-
1
-
-
57449108684
-
The American Heart Association's 2008 statement of principles for healthcare reform
-
Gibbons RJ, Jones DW, Gardner TJ, Goldstein LB, Moller JH, Yancy CW: The American Heart Association's 2008 statement of principles for healthcare reform. Circulation 118, 2209-2218 (2008).
-
(2008)
Circulation
, vol.118
, pp. 2209-2218
-
-
Gibbons, R.J.1
Jones, D.W.2
Gardner, T.J.3
Goldstein, L.B.4
Moller, J.H.5
Yancy, C.W.6
-
2
-
-
39749191084
-
Heart disease and stroke statistics - 2008 update: A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
-
Rosamond W, Flegal K, Furie K et al.: Heart disease and stroke statistics - 2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 117, E25-E146 (2008).
-
(2008)
Circulation
, vol.117
-
-
Rosamond, W.1
Flegal, K.2
Furie, K.3
-
3
-
-
37249051700
-
Achieving blood pressure goals globally: Five core actions for health-care professionals. A worldwide call to action
-
Bakris G, Hill M, Mancia G et al.: Achieving blood pressure goals globally: five core actions for health-care professionals. A worldwide call to action. J. Hum. Hypertens. 22, 63-70 (2008).
-
(2008)
J. Hum. Hypertens
, vol.22
, pp. 63-70
-
-
Bakris, G.1
Hill, M.2
Mancia, G.3
-
4
-
-
12344282783
-
Global burden of hypertension: Analysis of worldwide data
-
Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J: Global burden of hypertension: analysis of worldwide data. Lancet 365, 217-223 (2005).
-
(2005)
Lancet
, vol.365
, pp. 217-223
-
-
Kearney, P.M.1
Whelton, M.2
Reynolds, K.3
Muntner, P.4
Whelton, P.K.5
He, J.6
-
5
-
-
33646830648
-
Role of the renin - angiotensin - aldosterone system in vascular remodeling and inflammation: A clinical review
-
Duprez DA: Role of the renin - angiotensin - aldosterone system in vascular remodeling and inflammation: a clinical review. J. Hypertension 24, 983-991 (2006).
-
(2006)
J. Hypertension
, vol.24
, pp. 983-991
-
-
Duprez, D.A.1
-
6
-
-
20544440652
-
Renin inhibition: What are the therapeutic opportunities?
-
Fisher ND, Hollenberg NK: Renin inhibition: what are the therapeutic opportunities? J. Am. Soc. Nephrol. 16, 592-599 (2005).
-
(2005)
J. Am. Soc. Nephrol
, vol.16
, pp. 592-599
-
-
Fisher, N.D.1
Hollenberg, N.K.2
-
8
-
-
0042661157
-
Structure-based design of aliskiren, a novel orally effective renin inhibitor
-
Wood JM, Maibaum J, Rahuel J et al.: Structure-based design of aliskiren, a novel orally effective renin inhibitor. Biochem. Biophys. Res. Commun. 308, 698-705 (2003).
-
(2003)
Biochem. Biophys. Res. Commun
, vol.308
, pp. 698-705
-
-
Wood, J.M.1
Maibaum, J.2
Rahuel, J.3
-
9
-
-
34547726196
-
Plasma renin and the antihyperten effect of the orally active renin inhibitor aliskiren in clinical hypertension
-
Nussberger J, Gradman AH, Schmieder RE, Lins RL, Chiang Y, Prescott MF: Plasma renin and the antihyperten effect of the orally active renin inhibitor aliskiren in clinical hypertension. Int. J. Clin. Pract. 61, 1461-1468 (2007).
-
(2007)
Int. J. Clin. Pract
, vol.61
, pp. 1461-1468
-
-
Nussberger, J.1
Gradman, A.H.2
Schmieder, R.E.3
Lins, R.L.4
Chiang, Y.5
Prescott, M.F.6
-
10
-
-
47049089844
-
Clinical pharmacokinetics and pharmacodynamics of aliskiren
-
Vaidyanathan S, Jarugula V, Dieterich HA, Howard D, Dole WP: Clinical pharmacokinetics and pharmacodynamics of aliskiren. Clin. Pharmacokinet. 47, 515-531 (2008).
-
(2008)
Clin. Pharmacokinet
, vol.47
, pp. 515-531
-
-
Vaidyanathan, S.1
Jarugula, V.2
Dieterich, H.A.3
Howard, D.4
Dole, W.P.5
-
11
-
-
33750357566
-
Aliskiren, a novel orally effective renin inhibitor, exhibits similar pharmacokinetics and pharmacodynamics in Japanese and Caucasian subjects
-
Vaidyanathan S, Jermany J, Yeh C, Bizot MN, Camisasca R: Aliskiren, a novel orally effective renin inhibitor, exhibits similar pharmacokinetics and pharmacodynamics in Japanese and Caucasian subjects. Br. J. Clin. Pharmacol. 62, 690-698 (2006).
-
(2006)
Br. J. Clin. Pharmacol
, vol.62
, pp. 690-698
-
-
Vaidyanathan, S.1
Jermany, J.2
Yeh, C.3
Bizot, M.N.4
Camisasca, R.5
-
12
-
-
33750289480
-
Aliskiren exhibits similar pharmacokinetics in healthy volunteers and patients with Type 2 diabetes mellitus
-
Zhao C, Vaidyanathan S, Yeh CM, Maboudian M, Armin Dieterich H: Aliskiren exhibits similar pharmacokinetics in healthy volunteers and patients with Type 2 diabetes mellitus. Clin. Pharmacokinet. 45, 1125-1134 (2006).
-
(2006)
Clin. Pharmacokinet
, vol.45
, pp. 1125-1134
-
-
Zhao, C.1
Vaidyanathan, S.2
Yeh, C.M.3
Maboudian, M.4
Armin Dieterich, H.5
-
13
-
-
33644789557
-
Renin inhibition with aliskiren: Where are we now, and where are we going?
-
Azizi M, Webb R, Nussberger J, Hollenberg NK: Renin inhibition with aliskiren: where are we now, and where are we going? J. Hypertens. 24, 243-256 (2006).
-
(2006)
J. Hypertens
, vol.24
, pp. 243-256
-
-
Azizi, M.1
Webb, R.2
Nussberger, J.3
Hollenberg, N.K.4
-
14
-
-
0031688757
-
Pathways for angiotensin II generation in intact human tissue: Evidence from comparative pharmacological interruption of the renin system
-
Hollenberg NK, Fisher ND, Price DA: Pathways for angiotensin II generation in intact human tissue: evidence from comparative pharmacological interruption of the renin system. Hypertension 32, 387-392 (1998).
-
(1998)
Hypertension
, vol.32
, pp. 387-392
-
-
Hollenberg, N.K.1
Fisher, N.D.2
Price, D.A.3
-
15
-
-
0025073099
-
Reactive hyperreninemia is a major determinant of plasma angiotensin II during ACE inhibition
-
Mooser V, Nussberger J, Juillerat L et al.: Reactive hyperreninemia is a major determinant of plasma angiotensin II during ACE inhibition. J. Cardiovasc. Pharmacol. 15, 276-282 (1990).
-
(1990)
J. Cardiovasc. Pharmacol
, vol.15
, pp. 276-282
-
-
Mooser, V.1
Nussberger, J.2
Juillerat, L.3
-
16
-
-
0034685168
-
Angiotensin II receptof antagonists
-
Burnier M, Brunner HR: Angiotensin II receptof antagonists. Lancet 355, 637-645 (2000).
-
(2000)
Lancet
, vol.355
, pp. 637-645
-
-
Burnier, M.1
Brunner, H.R.2
-
17
-
-
0037032257
-
Beneficial neurohormonal profile of spironolactone in severe congestive heart failure: Results from the RALES neurohormonal substudy
-
Rousseau MF, Gurne O, Duprez D et al.: Beneficial neurohormonal profile of spironolactone in severe congestive heart failure: results from the RALES neurohormonal substudy. J. Am. Coll. Cardiol. 40, 1596-1601 (2002).
-
(2002)
J. Am. Coll. Cardiol
, vol.40
, pp. 1596-1601
-
-
Rousseau, M.F.1
Gurne, O.2
Duprez, D.3
-
18
-
-
33746566456
-
Beneficial impact of spironolactone on nephrotic range albuminuria in diabetic nephropathy
-
Schjoedt KJ, Rossing K, Juhl TR et al.: Beneficial impact of spironolactone on nephrotic range albuminuria in diabetic nephropathy. Kidney Int. 70, 536-542 (2006).
-
(2006)
Kidney Int
, vol.70
, pp. 536-542
-
-
Schjoedt, K.J.1
Rossing, K.2
Juhl, T.R.3
-
19
-
-
28844457541
-
Determinants of increased angiotensin II levels in severe chronic heart failure patients despite ACE inhibition
-
van de Wal RM, Plokker HW, Lok DJ et al.: Determinants of increased angiotensin II levels in severe chronic heart failure patients despite ACE inhibition. Int. J. Cardiol. 106, 367-372 (2006).
-
(2006)
Int. J. Cardiol
, vol.106
, pp. 367-372
-
-
van de Wal, R.M.1
Plokker, H.W.2
Lok, D.J.3
-
20
-
-
0036372173
-
Angiotensin II suppression in humans by the orally active renin inhibitor aliskiren (SPP100): Comparison with enalapril
-
Nussberger J, Wuerzner G, Jensen C, Brunner HR: Angiotensin II suppression in humans by the orally active renin inhibitor aliskiren (SPP100): comparison with enalapril. Hypertension 39, E1-E8 (2002).
-
(2002)
Hypertension
, vol.39
-
-
Nussberger, J.1
Wuerzner, G.2
Jensen, C.3
Brunner, H.R.4
-
21
-
-
0347479295
-
Blood pressure lowering in essential hypertension with an oral renin inhibitor, aliskiren
-
Stanton A, Jensen C, Nussberger J, O'Brien E: Blood pressure lowering in essential hypertension with an oral renin inhibitor, aliskiren. Hypertension 42, 1137-1143 (2003).
-
(2003)
Hypertension
, vol.42
, pp. 1137-1143
-
-
Stanton, A.1
Jensen, C.2
Nussberger, J.3
O'Brien, E.4
-
22
-
-
14844363404
-
Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients
-
Gradman AH, Schmieder RE, Lins RL, Nussberger J, Chiang Y, Bedigian MP: Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients. Circulation 111, 1012-1018 (2005).
-
(2005)
Circulation
, vol.111
, pp. 1012-1018
-
-
Gradman, A.H.1
Schmieder, R.E.2
Lins, R.L.3
Nussberger, J.4
Chiang, Y.5
Bedigian, M.P.6
-
23
-
-
33845366982
-
Renin inhibition with aliskiren provides additive antihypertensive efficacy when used in combination with hydrochlorothiazide
-
Villamil A, Chrysant SG, D Calhoun et al.: Renin inhibition with aliskiren provides additive antihypertensive efficacy when used in combination with hydrochlorothiazide. J. Hypertens. 25, 217-226 (2007).
-
(2007)
J. Hypertens
, vol.25
, pp. 217-226
-
-
Villamil, A.1
Chrysant, S.G.2
Calhoun, D.3
-
24
-
-
34447621764
-
Antihypertensive efficacy, safety, and tolerability of the oral direct renin inhibitor aliskiren in patients with hypertension: A pooled analysis
-
Weir MR, Bush C, Anderson DR, Zhang J, Keefe D, Satlin A: Antihypertensive efficacy, safety, and tolerability of the oral direct renin inhibitor aliskiren in patients with hypertension: a pooled analysis. J. Am. Soc. Hypertens. 1, 264-277 (2007).
-
(2007)
J. Am. Soc. Hypertens
, vol.1
, pp. 264-277
-
-
Weir, M.R.1
Bush, C.2
Anderson, D.R.3
Zhang, J.4
Keefe, D.5
Satlin, A.6
-
25
-
-
33846781398
-
Aliskiren, a novel oral renin inhibitor, provides dose-dependent efficacy and placebo-like tolerability in Japanese patients with hypertension
-
Kushiro T, Itakura H, Ato Y, Gotou H, Terao S, Keefe DL: Aliskiren, a novel oral renin inhibitor, provides dose-dependent efficacy and placebo-like tolerability in Japanese patients with hypertension. Hypertens. Res. 29, 997-1005 (2006).
-
(2006)
Hypertens. Res
, vol.29
, pp. 997-1005
-
-
Kushiro, T.1
Itakura, H.2
Ato, Y.3
Gotou, H.4
Terao, S.5
Keefe, D.L.6
-
26
-
-
33947182655
-
Aliskiren, an oral renin inhibitor, provides dose-dependent efficacy and sustained 24-hour blood pressure control in patients with hypertension
-
Oh BH, Mitchell J, Herron JR, Chung J, Khan M, Keefe DL: Aliskiren, an oral renin inhibitor, provides dose-dependent efficacy and sustained 24-hour blood pressure control in patients with hypertension. J. Am. Coll. Cardiol. 49, 1157-1163 (2007).
-
(2007)
J. Am. Coll. Cardiol
, vol.49
, pp. 1157-1163
-
-
Oh, B.H.1
Mitchell, J.2
Herron, J.R.3
Chung, J.4
Khan, M.5
Keefe, D.L.6
-
27
-
-
60549087324
-
Long-term antihypertensive efficacy and safety of the oral direct renin inhibitor aliskiren: A 12-month randomized, double-blind comparator trial with hydrochlorothiazide
-
Schmieder RE, Philipp T, Guerediaga J et al.: Long-term antihypertensive efficacy and safety of the oral direct renin inhibitor aliskiren: a 12-month randomized, double-blind comparator trial with hydrochlorothiazide. Circulation 119, 417-425 (2009).
-
(2009)
Circulation
, vol.119
, pp. 417-425
-
-
Schmieder, R.E.1
Philipp, T.2
Guerediaga, J.3
-
28
-
-
39849089447
-
Comparative efficacy and safety of aliskiren, an oral direct renin inhibitor, and ramipril in hypertension: A 6-month, randomized, double-blind trial
-
Andersen K, Weinberger MH, Egan B et al.: Comparative efficacy and safety of aliskiren, an oral direct renin inhibitor, and ramipril in hypertension: a 6-month, randomized, double-blind trial. J. Hypertens. 26, 589-599 (2008).
-
(2008)
J. Hypertens
, vol.26
, pp. 589-599
-
-
Andersen, K.1
Weinberger, M.H.2
Egan, B.3
-
29
-
-
34548855067
-
A comparison of the tolerability of the direct renin inhibitor aliskiren and lisinopril in patients with severe hypertension
-
Strasser RH, Puig JG, Farsang C, Croket M, Li J, van Ingen H: A comparison of the tolerability of the direct renin inhibitor aliskiren and lisinopril in patients with severe hypertension. J. Hum. Hypertens. 21, 780-787 (2007).
-
(2007)
J. Hum. Hypertens
, vol.21
, pp. 780-787
-
-
Strasser, R.H.1
Puig, J.G.2
Farsang, C.3
Croket, M.4
Li, J.5
van Ingen, H.6
-
30
-
-
34547615709
-
Guidelines for the management of arterial hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)
-
Mancia G, De Backer G, Dominiczak A et al.: 2007 Guidelines for the management of arterial hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur. Heart J. 28, 1462-1536 (2007).
-
(2007)
Eur. Heart J
, vol.28
, pp. 1462-1536
-
-
Mancia, G.1
De Backer, G.2
Dominiczak, A.3
-
31
-
-
36248931230
-
Antihypertensive efficacy of the oral direct renin inhibitor aliskiren as add-on therapy in patients not responding to amlodipine monotherapy
-
Drummond W, Munger MA, Rafique Essop M, Maboudian M, Khan M, Keefe DL: Antihypertensive efficacy of the oral direct renin inhibitor aliskiren as add-on therapy in patients not responding to amlodipine monotherapy. J. Clin. Hypertens. (Greenwich) 9, 742-750 (2007).
-
(2007)
J. Clin. Hypertens. (Greenwich)
, vol.9
, pp. 742-750
-
-
Drummond, W.1
Munger, M.A.2
Rafique Essop, M.3
Maboudian, M.4
Khan, M.5
Keefe, D.L.6
-
32
-
-
38649102508
-
Efficacy and safety of the direct renin inhibitor aliskiren and ramipril alone or in combination in patients with diabetes and hypertension
-
Uresin Y, Taylor AA, Kilo C et al.: Efficacy and safety of the direct renin inhibitor aliskiren and ramipril alone or in combination in patients with diabetes and hypertension. J. Renin Angiotensin Aldosterone Syst. 8, 190-198 (2007).
-
(2007)
J. Renin Angiotensin Aldosterone Syst
, vol.8
, pp. 190-198
-
-
Uresin, Y.1
Taylor, A.A.2
Kilo, C.3
-
33
-
-
34447521458
-
Efficacy and safety of combined use of aliskiren and valsartan in patients with hypertension: A randomised, double-blind trial
-
Oparil S, Yarows SA, Patel S, Fang H, Zhang J, Satlin A: Efficacy and safety of combined use of aliskiren and valsartan in patients with hypertension: a randomised, double-blind trial. Lancet 370, 221-229 (2007).
-
(2007)
Lancet
, vol.370
, pp. 221-229
-
-
Oparil, S.1
Yarows, S.A.2
Patel, S.3
Fang, H.4
Zhang, J.5
Satlin, A.6
-
34
-
-
10744232800
-
The comparative prognostic value of plasma neurohormones at baseline in patients with heart failure enrolled in Val-HeFT
-
Latini R, Masson S, Anand I et al.: The comparative prognostic value of plasma neurohormones at baseline in patients with heart failure enrolled in Val-HeFT. Eur. Heart J. 25, 292-299 (2004).
-
(2004)
Eur. Heart J
, vol.25
, pp. 292-299
-
-
Latini, R.1
Masson, S.2
Anand, I.3
-
36
-
-
79958249630
-
Effect of the oral direct renin inhibitor aliskiren in patients with symptomatic heart failure
-
McMurray JJ, Pitt B, Latini R et al.: Effect of the oral direct renin inhibitor aliskiren in patients with symptomatic heart failure. Circ. Heart Fail. 1, 17-24 (2008).
-
(2008)
Circ. Heart Fail
, vol.1
, pp. 17-24
-
-
McMurray, J.J.1
Pitt, B.2
Latini, R.3
-
37
-
-
35449001223
-
Neurohumoral effects of the new orally active renin inhibitor, aliskiren, in chronic heart failure
-
Seed A, Gardner R, McMurray J et al.: Neurohumoral effects of the new orally active renin inhibitor, aliskiren, in chronic heart failure, Eur. J. Heart Fail. (2007).
-
(2007)
Eur. J. Heart Fail
-
-
Seed, A.1
Gardner, R.2
McMurray, J.3
-
38
-
-
44849114597
-
Aliskiren combined with losartan in type 2 diabetes and nephropathy
-
Parving HH, Persson F, Lewis JB, Lewis EJ, Hollenberg NK: Aliskiren combined with losartan in type 2 diabetes and nephropathy. N. Engl. J. Med. 358, 2433-2446 (2008).
-
(2008)
N. Engl. J. Med
, vol.358
, pp. 2433-2446
-
-
Parving, H.H.1
Persson, F.2
Lewis, J.B.3
Lewis, E.J.4
Hollenberg, N.K.5
-
39
-
-
43449139264
-
Time course of the antiproteinuric and antihypertensive effects of direct renin inhibition in Type 2 diabetes
-
Persson F, Rossing P, Schjoedt KJ et al.: Time course of the antiproteinuric and antihypertensive effects of direct renin inhibition in Type 2 diabetes. Kidney Int. 73, 1419-1425 (2008).
-
(2008)
Kidney Int
, vol.73
, pp. 1419-1425
-
-
Persson, F.1
Rossing, P.2
Schjoedt, K.J.3
-
40
-
-
61349170589
-
Effect of the direct renin inhibitor aliskiren, the angiotensin receptor blocker losartan, or both on left ventricular mass in patients with hypertension and left ventricular hypertrophy
-
Solomon SD, Appelbaum E, Manning WJ et al.: Effect of the direct renin inhibitor aliskiren, the angiotensin receptor blocker losartan, or both on left ventricular mass in patients with hypertension and left ventricular hypertrophy. Circulation 119, 530-537 (2009).
-
(2009)
Circulation
, vol.119
, pp. 530-537
-
-
Solomon, S.D.1
Appelbaum, E.2
Manning, W.J.3
-
41
-
-
33947543780
-
Pharmacokinetics, safety, and tolerability of the novel oral direct renin inhibitor aliskiren in elderly healthy subjects
-
Vaidyanathan S, Reynolds C, Yeh CM et al.: Pharmacokinetics, safety, and tolerability of the novel oral direct renin inhibitor aliskiren in elderly healthy subjects. J. Clin. Pharmacol. 47, 453-460 (2007).
-
(2007)
J. Clin. Pharmacol
, vol.47
, pp. 453-460
-
-
Vaidyanathan, S.1
Reynolds, C.2
Yeh, C.M.3
-
42
-
-
36949012071
-
Safety and efficacy of the oral direct renin inhibitor aliskiren in elderly patients with hypertension
-
Verdecchia P, Calvo C, Mockel V, Keeling L, Satlin A: Safety and efficacy of the oral direct renin inhibitor aliskiren in elderly patients with hypertension. Blood Press. 16, 381-391 (2007).
-
(2007)
Blood Press
, vol.16
, pp. 381-391
-
-
Verdecchia, P.1
Calvo, C.2
Mockel, V.3
Keeling, L.4
Satlin, A.5
-
43
-
-
70249112451
-
-
New Orleans, LA, USA, 8-12 November
-
Duprez D, Davis P, Botha J: The AGELESS Study: the effect of aliskiren vs ramipril alone or in combination with hydrochlorothiazide and amlodipine in patients greater than 65 years of age with systolic hypertension (late breaker presentation). Presented at: The American Heart Association Scientific Sessions 2008. New Orleans, LA, USA, 8-12 November 2008.
-
(2008)
The AGELESS Study: The effect of aliskiren vs ramipril alone or in combination with hydrochlorothiazide and amlodipine in patients greater than 65 years of age with systolic hypertension (late breaker presentation). Presented at: The American Heart Association Scientific Sessions
-
-
Duprez, D.1
Davis, P.2
Botha, J.3
-
44
-
-
4744348177
-
Effect of the oral renin inhibitor aliskiren on the pharmacokinetics and pharmacodynamics of a single dose of warfarin in healthy subjects
-
Dieterle W, Corynen S, Mann J: Effect of the oral renin inhibitor aliskiren on the pharmacokinetics and pharmacodynamics of a single dose of warfarin in healthy subjects. Br. J. Clin. Pharmacol. 58, 433-436 (2004).
-
(2004)
Br. J. Clin. Pharmacol
, vol.58
, pp. 433-436
-
-
Dieterle, W.1
Corynen, S.2
Mann, J.3
-
45
-
-
33749853955
-
Lack of pharmacokinetic interactions of aliskiren, a novel direct renin inhibitor for the treatment of hypertension, with the antihypertensives amlodipine, valsartan, hydrochlorothiazide (HCTZ) and ramipril in healthy volunteers
-
Vaidyanathan S, Valencia J, Kemp C et al.: Lack of pharmacokinetic interactions of aliskiren, a novel direct renin inhibitor for the treatment of hypertension, with the antihypertensives amlodipine, valsartan, hydrochlorothiazide (HCTZ) and ramipril in healthy volunteers. Int. J. Clin. Pract. 60, 1343-1356 (2006).
-
(2006)
Int. J. Clin. Pract
, vol.60
, pp. 1343-1356
-
-
Vaidyanathan, S.1
Valencia, J.2
Kemp, C.3
-
46
-
-
54049086657
-
Pharmacokinetics of the oral direct renin inhibitor aliskiren in combination with digoxin, atorvastatin, and ketoconazole in healthy subjects: The role of P-glycoprotein in the disposition of aliskiren
-
Vaidyanathan S, Camenisch G, Schuetz H et al.: Pharmacokinetics of the oral direct renin inhibitor aliskiren in combination with digoxin, atorvastatin, and ketoconazole in healthy subjects: the role of P-glycoprotein in the disposition of aliskiren. J. Clin. Pharmacol. 48, 1323-1338 (2008).
-
(2008)
J. Clin. Pharmacol
, vol.48
, pp. 1323-1338
-
-
Vaidyanathan, S.1
Camenisch, G.2
Schuetz, H.3
-
47
-
-
47049093197
-
Renal and hormonal responses to direct renin inhibition with aliskiren in healthy humans
-
Fisher ND, Jan Danser AH, Nussberger J, Dole WP, Hollenberg NK: Renal and hormonal responses to direct renin inhibition with aliskiren in healthy humans. Circulation 117, 3199-3205 (2008).
-
(2008)
Circulation
, vol.117
, pp. 3199-3205
-
-
Fisher, N.D.1
Jan Danser, A.H.2
Nussberger, J.3
Dole, W.P.4
Hollenberg, N.K.5
-
48
-
-
0036266596
-
Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin
-
Nguyen G, Delarue F, Burckle C, Bouzhir L, Giller T, Sraer JD: Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J. Clin. Invest. 109, 1417-1427 (2002).
-
(2002)
J. Clin. Invest
, vol.109
, pp. 1417-1427
-
-
Nguyen, G.1
Delarue, F.2
Burckle, C.3
Bouzhir, L.4
Giller, T.5
Sraer, J.D.6
-
49
-
-
57449100853
-
Aliskiren accumulates in renin secretory granules and binds plasma prorenin
-
Krop M, Garrelds IM, de Bruin RJ et al.: Aliskiren accumulates in renin secretory granules and binds plasma prorenin. Hypertension 52, 1076-1083 (2008).
-
(2008)
Hypertension
, vol.52
, pp. 1076-1083
-
-
Krop, M.1
Garrelds, I.M.2
de Bruin, R.J.3
-
50
-
-
33845254840
-
Prorenin and angiotensin-dependent renal vasoconstriction in Type 1 and Type 2 diabetes
-
Stankovic AR, Fisher ND, Hollenberg NK: Prorenin and angiotensin-dependent renal vasoconstriction in Type 1 and Type 2 diabetes. J. Am. Soc. Nephrol. 17, 3293-3299 (2006).
-
(2006)
J. Am. Soc. Nephrol
, vol.17
, pp. 3293-3299
-
-
Stankovic, A.R.1
Fisher, N.D.2
Hollenberg, N.K.3
-
51
-
-
67650348428
-
The AGELESS Study: The effect of aliskiren vs ramipril alone or in combination with hydrochlorothiazide and amlodipine in patients greater than 65 years of age with systolic hypertension (late breaker presentation)
-
Duprez D, Davis P, Botha J: The AGELESS Study: the effect of aliskiren vs ramipril alone or in combination with hydrochlorothiazide and amlodipine in patients greater than 65 years of age with systolic hypertension (late breaker presentation). Circulation 118, S886-S887 (2008).
-
(2008)
Circulation
, vol.118
-
-
Duprez, D.1
Davis, P.2
Botha, J.3
-
52
-
-
65249182083
-
Aliskiren Trial in Type 2 Diabetes Using Cardio-Renal Endpoints (ALTITUDE): Rationale and study design
-
Parving HH, Brenner BM, McMurray JJ et al.: Aliskiren Trial in Type 2 Diabetes Using Cardio-Renal Endpoints (ALTITUDE): rationale and study design. Nephrol. Dial. Transplant. 24(5), 1663-1671 (2009).
-
(2009)
Nephrol. Dial. Transplant
, vol.24
, Issue.5
, pp. 1663-1671
-
-
Parving, H.H.1
Brenner, B.M.2
McMurray, J.J.3
|