Treatment of stable angina pectoris by ivabradine in every day practice: The REDUCTION Study

American Heart Journal

Volumn 158, Issue 4, 2009, Pages

  Köster, Ralf ^a   Kaehler, Jan ^a   Meinertz, Thomas ^a  

^a UNIVERSITY HEART CENTER HAMBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIDEPRESSANT AGENT; ANTIDIABETIC AGENT; ANTILIPEMIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BRONCHODILATING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CLOPIDOGREL; CORTICOSTEROID; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INSULIN; IVABRADINE; MOLSIDOMINE; NITRIC ACID DERIVATIVE; THEOPHYLLINE; TICLOPIDINE;

ADULT; AGED; ANGINA PECTORIS; ARTICLE; ATRIOVENTRICULAR BLOCK; BLURRED VISION; BRADYCARDIA; CLINICAL TRIAL; COMORBIDITY; DIZZINESS; DRUG DOSE COMPARISON; ELECTROCARDIOGRAM; EYE DISEASE; FEMALE; FOLLOW UP; HEADACHE; HEART ARRHYTHMIA; HEART ATRIUM FIBRILLATION; HEART DISEASE; HEART PALPITATION; HEART RATE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NAUSEA; OPEN STUDY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; STABLE ANGINA PECTORIS; SYNCOPE; TACHYCARDIA;

AGED; ANGINA PECTORIS; BENZAZEPINES; CYCLIC NUCLEOTIDE-GATED CATION CHANNELS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROCARDIOGRAPHY; FEMALE; FOLLOW-UP STUDIES; GERMANY; HEART RATE; HUMANS; MALE; PROSPECTIVE STUDIES; QUESTIONNAIRES; TIME FACTORS; TREATMENT OUTCOME;

EID: 70349203826     PISSN: 00028703     EISSN: 10976744     Source Type: Journal    
DOI: 10.1016/j.ahj.2009.06.008     Document Type: Article

References (29)

1. McLenachan J.M., Weidinger F.F., Barry J., et al. Relations between heart rate, ischemia, and drug therapy during daily life in patients with coronary artery disease. Circulation 83 (1991) 1263-1270
2. Andrews T.C., Fenton T., Toyosaki N., et al. Subsets of ambulatory myocardial ischemia based on heart rate activity. Circadian distribution and response to anti-ischemic medication. The Angina and Silent Ischemia Study Group (ASIS). Circulation 88 (1993) 92-100
3. Heusch G., and Schulz R. The role of heart rate and the benefits of heart rate reduction in acute myocardial ischemia. Eur Heart J 9 Suppl F (2007) F8-F14
4. Fraker T.D., and Fihn S.D. 2007 Chronic Angina Focused Update of the ACC/AHA 2002 guidelines for the management of patients with chronic stable angina. Circulation 116 (2007) 2762-2772
5. Fox K., Garcia M.A., Ardissino D., et al. Guidelines on the management of stable angina pectoris. Eur Heart J 27 (2006) 1341-1381
6. Donner-Banzhoff N., Held K., Laufs U., et al. Nationale Versorgungsleitlinie Chronische KHK. Version 2008. Available at. http://www.versorgungsleitlinien.de/themen/khk/pdf/nvl_khk_lang.pdf Last accessed January 22, 2009
7. Dyer A.R., Persky V., Stamler J., et al. Heart rate as a prognostic factor for coronary heart disease and mortality: findings in three Chicago epidemiologic studies. Am J Epidemiol 112 (1980) 736-749
8. Kannel W.B., Kannel C., Paffenbarger Jr. R.S., et al. Heart rate and cardiovascular mortality: the Framingham Study. Am Heart J 113 (1987) 1489-1494
9. Diaz A., Bourassa M.G., Guertin M.C., and Tardif J.C. Long-term prognostic value of resting heart rate in patients with suspected or proven coronary artery disease. Eur Heart J 26 (2005) 967-974
10. Cook S., Togni M., Schaub M.C., Wenaweser P., and Hess O.M. High heart rate: a cardiovascular risk factor?. Eur Heart J 27 (2006) 2387-2393
11. Fox K., Borer J., Camm A.J., et al. Resting heart rate in cardiovascular disease. J Am Coll Cardiol 50 (2007) 823-830
12. Palatini P. Heart rate as an independent risk factor for cardiovascular disease. Current evidence and basic mechanisms. Drugs 67 Suppl 2 (2007) 3-13
13. Fox K., Ford I., Steg P.G., et al. Heart rate as a prognostic risk factor in patients with coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a subgroup analysis of a randomised controlled trial. Lancet 372 (2008) 817-821
14. DiFrancesco D. Funny channels in the control of cardiac rhythm and mode of action of selective blockers. Pharmacol Res 53 (2006) 399-406
15. DiFrancesco D., and Camm J.A. Heart rate lowering by specific and selective If current inhibition with ivabradine. Drugs 64 (2004) 1757-1765
16. Borer J.S., Fox K., Jaillon P., et al. Antianginal and antiischemic effects of ivabradine, an If inhibitor, in stable angina. A randomized, double-blind, multicentered, placebo-controlled trial. Circulation 107 (2003) 817-823
17. Tardiff J.C., Ford I., Tendera M., et al. Efficacy of ivabradine, a new selective If inhibitor, compared with atenolol in patients with chronic stable angina. Eur Heart J 26 (2005) 2529-2536
18. Ferrari R., Cargnoni A., and Ceconi C. Anti-ischaemic effect of ivabradine. Pharmacol Res 53 (2006) 435-439
19. Lopez-Bescos L., Filipova S., and Martos R. Long-term safety and efficacy of ivabradine in patients with chronic stable angina. Cardiology 108 (2007) 387-396
20. Ruzyllo W., Tendera M., Ford I., et al. Antianginal efficacy and safety of ivabradine compared with amlodipine in patients with stable effort angina pectoris: a 3 month randomised, double blind, multicentre, noninferiority trial. Drugs 67 (2007) 393-405
21. Concato J., Shah N., and Horwitz R.I. Randomized, controlled trials, observational studies, and the hierarchy of research designs. N Engl J Med 342 (2000) 1887-1892
22. Pocock S.J., and Elbourne D.R. Randomized trials or observational tribulations?. N Engl J Med 342 (2000) 1907-1909
23. Campeau L. Grading of angina pectoris. Circulation 54 (1976) 522-523
24. Tardiff J.C. Clinical results of If current inhibition by ivabradine. Drugs 67 Suppl 2 (2007) 35-41
25. Psaty B.M., Manolio T.A., and Kuller L.H. Incidence of and risk factors for atrial fibrillation in older adults. Circulation 96 (1997) 2455-2461
26. Krahn A.D., Manfreda J., and Tate R.B. The natural history of atrial fibrillation: incidence, risk factors, and prognosis in the Manitoba Follow-Up Study. Am J Med 98 (1995) 476-484
27. Robinson B.F. Relation of heart rate and systolic blood pressure to the onset of pain in angina pectoris. Circulation 35 (1967) 1073-1083
28. Siegel R.K. Hallucinations. Sci Am 237 (1977) 132-140
29. Cervetto L., Demontis G.C., and Gargini C. Cellular mechanisms underlying the pharmacological induction of phosphens. Br J Pharmacol 150 (2007) 383-390