Equine laminitis: Ultrastructural lesions detected in ponies following hyperinsulinaemia

Equine Veterinary Journal

Volumn 41, Issue 7, 2009, Pages 671-677

  Nourian, A R ^a   Asplin, K E ^a   McGowan, C M ^a   Sillence, M N ^b   Pollitt, C C ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

Author keywords

Basement membrane; Horse; Insulin; Laminitis; Mitosis; Ultrastructural

Indexed keywords

INSULIN;

ANIMAL; ANIMAL DISEASE; ARTICLE; CHEMICALLY INDUCED DISORDER; FOOT DISEASE; HOOF AND CLAW; HORSE; HORSE DISEASE; INFLAMMATION; PATHOLOGY; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE;

ANIMALS; FOOT DISEASES; HOOF AND CLAW; HORSE DISEASES; HORSES; INFLAMMATION; INSULIN; MICROSCOPY, ELECTRON, TRANSMISSION;

EQUIDAE;

EID: 70349192750     PISSN: 04251644     EISSN: None     Source Type: Journal    
DOI: 10.2746/042516409X407648     Document Type: Article

References (34)

1. Adair, H.S., Goble, D., Schmidhammer, J.L. and Shires, G.M. (2004) Evaluation of laminar microvascular flow during the prodromal stages of black walnut induced laminitis. In: Equine Laminitis Research Meeting and Panel, American Association of Equine Practitioners, Lexington. pp 95-101.
2. Asplin, K.E., Sillence, M.N., Pollitt, C.C. and McGowan, C.M. (2007) Induction of laminitis by prolonged hyperinsulinaemia in clinically normal ponies. Vet. J. 174, 530-535.
3. Bailey, S.R., Baillon, M.L., Rycroft, A.N., Harris, P.A. and Elliott, J. (2003) Identification of equine cecal bacteria producing amines in an in vitro model of carbohydrate overload. Appl. Environ. Microbiol. 69, 2087-2093.
4. Belknap, J.K., Giguere, S., Pettigrew, A., Cochran, A.M., van Eps, A.W. and Pollitt, C.C. (2007) Lamellar pro-inflammatory cytokine expression patterns in laminitis at the developmental stage and at the onset of lameness: innate vs. adaptive immune response. Equine vet. J. 39, 42-47.
5. Black, S.J., Lunn, D.P., Yin, C., Hwang, M., Lenz, S.D. and Belknap, J.K. (2006) Leukocyte emigration in the early stages of laminitis. Vet. Immunol. Immunopathol. 109, 161-166.
6. Black, S.J., Stewart, A., Blikslager, A., Allen, D. and Belknap, J.K. (2004) The role of inflammation in the developmental stages of laminitis. In: Equine Laminitis Research Meeting and Panel, American Association of Equine Practitioners, Lexington. pp 24-27.
7. Cheville, N.F. (1994) Ultrastructural Pathology: An Introduction to Interpretation, Iowa State University Press, Ames.
8. Croser, E.L. and Pollitt, C.C. (2006) Acute laminitis: descriptive evaluation of serial hoof biopsies. Proc. Am. Ass. equine Practnrs. 52, 542-546.
9. Daradka, M. and Pollitt, C.C. (2004) Epidermal cell proliferation in the equine hoof wall. Equine vet. J. 36, 236-241.
10. DeFronzo, R.A., Tobin, J.D. and Andres, R. (1979) Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am. J. Physiol. 237, 214-223.
11. Faleiros, R.R., Stokes, A.M., Eades, S.C., Kim, D.Y., Paulsen, D.B. and Moore, R.M. (2004) Assessment of apoptosis in epidermal lamellar cells in clinically normal horses and those with laminitis. Am. J. vet. Res. 65, 578-585.
12. Fischoeder, A., Meyborg, H., Stibenz, D., Fleck, E., Graf, K. and Stawowy, P. (2007) Insulin augments matrix metalloproteinase-9 expression in monocytes. Cardiovasc. Res. 73, 841-848.
13. Fontaine, G.L., Belknap, J.K., Allen, D., Moore, J.N. and Kroll, D.L. (2001) Expression of interleukin-1beta in the digital laminae of horses in the prodromal stage of experimentally induced laminitis. Am. J. vet. Res. 62, 714-720.
14. French, K.R. and Pollitt, C.C. (2004) Equine laminitis: Loss of hemidesmosomes in hoof secondary epidermal lamellae correlates to dose in an oligofructose induction model: An ultrastructural study. Equine vet. J. 36, 230-235.
15. Garner, H.E., Coffman, J.R., Hahn, A.W., Hutcheson, D.P. and Tumbleson, M.E. (1975) Equine laminitis of alimentary origin: an experimental model. Am. J. vet. Res. 36, 441-444.
16. Ghadially, F.N. (1982) Ultrastructural Pathology of the Cell and Matrix: A text and Atlas of Physiological and Pathological Alterations in the Fine Structure of Cellular and Extracellular Components, 2nd edn., Butterworths, London.
17. Johnson, P.J. (2002) The equine metabolic syndrome peripheral Cushing's syndrome. Vet. Clin. N. Am.: Equine Pract. 18, 271-293.
18. Johnson, P.J., Messer, N.T., Slight, S.H., Wiedmeyer, C., Buff, P. and Ganjam, V.K. (2004) Endocrinopathic laminitis in the horse. In: Equine Laminitis Research Meeting and Panel, Louisville.
19. Kyaw-Tanner, M.T., Wattle, O., van Eps, A.W. and Pollitt, C.C. (2008) Equine laminitis: Membrane type matrix metalloproteinase-1 (MMP-14) is involved in acute phase onset. Equine vet. J. 40, 482-487.
20. McMillan, J.R. and Eady, R.A. (1996) Hemidesmosome ontogeny in digit skin of the human fetus. Arch. Dermatol. Res. 288, 91-97.
21. Minnick, P.D., Brown, C.M., Braselton, W.E., Meerdink, G.L. and Slanker, M.R. (1987) The induction of equine laminitis with an aqueous extract of the heartwood of black walnut (Juglans nigra). Vet. human Toxicol. 29, 230-233.
22. Miyatake, N., Shikata, K., Maruyama, K., Sugimoto, H. and Makino, H. (1998) Newly diagnosed insulin-dependent diabetes mellitus with rapid severe thickening of the glomerular basement membrane. Nephron 80, 100-101.
23. Nourian, A.R., Baldwin, G.I., van Eps, A.W. and Pollitt, C.C. (2007) Equine laminitis: ultrastructural lesions detected 24-30 hours after induction with oligofructose. Equine vet. J. 39, 360-364.
24. Peloso, J.G., Cohen, N.D., Walker, M.A., Watkins, J.P., Gayle, J.M. and Moyer, W. (1996) Case-control study of risk factors for the development of laminitis in the contralateral limb in Equidae with unilateral lameness. J. Am. vet. med. Ass. 209, 1746-1749.
25. Pollitt, C.C. (1994) The basement membrane at the equine hoof dermal epidermal junction. Equine vet. J. 26, 399-407.
26. Pollitt, C.C. (1996) Basement membrane pathology: A feature of acute equine laminitis. Equine vet. J. 28, 38-46.
27. Pollitt, C.C. (1999a) Equine laminitis: A revised pathophysiology. Proc. Am. Ass. equine Practnrs. 45, 188-192.
28. Pollitt, C.C. (1999b) Laminitis. In: Equine Medicine and Surgery, 5th edn., Eds: P.T. Colahan, A.M. Merritt, J.N. Moore and I.G.J. Mayhew, Mosby, St. Louis. pp 1521-1542.
29. Pollitt, C.C., Pass, M.A. and Pollitt, S. (1998) Batimastat (BB-94) inhibits matrix metalloproteinases of equine laminitis. Equine vet. J., Suppl. 26, 119-124.
30. Thomson, S.E., McLennan, S.V., Kirwan, P.D., Heffernan, S.J., Hennessy, A., Yue, D.K. and Twigg, S.M. (2008) Renal connective tissue growth factor correlates with glomerular basement membrane thickness and prospective albuminuria in a non-human primate model of diabetes: possible predictive marker for incipient diabetic nephropathy. J. Diabetes Complications 22, 284-294.
31. Tran, T.T., Naigamwalla, D., Oprescu, A.I., Lam, L., McKeown-Eyssen, G., Bruce, W.R. and Giacca, A. (2006) Hyperinsulinemia, but not other factors associated with insulin resistance, acutely enhances colorectal epithelial proliferation in vivo. Endocrinol. 147, 1830-1837.
32. Treiber, K.H., Kronfeld, D.S., Hess, T.M., Byrd, B.M., Splan, R.K. and Staniar, W.B. (2006) Evaluation of genetic and metabolic predispositions and nutritional risk factors for pasture-associated laminitis in ponies. J. Am. vet. med. Ass. 228, 1538-1545.
33. van Eps, A.W. and Pollitt, C.C. (2006) Equine laminitis induced with oligofructose. Equine vet. J. 38, 203-208.
34. Walsh, D., McGowan, C., McGowan, T., Lamb, S., Schanbacher, B. and Place, N. (2009) Correlation of plasma insulin concentration with laminitis score in a field study of equine Cushing's disease and equine metabolic syndrome. J. equine vet. sci. 29, 87-94.