A pilot study on hyperinsulinaemic euglycaemic clamp based insulin sensitivity in young adult Indian males with low body mass index

Indian Journal of Medical Research

Volumn 129, Issue 4, 2009, Pages 409-417

  Ramakrishnan, Gajalakshmi ^a   Unni, Uma S ^a   Raj, Tony ^a   Thomas, Tinku ^a   Vaz, Mario ^a   Kurpad, Anura V ^a  

^a ST JOHN'S NATIONAL ACADEMY OF HEALTH SCIENCES   (India)

Author keywords

HOMA; Hyperinsulinaemic euglycaemic clamp; Insulin resistance; Insulin sensitivity; Percentage body fat

Indexed keywords

GLUCOSE; INSULIN;

ADULT; ANTHROPOMETRIC PARAMETERS; ARTICLE; BODY FAT DISTRIBUTION; BODY MASS; CONTROLLED STUDY; GLUCOSE ABSORPTION; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; GLUCOSE METABOLISM; HUMAN; HUMAN EXPERIMENT; HYPERINSULINEMIC EUGLYCEMIC CLAMP TECHNIQUE; INDIAN; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; MALE; NORMAL HUMAN; PILOT STUDY; ANTHROPOMETRY; BIOLOGICAL MODEL; BLOOD; BODY WEIGHT; COMPARATIVE STUDY; ETHNIC GROUP; INDIA; INSULIN RESISTANCE; METHODOLOGY; NONPARAMETRIC TEST; PHYSIOLOGY;

ADULT; ANTHROPOMETRY; BODY MASS INDEX; ETHNIC GROUPS; GLUCOSE CLAMP TECHNIQUE; HUMANS; INDIA; INSULIN; INSULIN RESISTANCE; MALE; MODELS, BIOLOGICAL; PILOT PROJECTS; STATISTICS, NONPARAMETRIC; THINNESS;

EID: 70149114682     PISSN: 09715916     EISSN: 09715916     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Sicree R, Shaw J, Zimmet P. Diabetes and impaired glucose tolerance. In: Gan D, editor. Diabetes Atlas. 3rd ed. Belgium: International Diabetes federation; 2006. p. 15-103.
2. Raji A, Seely EW, Arky RA, Simonson DC. Body fat distribution and insulin resistance in healthy Asian Indians and Caucasians. J Clin Endocrinol Metab 2001; 86: 5366-71.
3. Chandalia M, Abate N, Garg A, Stray Gundersen J, Grundy SM. Relationship between generalized and upper body obesity to insulin resistance to Asian Indian men. J Clin Endocrinol Metab 1999; 84: 2329-35.
4. Ghafoorunissa. Requirements of dietary fats to meet nutritional needs & prevent the risk of atherosclerosis-an Indian perspective. Indian J Med Res 1998; 108: 191-202.
5. Borgonha S, Shetty PS, Kurpad AV. Total energy expenditure & physical activity level in chronically energy deficient Indian males measured by the doubly labelled water technique. Indian J Med Res 2000; 111: 138-46.
6. Vaz M, Yusuf S, Bharathi AV, Kurpad AV, Swaminathan S. The nutrition transition in India. South Afr J Clin Nutr 2005; 18: 198-201.
7. Banerji MA, Faridi N, Atluri R, Chaiken RL, Lebovitz HE. Body composition, visceral fat, leptin, and insulin resistance in Asian Indian men. J Clin Endocrinol Metab 1999; 84: 137-44.
8. Deurenberg-Yap M, Chew SK, Deurenberg P. Elevated body fat percentage and cardiovascular risks at low body mass index levels among Singaporean Chinese, Malays and Indians. Obes Rev 2002; 3: 209-15.
9. Chowdhury B, Lantz H, Sjostrom L. Computed tomography-determined body composition in relation to cardiovascular risk factors in Indian and matched Swedish males. Metabolism 1996; 45: 634-44.
10. Misra A, Vikram NK. Insulin resistance syndrome (metabolic syndrome) and Asian Indians. Curr Sci 2002; 83: 1483-96.
11. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-9.
12. Bonora E, Targher G, Alberiche M, Bonadonna RC, Saggiani F, Zenere MB, et al. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care 2000; 23: 57-63.
13. Katz A, Nambi SS, Mather K, Baron AD, Follmann DA, Sullivan G, et al. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab 2000; 85: 2402-10.
14. National Family Health Survey (NFHS-3) 2005-2006, National Fact Sheet India (Provisional data). Available at http://www.nfhsindia.org/pdf/ IN.pdf, accessed on May 28, 2007.
15. WHO Expert Consultation. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet 2004; 363: 157-63.
16. Rao RH. The role of undernutrition in the pathogenesis of diabetes mellitus. Diabetes Care 1984; 7: 595-601.
17. FAO/WHO/UNU. Human energy requirements. Report of a joint FAO/WHO/ UNU expert consultation. Rome, 17-14 Oct 2001 FAO Food and Nutrition Tech Rep Ser 1, 2004. p. 92-96.
18. Kumar N, Shekhar C, Kumar P, Kundu AS. Kuppuswamy's socioeconomic status scale-updating for 2007. Indian J Pediatr 2007; 74: 1131-2.
19. World Health Organization: Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications: Report of a WHO Consultation. Part 1: Diagnosis and Classification of Diabetes Mellitus. Geneva, Department of Noncommunicable Disease Surveillance. World Health Organization; 1999.
20. Genutts S, Albertika S, Bennett P, Buse J, Defronzo R, Kahn R, et al. The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus: Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care 2003; 26: 3160-7.
21. Harrison GG, Buskirk ER, Carter LGE, Johnston FE, Lohman TG, Pollock ML, et al. Skinfold thicknesses and measurement technique. In: Lohman GT, Roche AF, Martorell R, editors. Anthropometric standardization reference manual. Champaign, IL: Human Kinetics Books 1988. p. 55-70.
22. Durnin JV, Womersley J. Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. Br J Nutr 1974; 32: 77-97.
23. Siri WE. Body composition from fluid spaces and density: analysis of methods. In: Brozek J, Henschel A, editors. Techniques for Measuring Body Composition. Washington, DC: National Academy of Sciences, National Research Council 1961. p. 223-4.
24. Lee RC, Wang Z, Heo M, Ross R, Janssen I, Heymsfield SB. Total-body skeletal muscle mass: development and cross-validation of anthropometric prediction models. Am J Clin Nutr 2000; 72: 796-803.
25. Kuriyan R, Kurpad AV. Prediction of total body muscle mass from simple anthropometric measurements in young Indian males. Indian J Med Res 2004; 119: 121-8.
26. DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 1979; 237: E214-23.
27. Wallace TM, Levy JC, Matthews DR. Use and abuse of HOMA modeling. Diabetes care 2004; 27: 1487-95.
28. Radikova Z. Assesment of insulin sensitivity/resistance in epidemiological studies. Endo Regul 2003; 37: 189-94.
29. Liew CF, Seah ES, Yeo KP, Lee KO, Wise SD. Lean, nondiabetic Asian Indians have decreased insulin sensitivity and insulin clearance, and raised leptin compared to Caucasians and Chinese subjects. Int J Obes Relat Metab Disord 2003; 27: 784-9.
30. Song MY, Kim J, Horlick M, Wang J, Pierson RN Jr, Moo H et al. Prepubertal Asians have less limb skeletal muscle. J Appl Physiol 2002; 92: 2285-91.
31. Petersen KF, Dufour S, Feng J, Befroy D, Dziura J, Dalla Man C, et al. Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men. Proc Natl Acad Sci USA 2006; 103: 18273-7.
32. [No authors listed]. Consensus Development Conference on Insulin Resistance. 5-6 November 1997. American Diabetes Association. Diabetes Care 1998; 21: 310-4.