123 (Pubitemid 46100280)
76. AF Scarsbrook KM Bradley FV Gleeson 2007 Perfusion scintigraphy: diagnostic utility in pregnant women with suspected pulmonary embolic disease Eur Radiol 17 2554 2560 10.1007/s00330-007-0607-0 17342484
77. C Schuemichen 2005 Pulmonary embolism: is multislice CT the method of choice? Against Eur J Nucl Med Mol Imaging 32 107 112 10.1007/s00259-004-1679-6 15378287
78. M Bajc 2005 Value of ventilation/perfusion SPECT detecting extensive pulmonary embolism in a patient with pneumonia Thromb Haemost 93 993 994 15886820
79. Bajc M, Olsson CG, Palmer J, Jonson B. Quantitative ventilation/perfusion SPECT (QV/PSPECT): a primary method for diagnosis of pulmonary embolism. In: Freeman LM, editor. Nuclear Medicine Annual. Philadelphia: Lippincott Williams & Wilkins; 2004. p. 173-86.
80. JP Collart V Roelants D Vanpee M Lacrosse JP Trigaux L Delaunois, et al. 2002 Is a lung perfusion scan obtained by using single photon emission computed tomography able to improve the radionuclide diagnosis of pulmonary embolism? Nucl Med Commun 23 1107 1113 10.1097/00006231-200211000-00011 12411840 (Pubitemid 35398985)
81. P Reinartz JE Wildberger W Schaefer B Nowak AH Mahnken U Buell 2004 Tomographic imaging in the diagnosis of pulmonary embolism: a comparison between V/Q lung scintigraphy in SPECT technique and multislice spiral CT J Nucl Med 45 1501 1508 15347717
82. M Lemb H Pohlabeln 2001 Pulmonary thromboembolism: a retrospective study on the examination of 991 patients by ventilation/perfusion SPECT using Technegas Nucl Med (Stuttg) 40 179 186 1:CAS:528:DC%2BD38XmtVGnsQ%3D%3D
83. CW Davies J Wimperis ES Green K Pendry J Killen I Mehdi, et al. 2007 Early discharge of patients with pulmonary embolism: a two-phase observational study Eur Respir J 30 708 714 10.1183/09031936.00140506 17567672 1:STN:280:DC%2BD2srnvFKlsA%3D%3D (Pubitemid 351194831)
84. CG Olsson U Bitzen B Olsson P Magnusson MS Carlsson B Jonson, et al. 2006 Outpatient tinzaparin therapy in pulmonary embolism quantified with ventilation/perfusion scintigraphy Med Sci Monit 12 PI9 PI13 16449959
85. VF Tapson MV Huisman 2007 Home at last? Early discharge for acute pulmonary embolism Eur Respir J 30 613 615 10.1183/09031936.00098007 17906083 1:STN:280:DC%2BD2srotlKitw%3D%3D (Pubitemid 351194818)
86. MA Meignan 2002 Lung ventilation/perfusion SPECT: the right technique for hard times J Nucl Med 43 648 651 11994529
87. M Miniati M Pistolesi C Marini G Di Ricco B Formichi R Prediletto, et al. 1996 Value of perfusion lung scan in the diagnosis of pulmonary embolism: results of the Prospective Investigative Study of Acute Pulmonary Embolism Diagnosis (PISA-PED) Am J Respir Crit Care Med 154 1387 1393 8912753 1:STN:280:DyaK2s%2FmvFOksQ%3D%3D
88. HD Sostman M Miniati A Gottschalk F Matta PD Stein M Pistolesi 2008 Sensitivity and specificity of perfusion scintigraphy combined with chest radiography for acute pulmonary embolism in PIOPED II J Nucl Med 49 1741 1748 10.2967/jnumed.108.052217 18927339
89. Bajc M, Jonson B. Lung. In: Biersack HJ, Freeman LM, editors. Clinical nuclear medicine. Berlin Heidelberg: Springer-Verlag; 2007. p. 118-37.
90. M Bajc B Olsson J Palmer B Jonson 2008 Ventilation/perfusion SPECT for diagnostics of pulmonary embolism in clinical practise J Intern Med 264 379 387 18823506 1:STN:280:DC%2BD1cnjtlCmtQ%3D%3D
91. M Bajc CG Olsson B Olsson J Palmer B Jonson 2004 Diagnostic evaluation of planar and tomographic ventilation/perfusion lung images in patients with suspected pulmonary emboli Clin Physiol Funct Imaging 24 249 256 10.1111/j.1475-097X.2004.00546.x 15383080
92. J Jogi J Palmer B Jonson M Bajc 2008 Heart failure diagnostics based on ventilation/perfusion single photon emission computed tomography pattern and quantitative perfusion gradients Nucl Med Commun 29 666 673 10.1097/MNM. 0b013e328302cd26 18753817
93. M Leblanc F Leveillee E Turcotte 2007 Prospective evaluation of the negative predictive value of V/Q SPECT using 99mTc-Technegas Nucl Med Commun 28 667 672 10.1097/MNM.0b013e32827a8e99 17625390 (Pubitemid 47067055)
94. LM Freeman B Krynyckyi LS Zuckier 2001 Enhanced lung scan diagnosis of pulmonary embolism with the use of ancillary scintigraphic findings and clinical correlation Semin Nucl Med 31 143 157 10.1053/snuc.2001.21273 11330785 1:STN:280:DC%2BD3MrhsFaltg%3D%3D
95. PJ Hagen IJ Hartmann OS Hoekstra MP Stokkel GJ Teule MH Prins 2002 How to use a gestalt interpretation for ventilation-perfusion lung scintigraphy J Nucl Med 43 1317 1323 12368369
96. DM Howarth JA Booker DD Voutnis 2006 Diagnosis of pulmonary embolus using ventilation/perfusion lung scintigraphy: more than 0.5 segment of ventilation/perfusion mismatch is sufficient Intern Med J 36 281 288 10.1111/j.1445-5994.2006.01070.x 16650192 1:STN:280:DC%2BD283ktlGmtw%3D%3D
97. M Miniati M Bottai S Monti M Salvadori L Serasini M Passera 2008 Simple and accurate prediction of the clinical probability of pulmonary embolism Am J Respir Crit Care Med 178 290 294 10.1164/rccm.200802-207OC 18436792
98. A Perrier PM Roy D Aujesky I Chagnon N Howarth AL Gourdier, et al. 2004 Diagnosing pulmonary embolism in outpatients with clinical assessment, D-dimer measurement, venous ultrasound, and helical computed tomography: a multicenter management study Am J Med 116 291 299 10.1016/j.amjmed.2003.09.041 14984813 (Pubitemid 38230287)
99. PS Wells DR Anderson M Rodger I Stiell JF Dreyer D Barnes, et al. 2001 Excluding pulmonary embolism at the bedside without diagnostic imaging: management of patients with suspected pulmonary embolism presenting to the emergency department by using a simple clinical model and d-dimer Ann Intern Med 135 98 107 11453709 1:STN:280:DC%2BD3MvhtVOhtw%3D%3D
100. Bajc M, Neilly B, Miniati M, Schuemichen C, Meignan M, Jonson B. EAMN Guidelines for ventilation/perfusion scintigraphy, Part 2. Algorithms and clinical considerations for diagnosis of pulmonary emboli with V/P SPECT and MDCT. Eur J Nucl Med Mol Imaging 2009; doi: 10.1007/s00259-009-1169-y.
101. J Lewczuk P Piszko J Jagas A Porada S Wojciak B Sobkowicz, et al. 2001 Prognostic factors in medically treated patients with chronic pulmonary embolism Chest 119 818 823 10.1378/chest.119.3.818 11243963 1:STN:280: DC%2BD3M3hs1GisQ%3D%3D (Pubitemid 32197654)
102. M Riedel V Stanek J Widimsky I Prerovsky 1982 Longterm follow-up of patients with pulmonary thromboembolism. Late prognosis and evolution of hemodynamic and respiratory data Chest 81 151 158 10.1378/chest.81.2.151 7056079 1:STN:280:DyaL387hs1emtQ%3D%3D
103. R Lisbona H Kreisman J Novales-Diaz V Derbekyan 1985 Perfusion lung scanning: differentiation of primary from thromboembolic pulmonary hypertension AJR Am J Roentgenol 144 27 30 3871143 1:STN:280:DyaL2M%2FmvFSqtQ%3D%3D
104. KM Moser GT Page WL Ashburn PF Fedullo 1988 Perfusion lung scans provide a guide to which patients with apparent primary pulmonary hypertension merit angiography West J Med 148 167 170 3348025 1:STN:280:DyaL1c7mtVWgtg%3D%3D
105. N Tunariu SJ Gibbs Z Win W Gin-Sing A Graham P Gishen, et al. 2007 Ventilation-perfusion scintigraphy is more sensitive than multidetector CTPA in detecting chronic thromboembolic pulmonary disease as a treatable cause of pulmonary hypertension J Nucl Med 48 680 684 10.2967/jnumed.106.039438 17475953 (Pubitemid 47604965)
106. DF Worsley HI Palevsky A Alavi 1994 Ventilation-perfusion lung scanning in the evaluation of pulmonary hypertension J Nucl Med 35 793 796 8176460 1:STN:280:DyaK2c3jtFaltQ%3D%3D
107. CN Chapman JJ Sziklas RP Spencer RJ Rosenberg 1983 Pulmonary perfusion "without ventilation" J Nucl Med 24 1149 1150 6644374 1:STN:280:DyaL2c%2Fmtlyqtw%3D%3D
108. HD Sostman RD Neumann A Gottschalk RH Greenspan 1983 Perfusion of nonventilated lung: failure of hypoxic vasoconstriction? AJR Am J Roentgenol 141 151 156 6602512 1:STN:280:DyaL3s3islOgug%3D%3D
109. A Garg PG Gopinath JN Pande JS Guleria 1983 Role of radio-aerosol and perfusion lung imaging in early detection of chronic obstructive lung disease Eur J Nucl Med 8 167 171 10.1007/BF00252889 6222899 1:STN:280: DyaL3s3jsVGhtg%3D%3D
110. D Mispelaere JC Glerant M Audebert A Remond MA Sevestre-Pietri V Jounieaux 2002 Pulmonary embolism and sibilant types of chronic obstructive pulmonary disease decompensations Rev Mal Respir 19 415 423 12417857 1:STN:280:DC%2BD38nlsl2huw%3D%3D
111. I Tillie-Leblond CH Marquette T Perez A Scherpereel C Zanetti AB Tonnel, et al. 2006 Pulmonary embolism in patients with unexplained exacerbation of chronic obstructive pulmonary disease: prevalence and risk factors Ann Intern Med 144 390 396 16549851
112. B Schonhofer D Kohler 1998 Prevalence of deep-vein thrombosis of the leg in patients with acute exacerbation of chronic obstructive pulmonary disease Respiration 65 173 177 10.1159/000029254 9670296 1:STN:280:DyaK1czjsV2msA%3D%3D (Pubitemid 28302293)
113. WF Friedman E Braunwald 1966 Alterations in regional pulmonary blood flow in mitral valve disease studied by radioisotope scanning. A simple nontraumatic technique for estimation of left atrial pressure Circulation 34 363 376 5922704 1:STN:280:DyaF2s%2FktFCjtw%3D%3D
114. M Pistolesi M Miniati M Bonsignore F Andreotti G Di Ricco C Marini, et al. 1988 Factors affecting regional pulmonary blood flow in chronic ischemic heart disease J Thorac Imaging 3 65 72 3392762 1:STN:280:DyaL1c3nsV2ruw%3D%3D
115. DJ Li I Stewart KA Miles EP Wraight 1994 Scintigraphic appearances in patients with pulmonary infection and lung scintigrams of intermediate or low probability for pulmonary embolism Clin Nucl Med 19 1091 1093 10.1097/00003072-199419120-00011 7874809 1:STN:280:DyaK2M7nvFykuw%3D%3D
116. P Carvalho JP Lavender 1989 The incidence and etiology of the ventilation/perfusion reverse mismatch defect Clin Nucl Med 14 571 576 10.1097/00003072-198908000-00004 2805537 1:STN:280:DyaK3c%2FjtFalsg%3D%3D
117. WM Pace ML Goris 1998 Pulmonary SPECT imaging and the stripe sign J Nucl Med 39 721 723 9544688 1:STN:280:DyaK1c3gsVantQ%3D%3D
118. C Schümichen 2003 V/Q-scanning/SPECT for the diagnosis of pulmonary embolism Respiration 70 329 342 10.1159/000072892 14512664 (Pubitemid 37186696)
119. M Cei N Mumoli F Mariotti R Pardelli 2004 The importance of clinical suspicion in diagnosing pulmonary embolism: a case of false-positive high probability radionuclide perfusion lung scan Eur J Emerg Med 11 234 236 10.1097/01.mej.0000134839.34865.1f 15249815