Reexamining transaminase elevation in Phase i clinical trials: The importance of baseline and change from baseline

European Journal of Clinical Pharmacology

Volumn 65, Issue 10, 2009, Pages 1025-1035

  Cai, Zhaohui ^a   Christianson, Anastasia M ^a   Ståhle, Lars ^b   Keisu, Marianne ^c  

^a ASTRAZENECA   (United Kingdom)

^b ASTRAZENECA R AND D   (Sweden)

^c BIOVITRUM AB   (Sweden)

Author keywords

Alanine transaminase; Aminotransferase; Elevation rate; Healthy volunteers; Upper limit of normal values

Indexed keywords

ALANINE AMINOTRANSFERASE; PLACEBO;

ADULT; AFRICA; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASIAN; CAUCASIAN; DEMOGRAPHY; ETHNIC DIFFERENCE; FEMALE; HUMAN; MALE; METHODOLOGY; NORMAL HUMAN; PHASE 1 CLINICAL TRIAL; PREDICTION; PREVALENCE; PRIORITY JOURNAL; RETROSPECTIVE STUDY;

ADULT; AGE FACTORS; AGED; ALANINE TRANSAMINASE; AREA UNDER CURVE; BODY MASS INDEX; BODY WEIGHT; CLINICAL TRIALS, PHASE I AS TOPIC; CONTINENTAL POPULATION GROUPS; FEMALE; HUMANS; LENGTH OF STAY; LIVER; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; REFERENCE VALUES; RETROSPECTIVE STUDIES; SEX FACTORS; TRANSAMINASES;

EID: 70349229295     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-009-0684-x     Document Type: Article

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