Pivotal advance: Eosinophilia in the MES rat strain is caused by a loss-of-function mutation in the gene for cytochrome b(-245), alpha polypeptide (Cyba)

Journal of Leukocyte Biology

Volumn 86, Issue 3, 2009, Pages 473-478

  Mori, Masayuki ^a   Li, Guixin ^a   Hashimoto, Maiko ^a   Nishio, Ayako ^b   Tomozawa, Hiroshi ^b   Suzuki, Nobuyoshi ^c   Usami, Shin Ichi ^c   Higuchi, Keiichi ^a   Matsumoto, Kiyoshi ^b  

^a SHINSHU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b SHINSHU UNIVERSITY   (Japan)

^c SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Eosinophil; NADPH oxidase; Positional gene cloning

Indexed keywords

CYTOCHROME B; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHRONIC GRANULOMATOUS DISEASE; CONTROLLED STUDY; CYBA GENE; ENZYME ACTIVITY; ENZYME DEFECT; EOSINOPHILIA; GENE; GENE DELETION; HOMEOSTASIS; INFECTION SENSITIVITY; INNATE IMMUNITY; INNER EAR MALFORMATION; LEUKOCYTE COUNT; LOSS OF FUNCTION MUTATION; MATSUMOTO EOSINOPHILIA SHINSHU RAT; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PHAGOCYTOSIS; PRIORITY JOURNAL; RAT; RAT STRAIN; STAPHYLOCOCCUS INFECTION; TRANSGENE;

ANIMALS; BASE SEQUENCE; CYTOCHROME B GROUP; DNA; DNA PRIMERS; EOSINOPHILIA; FEMALE; HOMEOSTASIS; IMMUNITY, INNATE; INTRONS; LEUKOCYTES; MALE; MOLECULAR SEQUENCE DATA; MUTATION; NADPH OXIDASE; RATS; RATS, SPRAGUE-DAWLEY; RATS, TRANSGENIC; RNA SPLICE SITES; RNA, MESSENGER; SEQUENCE DELETION; TRANSGENES;

RATTUS; STAPHYLOCOCCUS AUREUS;

EID: 70149091507     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.1108715     Document Type: Article

References (27)

1. Brito-Babapulle, F. (2003) The eosinophilias, including the idiopathic hypereosinophilic syndrome. Br. J. Haematol. 121, 203-223. (Pubitemid 36560589)
2. Roufosse, F., Cogan, E., Goldman, M. (2004) Recent advances in pathogenesis and management of hypereosinophilic syndromes. Allergy 59, 673-689. (Pubitemid 38850341)
3. Matsumoto, K., Matsushita, N., Tomozawa, H., Tagawa, Y. (2000) Hematological characteristics of rats spontaneously developing eosinophilia. Exp. Anim. 49, 211-215.
4. Muto, S., Hayashi, M., Matsushita, N., Momose, Y., Shibata, N., Umemura, T., Matsumoto, K. (2001) Systemic and eosinophilic lesions in rats with spontaneous eosinophilia (mes rats). Vet. Pathol. 38, 346-350. (Pubitemid 33621799)
5. Sano, K., Kobayashi, M., Sakaguchi, N., Ito, M., Hotchi, M., Matsumoto, K. (2001) A rat model of hypereosinophilic syndrome. Pathol. Int. 51, 82-88.
6. Muto, S., Kawakubo, M., Matsushita, N., Maeda, N., Momose, Y., Matsumoto, K. (2005) Haematological data for Matsumoto Eosinophilic Shinshu rats as determined by an automated haematology analyzer. Lab. Anim. 39, 122-129. (Pubitemid 40187705)
7. Muto, S., Monnai, M., Okuhara, Y., Murakami, M., Kuroda, J., Ono, T., Matsumoto, K. (2005) Altered cytokine expression in mesenteric lymph nodes in a rat strain (Matsumoto Eosinophilic Shinshu) that spontaneously develops hypereosinophilia. Immunology 116, 373-380. (Pubitemid 41532128)
8. Li, G., Guo, Z., Higuchi, K., Kawakubo, M., Matsumoto, K., Mori, M. (2005) A locus for eosinophilia in the MES rat is on chromosome 19. Mamm. Genome 16, 516-523. (Pubitemid 41278428)
9. Mori, M., Higuchi, K., Matsumoto, K. (2006) A third locus for eosinophilia on chromosome 1 of the MES rats. Exp. Anim. 55, 497-500. (Pubitemid 44741726)
10. Steinberg, B. E., Grinstein, S. (2007) Unconventional Roles of the NADPH Oxidase: signaling, ion homeostasis, and cell death (Online). Sci. STKE, pe11.
11. Taylor, R. M., Burritt, J. B., Baniulis, D., Foubert, T. R., Lord, C. I., Dinauer, M. C., Parkos, C. A., Jesaitis, A. J. (2004) Site-specific inhibitors of NADPH oxidase activity and structural probes of flavocytochrome b: characterization of six monoclonal antibodies to the p22phox subunit. J. Immunol. 173, 7349-7357. (Pubitemid 39628173)
12. Hirokawa, T., Boon-Chieng, S., Mitaku, S. (1998) SOSUI: classification and secondary structure prediction system for membrane proteins. Bioinformatics 14, 378-379. (Pubitemid 28393805)
13. Nakano, Y., Longo-Guess, C. M., Bergstrom, D. E., Nauseef, W. M., Jones, S. M., Bánfi, B. (2008) Mutation of the Cyba gene encoding p22phox causes vestibular and immune defects in mice. J. Clin. Invest. 118, 1176-1185.
14. Jurkowska, M., Bernatowska, E., Bal, J. (2004) Genetic and biochemical background of chronic granulomatous disease. Arch. Immunol. Ther. Exp. (Warsz.) 52, 113-120 (Warsz). (Pubitemid 38685051)
15. Pollock, J. D., Williams, D. A., Gifford, M. A., Li, L. L., Du, X., Fisherman, J., Orkin, S. H., Doerschuk, C. M., Dinauer, M. C. (1995) Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production. Nat. Genet. 9, 202-209.
16. Jackson, S. H., Gallin, J. I., Holland, S. M. (1995) The p47phox mouse knock-out model of chronic granulomatous disease. J. Exp. Med. 182, 751-758.
17. Huang, C. K., Zhan, L., Hannigan, M. O., Ai, Y., Leto, T. L. (2000) p47(phox)-deficient NADPH oxidase defect in neutrophils of diabetic mouse strains, C57BL/6J-m db/db and db/+. J. Leukoc. Biol. 67, 210-215. (Pubitemid 30742790)
18. Roberts, R. L., Ohno, Y., Gallin, J. I. (1986) Staining of eosinophils with nitroblue tetrazolium in patients with chronic granulomatous disease. Pediatr. Res. 20, 378-380. (Pubitemid 16104452)
19. Schappi, M. G., Klein, N. J., Lindley, K. J., Rampling, D., Smith, V. V., Goldblatt, D., Milla, P. J. (2003) The nature of colitis in chronic granulomatous disease. J. Pediatr. Gastroenterol. Nutr. 36, 623-631. (Pubitemid 39274588)
20. Barese, C. N., Podesta, M., Litvak, E., Villa, M., Rivas, E. M. (2004) Recurrent eosinophilic cystitis in a child with chronic granulomatous disease. J. Pediatr. Hematol. Oncol. 26, 209-212. (Pubitemid 38314604)
21. Sharpe, M. A., Cooper, C. E. (1998) Reactions of nitric oxide with mitochondrial cytochrome c: a novel mechanism for the formation of nitroxyl anion and peroxynitrite. Biochem. J. 332, 9-19.
22. Kukreja, R. C., Hess, M. L. (1992) The oxygen free radical system: from equations through membrane-protein interactions to cardiovascular injury and protection. Cardiovasc. Res. 26, 641-655.
23. Pryor, W. A., Squadrito, G. L. (1995) The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide. Am. J. Physiol. 268, L699-L722.
24. Hogan, S. P., Rosenberg, H. F., Moqbel, R., Phipps, S., Foster, P. S., Lacy, P., Kay, A. B., Rothenberg, M. E. (2008) Eosinophils: biological properties and role in health and disease. Clin. Exp. Allergy 38, 709-750. (Pubitemid 351550670)
25. Yousefi, S., Gold, J. A., Andina, N., Lee, J. J., Kelly, A. M., Kozlowski, E., Schmid, I., Straumann, A., Reichenbach, J., Gleich, G. J., et al. (2008) Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense. Nat. Med. 14, 949-953.
26. Jackson, S. H., Devadas, S., Kwon, J., Pinto, L. A., Williams, M. S. (2004) T cells express a phagocyte-type NADPH oxidase that is activated after T cell receptor stimulation. Nat. Immunol. 5, 818-827. (Pubitemid 39172975)
27. Zhang, B., Hirahashi, J., Cullere, X., Mayadas, T. N. (2003) Elucidation of molecular events leading to neutrophil apoptosis following phagocytosis: cross-talk between caspase 8, reactive oxygen species, and MAPK/ERK activation. J. Biol. Chem. 278, 28443-28454. (Pubitemid 36935746)