PEL: An unbiased method for estimating age-dependent genetic disease risk from pedigree data unselected for family history

Genetic Epidemiology

Volumn 33, Issue 5, 2009, Pages 379-385

  Alarcon, Flora ^a,b   Bourgain, C ^a,b   Gauthier Villars, M ^c   Plante Bordeneuve V ^d   Stoppa Lyonnet, D ^c,e   Bonaiti Pellie C ^a,b  

^a UNIVERSITÉ PARIS SACLAY   (France)

^b INSERM   (France)

^c INSTITUT CURIE   (France)

^d BICÊTRE HOSPITAL   (France)

^e UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Ascertainment bias; Maximum likelihood method; Penetrance function; Risk estimation

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; PREALBUMIN;

AGE; AMYLOID NEUROPATHY; ARTICLE; BREAST CANCER; CANCER RISK; FAMILY HISTORY; FRANCE; GENE MUTATION; GENETIC MODEL; GENETIC RISK; GENETIC SCREENING; HUMAN; INTERMETHOD COMPARISON; MAXIMUM LIKELIHOOD METHOD; PEDIGREE ANALYSIS; PENETRANCE; PHENOTYPE EXCLUSION LIKELIHOOD; PORTUGAL; BIOLOGICAL MODEL; BREAST TUMOR; EPIDEMIOLOGY; GENETIC DISORDER; GENETICS; PEDIGREE; PHENOTYPE; RISK; STATISTICAL MODEL; TUMOR SUPPRESSOR GENE;

AGE FACTORS; AMYLOID NEUROPATHIES; BIAS (EPIDEMIOLOGY); BREAST NEOPLASMS; FRANCE; GENES, BRCA1; GENES, BRCA2; GENETIC DISEASES, INBORN; HUMANS; LIKELIHOOD FUNCTIONS; MODELS, GENETIC; MODELS, STATISTICAL; PEDIGREE; PHENOTYPE; PORTUGAL; PREALBUMIN; RISK;

EID: 70149091959     PISSN: 07410395     EISSN: 10982272     Source Type: Journal    
DOI: 10.1002/gepi.20390     Document Type: Article

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