Ascites improves upon plus serum sodium model for end-stage liver disease (MELD) for predicting mortality in patients with advanced liver disease

Alimentary Pharmacology and Therapeutics

Volumn 30, Issue 7, 2009, Pages 741-748

  Somsouk, M ^a,b   Guy, J ^a,b   Biggins, S W ^a,c   Vittinghoff, E ^c   Kohn, M A ^c   Inadomi, J M ^a,b  

^a SAN FRANCISCO GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SODIUM;

ADULT; AGED; ARTICLE; ASCITES; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; FEMALE; FOLLOW UP; HUMAN; LIVER CIRRHOSIS; LIVER FAILURE; MAJOR CLINICAL STUDY; MALE; MORTALITY; PREDICTION; PRIORITY JOURNAL; RISK ASSESSMENT; SODIUM BLOOD LEVEL;

ASCITES; CHRONIC DISEASE; EPIDEMIOLOGIC METHODS; FEMALE; HUMANS; LIVER CIRRHOSIS; LIVER FAILURE; MALE; PROGNOSIS; SODIUM;

EID: 69949186234     PISSN: 02692813     EISSN: 13652036     Source Type: Journal    
DOI: 10.1111/j.1365-2036.2009.04096.x     Document Type: Article

References (18)

1. D'Amico G, Morabito A, Pagliaro L, et al. Survival and prognostic indicators in compensated and decompensated cirrhosis. Dig Dis Sci 1986 31 : 468 475.
2. Child CG, Turcotte JG. Surgery and portal hypertension. Major Probl Clin Surg 1964 1 : 1 85.
3. Pugh RN, Murray-Lyon IM, Dawson JL, et al. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 1973 60 : 646 649.
4. Kamath PS, Wiesner RH, Malinchoc M, et al. A model to predict survival in patients with end-stage liver disease. Hepatology 2001 33 : 464 470.
5. Wiesner R, Edwards E, Freeman R, et al. Model for end-stage liver disease (MELD) and allocation of donor livers. Gastroenterology 2003 124 : 91 6.
6. Heuman DM, Abou-Assi SG, Habib A, et al. Persistent ascites and low serum sodium identify patients with cirrhosis and low MELD scores who are at high risk for early death. Hepatology 2004 40 : 802 810.
7. Heuman DM, Mihas A. Utility of the MELD score for assessing 3-month survival in patients with liver cirrhosis: one more positive answer. Gastroenterology 2003 125 : 992 993. author reply 994-5.
8. Saab S, Landaverde C, Ibrahim AB, et al. The MELD score in advanced liver disease: association with clinical portal hypertension and mortality. Exp Clin Transplant 2006 4 : 395 399.
9. Biggins SW, Kim WR, Terrault NA, et al. Evidence-based incorporation of serum sodium concentration into MELD. Gastroenterology 2006 130 : 1652 1660.
10. Biggins SW, Rodriguez HJ, Bacchetti P, et al. Serum sodium predicts mortality in patients listed for liver transplantation. Hepatology 2005 41 : 32 9.
11. Kim WR, Biggins SW, Kremers WK, et al. Hyponatremia and mortality among patients on the liver-transplant waiting list. N Engl J Med 2008 359 : 1018 1026.
12. Ruf AE, Kremers WK, Chavez LL, et al. Addition of serum sodium into the MELD score predicts waiting list mortality better than MELD alone. Liver Transpl 2005 11 : 336 343.
13. Harrell FE Jr., Lee KL, Mark DB. Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. Stat Med 1996 15 : 361 387.
14. Pencina MJ, D'Agostino RB Sr., D'Agostino RB Jr., et al. Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Stat Med 2008 27 : 157 172. discussion 207-12.
15. Ware JH. The limitations of risk factors as prognostic tools. N Engl J Med 2006 355 : 2615 2617.
16. Wang TJ, Gona P, Larson MG, et al. Multiple biomarkers for the prediction of first major cardiovascular events and death. N Engl J Med 2006 355 : 2631 2639.
17. Asbert M, Gines A, Gines P, et al. Circulating levels of endothelin in cirrhosis. Gastroenterology 1993 104 : 1485 1491.
18. Altman DG, Royston P. What do we mean by validating a prognostic model? Stat Med 2000 19 : 453 473.