메뉴 건너뛰기




Volumn 36, Issue 6, 2009, Pages 736-742

Monoclonal antibody S2C4 neutralizes the toxicity of shiga toxin 2 and its variants*

Author keywords

Monoclonal antibody (mab) s2c4; Neutralization; Shiga toxin 2 (stx2); Stx producing escherichia coli (stec)

Indexed keywords

ESCHERICHIA COLI; MUS;

EID: 70349207205     PISSN: 10003282     EISSN: None     Source Type: Journal    
DOI: 10.3724/SP.J.1206.2008.00415     Document Type: Article
Times cited : (3)

References (28)
  • 2
    • 29144530625 scopus 로고    scopus 로고
    • Stx2vha is the dominant genotype of Shiga toxin-producing Escherichia coli 0157: H7 isolated from patients and domestic animals in three regions of China
    • Zheng H, Jing H, Wang H, et al. stx2vha is the dominant genotype of Shiga toxin-producing Escherichia coli 0157 : H7 isolated from patients and domestic animals in three regions of China. Microbiol Immunol, 2005, 49(12): 1019-1026
    • (2005) Microbiol Immunol , vol.49 , Issue.12 , pp. 1019-1026
    • Zheng, H.1    Jing, H.2    Wang, H.3
  • 3
    • 0024444206 scopus 로고
    • Isolation and characterization of functional Shiga toxin subunits and renatured holotoxin
    • Donohue-Rolfe A, Jacewicz M, Keusch G T. Isolation and characterization of functional shiga toxin subunits and renatured holotoxin. Mol Microbiol, 1989, 3(9): 1231-1236 (Pubitemid 19239970)
    • (1989) Molecular Microbiology , vol.3 , Issue.9 , pp. 1231-1236
    • Donohue-Rolfe, A.1    Jacewicz, M.2    Keusch, G.T.3
  • 4
    • 0025370116 scopus 로고
    • Demonstration of RNA N-glycosidase activity of a verotoxin (VT2 variant) produced by escherichia coli 091: H21 from patient with the hemolytic uremic syndrome
    • Furutani M, Ito K, Oku Y, et al. Demonstration of RNA N-glycosidase activity of a verotoxin (VT2 variant) produced by Escherichia coli 091 : H21 from patient with the hemolytic uremic syndrome. Microbiol Immunol, 1990, 34(4): 387-392
    • (1990) Microbiol Immunol , vol.34 , Issue.4 , pp. 387-392
    • Furutani, M.1    Ito, K.2    Oku, Y.3
  • 5
    • 0023687040 scopus 로고
    • The primary structure of the operons coding for Shigella dysenteriae toxin and temperature phage H30 shiga-like toxin
    • Kozlov Yu V, Kabishev A A, Lukyanov E V, et al. The primary structure of the operons coding for Shigella dysenteriae toxin and temperature phage H30 shiga-like toxin. Gene, 1988, 67(2): 213-221
    • (1988) Gene , vol.67 , Issue.2 , pp. 213-221
    • Kozlov Yu, V.1    Kabishev, A.A.2    Lukyanov, E.V.3
  • 6
    • 0023121139 scopus 로고
    • Nucleotide sequence analysis of structural genes for shiga-like toxin i encoded by bacteriophage 933j from escherichia coli
    • Jackson M P, Newland J W, Holees R K, et al. Nucleotide sequence analysis of structural genes for Shiga-like toxin I encoded by bacteriophage 933J from Escherichia coli. Microb Pathog, 1987, 2 (2): 147-153
    • (1987) Microb Pathog , vol.2 , Issue.2 , pp. 147-153
    • Jackson, M.P.1    Newland, J.W.2    Holees, R.K.3
  • 7
    • 0027178560 scopus 로고
    • Comparison of the relative toxicities of shiga-like toxins type i and type II for mice
    • Tesh V L, Bums J A, Owens J W, et al. Comparison of the relative toxicities of Shiga-like toxins type I and type II for mice. Infect Immun, 1993, 61(8): 3392-3402
    • (1993) Infect Immun , vol.61 , Issue.8 , pp. 3392-3402
    • Tesh, V.L.1    Bums, J.A.2    Owens, J.W.3
  • 8
    • 0034729744 scopus 로고    scopus 로고
    • The risk of the hemolyticuremic syndrome after antibiotic treatment of escherichia coli 0157: H7 infections
    • Wong C S, Jelacic S, Habeeb R L, et al. The risk of the hemolyticuremic syndrome after antibiotic treatment of Escherichia coli 0157 : H7 infections. N Engl J Med, 2000, 342(26): 1930-1936
    • (2000) N Engl J Med , vol.342 , Issue.26 , pp. 1930-1936
    • Wong, C.S.1    Jelacic, S.2    Habeeb, R.L.3
  • 9
    • 0027316057 scopus 로고
    • Differences in verotoxin neutralizing activity of therapeutic immunoglobulins and sera from healthy controls
    • Bitzan M, Klemt M, Steffens R, et al. Differences in verotoxin neutralizing activity of therapeutic immunoglobulins and sera from healthy controls. Infection, 1993, 21(3): 140-145 (Pubitemid 23197139)
    • (1993) Infection , vol.21 , Issue.3 , pp. 140-145
    • Bitzan, M.1    Klemt, M.2    Steffens, R.3    Muller-Wiefel, D.E.4
  • 10
    • 0036156075 scopus 로고    scopus 로고
    • Human stx2-specific monoclonal antibodies prevent systemic complications of escherichia coli O157: H7 infection
    • Mukherjee J, Chios K, Fishwild D, et al. Human Stx2-Specific monoclonal antibodies prevent systemic complications of Escherichia coli ) O157 : H7 infection. Infect Immun, 2002, 70(2): 612-619
    • (2002) Infect Immun , vol.70 , Issue.2 , pp. 612-619
    • Mukherjee, J.1    Chios, K.2    Fishwild, D.3
  • 11
    • 0032733735 scopus 로고    scopus 로고
    • Monoclonal antibody to shiga toxin 2 which blocks receptor binding and neutralizes cytotoxicity
    • Nakao H, Kiyokawa N, Fujimoto J, et al. Monoclonal antibody to shiga toxin 2 which blocks receptor binding and neutralizes cytotoxicity. Infect Immun, 1999, 67(11): 5717-5722 (Pubitemid 29508090)
    • (1999) Infection and Immunity , vol.67 , Issue.11 , pp. 5717-5722
    • Nakao, H.1    Kiyokawa, N.2    Fujimoto, J.3    Yamasaki, S.4    Takeda, T.5
  • 12
    • 70349207879 scopus 로고    scopus 로고
    • Purification and functional characterization of enterohemorrhagic escherichia coli 0157: h7 shiga toxin ii
    • Jiao Y, Zeng X, Guo X, et al. Purification and functional characterization of enterohemorrhagic Escherichia coli 0157 : H7 Shiga toxin II. Chin Infect Dis, 2008, 26(4): 217-220
    • (2008) Chin Infect Dis , vol.26 , Issue.4 , pp. 217-220
    • Jiao, Y.1    Zeng, X.2    Guo, X.3
  • 13
    • 0016756272 scopus 로고
    • Continuous cultures of fused cells secreting antibody of predefined specificity
    • London, 5517
    • Kohler G, Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature (London), 1975, 256 (5517): 495-497
    • (1975) Nature , vol.256 , pp. 495-497
    • Kohler, G.1    Milstein, C.2
  • 14
    • 0035793091 scopus 로고    scopus 로고
    • Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways
    • Xiao G H, Jeffers M, Bellacosa A, et al. Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways. Proc Natl Acad Sci USA, 2001, 98(1): 247-252
    • (2001) Proc Natl Acad Sci USA , vol.98 , Issue.1 , pp. 247-252
    • Xiao, G.H.1    Jeffers, M.2    Bellacosa, A.3
  • 15
    • 0036139657 scopus 로고    scopus 로고
    • Escherichia coli harboring Shiga toxin 2 gene variants: Frequency and association with clinical symptoms
    • Friedrich A W, Bielaszewska M, Zhang W L, et al. Escherichia coli harboring Shiga toxin 2 gene variants: frequency and association with clinical symptoms. J Infect Dis, 2002, 185(1): 74-84
    • (2002) J Infect Dis , vol.185 , Issue.1 , pp. 74-84
    • Friedrich, A.W.1    Bielaszewska, M.2    Zhang, W.L.3
  • 16
    • 0025370411 scopus 로고
    • Mouse model for colonization and disease caused by enterohemorrhagic Escherichia coli 0157: H7
    • Wadolkowski E A, Burns J A, O'Brien A D. Mouse model for colonization and disease caused by enterohemorrhagic Escherichia coli 0157 : H7. Infect Immun, 1990, 58(8): 2438-2445
    • (1990) Infect Immun , vol.58 , Issue.8 , pp. 2438-2445
    • Wadolkowski, E.A.1    Burns, J.A.2    O'Brien, A.D.3
  • 17
    • 0025313405 scopus 로고
    • Molecular cloning and nucleotide sequence of another variant of the escherichia coli shiga-like toxin u family
    • Gannon V P, Teerling C, Masri S A, et al. Molecular cloning and nucleotide sequence of another variant of the Escherichia coli Shiga-like toxin U family. J Gen Microbiol, 1990, 136(6): 1125-1135
    • (1990) J Gen Microbiol , vol.136 , Issue.6 , pp. 1125-1135
    • Gannon, V.P.1    Teerling, C.2    Masri, S.A.3
  • 18
    • 0025333838 scopus 로고
    • Cloning and nucleotide sequencing of Vero toxin 2 variant genes from Escherichia coli 091: H21 isolated from a patient with the hemolytic uremic syndrome
    • Ito H, Terai A, Kurazono H, et al. Nishibuchi M. Cloning and nucleotide sequencing of Vero toxin 2 variant genes from Escherichia coli 091 : H21 isolated from a patient with the hemolytic uremic syndrome. Microb Pathog, 1990, 8(1): 47-60
    • (1990) Microb Pathog , vol.8 , Issue.1 , pp. 47-60
    • Ito, H.1    Terai, A.2    Kurazono, H.3    Nishibuchi, M.4
  • 19
    • 0026027180 scopus 로고
    • Two copies of Shiga-like toxin TJ -related genes common in enterohemorrhagic Escherichia coli strains are responsible for the antigenic heterogeneity of the 0157: H-strain E32511
    • Schmitt C K, McKee M L, O ' Brien A D. Two copies of Shiga-like toxin TJ -related genes common in enterohemorrhagic Escherichia coli strains are responsible for the antigenic heterogeneity of the 0157 : H-strain E32511. Infect Immun, 1991, 59(3): 1065-1073
    • (1991) Infect Immun , vol.59 , Issue.3 , pp. 1065-1073
    • Schmitt, C.K.1    McKee, M.L.2    'Brien A D, O.3
  • 20
    • 0031671439 scopus 로고    scopus 로고
    • Identification of new verocytotxin type 2 variant B-subunit genes in human and animal Escherichia coli isolates
    • Pierard D, Muyldermans G, Moriau L, et al. Identification of new verocytotxin type 2 variant B-subunit genes in human and animal Escherichia coli isolates. J Clin Microbiol, 1998, 36(11): 3317 - -3322
    • (1998) J Clin Microbiol , vol.36 , Issue.11 , pp. 3317-3322
    • Pierard, D.1    Muyldermans, G.2    Moriau, L.3
  • 21
    • 0038444124 scopus 로고    scopus 로고
    • Stx2-specific human monoclonal antibodies protect mice against lethal infection with Escherichia coli expressing Stx2 variants
    • Sheoran A S, Chapman S, Singh P, et al. Stx2-specific human monoclonal antibodies protect mice against lethal infection with Escherichia coli expressing Stx2 variants. Infect Immun, 2003, 71 (6): 3125-3130
    • (2003) Infect Immun , vol.71 , Issue.6 , pp. 3125-3130
    • Sheoran, A.S.1    Chapman, S.2    Singh, P.3
  • 22
    • 0033617003 scopus 로고    scopus 로고
    • The so-called chromosomal verotoxin genes are actually carried by defective prophages
    • Mizutani S, Nakazono N, Sugino Y. The so-called chromosomal verotoxin genes are actually carried by defective prophages. DNA Res, 1999, 6(2): 141-143 (Pubitemid 129705123)
    • (1999) DNA Research , vol.6 , Issue.2 , pp. 141-143
    • Mizutani, S.1    Nakazono, N.2    Sugino, Y.3
  • 23
    • 7744244887 scopus 로고    scopus 로고
    • Purification and characterization of the repressor of the shiga toxin-encoding bacteriophage 933W: DNA binding, gene regulation, and autocleavage
    • Koudelka A P, Hufnagel L A, Koudelka G B. Purification and characterization of the repressor of the shiga toxin-encoding bacteriophage 933W: DNA binding, gene regulation, and autocleavage. J Bacteriol, 2004, 186(22): 7659-7669
    • (2004) J Bacteriol , vol.186 , Issue.22 , pp. 7659-7669
    • Koudelka, A.P.1    Hufnagel, L.A.2    Koudelka, G.B.3
  • 24
    • 0031746606 scopus 로고    scopus 로고
    • Functional and genetic analysis of regulatory regions of coliphage H-19B: Location of Shiga-like toxin and lysis genes suggest a role for phage functions in toxin release
    • Neely M N, Friedman D I. Functional and genetic analysis of regulatory regions of coliphage H-19B: location of Shiga-like toxin and lysis genes suggest a role for phage functions in toxin release. Mol Microbiol, 1998, 28(6): 1255-1267
    • (1998) Mol Microbiol , vol.28 , Issue.6 , pp. 1255-1267
    • Neely, M.N.1    Friedman, D.I.2
  • 25
    • 0031693468 scopus 로고    scopus 로고
    • Bacteriophage biology and bacterial virulence
    • Waldor M K. Bacteriophage biology and bacterial virulence. Trends Microbiol, 1998, 6(8): 295-297
    • (1998) Trends Microbiol , vol.6 , Issue.8 , pp. 295-297
    • Waldor, M.K.1
  • 26
    • 0037188488 scopus 로고    scopus 로고
    • A therapeutic agent with oriented carbohydrates for treatment of infections by Shiga toxin-producing Escherichia coli 0157: H7
    • Nishikawa K, Matsuoka K, Kita E, et al. A therapeutic agent with oriented carbohydrates for treatment of infections by Shiga toxin-producing Escherichia coli 0157 : H7. Proc Natl Acad Sci USA, 2002, 99(11): 7669-7674
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.11 , pp. 7669-7674
    • Nishikawa, K.1    Matsuoka, K.2    Kita, E.3
  • 27
    • 0034059721 scopus 로고    scopus 로고
    • A new biological agent for treatment of Shiga toxigenic Escherichia coli infections and dysentery in humans
    • Paton A W, Morona R, Patón J C. A new biological agent for treatment of Shiga toxigenic Escherichia coli infections and dysentery in humans. Nat Med, 2000, 6(3): 265-270
    • (2000) Nat Med , vol.6 , Issue.3 , pp. 265-270
    • Paton, A.W.1    Morona, R.2    Patón, J.C.3
  • 28
    • 0035884459 scopus 로고    scopus 로고
    • Efficacy of postinfection treatment with anti-shiga toxin (stx) 2 humanized monoclonal antibody tma-15 in mice lethally challenged with stx-producing escherichia coli
    • DOI 10.1086/323082
    • Yamagami S, Motoki M, Kimura T, et al. Efficacy of postinfection treatment with anti-Shiga toxin (Stx) 2 humanized monoclonal antibody TMA-15 in mice lethally challenged with Stx-producing Escherichia coli. J Infect Dis, 2001, 184(6): 738-742 (Pubitemid 32826425)
    • (2001) Journal of Infectious Diseases , vol.184 , Issue.6 , pp. 738-742
    • Yamagami, S.1    Motoki, M.2    Kimura, T.3    Izumi, H.4    Takeda, T.5    Katsuura, Y.6    Matsumoto, Y.-I.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.