Liver transplantation, liver resection, and transarterial chemoembolization for hepatocellular carcinoma in cirrhosis: Which is the best oncological approach?

Digestive Diseases and Sciences

Volumn 54, Issue 10, 2009, Pages 2264-2273

  Sotiropoulos, Georgios C ^b   Drühe, Nina ^a   Sgourakis, George ^a   Molmenti, Ernesto P ^a   Beckebaum, Susanne ^a   Baba, Hideo A ^a   Antoch, Gerald ^a   Hilgard, Philip ^a   Radtke, Arnold ^a   Saner, Fuat H ^a   Nadalin, Silvio ^a   Paul, Andreas ^a   Malagó, Massimo ^a   Broelsch, Christoph E ^a   Lang, Hauke ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Cirrhosis; Hepatocellular carcinoma; Liver resection; Liver surgery; Liver transplantation; Patient outcome; Transarterial chemoembolization; Tumor recurrence

Indexed keywords

ANTINEOPLASTIC AGENT;

ADOLESCENT; ADULT; ADVERSE OUTCOME; AGED; ARTICLE; BRAIN DISEASE; CANCER PATIENT; CANCER SURVIVAL; CHEMOEMBOLIZATION; CHEMOTHERAPY INDUCED EMESIS; CONTROLLED STUDY; DISEASE FREE SURVIVAL; DISEASE SEVERITY; DRUG FEVER; FEMALE; HEPATITIS; HUMAN; INTERMETHOD COMPARISON; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER NECROSIS; LIVER RESECTION; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; MONOTHERAPY; OUTCOME ASSESSMENT; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; SCORING SYSTEM; SUPERINFECTION; SURVIVAL TIME; TERTIARY HEALTH CARE; THERAPY EFFECT; TUMOR VOLUME;

ADOLESCENT; ADULT; AGED; CARCINOMA, HEPATOCELLULAR; CHEMOEMBOLIZATION, THERAPEUTIC; COHORT STUDIES; FEMALE; HEPATECTOMY; HEPATIC ARTERY; HUMANS; LIVER CIRRHOSIS; LIVER NEOPLASMS; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; POSTOPERATIVE COMPLICATIONS; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 70149122973     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-008-0604-4     Document Type: Article

References (52)

1. FX Bosch J Ribes M Díaz R Cléries 2004 Primary liver cancer: worldwide incidence and trends Gastroenterology 127 suppl 1(5) S5 S16 10.1053/j.gastro.2004.09.011 (Pubitemid 39423365)
2. S Parikh D Hyman 2007 Hepatocellular cancer: a guide for the internist Am J Med 120 3 194 202 10.1016/j.amjmed.2006.11.020 (Pubitemid 46341174)
3. HB El-Serag 2002 Hepatocellular carcinoma: an epidemiologic view J Clin Gastroenterol 35 suppl 2(5) S72 S78 10.1097/00004836-200211002-00002 (Pubitemid 35278644)
4. D Motola-Kuba D Zamora-Valdés M Uribe N Méndez- Sánchez 2006 Hepatocellular carcinoma. An overview Ann Hepatol 5 1 16 24
5. GC Sotiropoulos M Malago E Momenti A Paul S Nadalin E Brokalaki 2005 Liver transplantation for hepatocellular carcinoma in cirrhosis: is clinical tumor classification before transplantation realistic? Transplantation 79 4 483 487 10.1097/01.TP.0000152801.82734.74 (Pubitemid 40280182)
6. J Bruix M Sherman JM Llovet M Beaugrand R Lencioni AK Burroughs 2001 Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona EASL conference. European Association for the study of the liver J Hepatol 35 3 421 430 10.1016/S0168-8278(01)00130-1 (Pubitemid 32844200)
7. JM Llovet J Fuster J Bruix Barcelona-Clínic Liver Cancer Group 2004 The Barcelona approach: diagnosis, staging, and treatment of hepatocellular carcinoma Liver Transpl 10 suppl 1(2) S115 S120 10.1002/lt.20034
8. Y Fong RL Sun W Jarnagin LH Blumgart 1999 An analysis of 412 cases of hepatocellular carcinoma at a western center Ann Surg 229 6 790 799 10.1097/00000658-199906000-00005 (Pubitemid 30191728)
9. H Bismuth L Chiche R Adam D Castaing T Diamond A Dennison 1993 Liver resection versus transplantation for hepatocellular carcinoma in cirrhotic patients Ann Surg 218 2 145 151 10.1097/00000658-199308000-00005 (Pubitemid 23229140)
10. J Michel B Suc F Montpeyroux S Hachemanne P Blanc J Domergue, et al. 1997 Liver resection or transplantation for hepatocellular carcinoma? Retrospective analysis of 215 patients with cirrhosis J Hepatol 26 6 1274 1280 10.1016/S0168-8278(97)80462-X (Pubitemid 27346640)
11. G Otto U Heuschen WJ Hofmann G Krumm U Hinz C Herfarth 1998 Survival and recurrence after liver transplantation versus liver resection for hepatocellular carcinoma: a retrospective analysis Ann Surg 227 3 424 432 10.1097/00000658- 199803000-00015 (Pubitemid 28131024)
12. YH Huang JC Wu GY Chau WY Lui KL King JH Chiang, et al. 1999 Supportive treatment, resection and transcatheter arterial chemoembolization in resectable hepatocellular carcinoma: an analysis of survival in 419 patients Eur J Gastroenterol Hepatol 11 3 315 321 10.1097/00042737-199903000-00017
13. J Figueras E Jaurrieta C Valls E Ramos T Serrano A Rafecas, et al. 2000 Resection or transplantation for hepatocellular carcinoma in cirrhotic patients: outcomes based on indicated treatment strategy J Am Coll Surg 190 5 580 587 10.1016/S1072-7515(00)00251-9
14. HS Lee KM Kim JH Yoon TR Lee KS Suh KU Lee, et al. 2002 Therapeutic efficacy of transcatheter arterial chemoembolization as compared with hepatic resection in hepatocellular carcinoma patients with compensated liver function in a hepatitis B virus-endemic area: a prospective cohort study J Clin Oncol 20 22 4459 4465 10.1200/JCO.2002.02.013 (Pubitemid 35334758)
15. JM Bigourdan D Jaeck N Meyer C Meyer E Oussoultzoglou P Bachellier, et al. 2003 Small hepatocellular carcinoma in child A cirrhotic patients: hepatic resection versus transplantation Liver Transpl 9 5 513 520 10.1053/jlts.2003. 50070 (Pubitemid 36621722)
16. ZY Tang XD Zhou ZC Ma ZQ Wu J Fan LX Qin, et al. 2004 Downstaging followed by resection plays a role in improving prognosis of unresectable hepatocellular carcinoma Hepatobiliary Pancreat Dis Int 3 4 495 498
17. FY Yao M Kinkhabwala JM LaBerge NM Bass R Brown Jr R Kerlan 2005 The impact of pre-operative loco-regional therapy on outcome after liver transplantation for hepatocellular carcinoma Am J Transplant 5 4 Pt1 795 804 10.1111/j.1600-6143.2005.00750.x (Pubitemid 40461290)
18. GC Sotiropoulos M Malago E Molmenti A Paul S Nadalin EI Brokalaki, et al. 2005 Efficacy of transarterial chemoembolization prior to liver transplantation for hepatocellular carcinoma as found in pathology Hepatogastroenterology 52 62 329 332
19. PE Majno FP Sarasin G Mentha A Hadengue 2000 Primary liver resection and salvage transplantation or primary liver transplantation in patients with single, small hepatocellular carcinoma and preserved liver function: an outcome-oriented decision analysis Hepatology 31 4 899 906 10.1053/he.2000.5763
20. R Adam D Azoulay D Castaing R Eshkenazy G Pascal K Hashizume, et al. 2003 Liver resection as a bridge to transplantation for hepatocellular carcinoma on cirrhosis: a reasonable strategy? Ann Surg 238 4 508 518
21. J Belghiti A Cortes EK Abdalla JM Régimbeau K Prakash F Durand, et al. 2003 Resection prior to liver transplantation for hepatocellular carcinoma Ann Surg 238 6 885 892 10.1097/01.sla.0000098621.74851.65
22. S Takano Y Watanabe H Ohishi S Kono M Nakamura N Kubota, et al. 2000 Multimodality treatment for patients with hepatocellular carcinoma: a single institution retrospective series Eur J Surg Oncol 26 1 67 72 10.1053/ejso.1999.0743 (Pubitemid 30102826)
23. KK Christians HA Pitt WS Rilling J Franco FA Quiroz MB Adams, et al. 2001 Hepatocellular carcinoma: multimodality management Surgery 130 4 554 559 10.1067/msy.2001.117106 (Pubitemid 32964598)
24. H Medina-Franco MT Sellers DE Eckhoff JS Bynon MM Urist MJ Heslin 2001 Multimodality treatment for patients with hepatocellular carcinoma: analysis of prognostic factors in a single Western institution series J Gastrointest Surg 5 6 638 645 10.1016/S1091-255X(01)80107-4 (Pubitemid 33651271)
25. GC Sotiropoulos H Lang A Frilling EP Molmenti A Paul S Nadalin, et al. 2006 Resectability of hepatocellular carcinoma: evaluation of 333 consecutive cases at a single hepatobiliary specialty center and systematic review of the literature Hepatogastroenterology 53 69 322 329
26. S Dharancy J Boitard T Decaens G Sergent E Boleslawski C Duvoux, et al. 2007 Comparison of two techniques of transarterial chemoembolization before liver transplantation for hepatocellular carcinoma: a case-control study Liver Transpl 13 5 665 671 10.1002/lt.21109 (Pubitemid 46796537)
27. MF Yuen AO Chan BC Wong CK Hui GC Ooi WK Tso, et al. 2003 Transarterial chemoembolization for inoperable, early stage hepatocellular carcinoma in patients with Child-Pugh grade A and B: results of a comparative study in 96 Chinese patients Am J Gastroenterol 98 5 1181 1185
28. V Mazzaferro E Regalia R Doci S Andreola A Pulvirenti F Bozzetti, et al. 1996 Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis N Engl J Med 334 11 693 699 10.1056/ NEJM199603143341104 (Pubitemid 26079803)
29. M Malago GC Sotiropoulos S Nadalin C Valentin-Gamazo A Paul H Lang, et al. 2006 Living donor liver transplantation for hepatocellular carcinoma: a single-center preliminary report Liver Transpl 12 6 934 940 10.1002/lt.20677 (Pubitemid 43960369)
30. L De Carlis A Giacomoni A Lauterio A Slim C Sammartino V Pirotta, et al. 2003 Liver transplantation for hepatocellular cancer: should the current indication criteria be changed? Transpl Int 16 2 115 122 10.1111/j.1432-2277. 2003.tb00272.x (Pubitemid 36682207)
31. CE Broelsch A Frilling M Malago 2005 Should we expand the criteria for liver transplantation for hepatocellular carcinoma-yes of course! J Hepatol 43 4 569 573 10.1016/j.jhep.2005.07.016 (Pubitemid 41253221)
32. JR Hiatt IC Carmody RW Busuttil 2005 Should we expand the criteria for hepatocellular carcinoma with living-donor liver transplantation?-no, never J Hepatol 43 4 573 577 10.1016/j.jhep.2005.07.017 (Pubitemid 41253222)
33. FY Yao L Ferrell NM Bass JJ Watson P Bacchetti A Venook, et al. 2001 Liver transplantation for hepatocellular carcinoma: expansion of the tumor size limits does not adversely impact survival Hepatology 33 6 1394 1403 10.1053/jhep.2001.24563 (Pubitemid 32496976)
34. TM Pawlik KA Delman JN Vauthey DM Nagorney IO Ng I Ikai, et al. 2005 Tumor size predicts vascular invasion and histologic grade: Implications for selection of surgical treatment for hepatocellular carcinoma Liver Transpl 11 9 1086 1092 10.1002/lt.20472 (Pubitemid 41341758)
35. Y Sasaki S Imaoka H Nakano O Ishikawa H Ohigashi T Yasuda, et al. 1998 Indications for hepatectomy for hepatocellular carcinoma-what stage of the disease is the best indication for surgery? J Hepatobiliary Pancreat Surg 5 1 14 17 10.1007/PL00009944
36. GC Sotiropoulos H Lang S Nadalin M Neuhäuser EP Molmenti HA Baba, et al. 2007 Liver transplantation for hepatocellular carcinoma: University Hospital Essen experience and metaanalysis of prognostic factors J Am Coll Surg 205 5 661 675 10.1016/j.jamcollsurg.2007.05.023 (Pubitemid 47615488)
37. GC Sotiropoulos M Malagó EP Molmenti C Lösch H Lang A Frilling, et al. 2007 Hilar lymph nodes sampling at the time of liver transplantation for hepatocellular carcinoma: to do or not to do? Meta-analysis to determine the impact of hilar lymph nodes metastases on tumor recurrence and survival in patients with hepatocellular carcinoma undergoing liver transplantation Transpl Int 20 2 141 146 10.1111/j.1432-2277.2006.00412.x (Pubitemid 46121992)
38. EC Lai ST Fan CM Lo KM Chu CL Liu J Wong 1995 Hepatic resection for hepatocellular carcinoma: an audit of 343 patients Ann Surg 221 3 291 298 10.1097/00000658-199503000-00012
39. BH Lang RT Poon ST Fan J Wong 2003 Perioperative and long-term outcome of major hepatic resection for small solitary hepatocellular carcinoma in patients with cirrhosis Arch Surg 138 11 1207 1213 10.1001/archsurg.138.11.1207 (Pubitemid 37392394)
40. K Hanazaki S Kajikawa N Shimozawa M Mihara K Shimada M Hiraguri, et al. 2000 Survival and recurrence after hepatic resection of 386 consecutive patients with hepatocellular carcinoma J Am Coll Surg 191 4 381 388 10.1016/S1072- 7515(00)00700-6 (Pubitemid 30757689)
41. K Takayasu S Arii I Ikai M Omata K Okita T Ichida Liver Cancer Study Group of Japan 2006 Prospective cohort study of transarterial chemoembolization for unresectable hepatocellular carcinoma in 8510 patients Gastroenterology 131 2 461 469 10.1053/j.gastro.2006.05.021 (Pubitemid 44142456)
42. M Biselli P Andreone A Gramenzi F Trevisani C Cursaro C Rossi, et al. 2005 Transcatheter arterial chemoembolization therapy for patients with hepatocellular carcinoma: a case-controlled study Clin Gastroenterol Hepatol 3 9 918 925 10.1016/S1542-3565(05)00425-8 (Pubitemid 41219296)
43. M Molinari JR Kachura E Dixon DK Rajan EB Hayeems MR Asch, et al. 2006 Transarterial chemoembolisation for advanced hepatocellular carcinoma: results from a North American cancer centre Clin Oncol 18 9 684 692 10.1016/j.clon.2006. 07.012 (Pubitemid 44464049)
44. AW Hemming MS Cattral AI Reed WJ Van Der Werf PD Greig RJ Howard 2001 Liver transplantation for hepatocellular carcinoma Ann Surg 233 5 652 659 10.1097/00000658-200105000-00009 (Pubitemid 32378649)
45. EP Molmenti GB Klintmalm 2002 Liver transplantation in association with hepatocellular carcinoma: an update of the International Tumor Registry Liver Transpl 8 9 736 748 10.1053/jlts.2002.34879 (Pubitemid 35012281)
46. L De Carlis A Giacomoni V Pirotta A Lauterio AO Slim C Sammartino, et al. 2003 Surgical treatment of hepatocellular cancer in the era of hepatic transplantation J Am Coll Surg 196 6 887 897 10.1016/S1072-7515(03)00140-6 (Pubitemid 36676550)
47. JY Leung AX Zhu FD Gordon DS Pratt A Mithoefer K Garrigan, et al. 2004 Liver transplantation outcomes for early-stage hepatocellular carcinoma: results of a multicenter study Liver Transpl 10 11 1343 1354 10.1002/lt.20311 (Pubitemid 39530049)
48. M Salizzoni F Zamboni F Lupo A Franchello E David M Rizzetto 2001 Liver transplantation for early-detected, multifocal hepatocellular carcinoma Br J Surg 88 9 1194 1195 10.1046/j.0007-1323.2001.01844.x (Pubitemid 34015602)
49. LL Wong N Tsai W Limm L Wong 2004 Liver transplant for hepatocellular cancer: a treatment for the select few Clin Transplant 18 2 205 210 10.1046/j.1399-0012.2003.00157.x (Pubitemid 38404653)
50. H Lang GC Sotiropoulos EI Brokalaki KJ Schmitz C Bertona G Meyer, et al. 2007 Survival and recurrence rates after resection for hepatocellular carcinoma in noncirrhotic livers J Am Coll Surg 205 1 27 36 10.1016/j.jamcollsurg.2007.03. 002 (Pubitemid 47016970)
51. C Laurent JF Blanc S Nobili A Sa Cunha B le Bail P Bioulac-Sage, et al. 2005 Prognostic factors and longterm survival after hepatic resection for hepatocellular carcinoma originating from noncirrhotic liver J Am Coll Surg 201 5 656 662 10.1016/j.jamcollsurg.2005.05.027 (Pubitemid 41539756)
52. E Dupont-Bierre P Compagnon JL Raoul G Fayet AS de Lajarte-Thirouard K Boudjema 2005 Resection of hepatocellular carcinoma in noncirrhotic liver: analysis of risk factors for survival J Am Coll Surg 201 5 663 670 10.1016/j.jamcollsurg.2005.06.265 (Pubitemid 41539757)