Macrolide antibiotics like azithromycin increase lipopolysaccharide-induced IL-8 production by human gingival fibroblasts

European Journal of Medical Research

Volumn 14, Issue 7, 2009, Pages 309-314

  Kamemoto, A ^a   Ara, T ^a   Hattori, T ^a   Fujinami, Y ^a   Imamura, Y ^a   Wang, Pao Li ^a  

^a MATSUMOTO DENTAL UNIVERSITY   (Japan)

Author keywords

Anti inflammatory effect; Azithromycin; Gingival fibroblast; Human; Interleukin 8; Macrolide antibiotics

Indexed keywords

AZITHROMYCIN; ERYTHROMYCIN; INTERLEUKIN 6; INTERLEUKIN 8; JOSAMYCIN; LIPOPOLYSACCHARIDE; MATRIX METALLOPROTEINASE; PROSTAGLANDIN E2; ANTIINFECTIVE AGENT; GELATINASE A; GELATINASE B;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; FIBROBLAST; GINGIVA; HUMAN; HUMAN CELL; BIOSYNTHESIS; CELL CULTURE; CYTOLOGY; METABOLISM; TIME;

ANTI-BACTERIAL AGENTS; AZITHROMYCIN; CELL PROLIFERATION; CELLS, CULTURED; DINOPROSTONE; FIBROBLASTS; GINGIVA; HUMANS; INTERLEUKIN-6; INTERLEUKIN-8; LIPOPOLYSACCHARIDES; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; TIME FACTORS;

EID: 70149096041     PISSN: 09492321     EISSN: None     Source Type: Journal    
DOI: 10.1186/2047-783x-14-7-309     Document Type: Article

References (34)

1. Costerton JW, Stewart PS and Greenberg EP. Bacterial biofilms: a common cause of persistent infections. Science (1999) 284: 1318-1322 (Pubitemid 29289651)
2. Girard AE, Girard D, English AR, Gootz TD, Cimochowski CR, Faiella JA, Haskell SL and Retsema JA. Pharmacokinetic and in vivo studies with azithromycin (CP-62,993), a new macrolide with an extended half-life and excellent tissue distribution. Antimicrob Agents Chemother (1987) 31: 1948-1954
3. Baldwin DR, Wise R, Andrews JM, Ashby JP and Honeybourne D. Azithromycin concentrations at the sites of pulmonary infection. Eur Respir J (1990) 3: 886-890
4. Davila D, Kolacny-Babic L and Plavsic F. Pharmacokinetics of azithromycin after single oral dosing of experimental animals. Biopharm Drug Dispos (1991) 12: 505-514
5. Blandizzi C, Malizia T, Lupetti A, Pesce D, Gabriele M, Giuca MR, Campa M, Del Tacca M and Senesi S. Periodontal tissue disposition of azithromycin in patients affected by chronic inflammatory periodontal diseases. J Periodontol (1999) 70: 960-966 (Pubitemid 29453273)
6. Tateda K, Comte R, Pechere JC, Kohler T, Yamaguchi K and Van Delden C. Azithromycin inhibits quorum sensing in Pseudomonas aeruginosa. Antimicrob Agents Chemother (2001) 45: 1930-1933 (Pubitemid 32466379)
7. Tamura A, Ara T, Imamura Y, Fujii T and Wang PL. The effects of antibiotics on in vitro biofilm model of periodontal disease. Eur J Med Res (2008) 13: 439-445
8. Fujii T, Wang PL, Hosokawa Y, Shirai S, Tamura A, Hikita K, Maida T, Ochi M and Baehni PC. Effect of systemically administrated azithromcycin in early onset aggressive periodontitis. Perio (2004) 1: 321-325
9. Smith SR, Foyle DM, Daniels J, Joyston-Bechal S, Smales FC, Sefton A and Williams J. A double-blind placebo-controlled trial of azithromycin as an adjunct to non-surgical treatment of periodontitis in adults: clinical results. J Clin Periodontol (2002) 29: 54-61 (Pubitemid 41697735)
10. Mascarenhas P, Gapski R, Al-Shammari K, Hill R, Soehren S, Fenno JC, Giannobile WV and Wang HL. Clinical response of azithromycin as an adjunct to nonsurgical periodontal therapy in smokers. J Periodontol (2005) 76: 426-436 (Pubitemid 40668390)
11. Gomi K, Yashima A, Nagano T, Kanazashi M, Maeda N and Arai T. Effects of full-mouth scaling and root planing in conjunction with systemically administered azithromycin. J Periodontol (2007) 78: 422-429
12. Haas AN, de Castro GD, Moreno T, Susin C, Albandar JM, Oppermann RV and Rösing CK. Azithromycin as an adjunctive treatment of aggressive periodontitis: 12-months randomized clinical trial. J Clin Periodontol (2008) 35: 696-704
13. Kurdowska A, Noble JM and Griffith DE. The effect of azithromycin and clarithromycin on ex vivo interleukin-8 (IL-8) release from whole blood and IL-8 production by human alveolar macrophages. J Antimicrob Chemother (2001) 47: 867-870 (Pubitemid 32519836)
14. Shinkai M, Foster GH and Rubin BK. Macrolide antibiotics modulate ERK phosphorylation and IL-8 and GM-CSF production by human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol (2006) 290: L75-85
15. Uriarte SM, Molestina RE, Miller RD, Bernabo J, Farinati A, Eiguchi K, Ramirez JA and Summersgill JT. Effect of macrolide antibiotics on human endothelial cells activated by Chlamydia pneumoniae infection and tumor necrosis factor-a. J Infect Dis (2002) 185: 1631-1636 (Pubitemid 34587525)
16. Cigana C, Nicolis E, Pasetto M, Assael BM and Melotti P. Anti-inflammatory effects of azithromycin in cystic fibrosis airway epithelial cells. Biochem Biophys Res Commun (2006) 350: 977-982 (Pubitemid 44584188)
17. Cigana C, Assael BM and Melotti P. Azithromycin selectively reduces tumor necrosis factor alpha levels in cystic fibrosis airway epithelial cells. Antimicrob Agents Chemother (2007) 51: 975-981 (Pubitemid 46355283)
18. Vanaudenaerde BM, Wuyts WA, Geudens N, Dupont LJ, Schoofs K, Smeets S, Van Raemdonck DE and Verleden GM. Macrolides inhibit IL17-induced IL8 and 8-isoprostane release from human airway smooth muscle cells. Am J Transplant (2007) 7: 76-82 (Pubitemid 44952858)
19. Ivetic Tkalcevic V, Bosnjak B, Hrvacic B, Bosnar M, Marjanovic N, Ferencic Z, Situm K, Culic O, Parnham MJ and Erakovic V. Anti-inflammatory activity of azithromycin attenuates the effects of lipopolysaccharide administration in mice. Eur J Pharmacol (2006) 539: 131-138
20. Bartold PM and Haynes DR. Interleukin-6 production by human gingival fibroblasts. J Periodontal Res (1991) 26: 339-345
21. Tamura M, Tokuda M, Nagaoka S and Takada H. Lipopolysaccharides of Bacteroides intermedius (Prevotella intermedia) and Bacteroides (Porphyromonas) gingivalis induce interleukin-8 gene expression in human gingival fibroblast cultures. Infect Immun (1992) 60: 4932-4937
22. 2 and interleukin-1b release from rat periosteal and human gingival fibroblasts in vitro. Oral Microbiol Immunol (1991) 6: 378-380
23. Wang PL and Ohura K. Porphyromonas gingivalis lipopolysaccharide signaling in gingival fibroblasts-CD14 and Toll-like receptors. Crit Rev Oral Biol Med (2002) 13: 132-142 (Pubitemid 34791214)
24. Ara T, Kurata K, Hirai K, Uchihashi T, Uematsu T, Imamura Y, Furusawa K, Kurihara S and Wang PL. Human gingival fibroblasts are critical in sustaining inflammation in periodontal disease. J Periodontal Res (2009) 44: 21-27
25. Ara T, Fujinami Y, Imamura Y and Wang PL. Lipopolysaccharide-treated human gingival fibroblasts continuously produce PGE2. J Hard Tissue Biol (2008) 17: 121-124
26. Wang PL, Sato K, Oido M, Fujii T, Kowashi Y, Shinohara M, Ohura K, Tani H and Kuboki Y. Involvement of CD 14 on human gingival fibroblasts in Porphyromonas gingivalis lipopolysaccharide-mediated interleukin-6 secretion. Arch Oral Biol (1998) 43: 687-694
27. Heussen C and Dowdle EB. Electrophoretic analysis of plasminogen activators in Polyacrylamide gels containing sodium dodecyl sulfate and copolymerized substrates. Anal Biochem (1980) 102: 196-202 (Pubitemid 10099499)
28. Kurata K, Ara T, Kurihara S, Yamada K and Wang PL. LPS-stimulated Apert syndrome gingival keratinocytes show markedly suppressed inflammatory cytokine production. J Oral Biosci (2008) 50: 59-67
29. R Development Core Team. R: A language and environment for statistical computing. R Foundation for Statistical Computing (2008)
30. Gomi K, Yashima A, lino F, Kanazashi M, Nagano T, Shibukawa N, Ohshima T, Maeda N and Arai T. Drug concentration in inflamed periodontal tissues after systemically administered azithromycin. J Periodontol (2007) 78: 918-923
31. Takada H, Mihara J, Morisaki I and Hamada S. Induction of interleukin-1 and -6 in human gingival fibroblast cultures stimulated with Bacteroides lipopolysaccharides. Infect Immun (1991) 59: 295-301
32. Okada H and Murakami S. Cytokine expression in periodontal health and disease. Crit Rev Oral Biol Med (1998) 9: 248-266 (Pubitemid 29080837)
33. 2 in periodontal disease. Periodontol 2000(2007)43:85-101
34. Bouwman JJ, Visseren FL, Bouter PK and Diepersloot RJ. Azithromycin inhibits interleukin-6 but not fibrinogen production in hepatocytes infected with cytomegalovirus and Chlamydia pneumoniae. J Lab Clin Med (2004) 144: 18-26