Paraneoplastic humorally mediated hypercalcemia induced by parathyroid hormone-related protein in gynecologic malignancies

Onkologie

Volumn 32, Issue 8-9, 2009, Pages 517-523

  Savvari, Paraskevi ^a   Peitsidis, Panagiotis ^a   Alevizaki, Maria ^a   Dimopoulos, Meletios A ^a   Antsaklis, Aristidis ^a   Papadimitriou, Christos A ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Gynecologic malignancies; Hypercalcemia; PTH rP

Indexed keywords

ANTINEOPLASTIC AGENT; BISPHOSPHONIC ACID DERIVATIVE; CALCITONIN; CALCIUM; CALCIUM ION; CORTICOSTEROID; LOOP DIURETIC AGENT; PAMIDRONIC ACID; PARATHYROID HORMONE; PARATHYROID HORMONE RELATED PROTEIN;

ABDOMINAL PAIN; ADULT; AGED; AMNION; ANOREXIA; ARTICLE; CALCIUM BLOOD LEVEL; CANCER ADJUVANT THERAPY; CANCER RADIOTHERAPY; CANCER STAGING; CHORION; CLEAR CELL CARCINOMA; CORRELATION ANALYSIS; CYTOREDUCTIVE SURGERY; DECIDUA; DISEASE ASSOCIATION; DYSGERMINOMA; ECTOPIC HORMONE PRODUCTION; EXTERNAL BEAM RADIOTHERAPY; FEMALE; GYNECOLOGIC CANCER; HORMONE RELEASE; HUMAN; HUMORAL HYPERCALCEMIA OF MALIGNANCY; HYDRATION; HYPERCALCEMIA; INFORMATION RETRIEVAL; MULTIMODALITY CANCER THERAPY; MYOMETRIUM; NAUSEA AND VOMITING; NORTHERN BLOTTING; OSTEOLYSIS; OVARY CANCER; OVERALL SURVIVAL; PAPILLARY CARCINOMA; PARANEOPLASTIC SYNDROME; PARATHYROID HORMONE BLOOD LEVEL; PLACENTA; POSTOPERATIVE CARE; PROTEIN EXPRESSION; RADIOIMMUNOASSAY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEMINOMA; SMALL CELL CARCINOMA; SQUAMOUS CELL CARCINOMA; SURGICAL TECHNIQUE; SYSTEMATIC REVIEW; UTERINE CERVIX CANCER; VULVA CANCER; WEAKNESS;

CAUSALITY; COMORBIDITY; FEMALE; GENITAL NEOPLASMS, FEMALE; HUMANS; HYPERCALCEMIA; INCIDENCE; PARANEOPLASTIC ENDOCRINE SYNDROMES; PARATHYROID HORMONE-RELATED PROTEIN; RISK ASSESSMENT; RISK FACTORS;

EID: 70149094635     PISSN: 0378584X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000226209     Document Type: Article

References (49)

1. Fisken RA, Heath DA, Somers S, Bold AM: Hyperealeemia in hospital patients. Clinical and diagnostic aspects. Lancet 1981;l:202-207.
2. Stewart AF: Clinical practice. Hypercalcemia associated with cancer. N Engl J Med 2005;352:373-379.
3. Wysolmerski JJ, Broadus AE: Hypercalcemia of malignancy: the central role of parathyroid hormone-related protein. Annu Rev Med 1994;45:189-200.
4. Broadus AE, Mangin M, Ikeda K, Insogna KL, Weir EC, Burtis WJ, Stewart AF: Humoral hypercalcemia of cancer. Identification of a novel parathyroid hormone-like peptide. N Engl J Med 1988;319: 556-563.
5. Clement PB, Young RH, Scully RE: Clinical syndromes associated with tumors of the female genital tract. Semin Diagn Pathol 1991;8:204-233.
6. Everhart-Caye M, Inzucchi SE, Guinness-Henry J, Mitnick MA, Stewart AF: Parathyroid hormone related protein(l-36) is equipotent to PTH(l-34) in humans. J Clin Endocrinol Metab 1996;81:199-208.
7. Ferguson JE 2nd, Gorman JV, Bruns DE, Weir EC, Burtis WJ, Martin TJ, Bruns ME: Abundant expression of parathyroid hormone-related protein in human amnion and its association with labor. Proc Natl Acad Sci USA 1992;89:8384-8388.
8. Hoshi S, Morimoto T, Saito H, Ichizuka K, Mat-suoka R, Yanaihara A, Suzuki M, Yanaihara T, Okai T: PTH-rP and PTH/PTH-rP receptor expressions in human endometrium. Endocr J 2001;48: 219-225.
9. Burtis WJ, Brady TG, Orloff JJ, Ersbak JB, Warrell RP, Jr, Olson BR, Wu TL, Mitnick ME, Broadus AE, Stewart AF: Immunochemical characterization of circulating parathyroid hormone-related protein in patients with humoral hypercalcemia of cancer. N Engl J Med 1990;322:1106-1112.
10. Allan SG, Lockhart SP, Leonard RC, Smyth JF: Paraneoplastic hypercalcaemia in ovarian carcinoma. Br Med J (Clin Res Ed) 1984;288:1715-11715
11. Louvet C, Guimaraes JL, Ostronoff M, Theodore C, Azab M, Leclercq B, Droz JP: Paraneoplastic hypercalcemia and ovarian seminoma. Review of the literature and etiological discussion apropos of a case. Bull Cancer 1989;76:347-352.
12. Hoekman K, Tjandra YI, Papapoulos SE: The role of 1,25-dihydroxyvitamin D in the maintenance of hypercalcemia in a patient with an ovarian carcinoma producing parathyroid hormone-related protein. Cancer 1991;68:642-647.
13. Fujino T, Watanabe T, Yamaguchi K, Nagasaki K, Onishi E, Iwamoto I, Dozono H, Nagata Y: The development of hypercalcemia in a patient with an ovarian tumor producing parathyroid hormone-related protein. Cancer 1992;70:2845-2850.
14. Inoue K, Kikuchi Y, Hirata J, Wada S, Seki K, Nagata I: Dysgerminoma of the ovary with hypercalcemia associated with elevated parathyroid hormone-related protein. Jpn J Clin Oncol 1995;25:113-117.
15. Kitazawa R, Kitazawa S, Matui T, Maeda S: In situ detection of parathyroid hormone-related protein in ovarian clear cell carcinoma. Hum Pathol 1997;28: 379-382.
16. Koshiyama M, Fujii H, Konishi M, Nanno H, Hay-ashi M, Tauchi K, Yoshida M: Recurrent clear cell carcinoma of the ovary changing into producing parathyroid hormone-related protein (PTH-rP) with hypercalcemia. Eur J Obstet Gynecol Reprod Biol 1999;82:227-229.
17. Tsunematsu R, Saito T, Iguchi H, Fukuda T, Tsu-kamoto N: Hypercalcemia due to parathyroid hormone-related protein produced by primary ovarian clear cell adenocarcinoma: case report. Gynecol Oncol 2000;76:218-222.
18. Takeuchi K, Murata K, Funaki K, Kitazawa S, Kitazawa R: Immunohistochemical detection of parathyroid hormone-related protein in a squa-mous cell carcinoma arising from mature cystic teratoma causing humoral hypercalcemia of malignancy. Gynecol Oncol 2000;79:504-507.
19. Schweiger LM, Hsiang HY: Pathological case of the month. Acute symptomatic hypercalcemia associated with ovarian small cell carcinoma. Arch Pediatr Adolesc Med 2002;156:83-84.
20. Suwaki N, Masuyama H, Mizutani Y, Kodama J, Hiramatsu Y: Parathyroid hormone-related protein as a potential tumor marker: a case report of ovarian clear cell carcinoma. J Obstet Gynaecol Res 2006;32:94-98.
21. Hwang CS, Park SY, Yu SH, Park JY, Park CT, Han KO: Hypercalcemia induced by ovarian clear cell carcinoma producing all transcriptional variants of parathyroid hormone-related peptide gene during pregnancy. Gynecol Oncol 2006;103:740-744.
22. Benit A, Allard J, Rimailho J, Fauvel J, Escourrou G, Vezzosi D, Donadille F, Bennet A, Caron P: Persistent and moderate hypercalcemia related to an ovarian clear cell adenocarcinoma: Pre- and postoperative parathyroid hormone related-peptide and 1,25-dihydroxyvitamin D3 levels. J Endocrinol Invest 2006;29:443-449.
23. Wynn D, Everetta G, Boothbyb R: Small cell carcinoma of the ovary with hypercalcemia causes severe pancreatitis and altered mental status. Gynecol Oncol 2004;95:716-718.
24. Piura B, Wiznitzer A, Shaco-Levy R: Juvenile gran-ulosa cell tumor of the ovary associated with hypercalcemia. Arch Gynecol Obstet 2008;277:257-262.
25. Okoye B, Harmston C, Buick RG: Dysgerminoma associated with hypercalcemia: a case report. J Pediatr Surg 2001;36:E10.
26. Radhakrishnan S, Haq S, Lofts F, Young M, Barton D: Ovarian dysgerminoma presenting with hyperealeemia. Br J Obstet Gynaeeol 2001;108: 1302-1304.
27. Fleisehhaeker D, Young R: Dysgerminoma of the ovary associated with hyperealeemia. Gynecol Oncol 1995;52:87-90.
28. Hiller N, Sonnenbliek M, Hershko C: Paraneoplas-tic hyperealeemia in endometrial carcinoma. Oncology 1989;46:45-48.
29. Hutchesson A, Dunne F, Bundred NJ, Gee H, Ratcliffe W: Parathyroid hormone related protein as a tumour marker in humoral hyperealeemia associated with occult malignancy. Postgrad Med J 1993;69:640-642.
30. Sachmechi I, Kalra J, Molho L, Chawla K: Paraneo-plastic hyperealeemia associated with uterine papillary serous carcinoma. Gynecol Oncol 1995;58: 378-382.
31. Tang S, Geevarghese S, Saab S, Martinez D, Van Herle A, Wallace WD, Cortina GR, Dry S, Busut-til RW: A parathyroid hormone-related protein-secreting metastatic epithelioid leiomyosarcoma: case report and review of the literature. Arch Pathol Lab Med 2003;127:el81-185.
32. Kinugasa Y, Morishige K, Kamiura S, Tsukamoto Y, Saji F: Parathyroid hormone-related protein-secreting uterine endometrioid adenocarcinoma. Jpn J Clin Oncol 2006;36:113-115.
33. Nichols CE, Bonney WA: Carcinoma of the vulva producing hyperealeemia. Obstet Gynecol 1973;42: 58-61.
34. Niebyl JR, Genadry R, Friedrich EG, Wilkinson EJ, Woodruff JD: Vulvar carcinoma with hyperealeemia. Obstet Gynecol 1075;45:343-348.
35. Bilenchi R, Poggiali S, Pisani C, Santopietro R, Miracco C, Vatti R, Lucani B, Andreassi A, Gon-nelli S: Malignant hyperealeemia in vulvar cancer. Minerva Ginecol 2005;57:569-574.
36. Lacey CG, Morrow CP: Hyperealeemia in patients with squamous cell carcinoma of the cervix. Gynecol Oncol 1979;7:215-222.
37. Suva LJ, Winslow GA, Wettenhall RE, et al.: A parathyroid hormone-related protein implicated in malignant hyperealeemia: Cloning and expression. Science 1987;237:893-896.
38. Gellhorn A, Plimpton CH: Hyperealeemia in malignant disease without evidence of bone destruction. Am J Med 1956;21:750-759.
39. Nishihara M, Nishihara M, Kanematsu T, Taguchi T, Razzaque MS: PTHrP and tumorigenesis. Is there a role in prognosis? Ann N Y Acad Sci 2007;1117: 385-392.
40. Hastings RH, Laux AM, Casillas A, Xu R, Lukas Z, Ernstrom K, Deftos LJ: Sex-specific survival advantage with PTH-rP in non-small cell lung carcinoma patients. Clin Cancer Res 2006;12:499-506.
41. Hastings RH, Quintana RA, Sandoval R, Duey D, Rascon Y, Burton DW, Deftos LJ: Proapoptotic effect of PTH-rP in type II pneumocytes. Am J Respir Cell Mol 2003;29:733-742.
42. Iwamura M, Hellman J, Cockett ATK, Lilja H, Gershagen S: Alteration of the hormonal bio-activity of parathyroid hormone-related protein (PTHrP) as a result of limited proteolysis by prostate-specific antigen. Urology 1996;48:317-325.
43. Powell GJ, Southby J, Danks JA, et al.: Localization of parathyroid hormone-related protein in breast cancer metastases: increased incidence in bone compared with other sites. Cancer Res 1991; 51:3059-3061.
44. Hoey RP Sanderson C, Iddon J, Brady G, Bundred NJ, Anderson NG: The parathyroid hormone-related protein receptor is expressed in breast cancer bone metastases and promotes autocrine proliferation in breast carcinoma cells. Br J Cancer 2003;88: 567-573.
45. Akino K, Ohtsuru A, Kanda K, Yasuda A, Yamamoto T, Akino Y, Naito S, Kurokawa M, Iwahori N, Yamashita S: Parathyroid hormone-related peptide is a potent tumor angiogenic factor. Endocrinology 2000;141:4313-4316.
46. Amling M, Neff L, Tanaka S, Inoue D, Kuida K, Weir E, Philbrick WM, Broadus AE, Baron R: Bcl-2 lies downstream of parathyroid hormone-related peptide in a signaling pathway that regulates chondrocyte maturation during skeletal development. J Cell Biol 1997;136:205-213.
47. Shen X, Mula RV, Evers BM, Falzon M: Increased cell survival, migration, invasion, and Akt expression in PTHrP-overexpressing LoVo colon cancer cell lines. Regul Pept 2007;141:61-72.
48. De Miguel F, Fiaschi-Taesch N, Lopez-Talavera JC, Takane KK, Massfelder T, Helwig JJ, Stewart AF: The C-terminal region of PTHrP, in addition to the nuclear localization signal, is essential for the intracrine stimulation of proliferation in vascular smooth muscle cells. Endocrinology 2001;142:4096-4105.
49. Penel N, Dewas S, Doutrelant P, Clisant S, Yazdan-panah Y, Adenis A: Cancer-associated hyperealeemia treated with intravenous diphosphonates: a survival and prognostic factor analysis. Support Care Cancer 2008;16:387-392.