메뉴 건너뛰기




Volumn 2, Issue 4, 2009, Pages 373-379

Antifungal drugs: Predicting clinical efficacy with pharmacodynamics

Author keywords

Antifungals; Efficacy; Pharmacodynamics

Indexed keywords

AMPHOTERICIN B; ANTIFUNGAL AGENT; CASPOFUNGIN; ECHINOCANDIN; FLUCONAZOLE; FLUCYTOSINE; ITRACONAZOLE; LIPOSOME; MICAFUNGIN; POSACONAZOLE; TRIAZOLE DERIVATIVE; VORICONAZOLE;

EID: 70149093202     PISSN: 17512433     EISSN: None     Source Type: Journal    
DOI: 10.1586/ecp.09.14     Document Type: Review
Times cited : (5)

References (53)
  • 2
    • 0242323689 scopus 로고    scopus 로고
    • Epidemiology of Candida species infections in critically ill non-immunosuppressed patients
    • Eggimann P, Garbino J, Pittet D. Epidemiology of Candida species infections in critically ill non-immunosuppressed patients. Lancet Infect. Dis. 3, 685-702 (2003).
    • (2003) Lancet Infect. Dis , vol.3 , pp. 685-702
    • Eggimann, P.1    Garbino, J.2    Pittet, D.3
  • 3
    • 0036720774 scopus 로고    scopus 로고
    • National Nosocomial Infections Surveillance System Hospitals. Secular trend of hospital-acquired candidemia among intensive care unit patients in the United States during 1989-1999
    • Trick WE, Fridkin SK, Edwards JR, Hajjeh RA, Gaynes RP; National Nosocomial Infections Surveillance System Hospitals. Secular trend of hospital-acquired candidemia among intensive care unit patients in the United States during 1989-1999. Clin. Infect. Dis. 35, 627-630 (2002).
    • (2002) Clin. Infect. Dis , vol.35 , pp. 627-630
    • Trick, W.E.1    Fridkin, S.K.2    Edwards, J.R.3    Hajjeh, R.A.4    Gaynes, R.P.5
  • 4
    • 0041766322 scopus 로고    scopus 로고
    • Opportunistic mycelial fungal infections in organ transplant recipients; emerging importance of non-Aspergillus mycelial fungi
    • Husain S, Alexander BD, Munoz P et al. Opportunistic mycelial fungal infections in organ transplant recipients; emerging importance of non-Aspergillus mycelial fungi. Clin. Infect. Dis. 37, 221-229 (2003).
    • (2003) Clin. Infect. Dis , vol.37 , pp. 221-229
    • Husain, S.1    Alexander, B.D.2    Munoz, P.3
  • 5
    • 0036532203 scopus 로고    scopus 로고
    • Epidemiology and outcome of mould infections in hematopoietic stem cell transplant recipients
    • Marr KA, Carter RA, Crippa F, Wald A, Corey L. Epidemiology and outcome of mould infections in hematopoietic stem cell transplant recipients. Clin. Infect. Dis. 34, 909-917 (2002).
    • (2002) Clin. Infect. Dis , vol.34 , pp. 909-917
    • Marr, K.A.1    Carter, R.A.2    Crippa, F.3    Wald, A.4    Corey, L.5
  • 6
    • 33748557483 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of antifungals
    • Andes D. Pharmacokinetics and pharmacodynamics of antifungals. Infect. Dis. Clin. North Am. 20, 679-697 (2006).
    • (2006) Infect. Dis. Clin. North Am , vol.20 , pp. 679-697
    • Andes, D.1
  • 7
    • 0036895274 scopus 로고    scopus 로고
    • In vitro activity of micafungin (FK-463) against Candida spp.: Microdilution, time-kill, and postantifungal-effect studies
    • Ernst EJ, Roling EE, Petzold CR et al. In vitro activity of micafungin (FK-463) against Candida spp.: microdilution, time-kill, and postantifungal-effect studies. Antimicrob. Agents Chemother. 46, 3846-3853 (2002).
    • (2002) Antimicrob. Agents Chemother , vol.46 , pp. 3846-3853
    • Ernst, E.J.1    Roling, E.E.2    Petzold, C.R.3
  • 8
    • 17044455920 scopus 로고    scopus 로고
    • In vitro preclinical evaluation studies with the echinocandin antifungal MK-0991 (L-743,872)
    • Bartizal K, Gill CJ, Abruzzo GK et al. In vitro preclinical evaluation studies with the echinocandin antifungal MK-0991 (L-743,872). Antimicrob. Agents Chemother. 41, 2326-2332 (1997).
    • (1997) Antimicrob. Agents Chemother , vol.41 , pp. 2326-2332
    • Bartizal, K.1    Gill, C.J.2    Abruzzo, G.K.3
  • 9
    • 28844486224 scopus 로고    scopus 로고
    • Pharmacodynamics of caspofungin in a murine model of systemic candidiasis: Importance of persistence of caspofungin in tissues to understanding drug activity
    • Louie A, Deziel M, Liu W et al. Pharmacodynamics of caspofungin in a murine model of systemic candidiasis: importance of persistence of caspofungin in tissues to understanding drug activity. Antimicrob. Agents Chemother. 49, 5058-5068 (2005).
    • (2005) Antimicrob. Agents Chemother , vol.49 , pp. 5058-5068
    • Louie, A.1    Deziel, M.2    Liu, W.3
  • 10
    • 0037377996 scopus 로고    scopus 로고
    • In vivo pharmacodynamics of HMR 3270, a glucan synthase inhibitor, in a murine candidiasis model
    • Andes D, Marchillo K, Lowther J et al. In vivo pharmacodynamics of HMR 3270, a glucan synthase inhibitor, in a murine candidiasis model. Antimicrob. Agents Chemother. 47, 1187-1192 (2003).
    • (2003) Antimicrob. Agents Chemother , vol.47 , pp. 1187-1192
    • Andes, D.1    Marchillo, K.2    Lowther, J.3
  • 11
    • 33748556087 scopus 로고    scopus 로고
    • Alternate day dosing of micafungin in treatment of esophageal candidiasis
    • Presented at:, San Francisco, CA, USA, 27-30 September, Abstract M719
    • Buell D, Kovand L, Drake T et al. Alternate day dosing of micafungin in treatment of esophageal candidiasis. Presented at: 46th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, CA, USA, 27-30 September 2006 (Abstract M719).
    • (2006) 46th Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Buell, D.1    Kovand, L.2    Drake, T.3
  • 12
    • 34848928703 scopus 로고    scopus 로고
    • Micafungin vs caspofungin for treatment of candidemia and other forms of invasive candidiasis
    • Pappas PG, Rotstein CM, Betts RF et al. Micafungin vs caspofungin for treatment of candidemia and other forms of invasive candidiasis. Clin. Infect. Dis. 45, 883-893 (2007).
    • (2007) Clin. Infect. Dis , vol.45 , pp. 883-893
    • Pappas, P.G.1    Rotstein, C.M.2    Betts, R.F.3
  • 14
    • 0031966359 scopus 로고    scopus 로고
    • Pharmacodynamics of fluconazole in a murine model of systemic candidiasis
    • Louie A, Drusano GL, Banerjee P et al. Pharmacodynamics of fluconazole in a murine model of systemic candidiasis. Antimicrob. Agents Chemother. 42, 1105-1109 (1998).
    • (1998) Antimicrob. Agents Chemother , vol.42 , pp. 1105-1109
    • Louie, A.1    Drusano, G.L.2    Banerjee, P.3
  • 15
    • 0032828929 scopus 로고    scopus 로고
    • Characterization and quantitation of the pharmacodynamics of fluconazole in a neutropenic murine disseminated candidiasis infection model
    • Andes D, Van Ogtrop M. Characterization and quantitation of the pharmacodynamics of fluconazole in a neutropenic murine disseminated candidiasis infection model. Antimicrob. Agents Chemother. 43, 2116-2120 (1999).
    • (1999) Antimicrob. Agents Chemother , vol.43 , pp. 2116-2120
    • Andes, D.1    Van Ogtrop, M.2
  • 16
    • 0141925590 scopus 로고    scopus 로고
    • In vivo pharmacokinetics and pharmacodynamics of a new triazole, voriconazole, in a murine candidiasis model
    • Andes D, Marchillo K, Stamstad T et al. In vivo pharmacokinetics and pharmacodynamics of a new triazole, voriconazole, in a murine candidiasis model. Antimicrob. Agents Chemother. 47, 3165-3169 (2003).
    • (2003) Antimicrob. Agents Chemother , vol.47 , pp. 3165-3169
    • Andes, D.1    Marchillo, K.2    Stamstad, T.3
  • 17
    • 0347361711 scopus 로고    scopus 로고
    • Pharmacodynamics of a new triazole, posaconazole, in a murine model of disseminated candidiasis
    • Andes D, Marchillo K, Conklin R et al. Pharmacodynamics of a new triazole, posaconazole, in a murine model of disseminated candidiasis. Antimicrob. Agents Chemother. 48, 137-142 (2004).
    • (2004) Antimicrob. Agents Chemother , vol.48 , pp. 137-142
    • Andes, D.1    Marchillo, K.2    Conklin, R.3
  • 18
    • 0031052377 scopus 로고    scopus 로고
    • Development of interpretive breakpoints for antifungal susceptibility testing: Conceptual framework and analysis of in vitro - in vivo correlation data for fluconazole, itraconazole, and Candida infections
    • Rex JH, Pfaller MA, Galgiani JN et al. Development of interpretive breakpoints for antifungal susceptibility testing: conceptual framework and analysis of in vitro - in vivo correlation data for fluconazole, itraconazole, and Candida infections. Clin. Infect. Dis. 24, 235-247 (1997).
    • (1997) Clin. Infect. Dis , vol.24 , pp. 235-247
    • Rex, J.H.1    Pfaller, M.A.2    Galgiani, J.N.3
  • 19
    • 0033807952 scopus 로고    scopus 로고
    • Clinical correlates of antifungal macrodilution susceptibility test results for non-AIDS patients with severe Candida infections treated with fluconazole
    • Lee SC, Fung CP, Huang JS et al. Clinical correlates of antifungal macrodilution susceptibility test results for non-AIDS patients with severe Candida infections treated with fluconazole. Antimicrob. Agents Chemother. 44, 2715-2718 (2000).
    • (2000) Antimicrob. Agents Chemother , vol.44 , pp. 2715-2718
    • Lee, S.C.1    Fung, C.P.2    Huang, J.S.3
  • 20
    • 23044487160 scopus 로고    scopus 로고
    • Fluconazole MIC and the fluconazole dose/MIC ratio correlate with therapeutic response among patients with candidemia
    • Clancy CJ, Yu VL, Morris AJ et al. Fluconazole MIC and the fluconazole dose/MIC ratio correlate with therapeutic response among patients with candidemia. Antimicrob. Agents Chemother. 49, 3171-3177 (2005).
    • (2005) Antimicrob. Agents Chemother , vol.49 , pp. 3171-3177
    • Clancy, C.J.1    Yu, V.L.2    Morris, A.J.3
  • 21
    • 0026012331 scopus 로고
    • Development of resistance in Candida isolates from patients receiving prolonged antifungal therapy
    • Fan-Havard P, Papano D, Smith SM et al. Development of resistance in Candida isolates from patients receiving prolonged antifungal therapy. Antimicrob. Agents Chemother. 35, 2302-2305 (1991).
    • (1991) Antimicrob. Agents Chemother , vol.35 , pp. 2302-2305
    • Fan-Havard, P.1    Papano, D.2    Smith, S.M.3
  • 22
    • 0035371319 scopus 로고    scopus 로고
    • Oropharyngeal candidiasis in patients with human immunodefiency virus: Correlation of clinical outcome with in vitro resistance, serum azole levels, and immunosuppression
    • Walmsley S, King S, McGeer A et al. Oropharyngeal candidiasis in patients with human immunodefiency virus: correlation of clinical outcome with in vitro resistance, serum azole levels, and immunosuppression. Clin. Infect. Dis. 32, 1554-1561 (2001).
    • (2001) Clin. Infect. Dis , vol.32 , pp. 1554-1561
    • Walmsley, S.1    King, S.2    McGeer, A.3
  • 23
    • 33645782259 scopus 로고    scopus 로고
    • A multicenter randomized trial evaluating posaconazole versus fluconazole for the treatment of oropharyngeal candidiasis in subjects with HIV/AIDS
    • Vazquez JA, Skiest DJ, Nieto L et al. A multicenter randomized trial evaluating posaconazole versus fluconazole for the treatment of oropharyngeal candidiasis in subjects with HIV/AIDS. Clin. Infect. Dis. 42, 1179-1186 (2006).
    • (2006) Clin. Infect. Dis , vol.42 , pp. 1179-1186
    • Vazquez, J.A.1    Skiest, D.J.2    Nieto, L.3
  • 24
    • 0036417340 scopus 로고    scopus 로고
    • Itraconazole solution: Summary of pharmacokinetic reatures and review of activity in the treatment of fluconazole-resistant oral candidosis in HIV-infected patients
    • Koks CHW, Meenhorst PL, Bult A et al. Itraconazole solution: summary of pharmacokinetic reatures and review of activity in the treatment of fluconazole-resistant oral candidosis in HIV-infected patients. Pharmacol. Res. 46, 195-201 (2002).
    • (2002) Pharmacol. Res , vol.46 , pp. 195-201
    • Koks, C.H.W.1    Meenhorst, P.L.2    Bult, A.3
  • 25
    • 0032886182 scopus 로고    scopus 로고
    • Breakthrough invasive fungal infections in neutropenic patients after prophylaxis with itraconazole
    • Glasmacher A, Hahn C, Leuner C et al. Breakthrough invasive fungal infections in neutropenic patients after prophylaxis with itraconazole. Mycoses 42, 443-451 (1999).
    • (1999) Mycoses , vol.42 , pp. 443-451
    • Glasmacher, A.1    Hahn, C.2    Leuner, C.3
  • 26
    • 0041422239 scopus 로고    scopus 로고
    • Pharmacokinetics, safety, and tolerability of oral posaconazole administered in single and multiple doses in healthy adults
    • Courtney R, Pai S, Laughlin M et al. Pharmacokinetics, safety, and tolerability of oral posaconazole administered in single and multiple doses in healthy adults. Antimicrob. Agents Chemother. 47, 2788-2795 (2003).
    • (2003) Antimicrob. Agents Chemother , vol.47 , pp. 2788-2795
    • Courtney, R.1    Pai, S.2    Laughlin, M.3
  • 27
    • 13244268757 scopus 로고    scopus 로고
    • Oral bioavailability of posaconazole in fasted healthy subjects: Comparison between three regimens and basis for clinical dosage recommendations
    • Ezzet F, Wexler D, Courtney R et al. Oral bioavailability of posaconazole in fasted healthy subjects: comparison between three regimens and basis for clinical dosage recommendations. Clin. Pharmacokinet. 44, 211-220 (2005).
    • (2005) Clin. Pharmacokinet , vol.44 , pp. 211-220
    • Ezzet, F.1    Wexler, D.2    Courtney, R.3
  • 28
    • 1242351713 scopus 로고    scopus 로고
    • Effect of food on the relative bioavailability of two oral formulations of posaconazole in healthy adults
    • Courtney R, Wexler D, Radwanski E et al. Effect of food on the relative bioavailability of two oral formulations of posaconazole in healthy adults. Br. J. Clin. Pharmacol. 57, 218-222 (2004).
    • (2004) Br. J. Clin. Pharmacol , vol.57 , pp. 218-222
    • Courtney, R.1    Wexler, D.2    Radwanski, E.3
  • 29
    • 33744498620 scopus 로고    scopus 로고
    • Pharmacokinetics and safety of oral posaconazole in neutropenic stem cell transplant receipients
    • Gubbins PO, Krishna G, Sansone-Parsons A et al. Pharmacokinetics and safety of oral posaconazole in neutropenic stem cell transplant receipients. Antimicrob. Agents Chemother. 50, 1993-1999 (2006).
    • (2006) Antimicrob. Agents Chemother , vol.50 , pp. 1993-1999
    • Gubbins, P.O.1    Krishna, G.2    Sansone-Parsons, A.3
  • 30
    • 36849064207 scopus 로고    scopus 로고
    • Pharmacokinetics of oral posaconazole in allogeneic hematopoietic stem cell transplant recipients with graft-versus-host disease
    • Krishna G, Martinho MS, Chandrasekar P et al. Pharmacokinetics of oral posaconazole in allogeneic hematopoietic stem cell transplant recipients with graft-versus-host disease. Pharmacotherapy 27, 1627-1636 (2007).
    • (2007) Pharmacotherapy , vol.27 , pp. 1627-1636
    • Krishna, G.1    Martinho, M.S.2    Chandrasekar, P.3
  • 31
    • 70049118984 scopus 로고    scopus 로고
    • Treatment of invasive aspergillosis with posaconazole in patients who are refractory to or intolerant of conventional therapy: An externally controlled trial
    • Walsh TJ, Raad I, Patterson TF et al. Treatment of invasive aspergillosis with posaconazole in patients who are refractory to or intolerant of conventional therapy: an externally controlled trial. Clin. Infect. Dis. 39, 842-849 (2004).
    • (2004) Clin. Infect. Dis , vol.39 , pp. 842-849
    • Walsh, T.J.1    Raad, I.2    Patterson, T.F.3
  • 32
    • 0035991878 scopus 로고    scopus 로고
    • Pharmacokinetics and safety of voriconazole following intravenous-to oral-dose escalation regimens
    • Purkins L, Wood N, Ghahramani P et al. Pharmacokinetics and safety of voriconazole following intravenous-to oral-dose escalation regimens. Antimicrob. Agents Chemother. 46, 2546-2553 (2002).
    • (2002) Antimicrob. Agents Chemother , vol.46 , pp. 2546-2553
    • Purkins, L.1    Wood, N.2    Ghahramani, P.3
  • 33
    • 32644459863 scopus 로고    scopus 로고
    • Pharmacokinetics of voriconazole and cytochrome P450 2C19 genetic status
    • Ikeda Y, Umemura K, Kondo D et al. Pharmacokinetics of voriconazole and cytochrome P450 2C19 genetic status. Clin. Infect. Dis. 75, 586-587 (2004).
    • (2004) Clin. Infect. Dis , vol.75 , pp. 586-587
    • Ikeda, Y.1    Umemura, K.2    Kondo, D.3
  • 34
    • 0037371527 scopus 로고    scopus 로고
    • Voriconazole: A new triazole antifungal agent
    • Johnson LB, Kauffman CA. Voriconazole: a new triazole antifungal agent. Clin. Infect. Dis. 36, 630-637 (2003).
    • (2003) Clin. Infect. Dis , vol.36 , pp. 630-637
    • Johnson, L.B.1    Kauffman, C.A.2
  • 35
    • 39449117139 scopus 로고    scopus 로고
    • Voriconazole therapeutic dtug monitoring in patients with invasive mycoses improves efficacy and safety outcomes
    • Pascual A, Calandra T, Bolay S et al. Voriconazole therapeutic dtug monitoring in patients with invasive mycoses improves efficacy and safety outcomes. Clin: Infect. Dis. 46, 201-211 (2008).
    • (2008) Clin: Infect. Dis , vol.46 , pp. 201-211
    • Pascual, A.1    Calandra, T.2    Bolay, S.3
  • 37
    • 65449123094 scopus 로고    scopus 로고
    • Aspergillosis
    • Segal BH. Aspergillosis. N. Engl. J. Med. 360, 1870-1884 (2009).
    • (2009) N. Engl. J. Med , vol.360 , pp. 1870-1884
    • Segal, B.H.1
  • 38
    • 39449095735 scopus 로고    scopus 로고
    • Treatment of aspergillosis: Clinical practice guidelines of the Infectious Diseases Society of America
    • Walsh TJ, Anaissie EJ, Denning DW et al. Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of America. Clin. Infect. Dis. 46, 327-360 (2008).
    • (2008) Clin. Infect. Dis , vol.46 , pp. 327-360
    • Walsh, T.J.1    Anaissie, E.J.2    Denning, D.W.3
  • 39
    • 0034102140 scopus 로고    scopus 로고
    • Postantifungal effects of echinocandin, azole, and polyene antifungal agens against Candida, albicans and Cryptococcus neoformans
    • Ernst EJ, Klepser ME, Pfaller MA. Postantifungal effects of echinocandin, azole, and polyene antifungal agens against Candida, albicans and Cryptococcus neoformans. Antimicrob. Agents Chemother. 44, 1108-1111 (2000).
    • (2000) Antimicrob. Agents Chemother , vol.44 , pp. 1108-1111
    • Ernst, E.J.1    Klepser, M.E.2    Pfaller, M.A.3
  • 40
    • 0028111473 scopus 로고
    • The postantibiotic effect of antifungal agents against common pathogenic yeasts
    • Turnidge JD, Gudmundsson S, Vogelman B et al. The postantibiotic effect of antifungal agents against common pathogenic yeasts. J. Antimicrob. Chemother. 34, 83-92 (1994).
    • (1994) J. Antimicrob. Chemother , vol.34 , pp. 83-92
    • Turnidge, J.D.1    Gudmundsson, S.2    Vogelman, B.3
  • 41
    • 0035115021 scopus 로고    scopus 로고
    • Pharmacodynamics of amphotericin B in a neutropenic-mouse disseminated-candidasis model
    • Andes D, Stamstad T, Conklin R. Pharmacodynamics of amphotericin B in a neutropenic-mouse disseminated-candidasis model. Antimicrob. Agents Chemother. 45, 922-926 (2001).
    • (2001) Antimicrob. Agents Chemother , vol.45 , pp. 922-926
    • Andes, D.1    Stamstad, T.2    Conklin, R.3
  • 42
    • 31944447689 scopus 로고    scopus 로고
    • Pharmacokinetic - pharmacodynamic comparison of amphotericin B (AMB) and two lipid-associated AMB preparations, liposomal AMB and AMB lipid complex, in murine candidiasis models
    • Andes D, Safdar N, Marchillo K et al. Pharmacokinetic - pharmacodynamic comparison of amphotericin B (AMB) and two lipid-associated AMB preparations, liposomal AMB and AMB lipid complex, in murine candidiasis models. Antimicrob. Agents Chemother. 50, 674-684 (2006).
    • (2006) Antimicrob. Agents Chemother , vol.50 , pp. 674-684
    • Andes, D.1    Safdar, N.2    Marchillo, K.3
  • 43
    • 31944450554 scopus 로고    scopus 로고
    • Pharmacodynamic activity of amphotericin B deoycholate is associated with peak plasma concentrations in a neutropenic murine model of invasive pulmonary aspergillosis
    • Wiederhold NP, Tam VH, Chi J et al. Pharmacodynamic activity of amphotericin B deoycholate is associated with peak plasma concentrations in a neutropenic murine model of invasive pulmonary aspergillosis. Antimicrob. Agents Chemother. 50, 469-473 (2006).
    • (2006) Antimicrob. Agents Chemother , vol.50 , pp. 469-473
    • Wiederhold, N.P.1    Tam, V.H.2    Chi, J.3
  • 44
    • 33748557483 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of antifungals
    • Andes D. Pharmacokinetics and pharmacodynamics of antifungals. Infect. Dis. Clin. North Am. 20, 679-697 (2006).
    • (2006) Infect. Dis. Clin. North Am , vol.20 , pp. 679-697
    • Andes, D.1
  • 45
    • 33645777826 scopus 로고    scopus 로고
    • Evaluation of amphotericin B interpretive breakpoints for Candida bloodstream isolates by correlation with therapeutic outcome
    • Park BJ, Arthington-Skaggs BA, Hajjeh RA et al. Evaluation of amphotericin B interpretive breakpoints for Candida bloodstream isolates by correlation with therapeutic outcome. Antimicrob. Agents Chemother. 50, 1287-1292 (2006).
    • (2006) Antimicrob. Agents Chemother , vol.50 , pp. 1287-1292
    • Park, B.J.1    Arthington-Skaggs, B.A.2    Hajjeh, R.A.3
  • 46
    • 46249098244 scopus 로고    scopus 로고
    • High-dose amphotericin B with flucytosine for the treatment of cryptococcal meningitis in HIV-infected patients: A randomized trial
    • Bicanic T, Wood R, Meintjes G et al. High-dose amphotericin B with flucytosine for the treatment of cryptococcal meningitis in HIV-infected patients: a randomized trial. Clin. Infect. Dis. 47, 123-130 (2008).
    • (2008) Clin. Infect. Dis , vol.47 , pp. 123-130
    • Bicanic, T.1    Wood, R.2    Meintjes, G.3
  • 47
    • 34248160575 scopus 로고    scopus 로고
    • Liposomal amphotericin B as initial therapy for invasive mold infection: A randomized trial comparing a high-loading dose regimen with standard dosing (AmbiLoad trial)
    • Cornely OA, Maertens J, Bresnik M et al. Liposomal amphotericin B as initial therapy for invasive mold infection: a randomized trial comparing a high-loading dose regimen with standard dosing (AmbiLoad trial). Clin. Infect. Dis. 44, 1289-1297 (2007).
    • (2007) Clin. Infect. Dis , vol.44 , pp. 1289-1297
    • Cornely, O.A.1    Maertens, J.2    Bresnik, M.3
  • 48
    • 0034063522 scopus 로고    scopus 로고
    • In vivo characterization of the pharmacodynamics of flucytosine in a neutropenic murine disseminated candidasis model
    • Andes D, Van Ogtrop M. In vivo characterization of the pharmacodynamics of flucytosine in a neutropenic murine disseminated candidasis model. Antimicrob. Agents Chemother. 44, 938-942 (2000).
    • (2000) Antimicrob. Agents Chemother , vol.44 , pp. 938-942
    • Andes, D.1    Van Ogtrop, M.2
  • 49
    • 0029834827 scopus 로고    scopus 로고
    • Efficacy of continuous flucytosine infusion against Candida lusitaniae in experimental hematogenous murine candidasis
    • Karyotakis NC, Anaissie EJ. Efficacy of continuous flucytosine infusion against Candida lusitaniae in experimental hematogenous murine candidasis. Antimicrob. Agents Chemother. 40, 2907-2908 (1996).
    • (1996) Antimicrob. Agents Chemother , vol.40 , pp. 2907-2908
    • Karyotakis, N.C.1    Anaissie, E.J.2
  • 50
    • 23244447174 scopus 로고    scopus 로고
    • Surface response modeling to examine the combination of amphotericin B deoycholate and 5-fluorocytosine for treatment of invasive candidiasis
    • Hope WW, Warn PS, Sharp A et al. Surface response modeling to examine the combination of amphotericin B deoycholate and 5-fluorocytosine for treatment of invasive candidiasis. J. Infect. Dis. 192, 673-680 (2005).
    • (2005) J. Infect. Dis , vol.192 , pp. 673-680
    • Hope, W.W.1    Warn, P.S.2    Sharp, A.3
  • 51
    • 2542445436 scopus 로고    scopus 로고
    • In vitro interactions between amphotericin B, itraconazole and flucytosine against 21 clinical Aspergillus isolates determined by two drug interaction models
    • Te Dorsthorst DT, Verweij PE, Meis JF et al. In vitro interactions between amphotericin B, itraconazole and flucytosine against 21 clinical Aspergillus isolates determined by two drug interaction models. Antimicrob. Agents Chemother. 48, 2007-2013 (2004)
    • (2004) Antimicrob. Agents Chemother , vol.48 , pp. 2007-2013
    • Te Dorsthorst, D.T.1    Verweij, P.E.2    Meis, J.F.3
  • 52
    • 25844461963 scopus 로고    scopus 로고
    • Efficacy and pharmadynamics of flucytosine monotherapy in a nonneutropenic murine model of invasive aspergillosis
    • Te Dorsthorst DT, Verweij PE, Meis JF et al. Efficacy and pharmadynamics of flucytosine monotherapy in a nonneutropenic murine model of invasive aspergillosis. Antimicrob. Agents Chemother. 49, 4220-4226 (2005).
    • (2005) Antimicrob. Agents Chemother , vol.49 , pp. 4220-4226
    • Te Dorsthorst, D.T.1    Verweij, P.E.2    Meis, J.F.3
  • 53
    • 0026564314 scopus 로고
    • Evolving role of flucytosine in immunocompromised patients: New insights into safety, pharmacokinetics, and antifungal therapy
    • Karyotakis NC, Anaissie EJ. Evolving role of flucytosine in immunocompromised patients: new insights into safety, pharmacokinetics, and antifungal therapy. Clin. Infect Dis. 15, 1003-1018 (1992).
    • (1992) Clin. Infect Dis , vol.15 , pp. 1003-1018
    • Karyotakis, N.C.1    Anaissie, E.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.