The presence of arginine may be a source of false positive results in the Ames test

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 679, Issue 1-2, 2009, Pages 65-71

  Khandoudi, Nassirah ^a   Porte, Pierre ^a   Chtourou, Sami ^a   Nesslany, Fabrice ^b   Marzin, Daniel ^b,c   Le Curieux, Frank ^b,c  

^a Laboratoire Francais du Fractionnement et des Biotechnologies   (France)

^b INSTITUT PASTEUR DE LILLE   (France)

^c France Institut Pasteur de Lille   (France)

Author keywords

Amino acids; Arginine; Artefact; False positive; Salmonella typhimurium

Indexed keywords

ARGININE; ASCORBIC ACID; GLYCINE; ISOLEUCINE; LYSINE;

AMES TEST; ARTICLE; CONTROLLED STUDY; DRUG SCREENING; FALSE POSITIVE RESULT; METABOLIC ACTIVATION; MUTAGEN TESTING; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REVERTANT; SALMONELLA TYPHIMURIUM;

AMINO ACIDS; ANIMALS; ARGININE; ASCORBIC ACID; BIOTRANSFORMATION; FALSE POSITIVE REACTIONS; MUTAGENICITY TESTS; SALMONELLA TYPHIMURIUM;

SALMONELLA TYPHIMURIUM;

EID: 70349163365     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2009.03.010     Document Type: Article

References (36)

1. Genotoxicity: Guidance on Specific Aspects of Regulatory Genotoxicity Tests for Pharmaceuticals, ICH Topic S2A, 1995.
2. Genotoxicity: A Standard Battery of Genotoxicity Testing of Pharmaceuticals, ICH Topic S2B, 1997.
3. Friederich U., Aeschbacher H.U., Seiler J.P., and Wurgler F.E. The Salmonella/microsome assay: some possible causes for interlaboratory variations. Mutat. Res. 103 (1982) 133-220
4. Aeschbacher H.U., Finot P.A., and Wolleb U. Interactions of histidine-containing test substances and extraction methods with the Ames mutagenicity test. Mutat. Res. 113 (1983) 103-116
5. Gocke E., and Albertini S. Synergistic/comutagenic action in the Ames test as an indication of irrelevant positive findings. Mutat. Res. 350 (1996) 51-57
6. Venitt S., and Bosworth D. The development of anaerobic methods for bacterial mutation assays: aerobic and anaerobic fluctuation tests of human faecal extracts and reference mutagens. Carcinogenesis 4 (1983) 339-345
7. Gatehouse D. Critical features of bacterial mutation assays. Mutagenesis 2 (1987) 397-409
8. Prival M.J., Simmon V.F., and Mortelmans K.E. Bacterial mutagenicity testing of 49 food ingredients gives very few positive results. Mutat. Res. 260 (1991) 321-329
9. Nylund L., and Einisto P. Mutagenicity testing of protein-containing and biological samples using the Ames/Salmonella plate incorporation test and the fluctuation test. Mutat. Res. 272 (1992) 205-214
10. Verhagen H., Bruijntjes-Rozier G.C., Coenen T.M., and Oosterom J. Modified suspension Ames test for testing proteinaceous substances: an initial step. Food Chem. Toxicol. 32 (1994) 1161-1166
11. Thompson P., Morley D., Kirkland R., and Proudlock. Modified bacterial mutation test procedures for evaluation of peptides and amino acid-containing material. Mutagenesis 20 (2005) 345-350
12. + revertants. Mutat. Res. 91 (1981) 407-411
13. Ames B.N., Mc Cann J., and Yamasaki E. Methods for detecting carcinogens and mutagens with the Salmonella/Mammalian-microsome mutagenicity test. Mutat. Res. 31 (1975) 347-364
14. Maron D.M., and Ames B.N. Revised methods for the Salmonella mutagenicity test. Mutat. Res. 113 (1983) 173-215
15. OECD Guidelines for the Testing of Chemicals, Bacterial Reverse Mutation Test 471, 1997.
16. Bartsch H., Camus A., and Malaveille C. Comparative mutagenicity of N-nitrosamines in a semi-solid and in a liquid incubation system in the presence of rat or human tissue fractions. Mutat. Res. 37 (1976) 149-162
17. Bridges B.A., Zeiger E., and McGregor D.B. Summary report on the performance of the bacterial mutation assays in: evaluation of short-term tests for carcinogens. In: De Serres F.J., and AshbyF J. (Eds). Progress in Mutation Research (1981), Elsevier, New York 49-67
18. Yamanaka H., Nagao M., Sugimurat T., Furuya T., Shirai A., and Matsushima T. Mutagenicity of pyrrolozidine alkaloids in the Salmonella/mammalian-microsome test. Mutat. Res. 68 (1979) 211-216
19. Lowry O.H., Rosebrough N.J., Farr A.L., and Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193 (1951) 265-275
20. G.A.T. Mahon, B. Middleton, W.D. Robinson, M.H.L. Green, I. Mitchell, D.J. Tweats. Analysis of data from microbial colony assays, in: Kirkland DJ (Eds), Statistical evaluation of mutagenicity test data-UKEMS sub-committee on guidelines for mutagenicity testing, Report Part III, Cambridge University Press, Cambridge, New York (1989), 26-65.
21. Busch D.B., and Bryan G.T. Presence and measurement of sample histidine in the Ames test: quantification and possible elimination of a source of false-positive mutagenicity test results. Environ. Mol. Mutagen. 10 (1987) 397-410
22. Ohtsuka M., Morinaga N., and Okada M. Utilization of d-histidine by the derivative strain TA100 of Salmonella typhimurium LT 2. Nippon Saikingaku Zasshi. 46 (1991) 929-931
23. Krajewska-Grynkiewicz C., Walczak W., and Kłopotowski T. Mutants of Salmonella typhimurium able to utilize d-histidine as a source of l-histidine. J. Bacteriol. 105 (1971) 28-37
24. Cunin R., Glansdorff N., Pierard A., and Stalon V. Biosynthesis and metabolism of arginine in bacteria. Microbiol. Rev. 50 (1986) 314-352
25. Ames G.F., and Lever J. Components of histidine transport: histidine-binding proteins and hisP protein. Proc. Natl. Acad. Sci. U.S.A. 66 (1970) 1096-1103
26. Ames G.F. Bacterial periplasmic transport systems: structure, mechanism, and evolution. Annu. Rev. Biochem. 55 (1986) 397-425
27. Furlong C.E. Binding protein-dependent active transport in Escherichia coli and Salmonella typhimurium. Methods Enzymol. 125 (1986) 279-289
28. Liu C.E., and Ames G.F. Permease using proteoliposomes reconstituted by dialysis. J. Biol. Chem. 272 (1997) 859-866
29. Kustu S.G., and Ames G.F. The hisP protein, a known histidine transport component in Salmonella typhimurium, is also an arginine transport component. J. Bacteriol. 116 (1973) 107-113
30. Ames G.F., and Nikaido K. Identification of a membrane protein as a histidine transport component in Salmonella typhimurium. Proc. Natl. Acad. Sci. U.S.A. 75 (1978) 5447-5451
31. Iyengar R., Stuehr D.J., and Marletta M.A. Macrophage synthesis of nitrite, nitrate, and N-nitrosamines: precursors and role of the respiratory burst. Proc. Natl. Acad. Sci. U.S.A. 84 (1987) 6369-6373
32. Choi D.W., Oh H.J., Hong S.Y., Han J.W., and Lee H.W. Idenfication and characterization of nitric oxide synthase in Salmonella typhimurium. Arch. Pharm. Res. 23 (2000) 407-412
33. Wink D.A., Kasprzak K.S., Maragos C.M., Elespuru R.K., Misra M., Dunams T.M., Cebula R.A., Koch W.H., Andrews A.W., Allen J.S., and Keefer L.K. DNA deaminating ability and genotoxicity of nitric oxide and its progenitors. Science 254 (1991) 1001-1003
34. Arroyo P.L., Hatch-Pigott V., Mower H.F., and Cooney R.V. Mutagenicity of nitric oxide and its inhibition by antioxidants. Mutat. Res. 28 (1992) 1193-1202
35. Zhuang J.C., Wright T.L., deRojas-Walker T., Tannenbaum S.R., and Wogan G.N. Nitric oxide-induced mutations in the HPRT gene of human lymphoblastoid TK6 cells and in Salmonella typhimurium. Environ. Mol. Mutagen. 35 (2000) 39-47
36. Abu-Shakra A. The mutagenic activity of the S-nitrosoglutathione/glutathione system in Salmonella typhimurium TA1535. Mutat. Res. 539 (2003) 203-206