Influence of L-arginine on the nitric oxide concentration and level of oxidative stress during ischemia-reperfusion injury in a rat model

International Journal of Clinical Pharmacology and Therapeutics

Volumn 47, Issue 8, 2009, Pages 533-538

  Krauss, H ^a   Jablecka, A ^a   Sosnowski, P ^a   Bogdanski, Pawel ^a  

^a POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

Author keywords

Ischemia and reperfusion; L arginine; Oxidative stress

Indexed keywords

ANTIOXIDANT; ARGININE; LIPID PEROXIDE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; PLACEBO;

ACUTE DISEASE; ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOCHEMISTRY; BLOOD SAMPLING; CONTROLLED STUDY; DISEASE COURSE; DRUG ACTIVITY; HEART RIGHT VENTRICLE; HINDLIMB; LEG ISCHEMIA; MALE; NONHUMAN; OXIDATIVE STRESS; PROTECTION; RAT; REPERFUSION INJURY; TOURNIQUET;

ANIMALS; ARGININE; ENZYME INHIBITORS; HINDLIMB; LIPID PEROXIDES; MALE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXIDATIVE STRESS; RATS; RATS, WISTAR; REPERFUSION INJURY;

EID: 70349093170     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: 10.5414/CPP47533     Document Type: Article

References (18)

1. Arslan S, Gelir E, Sayan H, Ozacmak V. L-Arginine and melatonin interaction in rat intestinal ischemia - reperfusion. Fundam Clin Pharmacol. 2005; 19: 533-535.
2. Bednarz B. Arginine - new effective drug in ischemic heart disease? Kardiol Pol. 2003; 59: 248-252.
3. Erdogan D, Omeroglu S, Sarban S, Atik O. Prevention of oxidative stress due to tourniquet application analysis of the effects of local hypothermia and systemic allopurinol administration. Acta Orthopaedica Belgia. 1999; 65: 164-169.
4. Gute D, Ishida Y, Yarimizu K, Korthuis R. Inflammation in Ischemia/reperfusion-induced Skeletal Muscle Injury: Role of neutrophil adhesion and ischemic preconditioning. Mol Cell Biochem. 1998; 179: 169-187.
5. Huang Y, Rabb H, Womer K. Ischemia-reperfusion and immediate T cell responses. Cell Immunol. 2007; 248: 4-11.
6. Hughes S, Hendricks B, Edwards D, Bastawrous S, Roberts G, Middleton J. Mild episodes of tourniquet-induced forearm ischemia-reperfusion injury results in leukocyte activation and changes in inflammatory and coagulation markers. J Inflamm (Lond). 2007; 30: 4-12.
7. Huk I, Nanobashvili J, Neumayer C, Punz A, Mueller M, Afkhampour K, Mittlboeck M, Losert U, Polterauer P, Roth E, Patton S, Malinski T. L-Arginine treatment alters the kinetics of nitric oxide and superoxide release and reduces ischemia/reperfusion injury in skeletal muscle. Circulation. 1997; 96: 667-675.
8. Jablecka A, Checinski P, Krauss H, Micker M, Ast J. The influence of two different doses of L-arginine oral supplementation on nitric oxide (NO) concentration and total antioxidant status (TAS) in atherosclerotic patients. Med Sci Monit. 2004; 10: 29-32.
9. Kirima K, Tsuchiya K, Sei H, Hasegawa T, Shikishima M, MotobayashiY, Morita K, Yoshizumi M, Tamaki T. Evaluation of systemic blood NO dynamics by EPR spectroscopy: HbNO as an endogenous index of NO. Am J Physiol Heart Circ Physiol. 2003; 285: 589-596.
10. Lindner-Ganz E, Gefen A. Mechanical compression-induced pressure sores in rat hindlimb: muscle stiffness, histology and computational models. J Appl Physiol. 2004; 96: 2034-2049.
11. Mullonkal C, Toledo-Pereyra L. Akt in ischemia and reperfusion. J Invest Surg. 2007; 20: 195-203.
12. Nanobashvili J, Neumayer C, Fuegl A, Punz A, Blumer R, Mittlböck M, Prager M, Polterauer P, Dobrucki L, Huk I, Malinski T. Combined L-arginine and antioxidative vitamin treatment mollifies ischemia-reperfusion injury of skeletal muscle. J Vasc Surg. 2004; 39: 868-877.
13. Panaza J, Casino P, Badar D, Quyyuami A. Effect of increased availability of endothelium-derived nitric oxide precursor on endothelium-dependent vascular relaxation in normal subjects and in patients with essential hypertension. Circulation. 1993; 87: 1475-1481.
14. Sampaio R, Tanus-Santos J, Melo S, Hyslop S, Franchini G, Luca J, Moreno H. Hypertension plus diabetes mimics the cardiomyopathy induced by nitric oxide inhibition in rats. Chest. 2002; 122: 1412-1420.
15. Szocs K. Endothelial dysfunction and reactive oxygen species production in ischemia/reperfusion and nitrate tolerance. Gen Physiol Biophys. 2004; 23: 265-295.
16. Yanni A, Margaritis E, Liarakos N, Pantopoulou A, Poulakou M, Kostakis M, Perrea D, Kostakis A. Time-dependent alterations in serum NO concentration after oral administration of L-arginine, L-NAME, and allopurinol in intestinal ischemia/reperfusion. Vasc Health Risk Manag. 2008; 4: 437-441.
17. Yaylak F, Canbaz H, Caglikulekci M, Dirlik M, Tamer L, Ogetman Z, Polat Y, Kanik A, Aydin S. Liver tissue inducible nitric oxide synthase (inos) expression and lipid peroxidation in experimental hepatic ischemia reperfusion injury stimulated with lipopolysaccharide: the role of aminoguanidine. J Surg Res. 2008; 148: 214-223.
18. Youn T, Kim H, Kang H, Kim D, Cho M, Kim C, Oh B, Lee M, Park Y. Inhibition of nitric oxide synthesis increase apoptotic cardiomyocyte death and myocardial angiotensin-converting enzyme gene expression in ischemia reperfusion-injured myocardium of rats. Heart Vessels. 2001; 16: 12-19.