-
1
-
-
0037179698
-
Peginterferon α-2a plus ribavirin for chronic hepatitis C virus infection
-
Fried MW, Shiffman ML, Reddy KR et al.: Peginterferon α-2a plus ribavirin for chronic hepatitis C virus infection. N. Engl. J. Med. 347(13), 975-982 (2002).
-
(2002)
N. Engl. J. Med
, vol.347
, Issue.13
, pp. 975-982
-
-
Fried, M.W.1
Shiffman, M.L.2
Reddy, K.R.3
-
2
-
-
17844403232
-
A randomized, double-blind trial comparing pegylated interferon α-2b to interferon α-2b as initial treatment for chronic hepatitis C
-
Lindsay KL, Trepo C, Heintges T et al.: A randomized, double-blind trial comparing pegylated interferon α-2b to interferon α-2b as initial treatment for chronic hepatitis C. Hepatology 34(2), 395-403 (2001).
-
(2001)
Hepatology
, vol.34
, Issue.2
, pp. 395-403
-
-
Lindsay, K.L.1
Trepo, C.2
Heintges, T.3
-
3
-
-
34548758435
-
Telaprevir and pegylated interferon α-2a inhibit wild-type and resistant genotype 1 hepatitis C virus replication in patients
-
Kieffer TL, Sarrazin C, Miller JS et al.: Telaprevir and pegylated interferon α-2a inhibit wild-type and resistant genotype 1 hepatitis C virus replication in patients. Hepatology 46, 631-639 (2007).
-
(2007)
Hepatology
, vol.46
, pp. 631-639
-
-
Kieffer, T.L.1
Sarrazin, C.2
Miller, J.S.3
-
4
-
-
10644237092
-
Epoetin-α improves quality of life in anemic HCV-infected patients receiving combination therapy
-
Pockros PJ, Shiffman M, Schiff ER et al.: Epoetin-α improves quality of life in anemic HCV-infected patients receiving combination therapy. Hepatology 40(6), 1450-1458 (2004).
-
(2004)
Hepatology
, vol.40
, Issue.6
, pp. 1450-1458
-
-
Pockros, P.J.1
Shiffman, M.2
Schiff, E.R.3
-
5
-
-
28444432873
-
Five million Americans infected with the hepatitis C virus: A corrected estimate
-
Edlin BR: Five million Americans infected with the hepatitis C virus: a corrected estimate. Hepatology 42(Suppl. 1), 213A (2005).
-
(2005)
Hepatology
, vol.42
, Issue.SUPPL. 1
-
-
Edlin, B.R.1
-
6
-
-
1842479859
-
Diagnosis, management, and treatment of hepatitis C
-
Strader DB, Wright T, Thomas DL, Seeff LB: Diagnosis, management, and treatment of hepatitis C. Hepatology 39(4), 1147-1171 (2004).
-
(2004)
Hepatology
, vol.39
, Issue.4
, pp. 1147-1171
-
-
Strader, D.B.1
Wright, T.2
Thomas, D.L.3
Seeff, L.B.4
-
7
-
-
0035934568
-
Peginterferon α-2b plus ribavirin compared wiuh interferon α-2b plus ribavirin for initial treatment of chronic hepatitis C: A randomised trial
-
Manns MP, McHutchison JG, Gordon SC et al.: Peginterferon α-2b plus ribavirin compared wiuh interferon α-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 358(9286), 958-965 (2001).
-
(2001)
Lancet
, vol.358
, Issue.9286
, pp. 958-965
-
-
Manns, M.P.1
McHutchison, J.G.2
Gordon, S.C.3
-
8
-
-
44949158356
-
Final results of the IDEAL (individualized dosing efficacy versus flat dosing to assess optimal pegylated interferon therapy) Phase IIIb study
-
Presented at:, Milan, Italy, 23-27 April
-
Sulkowski M, Lawitz E, Shiffman MI, et al.: Final results of the IDEAL (individualized dosing efficacy versus flat dosing to assess optimal pegylated interferon therapy) Phase IIIb study. Presented at: The 43rd Annual Meeting of the European Association for the Study of the Liver. Milan, Italy, 23-27 April 2008.
-
(2008)
The 43rd Annual Meeting of the European Association for the Study of the Liver
-
-
Sulkowski, M.1
Lawitz, E.2
Shiffman, M.I.3
-
9
-
-
33947366502
-
Peginterferon α-2b plus ribavirin vs interferon α-2b plus ribavirin for chronic hepatitis C in HIV-coinfected patients
-
Crespo M, Sauleda S, Esteban JI et al.: Peginterferon α-2b plus ribavirin vs interferon α-2b plus ribavirin for chronic hepatitis C in HIV-coinfected patients. Viral Hepat. 14(4), 228-238 (2007).
-
(2007)
Viral Hepat
, vol.14
, Issue.4
, pp. 228-238
-
-
Crespo, M.1
Sauleda, S.2
Esteban, J.I.3
-
10
-
-
33748497126
-
Hepatitis C recurrence after liver transplantation: Viral and histologic response to full-dose PEG-interferon and ribavirin
-
Oton E, Barcena R, Moreno-Planas JM et al.: Hepatitis C recurrence after liver transplantation: viral and histologic response to full-dose PEG-interferon and ribavirin. Am. J. Transplant. 6(10), 2348-2355 (2006).
-
(2006)
Am. J. Transplant
, vol.6
, Issue.10
, pp. 2348-2355
-
-
Oton, E.1
Barcena, R.2
Moreno-Planas, J.M.3
-
11
-
-
46249132509
-
PROVEI: Results from a Phase 2 study of telaprevir with peginterferon α-2a and ribavirin in treatment-naive subjects with hepatitis C
-
Presented at:, Milan, Italy, 23-27 April
-
Mchutchison JG, Everson GT, Gordon SC et al.: PROVEI: Results from a Phase 2 study of telaprevir with peginterferon α-2a and ribavirin in treatment-naive subjects with hepatitis C. Presented at: The 43rd Annual Meeting of the European Association for the Study of the Liver. Milan, Italy, 23-27 April 2008.
-
(2008)
The 43rd Annual Meeting of the European Association for the Study of the Liver
-
-
Mchutchison, J.G.1
Everson, G.T.2
Gordon, S.C.3
-
12
-
-
61849083229
-
Telaprevir in combination with peginterferon-α-2a with or without ribavirin in the treatment of chronic hepatitis C: Final results of the PROVE2 study
-
Zeuzem S, Hezode C, Ferenci P et al.: Telaprevir in combination with peginterferon-α-2a with or without ribavirin in the treatment of chronic hepatitis C: final results of the PROVE2 study. Hepatology 48(Suppl. 4), A243 (2008).
-
(2008)
Hepatology
, vol.48
, Issue.SUPPL. 4
-
-
Zeuzem, S.1
Hezode, C.2
Ferenci, P.3
-
13
-
-
79953227834
-
Interim results from HCV SPRINT-1: RVR/EVR from Phase 2 study of boceprevir plus peginterferon α-2b/ribavirin in treatment-naive subjects with genotype-1 CHC
-
Presented at:, Milan, Italy, 23-27 April
-
Kwo P, Lawitz E, McCone J et al.: Interim results from HCV SPRINT-1: RVR/EVR from Phase 2 study of boceprevir plus peginterferon α-2b/ribavirin in treatment-naive subjects with genotype-1 CHC. Presented at: The 43rd Annual Meeting of the European Association for the Study of the Liver. Milan, Italy, 23-27 April 2008.
-
(2008)
The 43rd Annual Meeting of the European Association for the Study of the Liver
-
-
Kwo, P.1
Lawitz, E.2
McCone, J.3
-
14
-
-
0037228456
-
Activation and deactivation of a broad-spectrum antiviral drug by a single enzyme: Adenosine deaminase catalyzes two consecutive deamination reactions
-
Wu JZ, Walker H, Lau JY et al.: Activation and deactivation of a broad-spectrum antiviral drug by a single enzyme: adenosine deaminase catalyzes two consecutive deamination reactions. Antimicrob. Agents Chemother. 47(1), 426-431 (2003).
-
(2003)
Antimicrob. Agents Chemother
, vol.47
, Issue.1
, pp. 426-431
-
-
Wu, J.Z.1
Walker, H.2
Lau, J.Y.3
-
15
-
-
0141928585
-
Ribavirin, viramidine and adenosine-deaminase-catalysed drug activation: Implication for nucleoside prodrug design
-
Wu JZ, Lin C, Hong Z: Ribavirin, viramidine and adenosine-deaminase-catalysed drug activation: implication for nucleoside prodrug design. J. Antimicrob. Chemother. 52(4), 543-546 (2003).
-
(2003)
J. Antimicrob. Chemother
, vol.52
, Issue.4
, pp. 543-546
-
-
Wu, J.Z.1
Lin, C.2
Hong, Z.3
-
17
-
-
16844364646
-
Ascending multiple-dose pharmacokinetics of viramidine, a prodrug of ribavirin, in adult subjects with compensated hepatitis C infection
-
Aora S, Xu C, Teng A et al.: Ascending multiple-dose pharmacokinetics of viramidine, a prodrug of ribavirin, in adult subjects with compensated hepatitis C infection. J. Clin. Pharmacol. 45(3), 275-285 (2005).
-
(2005)
J. Clin. Pharmacol
, vol.45
, Issue.3
, pp. 275-285
-
-
Aora, S.1
Xu, C.2
Teng, A.3
-
18
-
-
1242277744
-
Pharmacokinetics and safety of viramidine, a prodrug of ribavirin, in healthy volunteers
-
Lin CC, Philips L, Xu C, Yeh LT: Pharmacokinetics and safety of viramidine, a prodrug of ribavirin, in healthy volunteers. J. Clin. Pharmacol. 44(3), 265-275 (2004).
-
(2004)
J. Clin. Pharmacol
, vol.44
, Issue.3
, pp. 265-275
-
-
Lin, C.C.1
Philips, L.2
Xu, C.3
Yeh, L.T.4
-
19
-
-
34249309613
-
Virological response and safety outcomes in therapy-naive patients treated for chronic hepatitis C with taribavirin or ribavirin in combination with pegylated interferon α-2a: A randomized, Phase 2 study
-
Gish RG, Arora S, Reddy KR et al: Virological response and safety outcomes in therapy-naive patients treated for chronic hepatitis C with taribavirin or ribavirin in combination with pegylated interferon α-2a: a randomized, Phase 2 study. J. Hepatol. 47(1), 51-59 (2007).
-
(2007)
J. Hepatol
, vol.47
, Issue.1
, pp. 51-59
-
-
Gish, R.G.1
Arora, S.2
Reddy, K.R.3
-
20
-
-
33747775068
-
The safety and efficacy of viramidine plus PegIFN α-2b versus ribavirin plus PegIFN α-2b in therapy-naive patients infected with HCV: Phase 3 results (VISER1)
-
S
-
Benhamou Y, Pockros P, Rodriguez-Torres M et al.: The safety and efficacy of viramidine plus PegIFN α-2b versus ribavirin plus PegIFN α-2b in therapy-naive patients infected with HCV: Phase 3 results (VISER1). J. Hepatol. 44, S273 (2006).
-
(2006)
J. Hepatol
, vol.44
, pp. 273
-
-
Benhamou, Y.1
Pockros, P.2
Rodriguez-Torres, M.3
-
21
-
-
70349199426
-
Taribavirin comparable in efficacy to ribavirin and results in less anaemia in patients with chronic hepatitis c
-
Presented at:, Milan, Italy, 23-27 April
-
Poordad F, Lawitz, E, Chun E, Hammond J: Taribavirin comparable in efficacy to ribavirin and results in less anaemia in patients with chronic hepatitis c. Presented at: The 43rd Annual Meeting of the European Association for the Study of the Liver. Milan, Italy, 23-27 April 2008.
-
(2008)
The 43rd Annual Meeting of the European Association for the Study of the Liver
-
-
Poordad, F.1
Lawitz, E.2
Chun, E.3
Hammond, J.4
-
22
-
-
65549111065
-
Treatment week 24 results of weight-based taribavirin versus weight-based ribavirin, both with peginterferon α-2b, in naive chronic hepatitis C, genotype 1 patients
-
Lawitz E, Muir AJ, Poordad F et al.: Treatment week 24 results of weight-based taribavirin versus weight-based ribavirin, both with peginterferon α-2b, in naive chronic hepatitis C, genotype 1 patients. Hepatology 48(Suppl. 4), A272 (2008).
-
(2008)
Hepatology
, vol.48
, Issue.SUPPL. 4
-
-
Lawitz, E.1
Muir, A.J.2
Poordad, F.3
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