Biochemical changes in Wistar rats on oral doses of mistletoe (Loranthus micranthus)

American Journal of Pharmacology and Toxicology

Volumn 4, Issue 3, 2009, Pages 94-97

  Edem, D O ^a   Usoh, I F ^a  

^a UNIVERSITY OF UYO   (Nigeria)

Author keywords

Biochemical parameters; Leaf extract; Loranthus micranthus; Mistletoe

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ANTIDIABETIC AGENT; ANTIHYPERTENSIVE AGENT; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CHOLESTEROL; GLUCOSE; LORANTHUS MICRANTHUS EXTRACT; PLANT EXTRACT; PROTEIN; UNCLASSIFIED DRUG; UREA; WATER;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; BLOOD ANALYSIS; BLOOD SAMPLING; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG SCREENING; GLUCOSE BLOOD LEVEL; LORANTHUS MICRANTHUS; MALE; MEDICINAL PLANT; NONHUMAN; PLANT LEAF; PROTEIN BLOOD LEVEL; RAT; UREA BLOOD LEVEL; WISTAR RAT;

ANIMALIA; LORANTHUS MICRANTHUS; RATTUS; RATTUS NORVEGICUS;

EID: 70249124215     PISSN: 15574962     EISSN: 15574970     Source Type: Journal    
DOI: 10.3844/ajptsp.2009.94.97     Document Type: Article

References (22)

1. Dominguez, E., J.R. Canal, D.M. Torres, J.E. Campilo and C. Perez, 1996. Hypolipidemic activity of Ficus carica leaf extract in streptozocin diabetic rats. Phytother. Res., 10: 526-528. DOI: 10.1002/ (SIC)1099-573(199609)10:6<526::AID-PTR886>3.0.CO; 2-R
2. Udoh, F.V. and J.O. Akpan, 1996. Effects of extract of leaf and seed of Piper guineense on smooth muscle activity in rat, guinea pig and rabbit. Phytother. Res., 10: 596-599. DOI: 10.1002/ (SIC)1099-573(199611)10:7<596::AID-PTR915>30.CO; 2-T
3. Udoh, F.V. and T.Y. Lot, 1998. Effects of leaf and root extracts of Nuclea latifolia on cardiovascular system. Fitoterapia, 69: 141-146. http://cat.inist.fr/?aModele=afficheN&cpsidt=2237607
4. Udosen, E.O. and S.A. Ojong, 1998. Hepatoxic activity of Sacoglottis gabonensis in rats. Pharmaceut. Biol., 36: 368-371. DOI: 10.1076/ phbi.365368.4648
5. Osadebe, P.O. and I.C. Uzochukwu, 2006. Chromatographic and antimotility studies on extracts of Loranthus micranthus Linn. J. Pharmaceut. Allied Sci. 3: 263-268. http://ajol.info/index.php/jophas/article/view/ 34988
6. Bikomo, E.O., 1992. Hypoglycemic effect of African Mistletoe. Proceedings of the 6th Annual Conference of the Botanical Society of Nigeria, Mar. 29-Apr. 1, BOSON., Lagos, No. 9/2B/14, Nigeria, pp: 31-33.
7. Obatomi, D.K. E.O. Bikomo and V.J. Temple, 1994. Antidiabetic properties of African Mistletoe in streptozocin-induced diabetic rats. J. Ethnopharmacol., 43: 13-17. http://cat.inist.fr/ ?aModele=afficheN&cpsidt=4103280
8. Obatomi, D.K., V.O. Aina and V.J. Temple, 1996. Effect of African mistletoe on blood pressure in spontaneously hypertensive rats. Pharmaceut. Biol., 34: 124-127. DOI: 10.1076/phbi342.124.13197
9. Osadebe, P.O., G.B. Okide and I.C. Akabogu, 2004. Study of anti-diabetic activities of crude methanolic extracts of Loranthus micranthus (Linn.) sourced from five different host trees. J. Ethnopharmacol., 95: 133-138. DOI: 101016/j.jep.2004.06.029
10. Osadebe, P.O. and S.E. Ukweze, 2004. A comparative study of the phytochemical and antimicrobial properties of the Eastern Nigerian species of African Mistletoe (Loranthus micranthus) sourced from different host areas trees. Bio-Res. J. Biol. Res. Biotechnol., 2: 18-23. http://ajol.info/index.php/br/article/view/28537
11. Siedel, J., E.O. Hagele, J. Ziegenhorn and A. Wahlefed, 1983. Reagents for the determination of serum total cholesterol with improved lipolytic efficiency. Clin. Chem., 29: 1075-1080. http://www.clinchem.org/cgi/ content/abstract/29/6/1075
12. Wybenga, D.R., D. Giorgio and J.V. Pillegi, 1971. Urea estimation by the diacetyl monoxime method. Clin. Chem., 17: 891-895. http://www.clinchem.org/cgi/content/abstract/17/9/891
13. Kew, M.C., 2000. Serum aminotransferase concentration as evidence of hepatocellular damage. Lancet, 355: 591-592. DOI: 10.1016/ S0140-6376(99)00219-6
14. Eteng, M.U., P.E. Ebong, R.R. Ettarh and I.B. Umoh, 1998. Aminotransferase activity in serum, liver and heart tissue of rats exposed to threobromine. Indian J. Pharmacol., 30: 339-342. http://cat.inist.fr/?aModele=afficheN&cpsidt=9978248
15. Akinloye, O.A. and B.R. Olorede, 2000. Effect of Amaranthus spinosa leaf extract on haematology and serum chemistry of rats. Nigerian J. Nat. Prod. Med., 4: 79-81. http://www.ajol/info/ viewissue.php?jid=688ab=08id=352
16. Mayne, P.D., 1994. Clinical Chemistry in Diagnosis and Treatment. 6th Edn., Hodder Arnold (International Students Edition), London, ISBN: 13:978 0 340 700808, pp: 301-309.
17. Vasudevan, D.M. and S. Sreekumari, 2005. Textbook of Biochemistry (For Medical Students). 4th Edn., Jaypee Brothers Medical Publishers (P) Ltd., New Delhi, India, ISBN: 81-8061-369-0, pp: 502-503.
18. Lamela, M., I. Cadavid, A. Gato and M.J. Callega, 1985. Effects of Lythrum salicaria in normoglycemic rats. J. Ethnopharmacol., 14: 83-91. DOI: 10.1016/0378-8741(85)90032-7
19. Lamela, M., I. Cadavid, A. Gato and M.J. Callega, 1986. Effects of Lythrum salicaria extracts on hyperglycemia in rats and mice. J. Ethnopharmacol., 15: 153-160. DOI: 10.1016/0378-8741(86)90152-2
20. Eno, A.E. and E.H. Itam, 1996. Hypoglycemic agents in leaves of Eleophorbia drupifera. Phytother. Res., 10: 680-682. DOI: 10.1002/ (SIC)1099-1573(199612)10:8<680::AID-PTR881>3.0.CO; 2-C
21. Kako, M., T. Miura, Y. Nishiyama, M. Ichimaru, M. Moriyasa and A. Kato, 1996. Hypoglycemic effect of the rhizomes of Polygala senega in normal and diabetic mice and its component, the triterpenoid glycoside Senegin-II. Planta Med., 62: 440-443. DOI: 10.1055/s-2006-957935
22. Halim, A.B., O. El-Ahmady, S. Hassab-Allah, F. Abdel-Galil, Y. Hafez and A. Darwish 1997. Biochemical effect of antioxidants on lipids and liver function in experimentally-induced liver damage. Ann. Clin. Biochem., 34: 656-663. http://www.biomedexperts.com/abstract/bme/9367004