Comparative study of some mechanical and release properties of paracetamol tablets formulated with cashew tree gum, povidone and gelatin as binders

African Journal of Biotechnology

Volumn 8, Issue 16, 2009, Pages 3970-3973

  Okoye, E I ^a   Onyekweli, A O ^a   Ohwoavworhua, F O ^b   Kunle, O O ^b  

^a UNIVERSITY OF BENIN   (Nigeria)

^b NATIONAL INSTITUTE FOR PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (Nigeria)

Author keywords

Binder; Cashew gum; Gelatin; Mechanical; Povidone; Release properties of paracetamol tablets

Indexed keywords

GELATIN; PARACETAMOL; POVIDONE;

ARTICLE; CASHEW NUT; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG FORMULARY; DRUG RELEASE; TABLET;

ANACARDIUM OCCIDENTALE;

EID: 70349167075     PISSN: None     EISSN: 16845315     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Akoto GE, Oduro J, Amoah FM, Oldham JH, Ellis WD, Opoku-Ameyaw K (2007). Rheological properties of aqueous cashew tree gum solutions. Sci. Res. Essay, 2(10): 458-461.
2. British Pharmacopoeia (2003). Vol.4, Her Majesty stationery office, London, p. 2051.
3. Cunha PLR, Maciel JS, Sierakowski MR, De Paula RCM, Feitosa JPA (2007). Oxidation of cashew tree gum exudates polysaccharide with TEMPO reagent. J. Braz. Chem. Soc. 18(1): 85-92.
4. De Paula RCM, Heatley F, Budd PM (1998). Characterization of Anacardium occidentale exudate polysaccharide. Polym. Int. 45(1): 27-35
5. Eichie FE, Amaline AE (2007). Evaluation of the binder effects of the gum mucilage from Cissus populnea and Acacia senegal on the mechanical properties of paracetamol tablets. Afr. J. Biotech. 6(19): 2208-2211.
6. Eichie FE, Okor RS, Uhumwangho MU, Osakwe TY (2005). Relationship between slugging pressure and Brittle fracture tendency-a case study for Aspirin tablets. Trop. J. Pharm. Res. 4(2): 482-487.
7. Fell JT, Newton JM (1970). Determination of tablet strength by diametral compression test. J. Pharm. Sci. 59: 688-691.
8. Hiestand EN, Wells JE, Poet CE, Ochs JF (1977). Physical processes of tableting. J. Pharm. Sci. 66: 510-519.
9. th ed. 1, Lippinocott William and Wilkins, Philadelphia; pp. 91-123.
10. Itiola OA, Pilpel N (1986). Tableting characteristics of metronidazole formulation. Int. J. Pharm. 31: 99-105.
11. Itiola OA, Pilpel N (1982). Formulation effect on the mechanical properties of metronidazole tablets. J. Pharm. Phamcol. 43: 145-147.
12. Manuel E, Antonios K, Marilena V (2000). Development and evaluation of oral multi-unit and single-unit hydrophilic controlled-release systems. Pharm. Sci. Tech. 4: 34-37.
13. Nasipuri RN, Igwilo CI, Brown SA, Kunle OO (1996). Mucilage from Abelmoschus esculentus (Okra) fruits-a potential Pharmaceutical Raw Material. Part I: Physiochemical properties. J. Pharm. Res. Devt. 1: 22-28.
14. Ohwoavworhua FO, Adelakun TA, Kunle OO (2007). A comparative evaluation of the Flow and Compaction characteristics of a-cellulose obtained from Waste Paper. Trop. J. Pharm. Res. 6(1): 645-651.
15. Okor RS (2005). Brittle fracture during tableting, problem for the Pharmaceutical Industry. Trop. J. Pharm. Res. 4(2): 481-482.
16. Sinka IC, Cunningham JC, Zavaliangos A (2004). Analysis of tablet compaction. II finite element analysis of density distribution in convex tablets. J. Pharm. Sci. 93(8): 2040-2052.
17. Sumathi S, Ray AR (2002). Release behaviour of drugs from tamarind seed polysaccharide tablets. J. Pharm. Pharmceut. Sci. 5:512-518
18. Uhumwangho MU, Okor RS (2004). Anomalous effect of Compression pressure on the brittle fracture tendency of acellulose tablets. Int. J. Pharm. 284: 69-74.
19. Uhumwangho MU, Okor RS, Eichie FE, Abbah CM (2006). Influence of some starch binders on the brittle fracture tendency of paracetamol tablets. Afr. J. Biotech. 5(20): 1950-1953.
20. United States Pharmacopoeia 23/National Formulary 18 (UNP/NF) (1995). United States Pharmacopoeial Convention, Rockville. pp. 1942-1943.
21. Williams III RO, McGinity JW (1988). The use of tableting indices to study the compaction properties of powders. Drug Dev. Ind. Pharm. 14(13): 1823-1844.