Glutamate agonist LY404,039 for treating schizophrenia has affinity for the dopamine D2High receptor

Synapse

Volumn 63, Issue 10, 2009, Pages 935-939

  Seeman, Philip ^a   Guan, Hong Chang ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

D2High receptor; DA partial agonist; Glutamate agonist; LY404,039; Psychosis; Schizophrenia

Indexed keywords

DOMPERIDONE H 3; DOPAMINE 2 RECEPTOR; GLUTAMIC ACID; GUANINE NUCLEOTIDE; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); LIGAND; LY 404 039; NEUROLEPTIC AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CLONE; CONTROLLED STUDY; CORPUS STRIATUM; DISSOCIATION CONSTANT; DRUG MECHANISM; IC 50; LIGAND BINDING; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; SCHIZOPHRENIA;

ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; BINDING, COMPETITIVE; CHO CELLS; CORPUS STRIATUM; CRICETINAE; CRICETULUS; CYCLIC S-OXIDES; DOMPERIDONE; DOPAMINE ANTAGONISTS; EXCITATORY AMINO ACID AGONISTS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; PROTEIN BINDING; RADIOISOTOPES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DOPAMINE D2; TRANSFECTION; VITAMIN K 1;

EID: 70349123079     PISSN: 08874476     EISSN: 10982396     Source Type: Journal    
DOI: 10.1002/syn.20704     Document Type: Article

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