Airway surface liquid contains endogenous DNase activity which can be activated by exogenous magnesium

European Journal of Medical Research

Volumn 14, Issue 7, 2009, Pages 304-308

  Rosenecker, Joseph ^a   Naundorf, S ^a   Rudolph, C ^a,b  

^a UNIVERSITY OF MUNICH   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYRIBONUCLEASE; MAGNESIUM; DNA;

AIRWAY; ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; DRUG MECHANISM; ENZYME ACTIVITY; EXPIRED AIR; HUMAN; LUNG LAVAGE; MUCUS; ADULT; AGAR GEL ELECTROPHORESIS; CHEMISTRY; DRUG EFFECT; ENZYME ACTIVATION; ENZYMOLOGY; EXHALATION; GENETICS; METABOLISM; PLASMID; RESPIRATORY TRACT MUCOSA;

ADULT; BRONCHOALVEOLAR LAVAGE FLUID; CYSTIC FIBROSIS; DEOXYRIBONUCLEASES; DNA; ELECTROPHORESIS, AGAR GEL; ENZYME ACTIVATION; EXHALATION; HUMANS; MAGNESIUM; PLASMIDS; RESPIRATORY MUCOSA;

EID: 70149122456     PISSN: 09492321     EISSN: None     Source Type: Journal    
DOI: 10.1186/2047-783x-14-7-304     Document Type: Article

References (10)

1. Cystic Fibrosis Foundation. Patient registry 2001 Annual report. Bethesda, MD; 2002.
2. Riordan JR: The cystic fibrosis transmembrane conductance regulator. Annu Rev Physiol 1993; 55:609-630
3. Schwiebert EM, Egan ME, Hwang TH, Fulmer SB, Allen SS, Cutting GR, Guggino WB: CFTR regulates outwardly rectifying chloride channels through an autocrine mechanism involving ATP. Cell 1995; 81:1063-1073
4. Konstan MW, Berger M: Infection and inflammation of the lung in cystic fibrosis. In: Cystic fibrosis. Edited by Davis P. New York: Marcel Dekker; 1993; 219-276
5. Fuchs HJ, Borowitz DS, Christiansen DH, Morris EM, Nash ML, Ramsey BW, Rosenstein BJ, Smith AL, Wohl ME: Effect of aerosolized recombinant human DNase on exacerbations of respiratory symptoms and on pulmonary function in patients with cystic fibrosis. The Pulmozyme Study Group. N Engl J Med 1994; 331:637-642
6. Jones AP, Wallis CE: Recombinant human deoxyribonuclease for cystic fibrosis. Cochrane Database Syst Rev 2003, (3):CD001127.
7. Sanders NN, Franckx H, De Boeck K, Haustraete J, De Smedt SC, Demeester J: Role of magnesium in the failure of rhDNase therapy in patients with cystic fibrosis. Thorax 2006; 61:962-968 (Pubitemid 44787166)
8. Hughes R, Goldkorn A, Masoli M, Weatherall M, Burgess C, Beasley R: Use of isotonic nebulised magnesium sulphate as an adjuvant to salbutamol in treatment of severe asthma in adults: randomised placebo-controlled trial. Lancet 2003; 361:2114-2117 (Pubitemid 36782255)
9. Sheng S, Perry CJ, Kleyman TR: External nickel inhibits epithelial sodium channel by binding to histidine residues within the extracellular domains of alpha and gamma subunits and reducing channel open probability.J Biol Chem 2002; 277:50098-50111
10. Akbar A, Rees JH, Nyamugunduru G, English MW, Spencer DA, Weller PH: Aminoglycoside-associated hypomagnesaemia in children with cystic fibrosis. Acta Paediatr 1999; 88:783-785 (Pubitemid 29350152)