Diagnostic efficacy of C4d immunostaining in the detection of the humoral component of renal allograft rejection and therapeutic implications

Indian Journal of Pathology and Microbiology

Volumn 52, Issue 3, 2009, Pages 345-348

  Guduru, Sree Latha ^a   Kuruvilla, Sarah ^b   Abraham, Georgi ^c   Mathew, Milly ^c   Saravanan, S ^d  

^a Pinnamaneni Siddhartha Institute of Medical Sciences   (India)

^b SRI RAMACHANDRA UNIVERSITY   (India)

^c Madras Medical Mission ^*  (India)

^d Chennai Transplant Center   (India)

Author keywords

Acute humoral rejection; Antihumoral therapy; C4d

Indexed keywords

CALCINEURIN INHIBITOR; COMPLEMENT COMPONENT C4D; EVEROLIMUS; IMMUNOGLOBULIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; RITUXIMAB; STEROID;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; CLINICAL ARTICLE; COMPUTER PROGRAM; DIAGNOSTIC VALUE; DRUG PULSE THERAPY; FEMALE; GLOMERULUS CAPILLARY; GRAFT DYSFUNCTION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HUMORAL IMMUNITY; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE TREATMENT; IMMUNOTHERAPY; KIDNEY ALLOGRAFT; KIDNEY ALLOGRAFT REJECTION; KIDNEY BIOPSY; MALE; PLASMAPHERESIS; POLYMORPHIC LOCUS; PROTEIN EXPRESSION; SENSITIVITY AND SPECIFICITY; SINGLE DRUG DOSE; STEROID THERAPY;

ADOLESCENT; ADULT; AGED; BIOPSY; COMPLEMENT C4; FEMALE; GRAFT REJECTION; HUMANS; IMMUNOHISTOCHEMISTRY; KIDNEY; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; STAINING AND LABELING; TRANSPLANTATION, HOMOLOGOUS; YOUNG ADULT;

EID: 70249144741     PISSN: 03774929     EISSN: None     Source Type: Journal    
DOI: 10.4103/0377-4929.54990     Document Type: Article

References (16)

1. Racusen LC, Solez K, Colvin RB, Bonsib SM, Castro MC, Cavallo T, et al. The Banff .97 working classification of renal allograft pathology. Kidney Int 1999;55:713-723 (Pubitemid 29082898)
2. Colvin RB, Cohen AH, Saiontz C, Bonsib S, Buick M, Burke B, et al. Evaluation of Pathological criteria for acute renal allograft rejection: Reproducibility, Sensitivity and clinical correlation. J Am Soc Nephrol 1997;8:1930-1941
3. Collins AB, Schneeberger EE, Pascual MA, Saidman SL, Williams WW, Tolkoff-Rubin N, et al. Complement activation in acute humoral renal allograft rejection. J Am Soc Nephrol 1999;10:2208-2214
4. Crespo M, Pascual M, Tolkoff-Rubin N, Mauiyyedi S, Collins AB, Fitzpatrick D, et al. Acute humoral rejection in renal allograft recipients: Incidence, serology and clinical characteristics. Transplantation 2001;71:652-658
5. Trpkov K, Campbell P. Pazderka F, Cockfield S, Solez K, Halloran PF. Pathologic features of acute renal allograft rejection associated with donor-specific antibody analysis using the Banff grading schema. Transplantation 1996;61:1586-1592
6. Regele H, Exner M, Watschinger B, Wenter C, Wahrmann M, Osterreicher C, et al. Endothelial C4d deposition is associated with inferior kidney allograft outcome independently of cellular rejection. Nephrol Dial Transplant 2001;16:2058-2066
7. Truong LD, Barrios R, Adrogue HE, Gaber LW. Acute antibodymediated rejection of renal transplant: Pathogenetic and diagnostic considerations. Arch Path Lab Med 2007;131:1200-1208
8. Tanaka T, Kyo M, Kokado Y, Takahara S, Hatori M, Suzuki K, et al. Correlation between the Banff 97 classification of renal allograft biopsies and clinical outcome. Transpl Int 2004;17:59-64.
9. Racusen LC, Colvin RB, Solez K, Mihatsch MJ, Halloran PF, Campbell PM, et al. Antibody mediated rejection criteria -an addition to the Banff .s .97 classification of Renal allograft rejection. Amer J Transplant 2003; 3:708-714
10. Bates WD, Davies DR, Welsh K, Gray DW, Fuggle SV, Morris PJ. An evaluation of the Banff classification of early renal allograft biopsies and correlation with outcome. Nephrol Dial Transplant 1999;14:2364-2369
11. Becker YT, Becker BN, Pirsch JD, Sollinger HW. Rituximab as treatment for refractory kidney transplant rejection. Am J Transplant 2004;4:996-1001.
12. Montgomery RA, Zachary AA, Racusen LC, Leffell MS, King KE, Burdick J, et al. Plasmapheresis and intravenous immune globulin provides effective rescue therapy for refractory humoral rejection and allows kidney to be successfully transplanted into cross-match positive recipients. Transplantation 2000;70:887-895
13. Hara S, Matsushita H, Yamaguchi Y, Kawaminami K, Horita S, Furusawa M. Allograft glomerulitis: Histologic characteristics to detect chronic humoral rejection. Transplant Proc 2005;37:714-716
14. Joosten SA, Sijpkens YW, van Kooten C, Paul LC. Chronic renal allograft rejection: Pathophysiologic considerations Kidney Int 2005:68:1-13.
15. Vadivel N, Tullius SG, Chandraker A. Chronic renal allograft nephropathy. Semin Nephrol 2007;27:414-429
16. Faguer S, Kamar N, Guilbeaud-Frugier C, Fort M, Modesto A, Mari A, et al. Rituximab therapy for acute humoral rejection after kidney transplantation. Transplantation 2007;83:1277-1280