Histopathological changes of the heart after neonatal dexamethasone treatment: Studies in 4-, 8-, and 50-week-old rats

Pediatric Research

Volumn 66, Issue 1, 2009, Pages 74-79

  Bal, Miriam P ^a,b,c   De Vries, Willem B ^a   Steendijk, Paul ^b   Der Kraak, Petra Homoet Van ^a   Van Der Leij, Feike R ^c,e   Baan, Jan ^b   Van Oosterhout, Matthijs F M ^a,d   Van Bel, Frank ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF GRONINGEN   (Netherlands)

^d ST ANTONIUS HOSPITAL   (Netherlands)

^e Unit Life Sciences   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CADHERIN; COLLAGEN; DEXAMETHASONE; EOSIN; GLUCOCORTICOID; HEMATOXYLIN; PERIODIC ACID; SODIUM CHLORIDE; AZO COMPOUND; SOLAMINROT 4B;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC LUNG DISEASE; CONTROLLED STUDY; DEATH; FOLLOW UP; HEART DEVELOPMENT; HEART FAILURE; HISTOPATHOLOGY; HYPERTROPHY; MACROPHAGE; MAST CELL; MORPHOMETRICS; NONHUMAN; PERIODIC ACID SCHIFF STAIN; PRIORITY JOURNAL; RAT; TREATMENT DURATION; AGE; ANIMAL; DOSE RESPONSE; DRUG EFFECT; HEART; HEART MUSCLE CELL; METABOLISM; NEWBORN; PATHOLOGY;

AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; AZO COMPOUNDS; COLLAGEN; DEXAMETHASONE; DOSE-RESPONSE RELATIONSHIP, DRUG; EOSINE YELLOWISH-(YS); HEART; HEMATOXYLIN; MYOCYTES, CARDIAC; PERIODIC ACID-SCHIFF REACTION; RATS;

EID: 70149116209     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1203/PDR.0b013e3181a283a0     Document Type: Article

References (39)

1. Kinsella JP, Greenough A, Abman SH 2006 Bronchopulmonary dysplasia. Lancet 367:1421-1431
2. Watterberg KL, Demers LM, Scott SM, Murphy S 1996 Chorioamnionitis and early lung inflammation in infants in whom bronchopulmonary dysplasia develops. Pediatrics 97:210-215
3. Committee on Fetus and Newborn 2002 Postnatal corticosteroids to treat or prevent chronic lung disease in preterm infants. Pediatrics 109:330-338
4. Bakker JM, van Bel F, Heijnen CJ 2001 Neonatal glucocorticoids and the developing brain: short-term treatment with life-long consequences? Trends Neurosci 24:649-653
5. Kamphuis PJ, Gardoni F, Kamal A, Croiset G, Bakker JM, Cattabeni F, Gispen WH, van Bel F, Di Luca M, Wiegant VM 2003 Long-lasting effects of neonatal dexa-methasone treatment on spatial learning and hippocampal synaptic plasticity: involvement of the NMDA receptor complex. FASEB J 17:911-913
6. Murphy BP, Inder TE, Huppi PS, Warfield S, Zientara GP, Kikinis R, Jolesz FA, Volpe JJ 2001 Impaired cerebral cortical gray matter growth after treatment with dexamethasone for neonatal chronic lung disease. Pediatrics 107:217-221
7. Barrington KJ 2001 The adverse neuro-developmental effects of postnatal steroids in the preterm infant: a systematic review of RCTs. BMC Pediatr 1:1
8. Israel BA, Sherman FS, Guthrie RD 1993 Hypertrophic cardiomyopathy associated with dexamethasone therapy for chronic lung disease in preterm infants. Am J Perinatol 10:307-310
9. La Mear NS, MacGilvray SS, Myers TF 1997 Dexamethasone-induced myocardial hypertrophy in neonatal rats. Biol Neonate 72:175-180
10. Werner JC, Sicard RE, Hansen TW, Solomon E, Cowett RM, Oh W 1992 Hyper-trophic cardiomyopathy associated with dexamethasone therapy for bronchopulmo-nary dysplasia. J Pediatr 120:286-291
11. de Vries WB, Bal MP, Homoet-van der Kraak P, Kamphuis PJ, van der Leij FR, Baan J, Steendijk P, de Weger RA, van Bel F, van Oosterhout MF 2006 Suppression of physiological cardiomyocyte proliferation in the rat pup after neonatal glucocor-ticosteroid treatment. Basic Res Cardiol 101:36-42
12. Kamphuis PJ, de Vries WB, Bakker JM, Kavelaars A, van Dijk JE, Schipper ME, van Oosterhout MF, Croiset G, Heijnen CJ, van Bel F, Wiegant VM 2007 Reduced life expectancy in rats after neonatal dexamethasone treatment. Pediatr Res 61:72-76
13. Kamphuis PJ, Bakker JM, Broekhoven MH, Kunne C, Croiset G, Lentjes EG, Tilders FJ, van Bel F, Wiegant VM 2002 Enhanced glucocorticoid feedback inhibition of hypothalamo-pituitary-adrenal responses to stress in adult rats neona-tally treated with dexamethasone. Neuroendocrinology 76:158-169
14. Bal MP, de Vries WB, van der Leij FR, van Oosterhout MF, Berger RM, Baan J, van der Wall EE, van Bel F, Steendijk P 2005 Neonatal glucocorticosteroid treatment causes systolic dysfunction and compensatory dilation in early life: studies in 4-week-old prepubertal rats. Pediatr Res 58:46-52
15. Bal MP, de Vries WB, van Oosterhout MF, Baan J, van der Wall EE, van Bel F, Steendijk P 2008 Long-term cardiovascular effects of neonatal dexamethasone treatment: hemodynamic follow-up by left ventricular pressure-volume loops in rats. J Appl Physiol 104:446-450
16. Bruel A, Nyengaard JR 2005 Design-based stereological estimation of the total number of cardiac myocytes in histological sections. Basic Res Cardiol 100:311-319
17. van Oosterhout MF, Prinzen FW, Arts T, Schreuder JJ, Vanagt WY, Cleutjens JP, Reneman RS 1998 Asynchronous electrical activation induces asymmetrical hypertrophy of the left ventricular wall. Circulation 98:588-595
18. Vliegen HW, van der Laarse A, Huysman JA, Wijnvoord EC, Mentar M, Cornelisse CJ, Eulderink F 1987 Morphometric quantification of myocyte dimensions validated in normal growing rat hearts and applied to hypertrophic human hearts. Cardiovasc Res 21:352-357
19. Gerdes AM, Moore JA, Hines JM, Kirkland PA, Bishop SP 1986 Regional differences in myocyte size in normal rat heart. Anat Rec 215:420-426
20. Natali AJ, Turner DL, Harrison SM, White E 2001 Regional effects of voluntary exercise on cell size and contraction-frequency responses in rat cardiac myocytes. J Exp Biol 204:1191-1199
21. McCrossan ZA, Billeter R, White E 2004 Transmural changes in size, contractile and electrical properties of SHR left ventricular myocytes during compensated hypertrophy. Cardiovasc Res 63:283-292
22. Mayhew TM, Pharaoh A, Austin A, Fagan DG 1997 Stereological estimates of nuclear number in human ventricular cardiomyocytes before and after birth obtained using physical disectors. J Anat 191:107-115
23. Clubb FJ Jr, Bishop SP 1984 Formation of binucleated myocardial cells in the neonatal rat. An index for growth hypertrophy. Lab Invest 50:571-577
24. Loud AV, Anversa P, Giacomelli F, Wiener J 1978 Absolute morphometric study of myocardial hypertrophy in experimental hypertension. I. Determination of myocyte size. Lab Invest 38:586-596
25. Zak R 1974 Development and proliferative capacity of cardiac muscle cells. Circ Res 35:17-26
26. Li F, Wang X, Capasso JM, Gerdes AM 1996 Rapid transition of cardiac myocytes from hyperplasia to hypertrophy during postnatal development. J Mol Cell Cardiol 28:1737-1746
27. Baba HA, Takeda A, Schmid C, Nagano M 1996 Early proliferative changes in hearts of hypertensive Goldblatt rats: an immunohistochemical and flow-cytometrical study. Basic Res Cardiol 91:275-282
28. van Bel F, Dorrepaal CA, Benders MJ, Zeeuwe PE, van de Bor M, Berger HM 1993 Changes in cerebral hemodynamics and oxygenation in the first 24 hours after birth asphyxia. Pediatrics 92:365-372
29. Breall JA, Rudolph AM, Heymann MA 1984 Role of thyroid hormone in postnatal circulatory and metabolic adjustments. J Clin Invest 73:1418-1424
30. Murphy VE, Smith R, Giles WB, Clifton VL 2006 Endocrine regulation of human fetal growth: the role of the mother, placenta, and fetus. Endocr Rev 27:141-169
31. Nadal-Ginard B, Kajstura J, Leri A, Anversa P 2003 Myocyte death, growth, and regeneration in cardiac hypertrophy and failure. Circ Res 92:139-150 (Pubitemid 36254270)
32. Kajstura J, Leri A, Finato N, Di Loreto C, Beltrami CA, Anversa P 1998 Myocyte proliferation in end-stage cardiac failure in humans. Proc Natl Acad Sci USA 95:8801-8805
33. Anversa P, Palackal T, Sonnenblick EH, Olivetti G, Meggs LG, Capasso JM 1990 Myocyte cell loss and myocyte cellular hyperplasia in the hypertrophied aging rat heart. Circ Res 67:871-885
34. Rudolph AM, Roman C, Gournay V 1999 Perinatal myocardial DNA and protein changes in the lamb: effect of cortisol in the fetus. Pediatr Res 46:141-146
35. Devaux B, Scholz D, Hirche A, Klovekorn WP, Schaper J 1997 Upregulation of cell adhesion molecules and the presence of low grade inflammation in human chronic heart failure. Eur Heart J 18:470-479
36. Akgul A, Skrabal CA, Thompson LO, Loebe M, Lafuente JA, Noon GP, Youker KA 2004 Role of mast cells and their mediators in failing myocardium under mechanical ventricular support. J Heart Lung Transplant 23:709-715
37. Azzawi M, Kan SW, Hillier V, Yonan N, Hutchinson IV, Hasleton PS 2005 The distribution of cardiac macrophages in myocardial ischaemia and cardiomyopathy. Histopathology 46:314-319
38. Huttenbach Y, Ostrowski ML, Thaller D, Kim HS 2001 Cell proliferation in the growing human heart: MIB-1 immunostaining in preterm and term infants at autopsy. Cardiovasc Pathol 10:119-123
39. Muangmingsuk S, Ingram P, Gupta MP, Arcilla RA, Gupta M 2000 Dexamethasone induced cardiac hypertrophy in newborn rats is accompanied by changes in myosin heavy chain phenotype and gene transcription. Mol Cell Biochem 209:165-173