Highly Sensitive Troponins. The Answer or Just More Questions?

Journal of the American College of Cardiology

Volumn 54, Issue 13, 2009, Pages 1173-1175

  Hollander, Judd E ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

myocardial infarction; troponin I; unstable angina

Indexed keywords

BIOLOGICAL MARKER; CREATINE KINASE MB; TROPONIN;

ACUTE CORONARY SYNDROME; DIAGNOSTIC ACCURACY; EDITORIAL; EMERGENCY WARD; HEART INFARCTION; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; UNSTABLE ANGINA PECTORIS;

ACUTE CORONARY SYNDROME; BIOLOGICAL MARKERS; EMERGENCY SERVICE, HOSPITAL; HUMANS; MYOCARDIAL INFARCTION; RISK ASSESSMENT; TROPONIN I;

EID: 70049115580     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jacc.2009.05.052     Document Type: Editorial

References (20)

1. Institute of Medicine. Hospital-Based Emergency Care: At the Breaking Point. 2006. http://www.nap.edu/catalog/11621.html#toc Accessed May 12, 2009
2. Pitts S.R., Niska R.W., Xu J., and Burt C.W. National Hospital Ambulatory Medical Care Survey: 2006 emergency department summary. National Health Statistics Reports; No. 7 (2008), National Center for Health Statistics, Hyattsville, MD
3. Bayley M.D., Schwartz J.S., Shofer F.S., et al. The financial burden of emergency department congestion and hospital crowding for chest pain patients awaiting admission. Ann Emerg Med 45 (2005) 110-117
4. Pope J.H., Aufderheide T.P., Ruthazer R., et al. Missed diagnosis of acute cardiac ischemia in the emergency department. N Engl J Med 342 (2000) 1163-1170
5. Chalfin D.B., Trzeciak S., Likourezos A., et al. Impact of delayed transfer of critically ill patients from the emergency department to the intensive care unit. Crit Care Med 35 (2007) 1477-1483
6. Carr B.G., Kaye A.J., Wiebe D.J., et al. Emergency department length of stay: a major risk factor for pneumonia in intubated blunt trauma patients. J Trauma 63 (2007) 9-12
7. Pines J.M., Pollack Jr. C.V., Diercks D.B., Chang A.M., Shofer F.S., and Hollander J.E. The association between emergency department crowding and adverse cardiovascular outcomes in patients with chest pain. Acad Emerg Med (2009 Jun 22) [E-pub ahead of print]
8. Hollander J.E., and Pines J.M. The emergency department crowding paradox: the longer you stay, the less care you get. Ann Emerg Med 50 (2007) 497-499
9. Selker H.P., Zalenski R.J., Antman E.M., et al. An evaluation of technologies for identification of acute cardiac ischemia in the emergency department: a report form a National Heart Attack Alert Program Working Group. Ann Emerg Med 29 (1997) 13-87
10. Antman E.M., Cohen M., Bernink P.J., et al. The TIMI risk score for unstable angina/non-ST elevation MI: a method for prognostication and therapeutic decision making. JAMA 284 (2000) 835-842
11. Chase M., Robey J.L., Zogby K.E., Sease K.L., Shofer F.S., and Hollander J.E. Prospective validation of the TIMI risk score in the emergency department chest pain patient population. Ann Emerg Med 48 (2006) 252-259
12. McCord J., Nowak R.M., McCullough P.A., et al. Ninety-minute exclusion of acute myocardial infarction by use of quantitative point-of-care testing of myoglobin and troponin I. Circulation 104 (2001) 1483-1488
13. Newby L.K., Storrow A.B., Gibler W.B., et al. Bedside multimarker testing for risk stratification in chest pain units: the chest pain evaluation by creatine kinase-MB, myoglobin, and troponin I (CHECKMATE) study. Circulation 103 (2001) 1832-1837
14. Kontos M.C., Anderson F.P., Hanbury C.M., et al. Use of the combination of myoglobin and CKMB mass for the rapid diagnosis of acute myocardial infarction. Am J Emerg Med 15 (1997) 14-19
15. Hollander J.E., Muttreja M.R., Dalesandro M.R., and Shofer F.S. Risk stratification of ED patients with acute coronary syndromes using P-selectin. J Am Coll Cardiol 34 (1999) 95-105
16. Brown A.M., Sease K.L., Robey J.L., Shofer F.S., and Hollander J.E. The impact of BNP in addition to troponin I, CK-MB, and myoglobin on the risk stratification of ED chest pain patients with potential ACS. Ann Emerg Med 49 (2007) 153-163
17. Green G.B., Beaudreau R.W., Chan D.W., DeLong D., Kelley C.A., and Kelen G.D. Use of troponin T and creatine kinase MB subunit levels for risk stratification of emergency department patients with possible myocardial ischemia. Ann Emerg Med 31 (1998) 19-29
18. Venge P., Johnston N., Lindahl B., and James S. Normal plasma levels of cardiac troponin I measured by the high-sensitivity cardiac troponin I access prototype assay and the impact on the diagnosis of myocardial ischemia. J Am Coll Cardiol 54 (2009) 1165-1172
19. Wilson S.R., Sabatine M.S., Braunwald E., Sloan S., Murphy S.A., and Morrow D.A. Detection of myocardial injury in patients with unstable angina using a novel nanoparticle cardiac troponin I assay: observations from the PROTECT-TIMI 30 trial. Am Heart J 158 (2009) 386-391
20. Apple F.S., Murakami M.A., Hollander J.E., and Shipp G.W. Preliminary performance of a high sensitive gold nanoparticle-based cardiac troponin I assay: proof of concept study of the Nanosphere Verigene System (letter). Clin Chem (2009) In press