Cloning, expression and the application of human, rat alcohol dehydrogenase and aldo-keto reductase

Yaoxue Xuebao

Volumn 44, Issue 7, 2009, Pages 778-784

  Gao, Ling Bo ^a   Wang, Jin Zhao ^a,b   Zeng, Su ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b Zhejiang Huahai Pharmaceutical Co Ltd   (China)

Author keywords

Alcohol dehydrogenase; Aldo keto reductase; Chiral inversion; Enantioselective metabolism; Mandelic acid

Indexed keywords

ALCOHOL DEHYDROGENASE; ALDO KETO REDUCTASE; ENZYME; MANDELIC ACID; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

AFFINITY CHROMATOGRAPHY; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENANTIOSELECTIVITY; ENZYME ACTIVITY; ENZYME METABOLISM; ESCHERICHIA COLI; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; LIVER; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEREOCHEMISTRY; WESTERN BLOTTING;

ALCOHOL DEHYDROGENASE; ALCOHOL OXIDOREDUCTASES; ANIMALS; CLONING, MOLECULAR; HUMANS; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RECOMBINANT PROTEINS; RNA, MESSENGER;

EID: 70049087327     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Tsukahara M, Yoshida A. Chromosomal assignment of the alcohol dehydrogenase cluster locus to human chromosome 4q21-23 by in situ hybridization [J]. Genomics, 1989, 4: 218-220.
2. Edenberg HJ. Regulation of the mammalian alcohol dehydrogenase genes [J]. Prog Nucleic Acid Res Mol Biol, 2000, 64: 295-341.
3. Smith M, Hopkinson DA, Harris H. Alcohol dehydrogenase isozymes in adult human stomach and liver: evidence for activity of the ADH 3 locus [J]. Ann Hum Genet, 1972, 35: 243-253.
4. Badger TM, Hoog JO, Svensson S, et al. Cyclic expression of class I alcohol dehydrogenase in male rats treated with ethanol [J]. Biochem Biophys Res Commun, 2000, 274: 684-688. (Pubitemid 30663679)
5. Nisha TP, Michael EB, Ronald GH, et al. The ubiquitous aldehyde reductase (AKR1A1) oxidizes proximate carcinogen trans-dihydrodiols to o-quinones: potential role in polycyclic aromatic hydrocarbon activation [J]. Biochemistry, 2001, 40: 10901-10910.
6. Manini P, Andreoli R, Poli D, et al. Liquid chromatography/electrospray tandem mass spectrometry characterization of styrene metabolism in man and in rat [J]. Rapid Commun Mass, 2002, 16: 2239-2248. (Pubitemid 36018727)
7. Wang JZ, Wang XJ, Tang YH, et al. Simultaneous determination of mandelic acid enantiomers and phenylglyoxylic acid in urine by high-performance liquid chromatography with precolumn derivatization [J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2006, 840: 50-55. (Pubitemid 44108801)
8. Drummond L, Caldwell J, Wilson HK. The stereoselectivity of 1,2-phenylethanediol and mandelic acid metabolism and disposition in the rat [J]. Xenobiotica, 1990, 20: 159-168. (Pubitemid 20044710)
9. Wang JZ. Study on the Stereoselective Metabolism of Styrene in SD Rat [D]. Hangzhou: Zhejiang University, 2006.
10. Wang JZ, Fan M. Handbook of Protein Technique (H ÙJtft Ê∅Ì) [M]. Beijing: Science Press, 2002: 77-100.
11. Lowry OH, Rosebrough NJ, Farr AL. Protein measurement with the Folin phenol reagent [J]. J Biol Chem, 1951, 193: 2651.
12. Hellgren M, Strömberg P, Gallego O, et al. Alcohol dehydrogenase 2 is a major hepatic enzyme for human retinol metabolism [J]. Cell Mol Life Sci, 2007, 64: 498-505. (Pubitemid 46318933)
13. Julià P, Farrés J, Parés X. Characterization of three isoenzymes of rat alcohol dehydrogenase. Tissue distribution and physical and enzymatic properties [J]. Eur J Biochem, 1987, 162: 179-189. (Pubitemid 17009463)
14. Laffon B, Lema M, Méndez J. Simultaneous high-performance liquid chromatographic determination of urinary mandelic and phenylglyoxylic acids as indirect evaluation of styrene exposure [J]. J Chromatogr B, 2001, 753: 385-393. (Pubitemid 32217740)
15. Zhang K, Tang C, Rashed M, et al. Metabolic chiral inversion of stiripentol in the rat. I. Mechanistic studies [J]. Drug Metab Dispos, 1994, 22: 544-553.
16. Reist M, Carrupt PA, Francotte E, et al. Chiral inversion and hydrolysis of thalidomide: mechanisms and catalysis by bases and serum albumin, and chiral stability of teratogenic metabolites [J]. Chem Res Toxicol, 1998, 11: 1521-1528. (Pubitemid 29013628)
17. Wsol V, Skalova L, Szotakova B. Chiral inversion of drugs, Coincidence or principle? [J]. Curr Drug Metab, 2004, 5: 517-533.