A functional antagonism between the pgc germline repressor and torso in the development of somatic cells

EMBO Reports

Volumn 10, Issue 9, 2009, Pages 1059-1065

  de las Heras, José Manuel ^a,b   Martinho, Rui Gonçalo ^c,d,e   Lehmann, Ruth ^c,d   Casanova, Jordi ^a,b  

^a INSTITUT DE BIOLOGIA MOLECULAR DE BARCELONA   (Spain)

^b INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Spain)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e INSTITUTO GULBENKIAN DE CIÊNCIA   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE PROTEIN; POLAR GRANULE COMPONENT; TORSO RECEPTOR TYROSINE KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; GERM LINE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SOMATIC CELL; TRANSCRIPTION REGULATION;

ANIMALS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MUTATION; PHENOTYPE; POSITIVE TRANSCRIPTIONAL ELONGATION FACTOR B; RECEPTOR PROTEIN-TYROSINE KINASES; TRANSCRIPTION, GENETIC;

EID: 69949181171     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/embor.2009.128     Document Type: Article

References (23)

1. Astigarraga S, Grossman R, Díaz-Delfín J, Caelles C, Paroush Z, Jiménez G (2007) A MAPK docking site is critical for downregulation of Capicua by Torso and EGFR RTK signaling. EMBO J 26: 668-677
2. Brönner G, Jäckle H (1991) Control and function of terminal gap gene activity in the posterior pole region of the Drosophila embryo. Mech Dev 35: 205-211
3. Cinalli RM, Rangan P, Lehmann R (2008) Germ cells are forever. Cell 132: 559-562
4. Cinnamon E, Helman A, Ben-Haroush Schyr R, Orian A, Jiménez G, Paroush Z (2008) Multiple RTK pathways downregulate Groucho-mediated repression in Drosophila embryogenesis. Development 135 829-837
5. Degelmann A, Hardy PA, Perrimon N, Mahowald AP (1986) Developmental analysis of the torso-like phenotype in Drosophila produced by a maternal-effect locus. Dev Biol 115: 479-489
6. Deshpande G, Calhoun G, Schedl P (2004) Overlapping mechanisms function to establish transcriptional quiescence in the embryonic Drosophila germline. Development 131: 1247-1257
7. Foe VE, Odell GM, Edgar BA (1993), In The Development of Drosophila melanogaster, Bate M, Arias AM (eds). Vol 1, pp 149-300. Plainview, NY, USA: Cold Spring Harbor Press
8. Furriols M, Casanova J (2003) In and out of Torso RTK signaling. EMBO J 22: 1947-1952
9. Hanyu-Nakamura K, Sonobe-Nojima H, Tanigawa A, Lasko P, Nakamura A (2008) Drosophila Pgc protein inhibits P-TEFb recruitment to chromatin in primordial germ cells. Nature 451: 730-733
10. Jiménez G, Guichet A, Ephrussi A, Casanova J (2000) Relief of gene repression by torso RTK signaling: Role of capicua in Drosophila terminal and dorsoventral patterning. Genes Dev 14: 224-231
11. Lasko P (1992) Molecular movements in oocyte patterning and pole cell differentiation. Bioessays 14: 507-512
12. Lecuit T, Wieschaus E (2000) Polarized insertion of new membrane from a cytoplasmic reservoir during cleavage of the Drosophila embryo. J Cell Biol 150: 849-860
13. Li J, Xia F, Li WX (2003) Coactivation of STAT and Ras is required for germ cell proliferation and invasive migration in Drosophila. Dev Cell 5: 787-798
14. Martinho RG, Kunwar PS, Casanova J, Lehmann R (2004) A noncoding RNA is required for the repression of RNApollI-dependent transcription in primordial germ cells. Curr Biol 14: 159-165
15. Pignoni F, Baldarelli RM, Steingrímsson E, Diaz RJ, Patapoutian A, Merriam JR, Lengyel JA (1990) The Drosophila gene tailless is expressed at the embryonic termini and is a member of the steroid receptor superfamily. Cell 62: 151-163
16. Proudfoot NJ, Furger A, Dye MJ (2002) Integrating mRNA processing with transcription. Cell 108: 501-512
17. Schüpbach T, Wieschaus E (1986) Maternal-effect mutations altering the anterior-posterior pattern of the Drosophila embryo. Roux's Arch Dev Biol 195: 302-317
18. Seydoux G, Dunn MA (1997) Transcriptionally repressed germ cells lack a subpopulation of phosphorylated RNA polymerase II in early embryos of Caenorhabditis elegans and Drosophila melanogaster. Development 124: 2191-2201
19. Stein JA, Broihier HT, Moore LA, Lehmann R (2002) Slow as molasses is required for polarized membrane growth and germ cell migration in Drosophila. Development 129: 3925-3934
20. Strome S, Lehmann R (2007) Germ versus soma decisions: Lessons from flies and worms. Science 316: 392-393
21. Van Doren M, Williamson AL, Lehmann R (1998) Regulation of zygotic gene expression in Drosophila primordial germ cells. Curr Biol 8: 243-246
22. Wieschaus E (1996) Embryonic transcription and the control of developmental pathways. Genetics 142: 5-10
23. Wieschaus E, Sweeton D (1988) Requirements for X-linked zygotic gene activity during cellularization of early Drosophila embryos. Development 104: 483-493