Incongruous Changes in Heart Period and Heart Rate Variability with Vagotonic Atropine: Implications for Rehabilitation Medicine

PM and R

Volumn 1, Issue 9, 2009, Pages 820-826

  Picard, Glen ^a   Tan, Can Ozan ^a   Zafonte, Ross ^b   Taylor, J Andrew ^b  

^a and Red Sox Foundation and Massachusetts General Hospital Home Base Program   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATROPINE;

ADULT; ARTICLE; BRADYCARDIA; BREATHING RATE; CARDIOVASCULAR AUTOREGULATION; CARDIOVASCULAR EFFECT; CHRONOTROPISM; CONTROLLED STUDY; FEMALE; HEART CYCLE; HEART RATE; HEART RATE VARIABILITY; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RR INTERVAL; VAGUS TONE;

ADULT; AGED; ANTI-ARRHYTHMIA AGENTS; ATROPINE; FEMALE; HEART RATE; HUMANS; INJECTIONS, INTRAVENOUS; MALE; MIDDLE AGED; YOUNG ADULT;

EID: 70349202224     PISSN: 19341482     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pmrj.2009.07.017     Document Type: Article

References (34)

1. Katona P.G., and Jih F. Respiratory sinus arrhythmia: Noninvasive measure of parasympathetic cardiac control. J Appl Physiol 39 (1975) 801-805
2. Kleiger R.E., Stein P.K., Bosner M.S., and Rottman J.N. Time domain measurements of heart rate variability. Cardiol Clin 10 (1992) 487-498
3. Malliani A., Pagani M., Lombardi F., and Cerutti S. Cardiovascular neural regulation explored in the frequency domain. Circulation 84 (1991) 482-492
4. Scalvini S., Volterrani M., Zanelli E., et al. Is heart rate variability a reliable method to assess autonomic modulation in left ventricular dysfunction and heart failure?. Assessment of autonomic modulation with heart rate variability. Int J Cardiol 67 (1998) 9-17
5. Kleiger R.E., Miller J.P., Bigger Jr. J.T., and Moss A.J. Decreased heart rate variability and its association with increased mortality after acute myocardial infarction. Am J Cardiol 59 (1987) 256-262
6. Grimm D.R., De Meersman R.E., Almenoff P.L., Spungen A.M., and Bauman W.A. Sympathovagal balance of the heart in subjects with spinal cord injury. Am J Physiol 272 (1997) H835-H842
7. Baguley I.J., Heriseanu R.E., Felmingham K.L., and Cameron I.D. Dysautonomia and heart rate variability following severe traumatic brain injury. Brain Inj 20 (2006) 437-444
8. Korpelainen J.T., Sotaniemi K.A., Makikallio A., Huikuri H.V., and Myllyla V.V. Dynamic behavior of heart rate in ischemic stroke. Stroke 30 (1999) 1008-1013
9. Cohen H., Neumann L., Alhosshle A., Kotler M., bu-Shakra M., and Buskila D. Abnormal sympathovagal balance in men with fibromyalgia. J Rheumatol 28 (2001) 581-589
10. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability: Standards of measurement, physiological interpretation and clinical use. Circulation 93 (1996) 1043-1065
11. Taylor J.A., Myers C.W., Halliwill J.R., Seidel H., and Eckberg D.L. Sympathetic restraint of respiratory sinus arrhythmia: Implications for vagal-cardiac tone assessment in humans. Am J Physiol Heart Circ Physiol 280 (2001) H2804-H2814
12. Martinmaki K., Rusko H., Kooistra L., Kettunen J., and Saalasti S. Intraindividual validation of heart rate variability indexes to measure vagal effects on hearts. Am J Physiol Heart Circ Physiol 290 (2006) H640-H647
13. Pyetan E., and Akselrod S. A theoretical appraisal of the dependence of respiratory sinus arrhythmia on gradual vagal blockade. Methods Inf Med 43 (2004) 52-55
14. Pyetan E., Toledo E., Zoran O., and Akselrod S. Parametric description of cardiac vagal control. Auton Neurosci 109 (2003) 42-52
15. Pyetan E., and Akselrod S. Do the high-frequency indexes of HRV provide a faithful assessment of cardiac vagal tone?. A critical theoretical evaluation. IEEE Trans Biomed Eng 50 (2003) 777-783
16. Katona P.G., Lipson D., and Dauchot P.J. Opposing central and peripheral effects of atropine on parasympathetic cardiac control. Am J Physiol 232 (1977) H146-H151
17. Wellstein A., and Pitschner H.F. Complex dose-response curves of atropine in man explained by different functions of M1- and M2-cholinoceptors. Naunyn Schmiedebergs Arch Pharmacol 338 1 (1988) 19-27
18. Lee K., Picard G., Beske S.D., Hwang G.S., and Taylor J.A. Effects of fitness and age on the response to vagotonic atropine. Auton Neurosci 139 (2008) 60-67
19. Medigue C., Girard A., Laude D., Monti A., Wargon M., and Elghozi J.L. Relationship between pulse interval and respiratory sinus arrhythmia: A time- and frequency-domain analysis of the effects of atropine. Pflugers Arch 441 (2001) 650-655
20. Koizumi K., Terui N., and Kollai M. Effect of cardiac vagal and sympathetic nerve activity on heart rate in rhythmic fluctuations. J Auton Nerv Syst 12 (1985) 251-259
21. Parker P., Celler B.G., Potter E.K., and McCloskey D.I. Vagal stimulation and cardiac slowing. J Auton Nerv Syst 11 (1984) 226-231
22. Kollai M., Jokkel G., Bonyhay I., Tomcsanyi J., and Naszlady A. Relation between baroreflex sensitivity and cardiac vagal tone in humans. Am J Physiol 266 (1994) H21-H27
23. Robinson B.F., Epstein S.E., Beiser G.D., and Braunwald E. Control of heart rate by the autonomic nervous system. Studies in man on the interrelation between baroreceptor mechanisms and exercise. Circ Res 19 (1966) 400-411
24. Averill K.H., and Lamb L.E. Less commonly recognized actions of atropine on cardiac rhythm. Am J Med Sci 237 (1959) 304-318
25. Epstein A.E., Hirschowitz B.I., Kirklin J.K., Kirk K.A., Kay G.N., and Plumb V.J. Evidence for a central site of action to explain the negative chronotropic effect of atropine: Studies on the human transplanted heart. J Am Coll Cardiol 15 (1990) 1610-1617
26. Oberhauser V., Schwertfeger E., Rutz T., Beyersdorf F., and Rump L.C. Acetylcholine release in human heart atrium: influence of muscarinic autoreceptors, diabetes, and age. Circulation 103 (2001) 1638-1643
27. Goldberger J.J., Kim Y.H., Ahmed M.W., and Kadish A.H. Effect of graded increases in parasympathetic tone on heart rate variability. J Cardiovasc Electrophysiol 7 (1996) 594-602
28. Esler M.D., Turner A.G., Kaye D.M., et al. Aging effects on human sympathetic neuronal function. Am J Physiol 268 (1995) R278-R285
29. Baguley I.J., Nott M.T., Slewa-Younan S., Heriseanu R.E., and Perkes I.E. Diagnosing dysautonomia after acute traumatic brain injury: evidence for overresponsiveness to afferent stimuli. Arch Phys Med Rehabil 90 (2009) 580-586
30. Furlan J.C., and Fehlings M.G. Cardiovascular complications after acute spinal cord injury: Pathophysiology, diagnosis, and management. Neurosurg Focus 25 (2008) E13
31. Claydon V.E., and Krassioukov A.V. Clinical correlates of frequency analyses of cardiovascular control after spinal cord injury. Am J Physiol Heart Circ Physiol 294 (2008) H668-H678
32. Keren O., Yupatov S., Radai M.M., et al. Heart rate variability (HRV) of patients with traumatic brain injury (TBI) during the post-insult sub-acute period. Brain Inj 19 (2005) 605-611
33. Saul J.P., Rea R.F., Eckberg D.L., Berger R.D., and Cohen R.J. Heart rate and muscle sympathetic nerve variability during reflex changes of autonomic activity. Am J Physiol 258 (1990) H713-H721
34. Taylor J.A., Carr D.L., Myers C.W., and Eckberg D.L. Mechanisms underlying very-low-frequency RR-interval oscillations in humans. Circulation 98 (1998) 547-555