Dronedarone: A new antiarrhythmic agent for the treatment of atrial fibrillation

Cardiology in Review

Volumn 17, Issue 5, 2009, Pages 230-234

  Garcia, Danielle ^a   Cheng Lai, Angela ^a,b  

^a MONTEFIORE MEDICAL CENTER   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Amiodarone; Antiarrhythmic; Atrial fibrillation; Atrial flutter; Dronedarone

Indexed keywords

AMIODARONE; ANTIARRHYTHMIC AGENT; CARBAMAZEPINE; CLARITHROMYCIN; CYCLOSPORIN; DRONEDARONE; HYPERICUM PERFORATUM EXTRACT; ITRACONAZOLE; KETOCONAZOLE; MACROLIDE; NEFAZODONE; PHENOBARBITAL; PHENOTHIAZINE; PHENYTOIN; PLACEBO; RIFAMPICIN; RITONAVIR; TELITHROMYCIN; TRICYCLIC ANTIDEPRESSANT AGENT; VORICONAZOLE;

ANTIARRHYTHMIC ACTIVITY; BRADYCARDIA; CLINICAL TRIAL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIARRHEA; DISTRIBUTION VOLUME; DRUG BLOOD LEVEL; DRUG CONTRAINDICATION; DRUG EFFICACY; DRUG ERUPTION; DRUG HALF LIFE; DRUG METABOLISM; DRUG SAFETY; DRUG STRUCTURE; DRUG TISSUE LEVEL; DRUG WITHDRAWAL; EVENING DOSAGE; GASTROINTESTINAL SYMPTOM; HEART ATRIUM FIBRILLATION; HEART ATRIUM FLUTTER; HEART ELECTROPHYSIOLOGY; HEART FAILURE; HEART LEFT VENTRICLE FAILURE; HEART VENTRICLE FUNCTION; HUMAN; LOADING DRUG DOSE; LUNG DISEASE; LUNG FIBROSIS; MORBIDITY; MORNING DOSAGE; MORTALITY; NAUSEA; OPTIMAL DRUG DOSE; PROGNOSIS; QT PROLONGATION; RECURRENT DISEASE; REVIEW; SIDE EFFECT; SINUS RHYTHM; THYROID DISEASE; VOMITING;

AMIODARONE; ANTI-ARRHYTHMIA AGENTS; ATRIAL FIBRILLATION; DIARRHEA; HUMANS; NAUSEA;

EID: 70349140020     PISSN: 10615377     EISSN: None     Source Type: Journal    
DOI: 10.1097/CRD.0b013e3181b15ab9     Document Type: Review

References (17)

1. ACC/AHA/ESC 2006 Writing Committee. Guidelines for the management of patients with atrial fibrillation. Circulation. 2006;114:e257-e354.
2. Hohnloser SH, Crijns HJ, van Eickels M, et al. Effect of dronedarone on cardiovascular events in atrial fibrillation. N Engl J Med. 2009;360:668-678.
3. Falk RH. Atrial fibrillation. N Engl J Med. 2001;344:1067-1078.
4. Laughlin JC, Kowey PR. Dronedarone: a new treatment for atrial fibrillation J Cardiovasc Electrophysiol. 2008;19:1220-1226.
5. Multaq-(dronedarone tablets) [prescribinginformation]. Bridgewater, NJ: sanofi-aventis; 2009.
6. Singh BN. Amiodarone as paradigm for developing new drugs for atrial fibrillation. J Cardiovasc Pharmacol. 2008;52:300-305.
7. Dale KM, White CM. Dronedarone: an amiodarone analog for the treatment of atrial fibrillation and atrial flutter. Ann Pharmacother. 2007;41:599-605.
8. Ehrlich JR, Nattel S. Atrial-selective pharmacological therapy for atrial fibrillation: hype or hope? Curr Opin Cardiol. 2008;24:50-55.
9. Tschuppert Y, Buclin T, Rothuizen LE, et al. Effect of dronedarone on renal function in healthy subjects. Br J Clin Pharmacol. 2007;64:185-791.
10. Touboula P, Brugadab J, Capuccic A, et al. Dronedarone for prevention of atrial fibrillation: a dose-ranging study. Eur Heart J. 2003;24:1481-1487.
11. Naccarelli GV, Wolbrette DL, Khan M, et al. Old and new antiarrhythmic drugs for converting and maintaining sinus rhythm in atrial fibrillation: comparative efficacy and results of trials. Am J Cardiol. 2003;91(suppl): 15D-26D.
12. Singh BN, Connolly SJ, Crijns HJ, et al. Dronedarone for maintenance of sinus rhythm in atrial fibrillation or flutter. N Engl J Med. 2007;357:987-999.
13. Davy JM, Herold M, Hoglund C, et al. Dronedarone for the control of ventricular rate in permanent atrial fibrillation: the efficacy and safety of dRonedArone for the control of ventricular rate during atrial fibrillation (ERATO) study. Am Heart J. 2008;156:527e1-527e9.
14. Kober L, Torp-Pederson C, McMurray J, et al. Increased mortality after dronedarone therapy for severe heart failure (the ANDROMEDA study). N Engl J Med. 2008;358:2678-2687.
15. Hohnloser SH, Crijns HJ, van Eickels M, et al. Effect of dronedarone on cardiovascular events in atrial fibrillation (the ATHENA trial). N Engl J Med. 2009;360:668-678.
16. press release-. Paris, France: Sanofi-Aventis; 2008.
17. Zimetbaum PJ. Dronedarone for atrial fibrillation-an odyssey. N Engl J Med. 2009;360:1811-1813.