Bioactivation of minocycline to reactive intermediates by myeloperoxidase, horseradish peroxidase, and hepatic microsomes: Implications for minocycline-induced lupus and hepatitis

Drug Metabolism and Disposition

Volumn 37, Issue 9, 2009, Pages 1806-1818

  Mannargudi, Baskar ^a   McNally, David ^a   Reynolds, William ^a   Uetrecht, Jack ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; AROMATIC COMPOUND; CHLORINE; DIMETHYLAMINE; HORSERADISH PEROXIDASE; HYDROGEN PEROXIDE; HYPOCHLOROUS ACID; ION; MINOCYCLINE; MYELOPEROXIDASE; QUINONE DERIVATIVE;

ADDITION REACTION; ADDUCTION; ANIMAL CELL; AROMATIZATION; ARTICLE; CHEMICAL BOND; CONTROLLED STUDY; DRUG ISOLATION; DRUG OXIDATION; DRUG STRUCTURE; LIVER MICROSOME; LUPUS ERYTHEMATOSUS; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTON TRANSPORT; RAT; TOXIC HEPATITIS;

ACETYLCYSTEINE; ANIMALS; ANTI-BACTERIAL AGENTS; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FREE RADICAL SCAVENGERS; FREE RADICALS; HEPATITIS, AUTOIMMUNE; HORSERADISH PEROXIDASE; LUPUS ERYTHEMATOSUS, SYSTEMIC; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICROSOMES, LIVER; MINOCYCLINE; OXIDATION-REDUCTION; PEROXIDASE; RATS; RATS, INBRED BN; TANDEM MASS SPECTROMETRY;

ARMORACIA RUSTICANA;

EID: 70349138111     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.109.027292     Document Type: Article

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