NAG7 promotes human nasopharyngeal carcinoma invasion through inhibition of estrogen receptor alpha and up-regulation of JNK2/AP-1/MMP1 pathways

Journal of Cellular Physiology

Volumn 221, Issue 2, 2009, Pages 394-401

  Chen, Huang ^a   Minghua, Wu ^a   Yunlian, Tang ^a   Xiaoling, Li ^a   Jue, Ouyang ^a   Lan, Xiao ^a   Dan, Li ^a   Guiyuan, Li ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR NAG7; INTERSTITIAL COLLAGENASE; MITOGEN ACTIVATED PROTEIN KINASE 9; RAF PROTEIN; RAS PROTEIN; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; ESTRADIOL; HRAS PROTEIN, HUMAN; LOH3CR2A PROTEIN, HUMAN; MEMBRANE PROTEIN; PROTEIN KINASE INHIBITOR; PROTEIN P21; TUMOR SUPPRESSOR PROTEIN;

ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CANCER INVASION; CELL ADHESION; CELL MIGRATION; CONTROLLED STUDY; DNA FLANKING REGION; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NASOPHARYNX CARCINOMA; NONHUMAN; ONCOGENE H RAS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; REGULATOR GENE; SIGNAL TRANSDUCTION; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NASOPHARYNX TUMOR; PATHOLOGY; TUMOR CELL LINE; UPREGULATION;

ANIMALS; CELL CYCLE PROTEINS; CELL LINE, TUMOR; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MATRIX METALLOPROTEINASE 1; MEMBRANE PROTEINS; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 9; NASOPHARYNGEAL NEOPLASMS; NEOPLASM INVASIVENESS; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-RAF; PROTO-ONCOGENE PROTEINS P21(RAS); SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1; TUMOR SUPPRESSOR PROTEINS; UP-REGULATION;

EID: 70149083979     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.21867     Document Type: Article

References (31)

1. Aguirre-Ghiso JA, Ossowski L, Rosenbaum SK. 2004. Green fluorescent protein tagging of extracellular signal-regulated kinase and p38 pathways reveals novel dynamics of pathway activation during primary and metastatic growth. Cancer Res 64:7336-7345. (Pubitemid 39372072)
2. Campbell PM, Der CJ. 2004. Oncogenic Ras and its role in tumor cell invasion and metastasis. Semin Cancer Biol 14:105-114.
3. Clayton SJ, May FE, Westley BR. 1997. Insulin-like growth factors control the regulation of oestrogen and progesterone receptor expression by oestrogens. Mol Cell Endocrinol 128:57-68. (Pubitemid 27158131)
4. Davidson B, Konstantinovsky S, Kleinberg L, Nguyen MT, Bassarova A, Kvalheim G, Nesland JM, Reich R. 2006. The mitogen-activated protein kinases (MAPK) p38 and JNK are markers of tumor progression in breast carcinoma. Gynecol Oncol 102:453-461. (Pubitemid 44376656)
5. Fujita T, Kobayashi Y, Wada O, Tateishi Y, Kitada L, Yamamoto Y, Takashima H, Murayama A, Yano T, Baba T, Kato S, Kawabe Y, Yanagisawa J. 2003. Full activation of estrogen receptor alpha activation function-1 induces proliferation of breast cancer cells. J Biol Chem 278:26704-26714. (Pubitemid 36876816)
6. Garcia M, Derocq D, Freiss G, Rochefort H. 1992. Activation of estrogen receptor transfected into a receptor-negative breast cancer cell line decreases the metastatic and invasive potential of the cells. Proc Natl Acad Sci USA 89:11538-11542.
7. Gee JM, Barroso AF, Ellis IO, Robertson JF, Nicholson RI. 2000. Biological and clinical associations of c-jun activation in human breast cancer. Int J Cancer 89:177-186.
8. Glaser R, Zhang HY, Yao KT, Zhu HC, Wang FX, Li GY, Wen DS, Li YP. 1989. Two epithelial tumor cell lines (HNE-1 and HONE-1) latently infected with Epstein-Barr virus that were derived from nasopharyngeal carcinomas. Proc Natl Acad Sci USA 86:9524-9528. (Pubitemid 20010459)
9. Hofmann UB, Westphal JR, Van Muijen GN, Ruiter DJ. 2000. Matrix metalloproteinases in human melanoma. J Invest Dermatol 115:337-344.
10. Khatlani TS, Wislez M, Sun M, Srinivas H, Iwanaga K, Ma L, Hanna AE, Liu D, Girard L, Kim YH, Pollack JR, Minna JD, Wistuba II, Kurie JM. 2007. c-JunN-terminal kinase is activated in non-small-cell lung cancer and promotes neoplastic transformation in human bronchial epithelial cells. Oncogene 26:2658-2666. (Pubitemid 46632007)
11. Koochekpour S, Sartor O, Hiraiwa M, Lee TJ, Rayford W, Remmel N, Sandhoff K, Minokadeh A, Patten DY. 2005. Saposin C stimulates growth and invasion, activates p42/44 and SAPK/JNK signaling pathways of MAPK and upregulates uPA/uPAR expression in prostate cancer and stromal cells. Asian J Androl 7:147-158. (Pubitemid 41051420)
12. Krueger JS, Keshamouni VG, Atanaskova N, Reddy KB. 2001. Temporal and quantitative regulation of mitogen-activated protein kinase (MAPK) modulates cell motility and invasion. Oncogene 20:4209-4218. (Pubitemid 32762195)
13. Ma J, Liu L, Tang L, Zong J, Lin A, Lu T, Cui N, Cui C, Li L. 2007. Retropharyngeal lymph node metastasis in nasopharyngeal carcinoma: Prognostic value and staging categories. Clin Cancer Res 13:1445-1452. (Pubitemid 46450434)
14. Meng Q, Zhao Z, Yan M, Zhou L, Li J, Kitt C, Bin G, Fan S. 2004. ERR-10: A new repressor in transcriptional signaling activation of estrogen receptor-alpha. FEBS Lett 576:190-200. (Pubitemid 39330482)
15. Murray GI, Duncan ME, O'Neil P, Melvin WT, Fothergill JE. 1996. Matrix metalloproteinase-1 is associated with poor prognosis in colorectal cancer. Nat Med 2:461-462. (Pubitemid 26191919)
16. Murray GI, Duncan ME, O'Neil P, McKay JA, Melvin WT, Fothergill JE. 1998. Matrix metalloproteinase-1 is associated with poor prognosis in oesophageal cancer. J Pathol 185:256-261. (Pubitemid 28320046)
17. Nishimura S, Hirakawa-Chung KY, Yashiro M, Inoue T, Matsuoka T, Fujihara T, Murahashi K, Sawada T, Nakata B, Jikihara I, Takagi H, Sowa M. 1998. TGF-beta1 produced by gastric cancer cells affects mesothelial cell morphology in peritoneal dissemination. Int J Oncol 12:847-851. (Pubitemid 28133577)
18. Pinzone JJ, Stevenson H, Strobl JS, Berg PE. 2004. Molecular and cellular determinants of estrogen receptor alpha expression. Mol Cell Biol 24:4605-4612. (Pubitemid 38668029)
19. Platet N, Cunat S, Chalbos D, Rochefort H, Garcia M. 2000. Unliganded and liganded estrogen receptors protect against cancer invasion via different mechanisms. Mol Endocrinol (Baltimore, MD) 14:999-1009. (Pubitemid 32250517)
20. Platet N, Cathiard AM, Gleizes M, Garcia M. 2004. Estrogens and their receptors in breast cancer progression: A dual role in cancer proliferation and invasion. Crit Rev Oncol/Hematol 51:55-67. (Pubitemid 38781751)
21. Read LD, Greene GL, Katzenellenbogen BS. 1989. Regulation of estrogen receptor messenger ribonucleic acid and protein levels in human breast cancer cell lines by sex steroid hormones, their antagonists, and growth factors. Mol Endocrinol (Baltimore, MD) 3:295-304.
22. Shintani Y, Hollingsworth MA, Wheelock MJ, Johnson KR. 2006. Collagen I promotes metastasis in pancreatic cancer by activating c-Jun NH(2)-terminal kinase 1 and upregulating N-cadherin expression. Cancer Res 66:11745-11753. (Pubitemid 46094186)
23. Song RX, Zhang Z, Chen Y, Bao Y, Santen RJ. 2007. Estrogen signaling via a linear pathway involving insulin-like growth factor I receptor, matrix metalloproteinases, and epidermal growth factor receptor to activate mitogen-activated protein kinase in MCF-7 breast cancer cells. Endocrinology 148:4091-4101.
24. Sugioka Y, Watanabe T, Inagaki Y, Kushida M, Niioka M, Endo H, Higashiyama R, Okazaki I. 2004. c-Jun NH2-terminal kinase pathway is involved in constitutive matrix metalloproteinase-1 expression in a hepatocellular carcinoma-derived cell line. Int J Cancer 109:867-874. (Pubitemid 38500743)
25. Tan C, Li J, Xie Y, Xiang Q, Wang JR, Liang SP, Li GY. 2001. Preliminary function study of NAG7 using two-dimensional electrophoresis and mass spectrometry. Acta Biochim Biophys Sinica (Sheng wu hua xue yu sheng wu wu li xue bao) 33:373-378. (Pubitemid 33307641)
26. Tan C, Li J, Wang J, Xiang Q, Zhang X, Dong L, Shen S, Liang S, Li G. 2002a. Proteomic analysis of differential protein expression in human nasopharyngeal carcinoma cells induced by NAG7 transfection. Proteomics 2:306-312. (Pubitemid 34269984)
27. Tan C, Peng C, Huang YC, Zhang QH, Tang K, Li XL, Li GY. 2002b. Effects of NPC-associated gene NAG7 on cell cycle and apoptosis in nasopharyngeal carcinoma cells. Chin J Cancer (Ai zheng=Aizheng) 21:449-455.
28. Wang L, Ma J, Li J, Li X, Zhang Q, Peng S, Peng C, Zhou M, Xiong W, Yang J, Zhou J, Fan S, Tan C, Yan Q, Shen S, Li G. 2005. NGX6 gene inhibits cell proliferation and plays a negative role in EGFR pathway in nasopharyngeal carcinoma cells. J Cell Biochem 95:64-73. (Pubitemid 41420216)
29. Westley BR, May FE. 1988. Oestrogen regulates oestrogen receptor mRNA levels in an oestrogen-responsive human breast cancer cell line. Biochem Biophys Res Commun 155:1113-1118. (Pubitemid 18235311)
30. White MA, Nicolette C, Minden A, Polverino A, Van Aelst L, Karin M, Wigler MH. 1995. Multiple Ras functions can contribute to mammalian cell transformation. Cell 80:533-541.
31. Xie Y, Bin L, Yang J, Li Z, Yu Y, Zhang X, Cao L, Li G. 2001. Molecular cloning and characterization of NAG-7: A novel gene downregulated in human nasopharyngeal carcinoma. Chin Med J 114:530-534. (Pubitemid 33622038)