Arsenic trioxide exerts synergistic effects with cisplatin on non-small cell lung cancer cells via apoptosis induction

Journal of Experimental and Clinical Cancer Research

Volumn 28, Issue 1, 2009, Pages

  Li, Hecheng ^a,b   Zhu, Xioli ^a   Zhang, Yawei ^a,b   Xiang, Jiaqing ^a,b   Chen, Haiquan ^a,b  

^a FUDAN UNIVERSITY SHANGHAI CANCER CENTER   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ARSENIC TRIOXIDE; CASPASE 3; CISPLATIN; CLUSTERIN; CYCLIN D1; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P21; ANTINEOPLASTIC AGENT; CASPASE; ORGANOARSENIC DERIVATIVE; OXIDE;

APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE; CELL GROWTH; CELL PROLIFERATION; CLONOGENIC ASSAY; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENTIATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; NICK END LABELING; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; WESTERN BLOTTING; LUNG TUMOR; METABOLISM; TUMOR CELL LINE;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; ARSENICALS; CARCINOMA, NON-SMALL-CELL LUNG; CASPASES; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CISPLATIN; DRUG SYNERGISM; FLOW CYTOMETRY; HUMANS; LUNG NEOPLASMS; OXIDES;

EID: 70349099274     PISSN: None     EISSN: 17569966     Source Type: Journal    
DOI: 10.1186/1756-9966-28-110     Document Type: Article

References (18)

1. Cancer statistics, 1998. SH Landis T Murray S Bolden PA Wingo, CA Cancer J Clin 1998 48 1 6 29 10.3322/canjclin.48.1.6 9449931
2. Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxide. SL Soignet P Maslak ZG Wang S Jhanwar E Calleja LJ Dardashti D Corso A DeBlasio J Gabrilove DA Scheinberg PP Pandolfi RP Warrell Jr, N Engl J Med 1998 339 19 1341 1348 10.1056/NEJM199811053391901 9801394 (Pubitemid 28509343)
3. Arsenic trioxide as an inducer of apoptosis and loss of PML/RAR alpha protein in acute promyelocytic leukemia cells. W Shao M Fanelli FF Ferrara R Riccioni A Rosenauer K Davison WW Lamph S Waxman PG Pelicci F Lo Coco G Avvisati U Testa C Peschle C Gambacorti-Passerini C Nervi WH Miller Jr, J Natl Cancer Inst 1998 90 2 124 133 10.1093/jnci/90.2.124 9450572
4. Arsenic and apoptosis in the treatment of acute promyelocytic leukemia. AT Look, J Natl Cancer Inst 1998 90 2 86 88 10.1093/jnci/90.2.86 9450562
5. Use of arsenic trioxide (As 2 O 3 ) in the treatment of acute promyelocytic leukemia (APL): I. As 2 O 3 exerts dose-dependent dual effects on APL cells. GQ Chen XG Shi W Tang SM Xiong J Zhu X Cai ZG Han JH Ni GY Shi PM Jia MM Liu KL He C Niu J Ma P Zhang TD Zhang P Paul T Naoe K Kitamura W Miller S Waxman ZY Wang H de The SJ Chen Z Chen, Blood 1997 89 9 3345 3353 9129041 (Pubitemid 27229821)
6. The human myoepithelial cell exerts antiproliferative effects on breast carcinoma cells characterized by p21WAF1/CIP1 induction, G2/M arrest, and apoptosis. ZM Shao M Nguyen ML Alpaugh JT O'Connell SH Barsky, Exp Cell Res 1998 241 2 394 403 10.1006/excr.1998.4066 9637781 (Pubitemid 28366565)
7. TRAIL and Taurolidine induce apoptosis and decrease proliferation in human fibrosarcoma. A Daigeler C Brenzel D Bulut A Geisler C Hilgert M Lehnhardt HU Steinau A Flier L Steinstraesser L Klein-Hitpass U Mittelkötter W Uhl AM Chromik, J Exp Clin Cancer Res 2008 27 82 19077262 10.1186/1756-9966-27-82
8. Dithiothreitol enhances arsenic trioxide-induced apoptosis in NB4 cells. JR Gurr DT Bau F Liu S Lynn KY Jan, Mol Pharmacol 1999 56 1 102 109 10385689
9. Arsenic-induced DNA-strand breaks associated with DNA-protein crosslinks in human fetal lung fibroblasts. JT Dong XM Luo, Mutat Res 1993 302 2 97 102 10.1016/0165-7992(93)90010-S 7684511 (Pubitemid 23151436)
10. Arsenic trioxide produces polymerization of microtubules and mitotic arrest before apoptosis in human tumor cell lines. YH Ling JD Jiang JF Holland R Perez-Soler, Mol Pharmacol 2002 62 3 529 538 10.1124/mol.62.3.529 12181429 (Pubitemid 36329371)
11. in vitro studies on cellular and molecular mechanisms of arsenic trioxide (As 2 O 3 ) in the treatment of acute promyelocytic leukemia: As 2 O 3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins. GQ Chen J Zhu XG Shi JH Ni HJ Zhong GY Si XL Jin W Tang XS Li SM Xong ZX Shen GL Sun J Ma P Zhang TD Zhang C Gazin T Naoe SJ Chen ZY Wang Z Chen, Blood 1996 88 3 I1052 1061
12. Arsenic trioxide, a novel mitochondriotoxic anticancer agent? G Kroemer H de The, J Natl Cancer Inst 1999 91 9 743 745 10.1093/jnci/91.9.743 10328097
13. Clusterin as a therapeutic target for radiation sensitization in a lung cancer model. C Cao ET Shinohara H Li KJ Niermann KW Kim KR Sekhar M Gleave M Freeman B Lu, Int J Radiat Oncol Biol Phys 2005 63 4 1228 1236 16253777 (Pubitemid 41505304)
14. Intracellular clusterin induces G2-M phase arrest and cell death in PC-3 prostate cancer cells1. M Scaltriti A Santamaria R Paciucci S Bettuzzi, Cancer research 2004 64 17 6174 6182 10.1158/0008-5472.CAN-04-0920 15342402 (Pubitemid 39129419)
15. A phase I study of OGX-011, a 2'-methoxyethyl phosphorothioate antisense to clusterin, in combination with docetaxel in patients with advanced cancer. KN Chi LL Siu H Hirte SJ Hotte J Knox C Kollmansberger M Gleave E Guns J Powers W Walsh D Tu E Eisenhauer, Clin Cancer Res 2008 14 3 833 839 10.1158/1078-0432. CCR-07-1310 18245546 (Pubitemid 351231167)
16. Arsenic trioxide uses caspase-dependent and caspase-independent death pathways in myeloma cells. J McCafferty-Grad NJ Bahlis N Krett TM Aguilar I Reis KP Lee LH Boise, Molecular cancer therapeutics 2003 2 11 1155 1164 14617789
17. Arsenic trioxide-induced apoptosis and differentiation are associated respectively with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelocytic leukemia. X Cai YL Shen Q Zhu PM Jia Y Yu L Zhou Y Huang JW Zhang SM Xiong SJ Chen ZY Wang Z Chen GQ Chen, Leukemia 2000 14 2 262 270 10.1038/sj.leu.2401650 10673743
18. Arsenic trioxide-induced death of neuroblastoma cells involves activation of Bax and does not require p53. J Karlsson I Ora I Porn-Ares S Pahlman, Clin Cancer Res 2004 10 9 3179 3188 10.1158/1078-0432.CCR-03-0309 15131059 (Pubitemid 38619699)