Design and evaluation of novel biphenyl sulfonamide derivatives with potent histamine H3 receptor inverse agonist activity

Journal of Medicinal Chemistry

Volumn 52, Issue 18, 2009, Pages 5603-5611

  Covel, Jonathan A ^a   Santora, Vincent J ^a   Smith, Jeffrey M ^a   Hayashi, Rena ^a   Gallardo, Charlemagne ^a   Weinhouse, Michael I ^a   Ibarra, Jason B ^a   Schultz, Jeffrey A ^a   Park, Douglas M ^a   Estrada, Scott A ^a   Hofilena, Brian J ^a   Pulley, Michelle D ^a   Smith, Brian M ^a   Ren, Albert ^a   Suarez, Marissa ^a   Frazer, John ^a   Edwards, Jeffrey ^a   Hauser, Erin K ^a   Lorea, Jodie ^a   Semple, Graeme ^a   Grottick, Andrew J ^a   more..

^a ARENA PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4' [2 (2 METHYLPYRROLIDIN 1 YL)ETHYL]BIPHENYL 4 SULFONIC ACID ETHYLAMIDE; ALPHA METHYLHISTAMINE; BIPHENYL DERIVATIVE; HISTAMINE H3 RECEPTOR ANTAGONIST; PHENETHYL 2 METHYLPYRROLIDINE; SULFONAMIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DAYTIME SOMNOLENCE; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; IN VIVO STUDY; MALE; NONHUMAN; PHARMACODYNAMICS; POLYDIPSIA; POLYSOMNOGRAPHY; RAT; WAKEFULNESS;

ADMINISTRATION, ORAL; ANIMALS; BIPHENYL COMPOUNDS; DRUG DESIGN; DRUG INVERSE AGONISM; HISTAMINE ANTAGONISTS; HUMANS; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, HISTAMINE H3; SULFONAMIDES; THIRST; WAKEFULNESS;

EID: 70349202209     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm900857n     Document Type: Article

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