Efficacy and mechanisms of vacuum-assisted closure (VAC) therapy in promoting wound healing: a rodent model

Journal of Plastic, Reconstructive and Aesthetic Surgery

Volumn 62, Issue 10, 2009, Pages 1331-1338

  Jacobs, Sharone' ^a   Simhaee, David A ^a   Marsano, Anna ^a   Fomovsky, Gregory M ^a   Niedt, George ^a   Wu, June K ^a  

^a Columbia University College of Physicians and Surgeons ^*  (United States)

Author keywords

Angiogenesis; Rat model; VAC device; Wound healing

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; CD31 ANTIGEN; COLLAGEN; DYE; EOSIN; FIBROBLAST GROWTH FACTOR 2; HEMATOXYLIN; POLYURETHAN; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DISEASE MODEL; FOAM; HISTOCHEMISTRY; MALE; NONHUMAN; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RAT; THERAPY EFFECT; TISSUE SECTION; TISSUE STRUCTURE; VACUUM ASSISTED CLOSURE; WESTERN BLOTTING; WOUND DRESSING; WOUND HEALING;

ANIMALS; COLLAGEN; DISEASE MODELS, ANIMAL; FIBROBLAST GROWTH FACTOR 2; GRANULATION TISSUE; MALE; NEGATIVE-PRESSURE WOUND THERAPY; NEOVASCULARIZATION, PHYSIOLOGIC; OCCLUSIVE DRESSINGS; RATS; RATS, INBRED LEW; TIME FACTORS; TREATMENT OUTCOME; VASCULAR ENDOTHELIAL GROWTH FACTOR A; WOUND HEALING;

EID: 70149116628     PISSN: 17486815     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bjps.2008.03.024     Document Type: Article

References (23)

1. Samson D., Lefevre F., and Aronson N. Wound-healing technologies: low-level laser and vacuum-assisted closure. Summary, evidence report/technology assessment: number 111. AHRQ publication number 05-E005-1 (December 2004), Agency for Healthcare Research and Quality, Rockville, MD. http://www.ahrq.gov/clinic/epcsums/woundsum.htm Available from:
2. Valencia I.C., Falabella A., Kirsner R.S., et al. Chronic venous insufficiency and venous leg ulceration. J Am Acad Dermatol 44 (2001) 401-421
3. Stadelmann W.K., Digenis A.D., and Tobin G.R. Physiology and healing dynamics of chronic cutaneous wounds. Am J Surg 176 (1998) 26S-38S
4. Frykberg R.G., Armstrong D.G., Giurini J., et al. Diabetic foot disorders: a clinical practice guideline. American College of Foot and Ankle Surgeons. J Foot Ankle Surg 39 (2000) S1-S60
5. Argenta L.C., and Morykwas M.J. Vacuum-assisted closure: a new method for wound control and treatment. Clinical experience. Ann Plast Surg 38 (1997) 563-576
6. Armstrong D.G., Lavery L.A., Abu-Rumman P., et al. Outcomes of subatmospheric pressure dressing therapy on wounds of the diabetic foot. Ostomy Wound Manage 48 (2002) 64-68
7. McCallon S.K., Knight C.A., Valiulus J.P., et al. Vacuum-assisted closure versus saline-moistened gauze in the healing of postoperative diabetic foot wounds. Ostomy Wound Manage 46 (2000) 28-32
8. Morykwas M.J., Argenta L.C., Shelton-Brown E.I., et al. Vacuum-assisted closure: A new method for wound control and treatment: animal studies and basic foundation. Ann Plast Surg 38 (1997) 553-562
9. Lambert K.V., Hayes P., and McCarthy M. Vacuum assisted closure: a review of development and current applications. Eur J Vasc Endovasc Surg 29 (2005) 219-226
10. Jones S.M., Banwell P.E., and Shakespeare P.G. Advances in wound healing: topical negative pressure therapy. Postgrad Med J 81 (2005) 353-357
11. Saxena V., Hwang C.W., Huang S., et al. Vacuum-assisted closure: microdeformations of wounds and cell proliferation. Plast Reconst Surg 114 (2004) 1086-1096
12. Chen S.Z., Li J., Li X.Y., et al. Effects of vacuum-assisted closure on wound microcirculation: an experimental study. Asian J Surg 28 (2005) 211-217
13. Greene A.K., Puder M., Roy R., et al. Microdeformational wound therapy: effects on angiogenesis and matrix metalloproteinases in chronic wounds of 3 debilitated patients. Ann Plast Surg 56 (2006) 418-422
14. Weidner N. Current pathologic methods for measuring intratumoral microvessel density within breast carcinoma and other solid tumors. Breast Cancer Res Treat 36 (1995) 169-180
15. Goddard J.C., Sutton C.D., Berry D.P., et al. The use of microvessel density in assessing human urological tumours. BJU Int 87 (2001) 866-875
16. Whittaker P., Kloner R.A., Boughner D.R., et al. Quantitative assessment of myocardial collagen with picrosirius red staining and circularly polarized light. Basic Res Cardiol 89 (1994) 397-410
17. Frohlich M.W. Birefringent objects visualized by circular polarization microscopy. Stain Technol 61 (1986) 139-143
18. Moues C.M., Vos M.C., van den Bemd G.J., et al. Bacterial load in relation to vacuum-assisted closure wound therapy: A prospective randomized trial. Wound Repair Regen 12 (2004) 11-17
19. Labler L., Mica L., Harter L., et al. Influence of V.A.C.-therapy on cytokines and growth factors in traumatic wounds. Zentralbl Chir 1 (2006) S62-S67
20. Fabian T.S., Kaufman H.J., Lett E.D., et al. The evaluation of subatmospheric pressure and hyperbaric oxygen in ischemic full-thickness wound healing. Am Surg 66 (2000) 1136-1143
21. Miller Q., Bird E., Bird K., et al. Effect of subatmospheric pressure on the acute healing wound. Curr Surg 61 (2004) 205-208
22. Galiano R., Tepper O., Pelo C., et al. Topical vascular endothelial growth factor accelerates diabetic wound healing through increased angiogenesis and by mobilizing and recruiting bone marrow-derived cells. Am J Pathol 164 (2004) 1935-1947
23. Saaristo A., Tammela T., Farkkila A., et al. Vascular endothelial growth factor-C accelerates diabetic wound healing. Am J Pathol 169 (2006) 1080-1087