Extramedullary hematopoiesis with spinal cord compression in a child with thalassemia intermedia

Journal of Pediatric Hematology/Oncology

Volumn 31, Issue 9, 2009, Pages 681-683

  Ileri, Talia ^a   Azk, Fatih ^a   Ertem, Mehmet ^a   Uysal, Zumrut ^a   Gozdasoglu, Sevgi ^a  

^a ANKARA UNIVERSITY   (Turkey)

Author keywords

Compression; Extramedullary hematopoiesis; Hydroxyurea; Radiation therapy; Spinal cord; Thalassemia

Indexed keywords

HYDROXYUREA; STEROID;

ALLOIMMUNIZATION; ARTICLE; BETA THALASSEMIA; BLOOD TRANSFUSION; CASE REPORT; CHILD; EXTRAMEDULLARY HEMATOPOIESIS; GENE MUTATION; HUMAN; LEG PAIN; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PHYSICAL EXAMINATION; PRIORITY JOURNAL; SCHOOL CHILD; SPINAL CORD COMPRESSION; SPLENECTOMY; STEROID THERAPY; TREATMENT OUTCOME;

BETA-THALASSEMIA; BLOOD GROUP ANTIGENS; BLOOD TRANSFUSION; CHILD; COMBINED MODALITY THERAPY; CYTOTOXINS; DECOMPRESSION, SURGICAL; ERYTHROPOIESIS; HEMATOPOIESIS, EXTRAMEDULLARY; HUMANS; HYDROXYUREA; LUMBAR VERTEBRAE; MAGNETIC RESONANCE IMAGING; MALE; POSTOPERATIVE COMPLICATIONS; SACRUM; SPINAL CORD COMPRESSION; SPLENECTOMY;

EID: 70349139672     PISSN: 10774114     EISSN: 15363678     Source Type: Journal    
DOI: 10.1097/MPH.0b013e3181a71843     Document Type: Article

References (16)

1. Camaschella C, Cappellini MD. Thalassemia intermedia. Haematologica. 1995;80:58-68.
2. Dore F, Cianciulli P, Rovasio S, et al. Incidence and clinical study of ectopic erythropoiesis in adult patients with thalassemia intermedia. Ann Ital Med Int. 1992;7:137-140.
3. Tan TC, Tsao J, Cheung FC. Extramedullary haemopoiesis in thalassemia intermedia presenting as paraplegia. J Clin Neurosci. 2002;9:721-725.
4. Cardia E, Toscano S, La Rosa G, et al. Spinal cord compression in homozygous beta-thalassemia intermedia. Pediatr Neurosurg. 1994;20:186-189.
5. Parsa K, Oreizy A. Nonsurgical approach to paraparesis due to extramedullary hematopoiesis. Report of two cases. J Neurosurg. 1995;82:657-660.
6. Kaufmann T, Coleman M, Giardina P, et al. The role of radiation therapy in the management of hematopoietic neurologic complications in thalassemia. Acta Haematol. 1991;85:156-159.
7. Chourmouzi D, Pistevou-Gompaki K, Plataniotis G, et al. MRI findings of extramedullary haemopoiesis. Eur Radiol. 2001;11:1803-1806.
8. Chiam QL, Lau KK. Extramedullary haematopoiesis in thalassaemia major causing spinal cord compression. Australas Radiol. 2007;51:168-171.
9. Coskun E, Keskin A, Suzer T, et al. Spinal cord compression secondary to extramedullary hematopoiesis in thalassemia intermedia. Eur Spine J. 1998;7:501-504.
10. Tai SM, Chan JS, Ha SY, et al. Successful treatment of spinal cord compression secondary to extramedullary hematopoietic mass by hypertransfusion in a patient with thalassemia major. Pediatr Hematol Oncol. 2006;23:317-321.
11. Chehal A, Aoun E, Koussa S, et al. Hypertransfusion: a successful method of treatment in thalassemia intermedia patients with spinal cord compression secondary to extramedullary hematopoiesis. Spine. 2003;28:E245-E249.
12. Malik M, Pillai LS, Gogia N, et al. Paraplegia due to extramedullary hematopoiesis in thalassemia treated successfully with radiation therapy. Haematologica. 2007;92:e28-e30.
13. Jackson DV Jr, Randall ME, Richards F II. Spinal cord compression due to extramedullary hematopoiesis in thalassemia: long-term follow-up after radiotherapy. Surg Neurol. 1988;29:389-392.
14. Cario H, Wegener M, Debatin KM, et al. Treatment with hydroxyurea in thalassemia intermedia with paravertebral pseudotumors of extramedullary hematopoiesis. Ann Hematol. 2002;81:478-482.
15. Cianciulli P, di Toritto TC, Sorrentino F, et al. Hydroxyurea therapy in paraparesis and cauda equina syndrome due to extramedullary haematopoiesis in thalassaemia: improvement of clinical and haematological parameters. Eur J Haematol. 2000;64:426-429.
16. Salehi SA, Koski T, Ondra SL. Spinal cord compression in beta thalassemia: case report and review of the literature. Spinal Cord. 2004;42:117-123.