Negation of the cancer-preventive actions of selenium by over-expression of protein kinase Cε and selenoprotein thioredoxin reductase

Carcinogenesis

Volumn 30, Issue 9, 2009, Pages 1553-1561

  Gundimeda, Usha ^a   Schiffman, Jason Eric ^a   Gottlieb, Simcha Neeli ^a   Roth, Brandon Ian ^a   Gopalakrishna, Rayudu ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AURANOFIN; METHYLSELENINIC ACID; PROTEIN KINASE C EPSILON; SELENIUM; THIOREDOXIN REDUCTASE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; BISINDOLYLMALEIMIDE; INDOLE DERIVATIVE; MALEIMIDE DERIVATIVE; METHYLNITROSOUREA; METHYLSELENIC ACID; ORGANOSELENIUM DERIVATIVE; PRKCE PROTEIN, HUMAN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CANCER INVASION; CANCER RESISTANCE; CONTROLLED STUDY; DRUG SENSITIVITY; ENZYME ACTIVITY; ENZYME INHIBITION; EPITHELIUM CELL; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; MALE; PATHOLOGY; PHYSIOLOGY; PROSTATE TUMOR; TUMOR CELL LINE;

ANTICARCINOGENIC AGENTS; CELL LINE, TUMOR; HUMANS; INDOLES; MALE; MALEIMIDES; METHYLNITROSOUREA; NEOPLASM INVASIVENESS; ORGANOSELENIUM COMPOUNDS; PROSTATIC NEOPLASMS; PROTEIN KINASE C-EPSILON; THIOREDOXIN-DISULFIDE REDUCTASE;

EID: 70249090797     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgp164     Document Type: Article

References (50)

1. Landis,S.H. et al. (1999) Cancer statistics, 1999. CA Cancer J. Clin., 49, 8-31.
2. Kelloff,G.J. et al. (1999) Chemoprevention of prostate cancer: concepts and strategies. Eur. Urol., 35, 342-350.
3. Helpap,B. et al. (1997) Relationship between atypical adenomatous hyperplasia (AAH), prostatic intraepithelial neoplasia (PIN) and prostatic adenocarcinoma. Pathologica, 89, 288-300.
4. McCormick,D.L. et al. (1999) Chemoprevention of rat prostate carcinogenesis by 9-cis-retinoic acid. Cancer Res., 59, 521-524.
5. Combs,G.F.Jr et al. (1998) Chemopreventive agents: Selenium. Pharmacol. Ther., 79, 179-192.
6. Ip,C. et al. (2002) New concepts in selenium chemoprevention. Cancer Metastasis Rev., 21, 281-289.
7. Lu,J. et al. (2005) Selenium and cancer chemoprevention: hypotheses integrating the actions of selenoproteins and selenium metabolites in epithelial and non-epithelial target cells. Antioxid. Redox Signal., 7, 1715-1727.
8. Clark,L.C. et al. (1996) Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. JAMA, 276, 1957-1963.
9. Lippman,S.M. et al. (2009) Effect of selenium and vitamin E on risk of prostate cancer and other cancers. JAMA, 301, 39-51.
10. Sinha,R. et al. (2001) Methylseleninic acid, a potent growth inhibitor of synchronized mouse mammary epithelial tumor cells in vitro. Biochem. Pharmacol., 61, 311-317.
11. Jiang,C. et al. (2001) Caspases as key executors of methyl selenium-induced apoptosis (anoikis) of DU-145 prostate cancer cells. Cancer Res., 61, 3062-3070.
12. Burk,R.F. (1973) Effect of dietary selenium level on Se binding to rat plasma proteins. Proc. Soc. Exp. Biol. Med., 143, 719-722.
13. Deagen,J.T. et al. (1993) Determination of the distribution of selenium between glutathione peroxidase, selenoprotein P, and albumin in plasma. Anal. Biochem., 208, 176-181.
14. Sharma,S. et al. (1994) Screening of potential chemopreventive agents using biochemical markers of carcinogenesis. Cancer Res., 54, 5848-5855.
15. Gopalakrishna,R. et al. (1997) Selenocompounds induce a redox modulation of protein kinase C in the cell, compartmentally independent from cytosolic glutathione: Its role in inhibition of tumor promotion. Arch. Biochem. Biophys., 348, 37-48.
16. Gopalakrishna,R. et al. (2000) Protein kinase C signaling and oxidative stress. Free Radic. Biol. Med., 28, 1349-1361.
17. Nishizuka,Y. (1992) Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science, 258 607-614.
18. Gopalakrishna,R. et al. (2001) Protein kinase C as a molecular target for cancer prevention by selenocompounds. Nutr. Cancer, 40, 55-63.
19. Gundimeda,U. et al. (2008) Locally generated methylseleninic acid induces specific inactivation of protein kinase C isoenzymes: Relevance to selenium-induced apoptosis in prostate cancer cells. J. Biol. Chem., 283, 34519-34531.
20. Webber,M.M. et al. (2001) Human cell lines as an in vitro/in vivo model for prostate carcinogenesis and progression. Prostate 47, 1-13.
21. Bello,D. et al. (1997) Androgen responsive adult human prostatic epithelial cell lines immortalized by human papillomavirus 18. Carcinogenesis, 18, 1215-1223.
22. Okamoto,M. et al. (1998) Interleukin-6 and epidermal growth factor promote anchorage-independent growth of immortalized human prostatic epithelial cells treated with N-methyl-N-nitrosourea. Prostate, 35, 255-262.
23. Tokar,E.J. et al. (2006) Cholecalciferol (vitamin D3) and the retinoid N-(4-hydroxyphenyl)retinamide (4-HPR) are synergistic for chemoprevention of prostate cancer. J. Exp. Ther. Oncol., 5, 323-333.
24. Gopalakrishna,R. et al. (1992) Rapid filtration assays for protein kinase C activity and phorbol ester binding using multiwell plates with fitted filtration discs. Anal. Biochem., 206, 24-35.
25. Olah,Z. et al. (1994) A cloning and epsilon-epitope-tagging insert for the expression of polymerase chain reaction-generated cDNA fragments in Escherichia coli and mammalian cells. Anal. Biochem., 221 94-102.
26. Holmgren,A. et al. (1995) Thioredoxin and thioredoxin reductase. Methods Enzymol., 252, 199-208.
27. Skehan,P. et al. (1990) New colorimetric cytotoxicity assay for anticancer-drug screening. J. Natl Cancer Inst., 82, 1107-1112.
28. Mosmann,T. (1983) Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunol. Methods, 65, 55-63.
29. Fujii,T. et al. (2000) Involvement of protein kinase C delta (PKCdelta) in phorbol ester-induced apoptosis in LNCaP prostate cancer cells. Lack of proteolytic cleavage of PKCdelta. J. Biol. Chem., 275, 7574-7582.
30. Repesh,L.A. (1989) A new in vitro assay for quantitating tumor cell invasion. Invasion Metastasis, 9, 192-208.
31. Ip,C. et al. (2000) In vitro and in vivo studies of methylseleninic acid: Evidence that a monomethylated selenium metabolite is critical for cancer chemoprevention. Cancer Res., 60, 2882-2886.
32. Li,G.-x et al. (2008) Superior in vivo inhibitory efficacy of methylseleninic acid against human prostate cancer over selenomethionine or selenite. Carcinogenesis, 29, 1005-1012.
33. Sun,S.-Y. et al. (2004) Apoptosis as a novel target for cancer chemoprevention. J. Natl Cancer Inst., 96, 662-672.
34. Gopalakrishna,R. et al. (1995) Modifications of cysteine-rich regions in protein kinase C induced by oxidant tumor promoters and enzyme-specific inhibitors. Methods Enzymol., 252, 132-146.
35. Martiny-Baron,G. et al. (1993) Selective inhibition of protein kinase C isozymes by the indolocarbazole Go 6976. J. Biol. Chem., 268, 9194-9197.
36. Griner,E.M. et al. (2007) Protein kinase C and other diacylglycerol effectors in cancer. Nature Rev. Cancer, 7, 281-294.
37. Gromer,S. et al. (1998) Human placenta thioredoxin reductase. Isolation of the selenoenzyme, steady state kinetics, and inhibition by therapeutic gold compounds. J. Biol. Chem., 273, 20096-20101.
38. Stranges,S. et al. (2007) Effects of long-term selenium supplementation on the incidence of type 2 diabetes: A randomized trial. Ann. Intern. Med., 147, 217-223.
39. Waters,D.J. et al. (2005) Prostate cancer risk and DNA damage: translational significance of selenium supplementation in a canine model. Carcinogenesis, 26, 1256-1262.
40. Nyman,D.W. et al. (2004) Selenium and selenomethionine levels in prostate cancer patients. Cancer Detect. Prev., 28, 8-16.
41. Rebsch,C.M. et al. (2006) Selenoprotein expression is regulated at multiple levels in prostate cells. Cell Res., 16, 940-948.
42. Ghosh,J. (2004) Rapid induction of apoptosis in prostate cancer cells by selenium: Reversal by metabolites of arachidonate 5-lipoxygenase. Biochem. Biophys. Res. Commun., 315, 624-635.
43. Spallholz,J.E. et al. (2001) Dimethyldiselenide and methylseleninic acid generate superoxide in an in vitro chemiluminescence assay in the presence of glutathione: Implications for the anticarcinogenic activity of L-selenomethionine and L-Se-methylselenocysteine. Nutr. Cancer, 40, 34-41.
44. Wycherly,B.J. et al. (2004) High dietary intake of sodium selenite induces oxidative DNA damage in rat liver. Nutr. Cancer, 48, 78-83.
45. Moak,M.A. et al. (2001) Promotion of lipid oxidation by selenate and selenite and indicators of lipid peroxidation in the rat. Biol. Trace Elem. Res., 79, 257-269.
46. Rigas,B. et al. (2008) Induction of oxidative stress as a mechanism of action of chemopreventive agents against cancer. Br. J. Cancer, 98, 1157-1160.
47. Yang,C.S. et al. (2004) Green tea polyphenols: Antioxidative and prooxidative effects. J. Nutr., 134, 3181S.
48. Singh,S.V. et al. (2005) Sulforaphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species. J. Biol. Chem., 280, 19911-19924.
49. Sun,Y. et al. (2008) The thioredoxin system mediates redox-induced cell death in human colon cancer cells: Implications for the mechanism of action of anticancer agents. Cancer Res., 68, 8269-8277.
50. Zhang,J. et al. (2003) Synergy between sulforaphane and selenium in the induction of thioredoxin reductase 1 requires both transcriptional and translational modulation. Carcinogenesis, 24, 497-503.