Innate and adaptive immune responses to ocular Acanthamoeba infections

Expert Review of Ophthalmology

Volumn 3, Issue 6, 2008, Pages 665-672

  Niederkorn, Jerry Y ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Acanthamoeba keratitis; Conjunctival macrophage; Contact lens; IgA antibodies; Neutrophil; T cell

Indexed keywords

CORTICOSTEROID; IMMUNOGLOBULIN A ANTIBODY; PARASITE ANTIGEN;

ACANTHAMOEBA KERATITIS; ADAPTIVE IMMUNITY; COMPLEMENT SYSTEM; CORNEA EPITHELIUM; CORNEA TRANSPLANTATION; CYTOLYSIS; CYTOPATHOGENIC EFFECT; CYTOTOXIC T LYMPHOCYTE; DELAYED HYPERSENSITIVITY; GRAFT REJECTION; HOST RESISTANCE; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; INNATE IMMUNITY; LACRIMAL FLUID; MACROPHAGE; MUCOSAL IMMUNITY; NEUTROPHIL; NONHUMAN; PARASITE TRANSMISSION; REVIEW; SOFT CONTACT LENS; TROPHOZOITE;

EID: 70049089831     PISSN: 17469899     EISSN: 17469902     Source Type: Journal    
DOI: 10.1586/17469899.3.6.665     Document Type: Review

References (79)

1. Alizadeh H, Niederkorn JY, McCulley JP. Acanthamoebic keratitis. In: Ocular Infection and Immunity. Pepose J, Holland GN, Wilhelmus KR (Eds). Mosby, MO, USA, 1062-1071 (1996).
2. Alizadeh H, Niederkorn JY, McCulley JP. Acanthamoeba keratitis. In: Cornea. Krachmer JH, Mannis MJ, Holland EJ (Eds). Elsevier, Amsterdam, The Netherlands, 1115-1122 (2005).
3. Clarke DW, Alizadeh H, Niederkorn JY. Intracorneal instillation of latex beads induces macrophage-dependent protection against Acanthamoeba keratitis. Invest. Ophthalmol. Vis. Sci. 47(11), 4917-4925 (2006).
4. Clarke DW, Niederkorn JY. The pathophysiology of Acanthamoeba keratitis. Trends Parasitol. 22(4), 175-180 (2006).
5. Weisman RA. Differentiation in Acanthamoeba castellanii. Annu. Rev. Microbiol. 30, 189-219 (1976).
6. Aksozek A, McClellan K, Howard K, Niederkorn JY, Alizadeh H. Resistance of Acanthamoeba castellanii cysts to physical, chemical, and radiological conditions. J. Parasitol. 88(3), 621-623 (2002).
7. Mazur T, Hadas E, Iwanicka I. The duration of the cyst stage and the viability and virulence of Acanthamoeba isolates. Trop. Med. Parasitol. 46(2), 106-108 (1995).
8. Radford CF, Minassian DC, Dart JK. Acanthamoeba keratitis in England and Wales: incidence, outcome, and risk factors. Br. J. Ophthalmol. 86(5), 536-542 (2002).
9. Stehr-Green JK, Bailey TM, Visvesvara GS. The epidemiology of Acanthamoeba keratitis in the United States. Am. J. Ophthalmol. 107(4), 331-336 (1989).
10. John T, Desai D, Sahm D. Adherence of Acanthamoeba castellanii to new daily wear, extended wear, and disposable soft contact lenses. CLAO J. 17(2), 109-113 (1991).
11. Sharma S, Ramachandran L, Rao GN. Adherence of cysts and trophozoites of Acanthamoeba to unworn rigid gas permeable and soft contact lenses. CLAO J. 21(4), 247-251 (1995).
12. Yang YF, Matheson M, Dart JK, Cree IA. Persistence of Acanthamoeba antigen following Acanthamoeba keratitis. Br. J. Ophthalmol. 85(3), 277-280 (2001).
13. Acharya NR, Lietman TM, Margolis TP. Parasites on the rise: a new epidemic of Acanthamoeba keratitis. Am. J. Ophthalmol. 144(2), 292-293 (2007).
14. Cavanagh HD. Acanthamoeba keratitis: 2007: a train wreck in slow motion. Eye Contact Lens 33(5), 209 (2007).
15. Schaumberg DA, Snow KK, Dana MR. The epidemic of Acanthamoeba keratitis: where do we stand? Cornea 17(1), 3-10 (1998).
16. Centers for Disease Control and Prevention (CDC). Acanthamoeba keratitis multiple states, 2005-2007. MMWR Morb. Mortal. Wkly Rep. 56, 532-534 (2007).
17. Joslin CE, Tu EY, McMahon TT et al. Epidemiological characteristics of a Chicago-area Acanthamoeba keratitis outbreak. Am. J. Ophthalmol. 142(2), 212-217 (2006).
18. Huws SA, McBain AJ, Gilbert P. Protozoan grazing and its impact upon population dynamics in biofilm communities. J. Appl. Microbiol. 98(1), 238-244 (2005).
19. LeChevallier MW, Babcock TM, Lee RG. Examination and characterization of distribution system biofilms. Appl. Environ. Microbiol. 53(12), 2714-2724 (1987).
20. Winiecka-Krusnell J, Linder E. Bacterial infections of free-living amoebae. Res. Microbiol. 152(7), 613-619 (2001).
21. Dorsch MM, Cameron AS, Robinson BS. The epidemiology and control of primary amoebic meningoencephalitis with particular reference to South Australia. Trans. R. Soc. Trop. Med. Hyg. 77(3), 372-377 (1983).
22. Kilvington S, Heaselgrave W, Lally JM, Ambrus K, Powell H. Encystment of Acanthamoeba during incubation in multipurpose contact lens disinfectant solutions and experimental formulations. Eye Contact Lens 34(3), 133-139 (2008).
23. Alizadeh H, Apte S, El-Agha et al. Tear IgA and serum IgG antibodies against Acanthmaoeba in patients with Acanthamoeba keratitis. Cornea 20(6), 622-627 (2001).
24. Cerva L. Acanthamoeba culbertsoni and Naegleria fowleri: occurrence of antibodies in man. J. Hyg. Epidemiol. Microbiol. Immunol. 33(1), 99-103 (1989).
25. Cursons RT, Brown TJ, Keys EA, Moriarty KM, Till D. Immunity to pathogenic free-living amoebae: role of humoral antibody. Infect. Immun. 29(2), 401-407 (1980).
26. Tanaka Y, Suguri S, Harada M et al. Acanthamoeba-specific human T-cell clones isolated from healthy individuals. Parasitol. Res. 80(7), 549-553 (1994).
27. He YG, McCulley JP, Alizadeh H et al. A pig model of Acanthamoeba keratitis: transmission via contaminated contact lenses. Invest. Ophthalmol. Vis. Sci. 33(1), 126-133 (1992).
28. van Klink F, Alizadeh H, He Y et al. The role of contact lenses, trauma, and Langerhans cells in a Chinese hamster model of Acanthamoeba keratitis. Invest. Ophthalmol. Vis. Sci. 34(6), 1937-1944 (1993).
29. Badenoch PR, Johnson AM, Christy PE, Coster DJ. Pathogenicity of Acanthamoeba and a Corynebacterium in the rat cornea. Arch. Ophthalmol. 108(1), 107-112 (1990).
30. Larkin DF, Easty DL. Experimental Acanthamoeba keratitis: II. Immunohistochemical evaluation. Br. J. Ophthalmol. 75(7), 421-424 (1991).
31. Said NA, Shoeir AT, Panjwani N, Garate M, Cao Z. Local and systemic humoral immune response during acute and chronic Acanthamoeba keratitis in rabbits. Curr. Eye Res. 29(6), 429-439 (2004).
32. Cao Z, Saravanan C, Goldstein MH et al. Effect of human tears on Acanthamoeba-induced cytopathic effect. Arch. Ophthalmol. 126(3), 348-352 (2008).
33. Saravanan C, Cao Z, Kumar J et al. Milk components inhibit Acanthamoeba-induced cytopathic effect. Invest. Ophthalmol. Vis. Sci. 49(3), 1010-1015 (2008).
34. Crouch AA, Seow WK, Whitman LM, Thong YH. Effect of human milk and infant milk formulae on adherence of Giardia intestinalis. Trans. R. Soc. Trop. Med. Hyg. 85(5), 617-619 (1991).
35. Alizadeh H, Neelam S, Niederkorn JY. Role of activated macrophages in Acanthamoeba keratitis. J. Parasitol. 93(5), 1114-1120 (2007).
36. Marciano-Cabral F, Toney DM. The interaction of Acanthamoeba spp. with activated macrophages and with macrophage cell lines. J. Eukaryot. Microbiol. 45(4), 452-458 (1998).
37. Stewart GL, Kim I, Shupe K et al. Chemotactic response of macrophages to Acanthamoeba castellanii antigen and antibody-dependent macrophage-mediated killing of the parasite. J. Parasitol. 78(5), 849-855 (1992).
38. Hurt M, Proy V, Niederkorn JY, Alizadeh H. The interaction of Acanthamoeba castellanii cysts with macrophages and neutrophils. J. Parasitol. 89(3), 565-572 (2003).
39. van Klink F, Taylor WM, Alizadeh H et al. The role of macrophages in Acanthamoeba keratitis. Invest. Ophthalmol. Vis. Sci. 37(7), 1271-1281 (1996).
40. Ferrante A, Staugas RE, Rowan-Kelly B et al. Production of tumor necrosis factors α and β by human mononuclear leukocytes stimulated with mitogens, bacteria, and malarial parasites. Infect. Immun. 58(12), 3996-4003 (1990).
41. Hurt M, Apte S, Leher H et al. Exacerbation of Acanthamoeba keratitis in animals treated with anti-macrophage inflammatory protein 2 or antineutrophil antibodies. Infect. Immun. 69(5), 2988-2995 (2001).
42. Mathers W, Stevens G Jr, Rodrigues M et al. Immunopathology and electron microscopy of Acanthamoeba keratitis. Am. J. Ophthalmol. 103(5), 626-635 (1987).
43. Ferrante A, Abell TJ. Conditioned medium from stimulated mononuclear leukocytes augments human neutrophil-mediated killing of a virulent Acanthamoeba sp. Infect. Immun. 51(2), 607-617 (1986).
44. Stewart GL, Shupe K, Kim I et al. Antibody-dependent neutrophil-mediated killing of Acanthamoeba castellanii. Int. J. Parasitol. 24(5), 739-742 (1994).
45. Awwad ST, Heilman M, Hogan RN et al. Severe reactive ischemic posterior segment inflammation in Acanthamoeba keratitis: a new potentially blinding syndrome. Ophthalmology 114(2), 313-320 (2007).
46. Burke JP, Webber SK, Kerr-Muir MG, Talbot JF, Parsons MA. Acanthamoeba polyphaga panophthalmitis. Cornea 11(3), 274-275 (1992).
47. Moshari A, McLean IW, Dodds MT, Damiano RE, McEvoy PL. Chorioretinitis after keratitis caused by Acanthamoeba: case report and review of the literature. Ophthalmology 108(12), 2232-2236 (2001).
48. Clarke DW, Alizadeh H, Niederkorn J Y. Failure of Acanthamoeba castellanii to produce intraocular infections. Invest. Ophthalmol. Vis. Sci. 46(7), 2472-2478 (2005).
49. Ferrante A, Rowan-Kelly B. Activation of the alternative pathway of complement by Acanthamoeba culbertsoni. Clin. Exp. Immunol. 54(2), 477-485 (1983).
50. Toney DM, Marciano-Cabral F. Resistance of Acanthamoeba species to complement lysis. J. Parasitol. 84(2), 338-344 (1998).
51. Lass JH, Walter EI, Burris TE et al. Expression of two molecular forms of the complement decay-accelerating factor in the eye and lacrimal gland. Invest. Ophthalmol. Vis. Sci. 31(6), 1136-1148 (1990).
52. Willcox MD, Morris CA, Thakur A et al. Complement and complement regulatory proteins in human tears. Invest. Ophthalmol. Vis. Sci. 38(1), 1-8 (1997).
53. McClellan K, Howard K, Mayhew E, Niederkorn J, Alizadeh H. Adaptive immune responses to Acanthamoeba cysts. Exp. Eye Res. 75(3), 285-293 (2002).
54. Niederkorn J, Alizadeh H, Taylor W et al. Oral immunization induces protective immunity against Acanthamoeba keratitis. In: Advances in Ocular Immunology. Nussenblatt R, Whitcup SM, Caspi RR, Gery I (Eds). Elsevier, Amsterdam, The Netherlands, 281-284 (1994).
55. Van Klink F, Leher H, Jager MJ et al. Systemic immune response to Acanthamoeba keratitis in the Chinese hamster. Ocul. Immunol. Inflamm. 5(4), 235-244 (1997).
56. Alizadeh H, He Y, McCulley JP et al. Successful immunization against Acanthamoeba keratitis in a pig model. Cornea 14(2), 180-186 (1995).
57. McClellan K, Howard K, Niederkorn JY, Alizadeh H. Effect of steroids on Acanthamoeba cysts and trophozoites. Invest. Ophthalmol. Vis. Sci. 42(12), 2885-2893 (2001).
58. Leher H, Kinoshita K, Alizadeh H et al. Impact of oral immunization with Acanthamoeba antigens on parasite adhesion and corneal infection. Invest. Ophthalmol. Vis. Sci. 39(12), 2337-2343 (1998).
59. Garate M, Cao Z, Bateman E, Panjwani N. Cloning and characterization of a novel mannose-binding protein of Acanthamoeba. J. Biol. Chem. 279(28), 29849-29856 (2004).
60. Alizadeh H, Neelam S, Hurt M, Niederkorn JY. Role of contact lens wear, bacterial flora, and mannose-induced pathogenic protease in the pathogenesis of amoebic keratitis. Infect. Immun. 73(2), 1061-1068 (2005).
61. Fullard RJ, Snyder C. Protein levels in nonstimulated and stimulated tears of normal human subjects. Invest. Ophthalmol. Vis. Sci. 31(6), 1119-1126 (1990).
62. Mestecky J. The common mucosal immune system and current strategies for induction of immune responses in external secretions. J. Clin. Immunol. 7(4), 265-276 (1987).
63. Mestecky J, McGhee JR. Immunoglobulin A (IgA): molecular and cellular interactions involved in IgA biosynthesis and immune response. Adv. Immunol. 40, 153-245 (1987).
64. Mestecky J, Russell MW, Jackson S, Brown TA. The human IgA system: a reassessment. Clin. Immunol. Immunopathol. 40(1), 105-114 (1986).
65. Peppard JV, Montgomery PC. Studies on the origin and composition of IgA in rat tears. Immunology 62(2), 193-198 (1987).
66. Sullivan DA. Immunology of the lacrimal gland and tear film. Dev. Ophthalmol. 30, 39-53 (1999).
67. Walochnik J, Obwaller A, Haller-Schober EM, Aspock H. Anti- Acanthamoeba IgG, IgM, and IgA immunoreactivities in correlation to strain pathogenicity. Parasitol. Res. 87(8), 651-656 (2001).
68. Alsam S, Jeong SR, Dudley R, Khan NA. Role of human tear fluid in Acanthamoeba interactions with the human corneal epithelial cells. Int. J. Med. Microbiol. 298(3-4), 329-336 (2008).
69. Alizadeh H, Neelam S, Niederkorn JY. Effect of immunization with the mannose-induced Acanthamoeba protein and Acanthamoeba plasminogen activator in mitigating Acanthamoeba keratitis. Invest. Ophthalmol. Vis. Sci. 48(12), 5597-5604 (2007).
70. Leher H, Zaragoza F, Taherzadeh S, Alizadeh H, Niederkorn JY. Monoclonal IgA antibodies protect against Acanthamoeba keratitis. Exp. Eye Res. 69(1), 75-84 (1999).
71. Leher HF, Alizadeh H, Taylor WM et al. Role of mucosal IgA in the resistance to Acanthamoeba keratitis. Invest. Ophthalmol. Vis. Sci. 39(13), 2666-2673 (1998).
72. Alizadeh H, He Y, McCulley JP et al. Successful immunization against Acanthamoeba keratitis in a pig model. Cornea 14(2), 180-186 (1995).
73. Hurt M, Neelam S, Niederkorn J, Alizadeh H. Pathogenic Acanthamoeba spp secrete a mannose-induced cytolytic protein that correlates with the ability to cause disease. Infect. Immun. 71(11), 6243-6255 (2003).
74. Hurt M, Niederkorn J, Alizadeh H. Effects of mannose on Acanthamoeba castellanii proliferation and cytolytic ability to corneal epithelial cells. Invest. Ophthalmol. Vis. Sci. 44(8), 3424-3431 (2003).
75. Leher H, Silvany R, Alizadeh H, Huang J, Niederkorn JY. Mannose induces the release of cytopathic factors from Acanthamoeba castellanii. Infect. Immun. 66(1), 5-10 (1998).
76. Garate M, Alizadeh H, Neelam S, Niederkorn JY, Panjwani N. Oral immunization with Acanthamoeba mannose-binding protein ameliorates amoebic keratitis. Infect. Immun. 74(12), 7032-7034 (2006).
77. Niederkorn JY, Alizadeh H, Leher HF, McCulley JP. The immunobiology of Acanthamoeba keratitis. Springer Semin. Immunopathol. 21(2), 147-160 (1999).
78. Kong HH, Kim TH, Chung DI. Purification and characterization of a secretory serine proteinase of Acanthamoeba healyi isolated from GAE. J. Parasitol. 86(1), 12-17 (2000).
79. Turner ML, Cockerell EJ, Brereton HM et al. Antigens of selected Acanthamoeba species detected with monoclonal antibodies. Int. J. Parasitol. 35(9), 981-990 (2005).