Reversed-phase liquid chromatographic determination of enantiomers of atenolol in rat plasma using derivation with Marfey's reagent

Biomedical Chromatography

Volumn 23, Issue 7, 2009, Pages 787-791

  Bhushan, Ravi ^a   Tanwar, Shivani ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY ROORKEE   (India)

Author keywords

(R,S) atenolol; Diastereomers; Marfey's reagent; Rat plasma; RP HPLC

Indexed keywords

AMINO ACIDS; BODY FLUIDS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; RATS;

(R,S)-ATENOLOL; ATENOLOL; CHROMATOGRAPHIC DETERMINATION; DIASTEREOMERS; LIMIT OF QUANTIFICATIONS; MARFEY REAGENT; PHASE LIQUIDS; RAT PLASMA; REVERSED PHASE; RP-HPLC;

ENANTIOMERS;

1 FLUORO 2,4 DINITROPHENYL 5 LEVO ALANINE AMIDE; ATENOLOL; REAGENT; UNCLASSIFIED DRUG; ALANINE; DRUG DERIVATIVE; MARFEY'S REAGENT; NITROBENZENE DERIVATIVE;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; CHIRALITY; DERIVATIZATION; DIASTEREOISOMER; DRUG DETERMINATION; DRUG STABILITY; ENANTIOMER; LINEAR SYSTEM; MALE; NONHUMAN; RAT; REVERSED PHASE LIQUID CHROMATOGRAPHY; ANIMAL; CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METHODOLOGY; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; STATISTICAL MODEL; STEREOISOMERISM; WISTAR RAT;

RATTUS;

ALANINE; ANIMALS; ATENOLOL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DINITROBENZENES; DRUG STABILITY; LINEAR MODELS; MALE; RATS; RATS, WISTAR; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; STEREOISOMERISM;

EID: 70149120119     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1187     Document Type: Article

References (20)

1. Agbaba D, Ivković B In Thin Layer Chromatography in Chiral Separations and Analysis, Kowalska T, Sherma J (eds.) Taylor & Francis: New York, 2007; 283-304.
2. Bhushan R and Arora M. Direct enantiomeric resolution of (±)-atenolol, (±)- metoprolol and (±)-propranolol by impregnated TLC using L-aspartic acid as chiral selector. Biomedical Chromatography 2003; 17: 226-230.
3. Bhushan R and Brückner H. Marfey's reagent for chiral amino acid analysis: a review. Amino Acids 2004; 27: 231-247.
4. Bhushan R and Gupta D. Ligand-exchange TLC resolution of some racemic β-adrenergic blocking agents. Journal of Planar Chromatography- Modern TLC 2006; 19: 241-245.
5. Bhushan R and Kumar V. Synthesis and application of new chiral variants of Marfey's reagent for liquid chromatographic separation of the enantiomers of α-amino acids. Acta Chromatographica 2008; 20: 329-347.
6. Bhushan R and Tanwar S. Direct TLC resolution of atenolol and propranolol into their enantiomers using three different chiral selectors as impregnating reagents. Biomedical Chromatography 2008; 22: 1028-1034.
7. Bhushan R and Thiongo GT. Direct enantioseparation of some beta-adrenergic blocking agents using impregnated thin-layer chromatography. Journal of Chromatography B, Biomedical Sciences and Applications 1998; 708: 330-334.
8. Bhushan R, Kumar V and Tanwar S. Liquid chromatographic enantioseparation of non-protein α-amino acids after derivatization with Marfey's reagent and its structural variants. Amino Acids 2008; DOI:10.1007/s00726-008-0135-5.
9. B'Hymer C, Montes-Bayon M and Caruso JA. Marfey's reagent: past, present, and future uses of 1-fluoro-2,4-dinitrophenyl-5-L-alanine amide. Journal of Separation Science 2003; 26: 7-19.
10. Boyd RA, Chin SK, Don-Pedro O, Williams RL and Giacomini KM. The pharmacokinetics of the enantiomers of atenolol. Clinical Pharmacology and Therapeutics 1989; 45: 403-410.
11. Brückner H and Keller-Hoehl C. HPLC separation of DL-amino acids derivatized with N2-(5-fluoro-2,4-dinitrophenyl)-L-amino acid amides. Chromatographia 1990; 30: 621-629.
12. Egginger G, Lindner W, Kahr S and Stoschitzky K. Stereoselective HPLC bioanalysis of atenolol enantiomers in plasma: application to a comparative human pharmacokinetic study. Chirality 1993; 5: 505-512.
13. Enquist M and Hermansson J. Separation and quantitation of (R)- and (S)-atenolol in human plasma and urine using an α1-AGP column. Chirality 1989; 1: 209-215.
14. Fornstedt T, Hesselgren A-M and Johansson M. Chiral assay of atenolol present in microdialysis and plasma samples of rats using chiral CBH as stationary phase. Chirality 1997; 9: 329-334.
15. Gilman AG and Goodman LS. In The Pharmacological Basics of Therapeutics, 7th edn. Macmillan: New York, 1985; 202-203.
16. Kofahl B, Henke D and Mutschler E. Direct enantiospecific HPLC bioanalysis of (R,S)-atenolol on a chiral stationary phase. Chirality 1993; 5: 479-482.
17. Marfey P. Determination of D-amino acids. II. Use of a bifunctional reagent, 1,5-difluoro-2,4-dinitrobenzene. Carlsberg Research Communications 1984; 49: 591-596.
18. Mehvar R and Brocks DR. Stereospecific pharmacokinetics and pharmacodynamics of β-adrenergic blockers in humans. Societe canadienne des sciences pharmaceutiques 2001; 4: 185-200.
19. Mehvar R, Gross ME and Kreamer RN. Pharmacokinetics of atenolol enantiomers in humans and rats. Journal of Pharmaceutical Sciences 1990; 79: 881-885.
20. Rosseel MT, Vermeulen AM and Belpaire FM. Reversed-phase high-performance liquid chromatographic analysis of atenolol enantiomers in plasma after chiral derivatization with (+)-1-(9-fluorenyl)ethyl chloroformate. Journal of Chromatography 1991; 568: 239-245.