Manipulation of mouse embryonic stem cells for knockout mouse production

Current Protocols in Cell Biology

Volumn , Issue SUPPL. 44, 2009, Pages

  Limaye, Advait ^a   Hall, Bradford ^a   Kulkarnil, Ashok B ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Homologous recombination; Mouse embryonic stem cells

Indexed keywords

PLASMID DNA;

CELL CULTURE; CELL DIFFERENTIATION; CELL GROWTH; CELL MANIPULATION; ELECTROPORATION; EMBRYONIC STEM CELL; EXPERIMENTATION; FIBROBLAST; GENE TARGETING; HETEROZYGOSITY; HOMOLOGOUS RECOMBINATION; HOMOZYGOSITY; KNOCKOUT GENE; KNOCKOUT MOUSE; MUTATION; NONHUMAN; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; REVIEW;

EID: 70349086211     PISSN: 19342500     EISSN: 19342616     Source Type: Journal    
DOI: 10.1002/0471143030.cb1913s44     Document Type: Review

References (61)

1. Baharvand, H. and Matthaei, K.I. 2004. Culture condition difference for establishment of new embryonic stem cell lines from the C57BL/6 and BALB/ c mouse strains. In Vitro Cell Dev. Biol. Anim. 40:76-81.
2. Bloch, K.D. and Grossman, B. 1995. Digestion of DNA with restriction enzymes. Curr. Protoc. Mol. Biol. 31:3.1.1-3.1.21.
3. Bradley, A., Evans, M., Kaufman, M.H., and Robertson, E. 1984. Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines Nature 309:255-256.
4. Brinster, R.L. 1974. The effect of cells transferred into the mouse blastocyst on subsequent development. J. Exp. Med. 14:1049-1056.
5. Brown, T. 1993. Southern blotting. Curr. Protoc. Mol. Biol. 22:2.9A.1-2.9A.15.
6. Burdon, T., Stracey, C., Chambers, I., Nichols, J., and Smith, A. 1999. Suppression of SHP- 2 and ERK signalling promotes self-renewal of mouse embryonic stem cells. Dev. Biol. 210:30-43.
7. Cole, R.J. and Paul, J. 1965. Properties of culturedmammalian ova. In Ciba Foundation Symposium, Preimplantation Stages of Pregnancy (G.E.W.Wolstenholme and M. O'Connor, eds.) pp. 95-98. Little, Brown and Company, Boston.
8. Dinkel, A., Aicher, W.K., Warnatz, K., Bürki, K., Eibel, H., and Ledermann, B. 1999. Efficient generation of transgenic BALB/c mice using BALB/c embryonic stem cells. J. Immunol. Methods 223:255-260.
9. Doetschman, T.C., Eistetter, H., Katz, M., Schmidt, W., and Kemler, R. 1985. The in vitro development of blastocyst-derived embryonic stem cell lines: Formation of visceral yolk sac, blood islands and myocardium. J. Embryol. Exp. Morphol. 87:27-45.
10. Doetschman, T., Gregg, R.G., Maeda, N., Hooper, M.L., Melton, D.W., Thompson, S., and Smithies, O. 1987. Targetted correction of a mutant HPRT gene in mouse embryonic stem cells. Nature 330:576-578.
11. Donovan, J. and Brown, P. 2006. Euthanasia. Curr. Protoc. Immunol. 73:1.8.1-1.8.4.
12. Downing, G.J. and Battey, J.F. 2004. Technical assessment of the first 20 years of research using mouse embryonic stem cell lines. Stem Cells 22:1168-1180.
13. Eakin, G.S. and Hadjantonakis, A.K. 2006. Production of chimeras by aggregation of embryonic stem cells with diploid or tetraploid mouse embryos. Nat. Protoc. 1:1145-1153.
14. Evans, M.J. and Kaufman, M.H. 1981. Establishment in culture of pluripotential cells from mouse embryos Nature 292:154-156.
15. Gardner, R.L. 1968. Mouse chimeras obtained by the injection of cells into the blastocyst. Nature 220:596-597.
16. Gossler, A., Doetschman, T., Korn, R., Serfling, E., and Kemler, R. 1986. Transgenesis by means of blastocyst-derived embryonic stem cell lines. Proc. Natl. Acad. Sci. U.S.A. 83:9065-9069.
17. Gossler, A., Joyner, A.L., Rossant, J., and Skarnes, W.C. 1989. Mouse embryonic stem cells and reporter constructs to detect developmentally regulated genes. Science 244:463-465.
18. Köntgen, F. and Stewart, C.L. 1993. Simple screening procedure to detect gene targeting events in embryonic stem cells. Methods Enzymol. 225:878-890.
19. Kosaka, Y., Kobayashi, N., Fukazawa, T., Totsugawa, T., Maruyama, M., Yong, C., Arata, T., Ikeda, H., Kobayashi, K., Ueda, T., Kurabayashi, Y., and Tanaka, N. 2004. Lentivirus-based gene delivery in mouse embryonic stem cells. Artif. Organs 28:271-277.
20. Laird, P.W., Zijderveld, A., Linders, K., Rudnicki, M.A., Jaenisch, R., and Berns, A. 1991. SimplifiedmammalianDNAisolation procedure. Nucl. Acids.Res. 19:4293.
21. Ledermann, B. and Bürki, K. 1991. Establishment of a germ-line competent C57BL/6 embryonic stem cell line. Exp. Cell Res. 197:254-258.
22. Li, E., Bestor, T.H., and Jaenisch, R. 1992. Targeted mutation of the DNAmethyltransferase gene results in embryonic lethality. Cell 69:915-926.
23. Longo, L., Bygrave, A., Grosveld, F.G., and Pandolfi, P.P. 1997. The chromosome make-up of mouse embryonic stem cells is predictive of somatic and germ cell chimaerism. Transgenic Res. 6:321-328
24. Maherali, N., Sridharan, R., Xie, W., Utikal, J., Eminli, S., Arnold, K., Stadtfeld, M., Yachechko, R., Tchieu, J., Jaenisch, R., Plath, K., and Hochedlinger, K. 2007. Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. Cell Stem Cell 1:55-70.
25. Mansour, S.L., Thomas, K.R., and Capecchi, M.R. 1988. Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: A general strategy for targeting mutations to nonselectable genes. Nature 336:348-352.
26. Martin, G.R. 1981. Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma. Proc. Natl. Acad. Sci. U.S.A. 78:7634-7638.
27. Martin, G.R. and Evans, M.J. 1974. The morphology and growth of a pluripotent teratocarcinoma cell line and its derivatives in tissue culture. Cell 2:163-172.
28. Martin, G.R. and Evans, M.J. 1975. Differentiation of clonal lines of teratocarcinoma cells: Formation of embryoid bodies in vitro. Proc. Natl. Acad. Sci. U.S.A. 72:1441-1445.
29. Mitsui, K., Tokuzawa, Y., Itoh, H., Segawa, K., Murakami, M., Takahashi, K., Maruyama, M., Maeda, M., and Yamanaka, S. 2003. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell 113:631-642.
30. Moore, D. and Dowhan, D. 2002. Purification and concentration of DNA from aqueous solutions. Curr. Protoc. Mol. Biol. 59:2.1A.1-2.1A.10.
31. Mortensen, R.M., Conner, D.A., Chao, S., Geister- Lowrance, A.A., and Seidman, J.G. 1992. Production of homozygous mutant ES cells with a single targeting construct. Mol. Cell Biol. 12:2391-2395.
32. Nagy, A. and Rossant, J. 2000. Production and analysis of ES cell aggregation chimeras. In Gene Targeting: A Practical Approach, 2nd edition. (A.L. Joyner, ed.) pp. 177-206. Oxford University Press, New York.
33. Nagy, A., Rossant, J., Nagy, R., Abramow- Newerly, W., and Roder, J.C. 1993. Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc. Natl. Acad. Sci. U.S.A. 90:8424-8428.
34. Nichols, J., Evans, E.P., and Smith, A.G. 1990. Establishment of germ-line competent embryonic stem (ES) cells using differentiation inhibiting activity. Development 110:1341-1348.
35. Niwa, H., Miyazaki, J., and Smith, A.G. 2000. Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat. Genet. 24:372-376.
36. Noben-Trauth, N., Köhler, G., Bürki, K., and Ledermann, B. 1996. Efficient targeting of the IL-4 gene in a BALB/c embryonic stem cell line. Transgenic Res. 5:487-491.
37. Okita, K., Ichisaka, T., and Yamanaka, S. 2007. Generation of germ line-competent induced pluripotent stem cells. Nature 448:313-317.
38. Papaioannou, V.E., McBurney, M.W., Gardner, R.L., and Evans, M.J. 1975. Fate of teratocarcinoma cells injected into early mouse embryos. Nature 258:70-73.
39. Pease, S., Braghetta, P., Gearing, D., Grail, D., and Williams, R.L. 1990. Isolation of embryonic stem (ES) cells in media supplementedwith recombinant leukemia inhibitory factor (LIF). Dev. Biol. 141:344-352.
40. Ramïrez-Solis, R., Davis, A.C., and Bradley, A. 1993. Gene targeting in embryonic stem cells. Methods Enzymol. 225:855-878.
41. Robertson, E.J. 1987. Embryo-derived stem cells. In Teratocarcinomas and Embryonic StemCells: A Practical Approach (E.J. Robertson, ed.) pp. 71-112. IRL Press, Oxford.
42. Robertson, E., Bradley, A., Kuehn, M., and Evans, M. 1986. Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector. Nature 323:445-448.
43. Salomon, B., Maury, S., Loubière, L., Caruso, M., Onclercq, R., and Klatzmann, D. 1995. A truncated herpes simplex virus thymidine kinase phosphorylates thymidine and nucleoside analogs and does not cause sterility in transgenic mice. Mol. Cell Biol. 15:5322-5328.
44. Schoonjans, L., Kreemers, V., Danloy, S., Moreadith, R.W., Laroche, Y., and Collen, D. 2003. Improved generation of germ linecompetent embryonic stem cell lines from inbred mouse strains. Stem Cells 21:90-97.
45. Schwartzberg, P.L., Goff, S.P., and Robertson, E.J. 1989. Germ-line transmission of a c-abl mutation produced by targeted gene disruption in ES cells. Science 246:799-803.
46. Seong, E., Saunders, T.L., Stewart, C.L., and Burmeister, M. 2004. To knockout in 129 or in C57BL/6: That is the question. Trends Genet. 20:59-62.
47. Sherman, M.I. 1975. The culture of cells derived from mouse blastocysts. Cell 5:343-349.
48. Simpson, E.M., Linder, C.C., Sargent, E.E., Davisson, M.T.,Mobraaten, L.E., and Sharp, J.J. 1997. Genetic variation among 129 substrains and its importance for targeted mutagenesis in mice. Nat. Genet. 16:19-27.
49. Smith-Arica, J.R., Thomson, A.J., Ansell, R., Chiorini, J., Davidson, B., and McWhir, J. 2003. Infection efficiency of human and mouse embryonic stem cells using adenoviral and adenoassociated viral vectors. Cloning Stem Cells 5:51-62.
50. Solter, D., Skreb, N., and Damjanov, I. 1970. Extrauterine growth of mouse egg-cylinders results in malignant teratoma. Nature 227:503-504.
51. Solter, D., Shevinsky, L., Knowles, B.B., and Strickland, S. 1979. The induction of antigenic changes in a teratocarcinoma stem cell line (F9) by retinoic acid. Dev Biol 70:515-521.
52. Stanford, W.L., Cohn, J.B., and Cordes, S.P. 2001. Gene-trap mutagenesis: Past, present and beyond. Nat. Rev. Genet. 2:756-768.
53. Stevens, L.C. 1970. The development of transplantable teratocarcinomas from intratesticular grafts of pre- and postimplantation mouse embryos. Dev. Biol. 21:364-382.
54. Stevens, L.C. and Little, C.C. 1954. Spontaneous testicular teratomas in an inbred strain of mice. Proc. Natl. Acad. Sci. U.S.A. 40:1080-1087.
55. te Riele, H., Maandag, E.R., and Berns, A. 1992. Highly efficient gene targeting in embryonic stem cells through homologous recombination with isogenicDNAconstructs. Proc. Natl. Acad. Sci. U.S.A. 89:5128-5132.
56. Thomas, K.R. and Capecchi, M.R. 1987. Sitedirected mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 51:503-512.
57. Vasquez, K.M., Marburger, K., Intody, Z., and Wilson, J.H. 2001. Manipulating the mammalian genome by homologous recombination Proc. Natl. Acad. Sci. U.S.A. 98:8403-8410.
58. Wernig,M., Meissner, A., Foreman, R., Brambrink, T., Ku, M., Hochedlinger, K., Bernstein, B.E., and Jaenisch, R. 2007. In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature 448:318-324.
59. Williams, R.L., Hilton, D.J., Pease, S., Willson, T.A., Stewart, C.L., Gearing, D.P., Wagner, E.F., Metcalf, D., Nicola, N.A., and Gough, N.M. 1988. Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells. Nature 336:684-687.
60. Voytas, D. 2000. Agarose gel electrophoresis. Curr. Protoc. Mol. Biol. 51:2.5A.1-2.5A.9.
61. Ying, Q.L., Stavridis, M., Griffiths, D., Li, M., and Smith, A. 2003. Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture. Nat. Biotechnol. 21:183-186.