Comparative study of aminoglycosides (Gentamicin & Streptomycin) and fluoroquinolone (Ofloxacin) antibiotics on testis tissue in rats: Light and transmission electron microscopic study

Pakistan Journal of Medical Sciences

Volumn 25, Issue 4, 2009, Pages 624-629

  Khaki, Arash ^a   Khaki, Amir Afshin ^b   Iraj, Sohrabihaghdost ^c   Bazi, Parviz ^d   Imani, Seyed Amir Mahdi ^a   Kachabi, Homan ^a  

^a ISLAMIC AZAD UNIVERSITY   (Iran)

^b UNIVERSITY OF TABRIZ   (Iran)

^c ISLAMIC AZAD UNIVERSITY   (Iran)

^d TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Gentamicin; Ofloxacin; Streptomycin; Testis; Testosterone

Indexed keywords

AMINOGLYCOSIDE; GENTAMICIN; OFLOXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; STREPTOMYCIN; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CELL DEATH; CONTROLLED STUDY; CYTOARCHITECTURE; ELECTRON MICROSCOPY; FIBROBLAST; GERM CELL; LEYDIG CELL; MALE; MALE FERTILITY; MICROSCOPY; NONHUMAN; RAT; SERTOLI CELL; SPERMATOGONIUM; TESTIS INJURY; TESTOSTERONE BLOOD LEVEL; TRANSMISSION ELECTRON MICROSCOPY; VENOUS CONGESTION;

EID: 70349087011     PISSN: 1682024X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Oliva A, Giami A, Multigner L. Environmental agents and erectile dysfunction: a study in a consulting population. J Andrology 2002;(23):546-550. (Pubitemid 34655088)
2. Magli MC, Gianaroli L, Fiorentino A, Ferraretti AP, Fortini D, Panzella S. Improved cleavage rate of human embryos cultured in antibiotic-free medium. Hum Reprod 1996;(11):1520-1524. (Pubitemid 26335106)
3. Herbold BA, Brendler-Schwaab SY, Ahr HJ. Ciprofloxacin: in vivo genotoxicity studies. Mutat Res 2001;(498):193-205.
4. Abd-Allah AR, Aly HA, Moustafa AM, Abdel-Aziz AA, Hamada FM. Adverse testicular effects of some quinolone members in rats. Pharmacol Res 2000;(41):211-219.
5. Demir A, Turker P, Onol FF, Sirvanci S, Findik A, Tarcan T. Effect of experimentally induced Escherichia coli epididymo-orchitis and Ciprofloxacin treatment on rat spermatogenesis. Int J Urol 2007;(14):268-272 (Pubitemid 46423251)
6. Khaki A, Heidari M, Ghaffari Novin M, Khaki AA. Adverse effects of Ciprofloxacin on testis apoptosis and sperm parameters in rats. Iranian J Reproductive Medicine 2008;(6):71-76.
7. Huang HFS, Linsenmeyer TA, Li MT, Giglio W, Anesetti R, von Hagen J, et al. Acute effects of spinal cord injury on the pituitary-testicular hormone axis and Sertoli cell functions: a time course study. J Androl 1995;(16):148-157.
8. Haidl G, Schuppe HC, Köhn FM, Leiber C. Evidence-based drug therapy for male infertility. Urologe A 2008;47(12):1555-1556
9. Andreessen R, Sudhoff F, Borgmann V, Nagel R. Results of Ofloxacin therapy in andrologic patients suffering from therapy-requiring asymptomatic infections. Andrologia 1995;(25):377-383. (Pubitemid 23332627)
10. Crotty KL, May R, Kulvicki A, Kumar D, Neal DE Jr. The effect of antimicrobical therapy on testicular aspirate flow cytometry. J Urol 1995;(153):835-838.
11. Schramm P. Ofloxacin: concentration in human ejaculate and influence on sperm motility. Infection 1986;(14):274-275. (Pubitemid 17222102)
12. King K, Chan PJ, Patton WC, King A. Antibiotics: effect on cryopreserved-thawed human sperm motility in vitro. Fertil Steril 1997;(67):1146-1151. (Pubitemid 27241912)
13. Khaki A, Ghaffari Novin M, Khaki AA, Nouri M, Sanati E, Nikmanesh M. Comparative study of the effects of Gentamicin, neomycin, Streptomycin and Ofloxacin antibiotics on sperm parameters and testis apoptosis in rats. Pak J Biological Sci 1998;(8):35-41.
14. Shen H, Ong C. Detection of oxidative DNA damage in human sperm and its association with sperm function and male infertility. Free Radic Med Biol 2000;(28):529-536 (Pubitemid 30136034)
15. Weyers AI, Ugnia LI, García Ovando H, Gorla NB. Ciprofloxacin increases hepatic and renal lipid hydroperoxides levels in mice. Biocell 2002;(26):225-228. (Pubitemid 35012807)
16. Sanchez G, Hidalgo ME, Vivanco JM, Escobar J. Induced and photoinduced DNA damage by quinolones: Ciprofloxacin, Ofloxacin and nalidixic acid determined by comet assay. J Photochem Photobiol 2005;(81):819-822. (Pubitemid 41265045)
17. Narayana K. An aminoglycoside antibiotic gentamycin induces oxidative stress, reduces antioxidant reserve and impairs spermatogenesis in rats. J Toxicol Sci 2008;(33):85-96. (Pubitemid 351340766)
18. Khaki A, Ghaffari Novin M, Khaki AA, Fathiazad F, Khaberi M, Hossinchi J, et al. Ultra structural study of gentamicin and ofloxacin effect on testis tissue in rats: Light and transmission electron microscopy. Afr J Pharmacy Pharmacology 2009;(4):105-109.