The Flk1-myr::mCherry mouse as a useful reporter to characterize multiple aspects of ocular blood vessel development and disease

Developmental Dynamics

Volumn 238, Issue 9, 2009, Pages 2318-2326

  Poché, Ross A ^a   Larina, Irina V ^a   Scott, Melissa L ^a   Saik, Jennifer E ^b   West, Jennifer L ^b   Dickinson, Mary E ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b Rice University   (United States)

Author keywords

Blood vessels; Choroid; Endothelial cells; Eye; Hyaloid; Retina

Indexed keywords

CHERRY FLUORESCENT PROTEIN; FLUORESCENT DYE; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 2;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY LABELING; APOPTOSIS; ARTICLE; ASSAY; BLOOD RHEOLOGY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CORNEA MICROPOCKET ANGIOGENIC ASSAY; CORNEA NEOVASCULARIZATION; GENE EXPRESSION; HYDROGEL; IMMUNOFLUORESCENCE; MOUSE; MYRISTYLATION; NEWBORN; NONHUMAN; OCULAR BLOOD VESSEL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RETINA NEOVASCULARIZATION; TRANSGENIC MOUSE;

ANIMALS; EYE; FLUORESCENT ANTIBODY TECHNIQUE; MICE; MICE, TRANSGENIC; MODELS, BIOLOGICAL; POLYMERASE CHAIN REACTION; RETINAL VESSELS; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

MUS MUSCULUS;

EID: 70349142737     PISSN: 10588388     EISSN: 10970177     Source Type: Journal    
DOI: 10.1002/dvdy.21886     Document Type: Article

References (37)

1. Ambati BK, Nozaki M, Singh N, Takeda A, Jani PD, Suthar T, Albuquerque RJ, Richter E, Sakurai E, Newcomb MT, Kleinman ME, Caldwell RB, Lin Q, Ogura Y, Orecchia A, Samuelson DA, Agnew DW, St Leger J, Green WR, Mahasreshti PJ, Curiel DT, Kwan D, Marsh H, Ikeda S, Leiper LJ, Collinson JM, Bogdanovich S, Khurana TS, Shibuya M, Baldwin ME, Ferrara N, Gerber HP, De Falco S, Witta J, Baffi JZ, Raisler BJ, Ambati J. 2006. Corneal avascularity is due to soluble VEGF receptor-1. Nature 443:993-997. (Pubitemid 44646176)
2. Bani-Yaghoub M, Tremblay RG, Lei JX, Zhang D, Zurakowski B, Sandhu JK, Smith B, Ribecco-Lutkiewicz M, Kennedy J, Walker PR, Sikorska M. 2006. Role of Sox2 in the development of the mouse neocortex. Dev Biol 295:52-66. (Pubitemid 44041325)
3. Beebe DC. 2008. Maintaining transparency: a review of the developmental physiology and pathophysiology of two avascular tissues. Semin Cell Dev Biol 19:125-133.
4. Campochiaro PA, Hackett SF. 2003. Ocular neovascularization: a valuable model system. Oncogene 22:6537-6548.
5. Chan-Ling TL, Halasz P, Stone J. 1990. Development of retinal vasculature in the cat: processes and mechanisms. Curr Eye Res 9:459-478. (Pubitemid 20203506)
6. Dorrell MI, Aguilar E, Friedlander M. 2002. Retinal vascular development is mediated by endothelial filopodia, a pre-existing astrocytic template and specific R-cadherin adhesion. Invest Ophthalmol Vis Sci 43:3500-3510. (Pubitemid 35334359)
7. Dyer MA, Farrington SM, Mohn D, Munday JR, Baron MH. 2001. Indian hedgehog activates hematopoiesis and vasculogenesis and can respecify prospective neurectodermal cell fate in the mouse embryo. Development 128:1717-1730. (Pubitemid 32514853)
8. Friedlander M. 2007. Fibrosis and diseases of the eye. J Clin Invest 117:576-586.
9. Fruttiger M. 2002. Development of the mouse retinal vasculature: angiogenesis versus vasculogenesis. Invest Ophthalmol Vis Sci 43:522-527. (Pubitemid 34113238)
10. Fruttiger M. 2007. Development of the retinal vasculature. Angiogenesis 10:77-88.
11. Gariano RF. 2003. Cellular mechanisms in retinal vascular development. Prog Retin Eye Res 22:295-306.
12. Gariano RF, Gardner TW. 2005. Retinal angiogenesis in development and disease. Nature 438:960-966.
13. Gimbrone MA Jr, Leapman SB, Cotran RS, Folkman J. 1973. Tumor angiogenesis: iris neovascularization at a distance from experimental intraocular tumors. J Natl Cancer Inst 50:219-228.
14. Gimbrone MA Jr, Cotran RS, Leapman SB, Folkman J. 1974. Tumor growth and neovascularization: an experimental model using the rabbit cornea. J Natl Cancer Inst 52:413-427.
15. Gimenez E, Montoliu L. 2001. A simple polymerase chain reaction assay for genotyping the retinal degeneration mutation (Pdeb(rd1)) in FVB/N-derived transgenic mice. Lab Anim 35:153-156. (Pubitemid 32273187)
16. Goldberg MF. 1997. Persistent fetal vasculature (PFV): an integrated interpretation of signs and symptoms associated with persistent hyperplastic primary vitreous (PHPV). LIV Edward Jackson Memorial Lecture. Am J Ophthalmol 124:587-626.
17. Hasegawa T, McLeod DS, Prow T, Merges C, Grebe R, Lutty GA. 2008. Vascular precursors in developing human retina. Invest Ophthalmol Vis Sci 49:2178-2192.
18. Ito M, Yoshioka M. 1999. Regression of the hyaloid vessels and pupillary membrane of the mouse. Anat Embryol (Berl) 200:403-411. (Pubitemid 29425705)
19. Kenyon BM, Voest EE, Chen CC, Flynn E, Folkman J, D'Amato RJ. 1996. A model of angiogenesis in the mouse cornea. Invest Ophthalmol Vis Sci 37:1625-1632.
20. Klein R, Klein BE, Linton KL. 1992. Prevalence of age-related maculopathy. The Beaver Dam Eye Study. Ophthalmology 99:933-943.
21. Komitova M, Eriksson PS. 2004. Sox-2 is expressed by neural progenitors and astroglia in the adult rat brain. Neurosci Lett 369:24-27. (Pubitemid 39369496)
22. Lang RA, Bishop JM. 1993. Macrophages are required for cell death and tissue remodeling in the developing mouse eye. Cell 74:453-462. (Pubitemid 23244611)
23. Lang R, Lustig M, Francois F, Sellinger M, Plesken H. 1994. Apoptosis during macrophage-dependent ocular tissue remodelling. Development 120:3395-3403. (Pubitemid 24366985)
24. Langham M. 1953. Observations on the growth of blood vessels into the cornea; application of a new experimental technique. Br J Ophthalmol 37:210-222.
25. Larina IV, Shen W, Kelly O, Hadjantonakis A-K, Baron M, Dickinson M. 2009. A membrane associated mCherry fluorescent reporter line for studying vascular remodeling and cardiac function during murine embryonic development. Anat Rec 292:333-341.
26. Lobov IB, Rao S, Carroll TJ, Vallance JE, Ito M, Ondr JK, Kurup S, Glass DA, Patel MS, Shu W, Morrisey EE, McMahon AP, Karsenty G, Lang RA. 2005. WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature. Nature 437:417-421. (Pubitemid 41613504)
27. McLeod DS, Hasegawa T, Prow T, Merges C, Lutty G. 2006. The initial fetal human retinal vasculature develops by vasculogenesis. Dev Dyn 235:3336-3347. (Pubitemid 44888199)
28. Meeson A, Palmer M, Calfon M, Lang R. 1996. A relationship between apoptosis and flow during programmed capillary regression is revealed by vital analysis. Development 122:3929-3938. (Pubitemid 27033887)
29. Millauer B, Wizigmann-Voos S, Schnurch H, Martinez R, Moller NP, Risau W, Ullrich A. 1993. High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell 72:835-846. (Pubitemid 23110226)
30. Muthukkaruppan V, Auerbach R. 1979. Angiogenesis in the mouse cornea. Science 205:1416-1418.
31. Panda A, Vanathi M, Kumar A, Dash Y, Priya S. 2007. Corneal graft rejection. Surv Ophthalmol 52:375-396.
32. Ritter MR, Aguilar E, Banin E, Scheppke L, Uusitalo-Jarvinen H, Friedlander M. 2005. Three-dimensional in vivo imaging of the mouse intraocular vasculature during development and disease. Invest Ophthalmol Vis Sci 46:3021-3026. (Pubitemid 44264283)
33. Rogers MS, Birsner AE, D'Amato RJ. 2007. The mouse cornea micropocket angiogenesis assay. Nat Protoc 2:2545-2550.
34. Saint-Geniez M, D'Amore PA. 2004. Development and pathology of the hyaloid, choroidal and retinal vasculature. Int J Dev Biol 48:1045-1058. (Pubitemid 40039191)
35. Shaner NC, Steinbach PA, Tsien RY. 2005. A guide to choosing fluorescent proteins. Nat Methods 2:905-909.
36. Speier S, Nyqvist D, Cabrera O, Yu J, Molano RD, Pileggi A, Moede T, Kohler M, Wilbertz J, Leibiger B, Ricordi C, Leibiger IB, Caicedo A, Berggren PO. 2008. Noninvasive in vivo imaging of pancreatic islet cell biology. Nat Med 14:574-578. (Pubitemid 351655207)
37. Yamaguchi TP, Dumont DJ, Conlon RA, Breitman ML, Rossant J. 1993. flk-1, an flt-related receptor tyrosine kinase is an early marker for endothelial cell precursors. Development 118:489-498. (Pubitemid 23214035)