Factors influencing histological response after neoadjuvant chemoradiation therapy for rectal carcinoma

Pathology Research and Practice

Volumn 205, Issue 10, 2009, Pages 695-699

  Moral, María ^a   Fdez Aceñero, Ma Jesús ^b   Cuberes, Rosa ^a   Suárez, Angel ^c  

^a HOSPITAL DE MÓSTOLES   (Spain)

^b Fundación Jiménez Díaz   (Spain)

^c Hospital UniversitarioFundación Jiménez Díaz   (Spain)

Author keywords

Chemoradiation therapy; Colon carcinoma; Histological response

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; CYCLIN D1; FLUOROURACIL; FOLINIC ACID; KI 67 ANTIGEN; PARAFFIN; PROTEIN BCL 2; PROTEIN P53;

ADJUVANT THERAPY; ADULT; AGE; ARTICLE; CANCER RADIOTHERAPY; CANCER RELAPSE; CANCER STAGING; CANCER SURVIVAL; CARDIOMYOPATHY; CLINICAL ARTICLE; COLON RESECTION; CONTROLLED STUDY; EMBEDDING; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; PREDICTION; PREOPERATIVE EVALUATION; PREOPERATIVE RADIOTHERAPY; RECTUM CARCINOMA; TENESMUS; TREATMENT OUTCOME;

AGE FACTORS; ANTINEOPLASTIC AGENTS; CARCINOEMBRYONIC ANTIGEN; COMBINED MODALITY THERAPY; CYCLIN D1; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NEOADJUVANT THERAPY; NEOPLASM STAGING; PROTO-ONCOGENE PROTEINS C-BCL-2; RADIOTHERAPY; RECTAL NEOPLASMS; RISK FACTORS; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN-PROTEIN LIGASES;

EID: 70249091436     PISSN: 03440338     EISSN: 16180631     Source Type: Journal    
DOI: 10.1016/j.prp.2009.04.006     Document Type: Article

References (13)

1. O'Neil B.H., and Tepper J.E. Current options for the management of rectal cancer. Curr. Treat Options Oncol. 8 (2007) 331-338
2. Borschitz T., Wachtlin D., Möhler M., Schmidberger H., and Junginger T. Neoadjuvant chemoradiation and local excision for T2-3 rectal cancer. Annu. Surg. Oncol. 15 (2008) 712-720
3. Chang F., Deere H., Mahadeva U., and George S. Histopathologic examination and reporting of esophageal carcinomas following preoperative neoadjuvant therapy: practical guidelines and current issues. Am. J. Clin. Pathol. 129 (2008) 252-262
4. Galindo Gallego M., Fernández Aceñero M.J., Sanz Ortega J., Aljama A., and Balibrea Cantero J.L. Prognostic influence of p53 nuclear expression in colorectal carcinoma. Dis. Colon Rectum 43 (2000) 971-975
5. Sanghera P., Wong D.W., McConkey C.C., Geh J.I., and Hartley A. Chemoradiotherapy for rectal cancer: an updated analysis of factors affecting pathological response. Clin. Oncol. (R. Coll. Radiol.) 20 (2008) 176-183
6. Das P., Skibber J.M., Rodriguez-Bigas M.A., Feig B.W., Chang G.J., Wolff R.A., Eng C., Krishnan S., Janjan N.A., and Crane C.H. Predictors of tumor response and downstaging in patients who receive preoperative chemoradiation for rectal cancer. Cancer 109 (2007) 1750-1755
7. Fdez-Aceñero M.J., Galindo Gallego M., Sanz Ortega J., and Aljama A. Prognostic influence of tumour associated eosinophilic infiltrate in colorectal cancer. Cancer 88 (2000) 1544-1548
8. Perez R.O., Habr-Gama A., dos Santos R.M., Proscurshim I., Campos F.G., Rawet V., Kiss D., and Cecconello I. Peritumoral inflammatory infiltrate is not a prognostic factor in distal rectal cancer following neoadjuvant chemoradiation therapy. J. Gastrointest Surg. 11 (2007) 1534-1540
9. Jakob C., Liersch T., Meyer W., Becker H., Baretton G.B., and Aust D.E. Predictive value of Ki67 and p53 in locally advanced rectal cancer: correlation with thymidylate synthase and histopathological tumor regression after neoadjuvant 5-FU-based chemoradiotherapy. World J. Gastroenterol. 14 (2008) 1060-1066
10. Ho-Pun-Cheung A., Assenat E., Thezenas S., Bibeau F., Rouanet P., Azria D., Cellier D., Grenier J., Ychou M., Senesse P., and Lopez-Crapez E. Cyclin D1 gene G870A polymorphism predicts response to neoadjuvant radiotherapy and prognosis in rectal cancer. Int. J. Radiat. Oncol. Biol. Phys. 68 (2007) 1094-1101
11. Zlobec I., Vuong T., Compton C.C., Lugli A., Michel R.P., Hayashi S., and Jass J.R. Combined analysis of VEGF and EGFR predicts complete tumour response in rectal cancer treated with preoperative radiotherapy. Br. J. Cancer 98 (2008) 450-456
12. Rosenberg R., Nekarda H., Zimmermann F., Becker K., Lordick F., Hofler H., Molls M., and Siewert J.R. Histopathological response after preoperative radiochemotherapy in rectal carcinoma is associated with improved overall survival. J. Surg. Oncol. 97 (2008) 8-13
13. Rödel C., Martus P., Papadoupolos T., Füzesi L., Klimpfinger M., Fietkau R., Liersch T., Hohenberger W., Raab R., Sauer R., and Wittekind C. Prognostic significance of tumor regression after preoperative chemoradiotherapy for rectal cancer. J. Clin. Oncol. 23 (2005) 8688-8696