DNA spike studies for demonstrating improved clearance on chromatographic media

Journal of Chromatography A

Volumn 1216, Issue 41, 2009, Pages 6938-6945

  Butler, Michelle D ^a   Kluck, Brian ^a   Bentley, Tracy ^a  

^a GENENTECH INC   (United States)

Author keywords

Anion exchange chromatography; Antibody fragment; Hydrophobic interaction chromatography; Monoclonal antibody; Polymerase chain reaction

Indexed keywords

ANION EXCHANGE; ANION EXCHANGE CHROMATOGRAPHY; ANION EXCHANGE COLUMNS; ANTIBODY FRAGMENT; BIOPHARMACEUTICAL PRODUCTS; CHINESE HAMSTER OVARY CELLS; CHROMATOGRAPHIC MEDIA; DNA CLEARANCE; E. COLI; HIGH CAPACITY; HUMAN THERAPEUTICS; HYDROPHOBIC INTERACTION CHROMATOGRAPHY; HYDROPHOBIC INTERACTIONS; INDUSTRIAL SCALE; LOG REDUCTION VALUES; LOG REDUCTIONS; PCR ASSAY; POLYMERASE CHAIN REACTION; PROCESS LEVELS; PRODUCTION PROCESS; REGULATORY STANDARDS;

CHROMATOGRAPHIC ANALYSIS; DNA; ESCHERICHIA COLI; GENES; HYDROPHOBICITY; IONS; MONOCLONAL ANTIBODIES; NUCLEIC ACIDS; POLYMERIZATION; SURFACE PLASMON RESONANCE;

HYDROPHOBIC CHROMATOGRAPHY;

MONOCLONAL ANTIBODY;

ANIMAL CELL; ANION EXCHANGE; ARTICLE; CHO CELL; CHROMATOGRAPHY; CONTROLLED STUDY; DNA DETERMINATION; DNA PURIFICATION; ESCHERICHIA COLI; FEMALE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY;

ANTIBODIES, MONOCLONAL; CHROMATOGRAPHY, AFFINITY; CHROMATOGRAPHY, LIQUID; CULTURE MEDIA, CONDITIONED; DNA; IMMUNOGLOBULIN FRAGMENTS; ION EXCHANGE RESINS; STAPHYLOCOCCAL PROTEIN A; TECHNOLOGY, PHARMACEUTICAL; ULTRAFILTRATION;

CRICETULUS GRISEUS; ESCHERICHIA COLI;

EID: 70249103093     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2009.08.049     Document Type: Article

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