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New antithrombotic drugs
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This is one basic article to know and understand new anticoagulant drugs, reviewing the main concerns of all of them
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Weitz JI, Hirsh J, Samama MM. New antithrombotic drugs. Chest 2008; 133:234S-256S. This is one basic article to know and understand new anticoagulant drugs, reviewing the main concerns of all of them.
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The novel anticoagulants: Entering a new era
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Dabigatran etexilate: An oral direct thrombin inhibitor for thromboprophylaxis and treatment of thromboembolic diseases
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Baetz BE, Spinler SA. Dabigatran etexilate: an oral direct thrombin inhibitor for thromboprophylaxis and treatment of thromboembolic diseases. Pharmacotherapy 2008; 28:1354-1373.
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Dabigatran etexilate versus enoxaparin for prevention of venous thromboembolism after total hip replacement: a randomised, double-blind, non-inferiority trial
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DOI 10.1016/S0140-6736(07)61445-7, PII S0140673607614457
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Eriksson BI, Dahl OE, Rosencher N, et al. Dabigatran etexilate versus enoxaparin for prevention of venous thromboembolism after total hip replacement: a randomised, double-blind, noninferiority trial. Lancet 2007; 370:949-956. (Pubitemid 47393577)
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Oral dabigatran etexilate vs. subcutaneous enoxaparin for the prevention of venous thromboembolism after total knee replacement: The RE-MODEL randomized trial
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DOI 10.1111/j.1538-7836.2007.02748.x
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Eriksson BI, Dahl OE, Rosencher N, et al. Oral dabigatran vs. subcutaneous enoxaparin for the prevention of venous thromboembolism after total knee replacement: the RE-MODEL randomized trial. J Thromb Haemost 2007; 5:2178-2185. (Pubitemid 47617868)
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Dabigatran with or without concomitant aspirin compared with warfarin alone in patients with nonvalvular atrial fibrilation (PETRO study)
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Ezekowitz MD, Reilly PA, Nehmiz G, et al. Dabigatran with or without concomitant aspirin compared with warfarin alone in patients with nonvalvular atrial fibrilation (PETRO study). Am J Cardiol 2007; 100:1419-1426.
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The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects
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Stangier J, Rathgen K, Staehle H, et al. The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects. Br J Clin Pharmacol 2007; 64:292-303.
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Comparative pharmacodynamics and pharmacokinetics of oral direct thrombin and factor Xa inhibitors in development
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In this paper, the authors review the pharmacological characteristics of new anticoagulants, and it should be read by anyone who wants to understand the differences between them
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Eriksson BI, Quinlan DJ, Weitz JI. Comparative pharmacodynamics and pharmacokinetics of oral direct thrombin and factor Xa inhibitors in development. Clin Pharmacokinet 2009; 48:1-22. In this paper, the authors review the pharmacological characteristics of new anticoagulants, and it should be read by anyone who wants to understand the differences between them
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Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty
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Eriksson BI, Borris LC, Friedman RJ, et al. Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty. N Engl J Med 2008; 358:2765-2775.
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Lassen MR, Ageno W, Borris LC, et al. Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty. N Engl J Med 2008; 358:2776-2786.
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Treatment of proximal deep-vein thrombosis with the oral direct factor Xa inhibitor rivaroxaban (BAY 59-7939)
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Agnelli, G.1
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Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY 59-7939 an oral, direct factor Xa inhibitor
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Kubitza D, Becka M, Voith B, et al. Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY 59-7939 an oral, direct factor Xa inhibitor. Clin Pharmacol Ther 2005; 78:412-421.
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Population pharmacokinetics and pharmacodynamics of once and twice daily rivaroxaban for the prevention of venous thromboembolism in patients undergoing total hip replacement
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Mueck W, Borris LC, Dahl OE, et al. Population pharmacokinetics and pharmacodynamics of once and twice daily rivaroxaban for the prevention of venous thromboembolism in patients undergoing total hip replacement. Thromb Haemost 2008; 100:453-461.
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Population model of the pharmacokinetics and pharmacodynamics of rivaroxaban: An oral direct factor Xa inhibitor - in healthy subjects
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Mueck W, Becka M, Kubitza D, et al. Population model of the pharmacokinetics and pharmacodynamics of rivaroxaban: an oral direct factor Xa inhibitor - in healthy subjects. Int J Clin Pharmacol Ther 2007; 45:335-344.
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Mueck, W.1
Becka, M.2
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Central neuraxial block and low molecular weight heparin (enoxaparin): Lessons learned from different dosages regimes in two continents
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Selected new antithrombotic agents and neuraxial anaesthesia for major orthopedic surgery: Management strategies
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This article is, probably, the cornerstone to make recommendations for the practice of regional anesthesia in the setting of the use of anticoagulants. It is a marvellous article
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Rosencher N, Bonnet MP, Sessler DI. Selected new antithrombotic agents and neuraxial anaesthesia for major orthopedic surgery: management strategies. Anaesthesia 2007; 62:1154-1160. This article is, probably, the cornerstone to make recommendations for the practice of regional anesthesia in the setting of the use of anticoagulants. It is a marvellous article.
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Anaesthesia
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Rosencher, N.1
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Sessler, D.I.3
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Epidural anaesthesia and spinal haematoma
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Wulf H. Epidural anaesthesia and spinal haematoma. Can J Anaesth 1996; 43:1260-1271.
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Anticlotting drugs and regional anaesthetic and analgesic drugs: Comparative update of safety recommendations
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Llau JV, De Andrés J, Gomar C, et al. Anticlotting drugs and regional anaesthetic and analgesic drugs: comparative update of safety recommendations. Eur J Anaesthesiol 2007; 24:387-394.
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Eur J Anaesthesiol
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Novel factor Xa inhibitors for prevention and treatment of thromboembolic diseases
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Perioperative management of antiplatelet agents in noncardiac surgery
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Recent review for current practice in patients receiving antiplatelet agents in which the anesthesiologist wants to perform general or regional anesthesia
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Llau JV, López-Forte C, Sapena L, Ferrandis R. Perioperative management of antiplatelet agents in noncardiac surgery. Eur J Anaesth 2009; 26:181-187. Recent review for current practice in patients receiving antiplatelet agents in which the anesthesiologist wants to perform general or regional anesthesia.
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Llau, J.V.1
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Regional anaesthesia and thromboembolism prophylaxis/anticoagulation: Revised recommendations of the German Society for Anaesthesiology and Intensive Care
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Gogarten W, Van Aken H, Büttner J, et al. Regional anaesthesia and thromboembolism prophylaxis/anticoagulation: revised recommendations of the German Society for Anaesthesiology and Intensive Care. Anästh Intensivmed 2007; 48:S109-S124.
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