Androgen modulators from the roots of Paeonia lactiflora (Paeoniae radix) grown and processed in Nara prefecture, Japan

Chemical and Pharmaceutical Bulletin

Volumn 57, Issue 9, 2009, Pages 971-974

  Washida, Kazuto ^a   Itoh, Yoshiyuki ^b   Iwashita, Takashi ^b   Nomoto, Kyosuke ^a  

^a The Nara Prefectural Agricultural Experiment Station   (Japan)

^b SUNTORY INSTITUTE FOR BIOORGANIC RESEARCH   (Japan)

Author keywords

Androgen receptor; Crude drug; LNCaP FGC (prostate cancer cell line); Monoterpene glycoside; Paeonia lactiflora; Paeoniaceae

Indexed keywords

3' O GALLOYLPAEONIFLORIN; 6' O BENZOYLPAEONIFLORIN; 6' O GALLOYLALBIFLORIN; 6' O GALLOYLPAEONIFLORIN; ALBIFLORIN; ANDROGEN RECEPTOR; GLUCOSE PENTAGALLATE; PAEONIA LACTIFLORA EXTRACT; PAEONIFLORIN; TESTOSTERONE; UNCLASSIFIED DRUG;

ARTICLE; CANCER INHIBITION; CELL STRAIN LNCAP; CONTROLLED STUDY; DRUG ISOLATION; DRUG RECEPTOR BINDING; DRUG STRUCTURE; HETERONUCLEAR MULTIPLE BOND CORRELATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IC 50; JAPAN; PLANT ROOT;

ANDROGEN ANTAGONISTS; ANDROGEN RECEPTOR ANTAGONISTS; CELL LINE, TUMOR; HUMANS; JAPAN; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MONOTERPENES; PAEONIA; PLANT ROOTS; RECEPTORS, ANDROGEN;

EID: 70349183769     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.57.971     Document Type: Article

References (13)

1. Kumagai Y., Hyuga S., Hyuga M., Watanabe K., Kawanishi T., Hanawa T., J. Trad. Med., 22, 228-236 (2005).
2. Watanabe K., Hyuga S., Hyuga M., Kawanishi T., Hanawa T., J. Trad. Med., 23, 203-207 (2006).
3. Heinlein C. A., Chang C., Endocr. Rev., 25, 276-308 (2004).
4. Takahashi H., Ishioka T., Koiso Y., Sodeoka M., Hashimoto Y., Biol. Pharm. Bull., 23, 1387-1390 (2000).
5. Gomez J.-L., Dupont A., Cusan L., Tremblay M., Suburu R., Lemay M., Labrie F., Am. J. Med., 92, 465-470 (1992).
6. Wysowski D. K., Fourcroy J. L., J. Urol., 155, 209-212 (1996).
7. Yen P. H., Kiem P. V., Nhiem N. X., Tung N. H., Quang T. H., Minh C. V., Kim J. W., Choi E. M., Kim Y. H., Arch. Pharm. Res., 30, 1179-1185 (2007).
8. Wang X. L., Jiao W., Liao X., Peng S. L., Ding L. S., Chin. Chem. Lett., 17, 916-918 (2006).
9. Nishizawa M., Yamagishi T., Nonaka G., Nishioka I., Bando H., Chem. Pharm. Bull., 30, 1094-1097 (1982).
10. Kang S. S., Shin K. H., Chi H.-J., Arch. Pharm. Res., 14, 52-54 (1991).
11. van Steenbrugge G. J., van Uffelen C. J., Bolt J., Schroder F. H., J. Steroid Biochem. Mol. Biol., 40, 207-214 (1991).
12. Lee H.-H., Ho C.-H., Lin J.-K., Carcinogenesis, 25, 1109-1118 (2004).
13. Long B. J., Grigoryev D. N., Nnane I. P., Liu Y., Ling Y.-Z., Brodie A. M., Cancer Res., 60, 6630-6640 (2000).