Beyond thermodynamics: Drug binding kinetics could influence epidermal growth factor signaling

Journal of Medicinal Chemistry

Volumn 52, Issue 18, 2009, Pages 5582-5585

  Goyal, Mayank ^a   Rizzo, Michael ^a   Schumacher, Frank ^a   Wong, Chung F ^a  

^a UNIVERSITY OF MISSOURI ST LOUIS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; EPIDERMAL GROWTH FACTOR; PROTEIN KINASE;

ARTICLE; BINDING KINETICS; DISSOCIATION; DRUG BINDING; DRUG POTENCY; DRUG PROTEIN BINDING; ENZYME INHIBITION; IC 50; LUNG NON SMALL CELL CANCER; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; THERMODYNAMICS;

EPIDERMAL GROWTH FACTOR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; MODELS, BIOLOGICAL; PHARMACEUTICAL PREPARATIONS; PHARMACOLOGICAL PROCESSES; PHOSPHORYLATION; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; THERMODYNAMICS;

EID: 70349199202     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm900974p     Document Type: Article

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